Journal of Clinical Pathology articles from January 2004

Journal of Clinical Pathology archives from January 2004

Guidelines for virological and non-viral serological examination of specimens in routine diagnostic microbiological laboratories; best practice no 175.(ACP)
January 1, 2004... Viral examination is routinely carried out in most routine diagnostic microbiology laboratories. Most often, this comprises the detection of viral antigens and antibodies, and less commonly the isolation of viruses and the detection of viral...

The eicosanoid cascade: possible role in gliomas and meningiomas.(Review)
January 1, 2004... Eicosanoids constitute a large family of biologically active lipid mediators that are produced by two enzyme classes, cyclooxygenases (COX-1 and COX-2) and lipoxygenases (5-LO, 12-LO, and 15-LO). Increasing evidence suggests that in addition...

Tissue grading system is a reliable assay of response to treatment in gastric MALT lymphoma.(Echo)
January 1, 2004... A histological grading system for gastric MALT lymphoma after treatment looks to be a promising tool for assessing residual disease in prospective drug trials. A pilot study has confirmed that the system has good internal reproducibility. ...

Micrometastases in neuroblastoma: are they clinically important?(Review)
January 1, 2004... Despite advances in the treatment of neuroblastoma (NBL), recurrence and metastases continue to pose major problems in clinical management. The relation between micrometastases and the development of secondary disease is not fully understood....

Minimal metastatic disease: clinical importance in neuroblastoma.(Editorial)
January 1, 2004... The article by Burchill (1) in this issue casts light on major technical advances in our ability to detect ever smaller numbers of neuroblastoma cells in the peripheral blood and bone marrow of children with this disease. But what of the...

Effects of clinical service reorganisation on cellular pathology workload.(Original Article)
January 1, 2004... Aims: To assess changes in volume and complexity of cellular pathology workload after clinical service reorganisation and alterations in pathology reporting practices, and to identify objective measures of change applicable to all cellular...

The impact of involvement of biomedical scientists in specimen dissection and selection of blocks for histopathology: a study of time benefits and specimen handling quality in Ayrshire and Arran area laboratory.(Original Article)
January 1, 2004... Aims: To assess possible time benefits of specimen dissection by biomedical scientists (BMSs) and the quality of specimen handling by BMSs, in a department where BMSs trim those specimens requiring simple descriptions, from which standard...

Decreased mineralocorticoid receptor expression in blood cells of kidney transplant recipients undergoing immunosuppressive treatment: cost efficient determination by quantitative PCR.(Original Article)
January 1, 2004... Aims: Electrolyte imbalances caused by impaired ion transport are a frequent side effect of immunosuppressive treatment in renal transplant recipients. Clinical symptoms resemble features of hypoaldosteronism, although concentrations of...

Prevalence of gastric precancerous lesions in Ardabil, a high incidence province for gastric adenocarcinoma in the northwest of Iran.(Original Article)
January 1, 2004... Background/Aims: Ardabil Province, in northwestern Iran, has the highest rate of gastric (predominantly cardia) adenocarcinoma in Iran. This study aimed to investigate the feasibility of endoscopic screening and to look for associated...

Lymph node harvests directly influence the staging of colorectal cancer: evidence from a regional audit.(Original Article)
January 1, 2004... Aims: To assess the quality of histopathology reporting and accuracy of Dukes's staging of colorectal cancers in the former South Western Health region and to determine the impact of numbers of lymph nodes examined on stage ascription. ...

Hep Par 1 expression in carcinoma of the cervix: implications for diagnosis and prognosis.(Original Article)
January 1, 2004... Aims: To determine the frequency and pattern of Hep Par 1 expression in cervical carcinomas of various histological types and to correlate expression with prognostic parameters. Methods: Twenty nine cervical carcinomas were analysed for...

Red cell [N.sup.5]-methyltetrahydrofolate concentrations and C677T methylenetetrahydrofolate reductase genotype in patients with stroke.(Original Article)
January 1, 2004... Aims: To investigate the relation between total red cell folate, red cell [N.sup.5]-methyltetrahydrofolate ([N.sup.5]MTHF) concentrations, and [N.sup.5][N.sup.10]-methylenetetrahydrofolate reductase (MTHFR) genotypes in stroke. Methods:...

Patients have no appetite for HSV-2 screening.(Echo)
January 1, 2004... Halting the spread of herpes simplex virus type 2 (HSV-2) in the UK remains a distant prospect, after a pilot study has shown that uptake of a type specific herpes antibody test would be too low to be effective. The study examined...

Analysis of cell cycle regulator proteins in non-small cell lung cancer.(Original Article)
January 1, 2004... Background/Aims: Abnormalities of the proteins involved in cell cycle checkpoints are extremely common among almost all neoplasms. This study aimed to investigate the expression of four components of the cell cycle machinery--p21, p16, p53,...

Histopathological patterns of melanoma metastases in sentinel lymph nodes.(Original Article)
January 1, 2004... Aims: Sentinel lymph node biopsy (SLNB) is an important component in the staging and treatment of cutaneous melanoma (CM). The medical literature provides only limited information regarding melanoma sentinel lymph node (SLN) histology. This...

