Neurology Alert articles from January 2003

Neurology Alert archives from January 2003

Do dietary antioxidants prevent Alzheimer's disease?
January 1, 2003... ABSTRACT & COMMENTARY Sources: Engelhart MJ, et al. Dietary intake of antioxidants and risk of Alzheimer disease. JAMA. 2002;287:3223-3229; Morris MC, et al. Dietary intake of antioxidant nutrients and the risk of incident Alzheimer...

Fibrates, statins, and myopathy.
January 1, 2003... ABSTRACT & COMMENTARY Source: Wortmann RL. Lipid-lowering agents and myopathy. Curr Opin Rheumatology. 2002;14:643-647. NICOTINIC ACID, FIBRATES, AND STATINS (HMG COA reductase inhibitors), by lowering serum lipid levels, reduce...

Dopamine agonists for Parkinson's monotherapy.
January 1, 2003... Source: Clarke CE, Guttman M. Dopamine agonist monotherapy in Parkinson's disease. Lancet. 2002;360:1767-1769. ABSTRACT & COMMENTARY THE AVAILABILITY OF NEW DOPAMINE AGONISTS, pergolide (Permax), ropinirole (Requip), and pramipexole...

Effects of losartan on cardiovascular morbidity and mortality in patients with isolated systolic hypertension and LVH. (Clinical Briefs in Primary Care[TM]).(left ventricular hypertrophy)(Brief Article)
January 1, 2003... Source: Kjeldsen SE, et al. JAMA. 2002;1491-1498. SINCE THE EARLY 1990s IT HAS BEEN recognized that left ventricular hypertrophy (LVH) is an important prognostic indicator for cardiovascular morbidity and mortality. More recently, it has...

Increase in nocturnal blood pressure and progression to microalbuminuria in type 1 diabetes. (Clinical Briefs in Primary Care[TM]).(Brief Article)
January 1, 2003... Source: Lurbe E, et al. N Engl J Med. 2002;347:797-805. IT HAS BEEN NOTED THAT AMONG persons with type I diabetes (DM-l), hypertension (HTN) often develops concomitantly with occurrence of microalbuminuria (MAU). Closer investigation with...

HRT, lipid, and glucose metabolism in diabetic and nondiabetic postmenopausal women. (Clinical Briefs in Primary Care[TM]).(hormone replacement therapy)(Brief Article)
January 1, 2003... Source: Crespo CJ, et al. Diabetes Care. 2002;25:1675-1680. LIKE CARDIOVASCULAR DISEASES, type 2 diabetes (DM-2) increases in postmenopausal women. Prospective randomized interventional trials have not shown a benefit for hormone...

Effects of long-term treatment with ACE inhibitors in the presence or absence of aspirin. (Clinical Briefs in Primary Care[TM]).(Brief Article)
January 1, 2003... Source: Teo Koon K, et al. Lancet. 2002;360:1037-1043. BOTH ANGIOTENSIN CONVERTING enzyme inhibitors (ACEI) and aspirin (ASA) have a proven valuable track record in a variety of cardiovascular preventive and therapeutic areas. One of the...

Long-term risks associated with atrial fibrillation: 20-year follow-up of the Renfrew/Paisley study. (Clinical Briefs in Primary Care[TM]).(Brief Article)
January 1, 2003... Source: Simon S, et al. Am J Med. 2002;113:359-364. MOST OF THE STUDIES OF ATRIAL fibrillation (AF) that address cardiovascular (CV) consequences provide only short-term or intermediate-term insight (6 months-24 months). Long-term...

Olfactory impairment in older adults. (Clinical Briefs in Primary Care[TM]).(Brief Article)
January 1, 2003... Source: Murphy C, et al. JAMA. 2002;288:2307-2312. DESPITE WIDESPREAD ATTENTION to the demographics and management of hearing and visual impairments in older adults, there has been little study of olfactory impairments (OLF). Olfactory...

FDA approves Claritin for OTC use for seasonal rhinitis. (Pharmacology Watch).(over-the-counter)
January 1, 2003... After years of legal wrangling, the FDA has approved loratadine (Claritin, Schering-Plough) as an over-the-counter (OTC) product for the treatment of seasonal rhinitis. Loratadine is considered a nonsedating antihistamine, and its OTC approval...

Alzheimer's vaccination re-examined.
January 1, 2003... ABSTRACTS & COMMENTARY Sources: Hock C, et al. Nature Medicine. 2002;8(11): 1270-1275; McLaurin J, et al. Nature Medicine. 2002; 8(11):1263-1269; Pfeifer M, et al. Science. 2002;298:1379. WHEN TRIALS OF ELAN'S ANI792 VACCINE FOR...

Warfarin vs aspirin in AF: a meta-analysis.(atrial fibrillation)
January 1, 2003... ABSTRACT & COMMENTARY Source: van Walraven C, et al. Oral anticoagulation vs aspirin in nonvalvular atrial fibrillation: An individual patient meta-analysis. JAMA. 2002;288:2441-2448. PATIENTS WITH NONVALVULAR ATRIAL FIBRILLAtion (AF)...

Late breakers.
January 1, 2003... FDA New Drug Approval Watch Aripiprazole (Abilify), a new drug for schizophrenia, received FDA approval November 15, 2002. Aripiprazole is a joint product of both Bristol-Myers Squibb and Otsuka Pharmaceutical Co. Aripiprazole is the first...