Journal of Clinical Pathology articles from March 2001

Journal of Clinical Pathology archives from March 2001

Application of quantitative techniques for the assessment of gastric atrophy.
March 1, 2001... Atrophic gastritis is seen as the result of long standing Helicobacter pylon infection and recent studies have shown that circulating IgG antibodies to CagA are associated with this condition. Gastric atrophy is also seen in patients with...

Papillomavirus research update: highlights of the Barcelona HPV 2000 international papillomavirus conference.
March 1, 2001... Abstract The 18th international papillomavirus conference took place in Barcelona, Spain in July 2000. The HPV clinical workshop was jointly organised with the annual meeting of the Spanish Association of Cervical Pathology and...

Antioxidants in health and disease.
March 1, 2001... Abstract Free radical production occurs continuously in all cells as part of normal cellular function. However, excess free radical production originating from endogenous or exogenous sources might play a role in many diseases....

Antibodies to extractable nuclear antigens. Has technological drift affected clinical interpretation?
March 1, 2001... Abstract Precipitating antibodies to extractable nuclear antigens are important in the diagnosis of connective tissue diseases. Disease associations are defined using gel based techniques. Alternative technologies have been introduced,...

Diagnosis of severe combined immunodeficiency.
March 1, 2001... Abstract Early diagnosis of severe combined immunodeficiency (SCID) is important to enable prompt referral to a supraregional centre for bone marrow transplantation before the occurrence of end organ damage secondary to infective...

The usefulness of tyrosinase in the immunohistochemical assessment of melanocytic lesions: a comparison of the novel T311 antibody (anti-tyrosinase) with S-100, HMB45, and A103 (anti-melan-A).
March 1, 2001... Abstract Aim--To compare the sensitivity and staining pattern of the new immunohistochemical antibody to tyrosinase (T311) with S-100, HMB45, and the recently evaluated antibody to melan-A (A103) in a range of melanocytic lesions. ...

Downregulation of transforming growth factor [beta] type II receptor in laryngeal carcinogenesis.
March 1, 2001... Abstract Aims--To investigate whether anomalies of transforming growth factor [beta] type II receptor (TGF-[beta] RII) expression occur in the early stages of laryngeal carcinogenesis and to assess their importance in the development of...

Acute erythremic myelosis (true erythroleukaemia): a variant of AML FAB-M6.(acute myeloid leukemia)
March 1, 2001... Abstract Aims--Classic erythroleukaemia (acute myeloid leukaemia M6, or M6 AML) is defined as an excess of myeloblasts in an erythroid predominant background. Leukaemia variants in which the primitive blast cells are demonstrably...

Immunohistochemical study of the expression of MUC5AC and MUC6 in breast carcinomas and adjacent breast tissues.
March 1, 2001... Abstract Aim-To study the protein expression patterns of MUC5AC and MUC6 in normal and diseased breast tissues and to compare their expression with that of a mucin (MUC1) normally expressed in mammary tissues. Methods--Formalin...

Overwhelming infection in asplenic patients: current best practice preventive measures are not being followed.
March 1, 2001... Abstract Aims--Patients without spleens are at increased risk of overwhelming infection. Recently, greater efforts, including the publication of national guidelines, have been made to improve the management of asplenic individuals. In...

Genetic diversity in the Helicobacter pylori cag pathogenicity island and effect on expression of anti-CagA serum antibody in UK patients with dyspepsia.
March 1, 2001... Abstract Aims--To investigate variation within the cag pathogenicity island (PAI) of Helicobacter pylor isolated from patients with dyspepsia in mid-Essex, and to evaluate the effect on expression of anti-CagA antibody. ...

Expression of killer cell inhibitory receptors is restricted to true NK cell lymphomas and a subset of intestinal enteropathy-type T cell lymphomas with a cytotoxic phenotype.
March 1, 2001... D F Dukers [*] M H Vermeer [*] Abstract Background/Aims--Killer inhibitory receptors (KIR) have a modulating effect on the cytotoxic functions of natural killer (NK) cells and T cells. Because lymphoma cells often have the same...

