Journal of Clinical Pathology articles from September 2001

Journal of Clinical Pathology archives from September 2001

Bone marrow aspiration.
September 1, 2001... Abstract Bone marrow aspiration biopsies are carried out principally to permit cytological assessment but also for immunophenotypic, cytogenetic, molecular genetic, and other specialised investigations. Often, a trephine biopsy is...

D-Dimer testing: the role of the clinical laboratory in the diagnosis of pulmonary embolism.
September 1, 2001... Abstract Pulmonary embolism is a common, yet often unsuspected and unrecognised disease associated with a high mortality. New, objective, "user friendly" and cost effective diagnostic strategies are being explored. D-Dimers, the...

Immune responses to tumour antigens: implications for antigen specific immunotherapy of cancer.
September 1, 2001... Abstract Tumour associated antigens recognised by cellular or humoral effectors of the immune system are potential targets for antigen specific cancer immunotherapy. Different categories of cancer antigens have been identified that...

Current problems in the development of specific immunotherapeutic approaches to cancer.
September 1, 2001... Over the past decade there has been a widespread resurgence of interest in the concept of cancer immunotherapy and the design of new cancer vaccines. The discovery of tumour specific and tumour associated antigens has resulted in a large...

Whither smooth muscle antibodies in the third millennium?(chronic active hepatitis research)
September 1, 2001... Lupoid hepatitis (now known as autoimmune hepatitis type I) was defined as an autoimmune disease by Mackay and colleagues in 1965. [1] An immunological marker of the disease was identified by Johnson et al in 1965 in the form of an...

Gastric intestinal metaplasia: subtypes and natural history.(Statistical Data Included)
September 1, 2001... Abstract Background--It has been suggested that the subtyping of intestinal metaplasia in the stomach is useful in stratifying patients with regard to risk of developing gastric cancer. Aim--To determine whether subtyping intestinal...

Immunohistochemical analysis of candidate gene product expression in the duodenal epithelium of children with coeliac sprue.
September 1, 2001... Abstract Background--Coeliac sprue is a chronic disease, in which there is a characteristic mucosal lesion of the small intestine and impaired nutrient absorption, which improves upon the withdrawal of wheat gliadins and related grain...

Loss of heterozygosity at cylindromatosis gene locus, CYLD, in sporadic skin adnexal tumours.(Statistical Data Included)
September 1, 2001... N Leonard [*] R Chaggar [*] Abstract Aim--The gene for familial cylindromatosis (CYLD) has been localised to chromosome 16q, and has recently been cloned. Loss of heterozygosity (LOH) at l6q has also been demonstrated in...

Optimising testing for phospholipid antibodies.(Statistical Data Included)
September 1, 2001... Abstract Aim--To compare anticardiolipin (ACL) and anti-[beta]2 glycoprotein 1 ([beta]2gp1) enzyme linked immunosorbent assays (ELISAs) in the diagnosis of antiphospholipid syndrome (APS) and to incorporate these results into a...

Uncertainty in estimating blood ethanol concentrations by analysis of vitreous humour.(Statistical Data Included)
September 1, 2001... Abstract Aims--To determine the concentrations of ethanol in femoral venous blood (FVB) and vitreous humour (VH) obtained during forensic necropsies. The ratios of ethanol concentrations in VH and FVB, the reference interval, and the...

Association between TNF-[alpha] promoter polymorphism and Helicobacter pylori cagA subtype infection.(Statistical Data Included)
September 1, 2001... Abstract Aims--To assess the importance of tumour necrosis factor [alpha] (TNF-[alpha] promoter polymorphism in relation to infection with the cytotoxin associated gene A (cagA) subtype of Helicobacter pylori within a dyspeptic Korean...

Adrenal lipomatous tumours: a 30-year clinico-pathological experience at a single institution.
September 1, 2001... Abstract Aims--Fatty tumours of the adrenal gland are uncommon and their features have received little attention in the literature. The aim of this study is to analyse the features of adrenal lipomatous tumours. Methods--The...

Long term recovery of IgG and IgM production during HIV infection in a patient with common variable immunodeficiency (CVID).
September 1, 2001... Abstract Aims--Common variable immunodeficiency (CVID) is the most common serious primary immunodeficiency. This paper describes the immunological consequences of human immunodeficiency virus (HIV) infection in a patient with familial...

Angiosarcoma arising from skeletal haemangiomatosis in an atomic bomb survivor.
September 1, 2001... Abstract The authors report a unique case in which an angiosarcoma arose from skeletal haemangiomatosis in a 72 year old man. This patient had a history of atomic bomb irradiation more than 50 years ago. Radiographically, the patient had...

Multifocal squamous cell carcinoma of the oesophagus following radiotherapy for bilateral breast carcinoma.
September 1, 2001... Abstract A 60 year old woman who presented with dysphagia and weight loss was found to have multiple foci of dysplasia and in situ and invasive squamous cell carcinoma scattered along the whole length of the oesophagus, with intervening...

Evidence of nerve sheath differentiation and high grade morphology in sclerosing epithelioid fibrosarcoma.
September 1, 2001... Abstract Sclerosing epithelioid fibrosarcoma is a recently described sarcoma in which ultrastructural evidence of fibroblastic differentiation forms part of the diagnostic criteria. This report describes a further case of this tumour,...

Peripheral blood lymphocyte appearance in a case of I cell disease.
September 1, 2001... Abstract In general, peripheral blood smears are performed to obtain information with regard to various morphological features as an aid in the diagnosis of infection or malignancy. This report presents a patient with I cell disease...

Merkel cell carcinoma can be distinguished from metastatic small cell carcinoma using antibodies to cytokeratin 20 and thyroid transcription factor 1.
September 1, 2001... Abstract Aim--To investigate whether immunohistochemical staining for cytokeratin 20 (CK20) and thyroid transcription factor 1 (TTF-1) is useful in distinguishing Merkel cell carcinomas (MCCs) from metastatic small cell carcinomas...

Dual colour FISH in paraffin wax embedded bone trephines for identification of numerical and structural chromosomal abnormalities in acute myeloid leukaemia and myelodysplasia.(Fluorescence in situ hybridization)
September 1, 2001... Abstract Aims/Background-The advent of new treatments for haematological malignancies has led to the need for a correlation between cytogenetic and morphological abnormalities. This study aimed to achieve this by the application of...

Correspondence.
September 1, 2001... Acridine orange stain in the histological identification of Helicobacter pylori The recent paper by Rotimi and colleagues [1] does nor mention the acridine orange stain [2] when comparing staining methods for the identification of...

Correction.
September 1, 2001... Predominant fatty variant of myeloblastoma of breast. Baxendine-Jones J, Theaker JM, Baldwin LJ. J Clin Pathol 2001;54:568-9. The correct author listing should have been Baxendine-Jones J, Baldwin LJ, Bateman AC, Theaker JM.