Expression of cyclins and cyclin dependent kinases in human benign and malignant melanocytic lesions [*].
March 1, 2001... Abstract Aims--The regulation of cell proliferation is a key event in normal development, pathophysiological responses to injury, and tumorigenesis. The orderly progression of cells through the cell cycle depends on a finely tuned...

Macrocryosectioning of the prostate: a simple technique.(prostate cancer diagnosis)
March 1, 2001... Abstract Whole mount sections of the prostate are widely used in many laboratories. Macrocryosections of the gland; that is, whole mount frozen sections of the prostate from radical prostatectomies represent a useful new research...

Detection of fastidious bacteria in cardiac valves in cases of blood culture negative endocarditis.
March 1, 2001... Abstract The diagnosis of blood culture negative endocarditis is still a problem. Fastidious bacteria such as bartonella and coxiella are responsible for cases of blood culture negative endocarditis, the identification of which is mainly...

Solid and papillary epithelial neoplasm arising in heterotopic pancreatic tissue of the mesocolon.
March 1, 2001... Abstract Aim--Solid and papillary epithelial neoplasm (SPEN) is an uncommon pancreatic tumour. Very rarely it has also been described outside the pancreas, usually arising from heterotopic pancreatic tissue. This report summarises all...

What constitutes a histological confirmation of cancer? A survey of terminology interpretation in two English regions.
March 1, 2001... Abstract Aims--To compare interpretation by cancer registries and histopathologists of phrases that might confirm a diagnosis of cancer. Methods--One hundred and thirty one consultant pathologists were sent a questionnaire containing...

Evidence for loss of heterozygosity of 5q in sporadic haemangiomas: are somatic mutations involved in haemangioma formation?
March 1, 2001... J N Berg [*] J W Walter [*] Abstract Background/Aims--Haemangiomas are common benign tumours of infancy that consist of rapidly proliferating endotheial cells. A locus for an autosomal dominant predisposition to haemangioma has...

Illustrated Pathology of the Spleen.(Review)
March 1, 2001... Illustrated Pathology of the Spleen. Wilkins B, Wright D. ([pound]65.00.) Cambridge University press, 2000. ISBN 0 521 62227 1. Illustrated Pathology of the Spleen by Bridget Wilkins and Dennis Wright is a beautiful book. It is a pleasure...

IgA Nephropathy: from Molecules to Man.(Review)
March 1, 2001... IgA Nephropathy: from Molecules to Man. Tomino Y. (S99.25.) Karger, 1999. ISBN 3 8055 6833 9. This book is volume 126 in the "Contributions to nephrology" series. Its stated purposes are to review the author's work on IgA nephropathy and...

The Principles of Clinical Cytogenetics.(Review)
March 1, 2001... The Principles of Clinical Cytogenetics. Gersen SL, Keagle MB, eds. ($79.50.) Humana Press, 1999. ISBN 0 89603 533 0. This book is introduced as being "suitable for cytogenetic technologists and clinicians alike", and at first glance,...

Rotaviruses, Methods and Protocols: Methods in Molecular Medicine.(Review)
March 1, 2001... Rotaviruses, Methods and Protocols. Methods in Molecular Medicine. Gray J, Desselberger U, eds. (US$89.50.) Humana Press, 1999. ISBN 0-896-03736-3. In the UK between January 1989 and December 1999 there were 164 279 reports to the PHLS...

Stomatology-ENT. Brocheriou C, Baglin AC.(Review)
March 1, 2001... Stomatology-ENT. Brocheriou C, Baglin AC, Wassef M, et al. ($149.00.) Springer-Verlag, 1998. ISBN 3 540 14654 7 This CD ROM of stomatology-ENT is a reference image database of the field of ENT. It is in English and in French. It contains...