Multiple high risk HPV infections are common in cervical neoplasia and young women in a cervical screening population.(Original Article)
January 1, 2004... Aims: If human papillomavirus (HPV) testing is to be included within cervical screening programmes, the importance of multiple HPV infections in cervical neoplasia needs to be determined. This study investigated the diversity of multiple HPV...

Factors affecting metastases to non-sentinel lymph nodes in breast cancer.(Original Article)
January 1, 2004... Aims: Because sentinel lymph node (SLN) biopsy for breast cancer has become well established, one of the challenges now is to determine which patients require a completion axillary dissection following a positive SLN biopsy. Methods: A...

Expression of DC-SIGN in human foreskin may facilitate sexual transmission of HIV.(Letter to JCP)
January 1, 2004... This study demonstrates that the human immunodeficiency virus (HIV) binding C-type lectin DC-SIGN is coexpressed with CD4 and CCR5 on dendritic cells/marcophages in human foreskin. It is hypothesised that DC-SIGN may contribute to the sexual...

HCV and HIV binding lectin, DC-SIGNR, is expressed at all stages of HCV induced liver disease.(Letter to JCP)
January 1, 2004... The process by which hepatitis C virus (HCV) enters cells and the reason for its hepatotropism remain obscure. Recently, the human immunodeficiency virus (HIV) binding lectins, DC-SIGN and DC-SIGNR, were shown to bind HCV. This article...

Clinical phenotype of haemoglobin Q-H disease.(Letter to JCP)
January 1, 2004... Seven patients of Chinese origin who had haemoglobin (Hb) Q-H disease were studied. They were found to have a similar clinical phenotype to that of patients with deletional Hb H disease, who have a near identical genotypic configuration. The...

Collagenous spherulosis in an adenomyoepithelioma of the breast.(Case Report)
January 1, 2004... Collagenous spherulosis (CS) is an incidental finding that usually occurs in association with benign proliferative and preinvasive lesions. Adenomyoepithelioma is a biphasic neoplasm of the breast, composed of both luminal epithelial and...

Interdigitating dendritic cell sarcoma of salivary gland associated lymphoid tissue not associated with HHV-8 or EBV infection.(Case Report)
January 1, 2004... Interdigitating dendritic cell sarcoma (IDCS) is an extremely rare malignancy derived from professional antigen presenting cells. This report describes a case of IDCS arising in the salivary gland associated lymphoid tissue of the parotid...

Primary sclerosing epithelioid fibrosarcoma of the sacrum: a case report and review of the literature.(Case Report)
January 1, 2004... Sclerosing epithelioid fibrosarcoma is a rare tumour characterised histologically by a predominant population of epithelioid cells arranged in strands and nests, embedded in a fibrotic and hyalinised stroma. It is a low grade tumour with an...

Characterisation of hexon and fibre genes of a novel strain of adenovirus involved in epidemic keratoconjunctivitis.(Short Report)
January 1, 2004... Aims: To characterise a novel strain (M86) of adenovirus (Ad) involved in epidemic keratoconjunctivitis (EKC). Methods/Results: The virus strain was neutralised by antisera to both Ad35 and Ad11. Restriction endonuclease analysis of...

Peroperative frozen section analysis of TTF-1 antigen expression.(Short Report)
January 1, 2004... Background: The assessment of thyroid transcription factor 1 (TTF-1) expression is a useful way to investigate the origin of lung adenocarcinomas or large cell carcinomas when dealing with a solitary lung nodule in a patient with a history of...

Influence of recipient and donor IL-1[alpha], IL-4, and TNF[alpha] genotypes on the incidence of acute renal allograft rejection.(Short Report)
January 1, 2004... Aims: To determine whether polymorphisms of the genes encoding donor or recipient interleukin 1[alpha] (IL-1[alpha]), tumour necrosis factor [alpha] (TNF[alpha]), or IL-4 have any impact on the incidence of acute rejection after renal...

A comparison of igG anti-rubella activity in frozen serum stored in primary gel separation tubes or secondary tubes.(Short Reports)
January 1, 2004... Aims: To determine the suitability of primary gel separation tubes for the storage of frozen sera intended for serological testing. Methods: Blood samples from 102 patients were collected into gel separation tubes. The sera from these...

Isolated bone marrow mycosis in a patient presenting with consumptive symptoms.(Postscript)
January 1, 2004... J Clin Pathol 2004;57:107-112 The incidence of systemic mycoses is increasing as a result of the escalating number of patients who are immunocompromised because of diabetes mellitus, haemodialysis, organ and bone marrow transplants,...

The exploding bullet.(Postscript)
January 1, 2004... The article entitled "Health and safety at necropsy" by Julian Burton provides a detailed and well written narrative regarding both the risks and hazards faced by professionals during postmortem examinations. (1) Despite the presence of a...

The role of mast cells in bone marrow diseases.(Postscript)
January 1, 2004... We read the article by Horny et al describing bone marrow mast cell (MC) specific protease expression patterns in cases of systemic mastocytosis and myelodysplastic syndromes (MDS) with great interest. (1) An increase in bone marrow MCs is a...

Malignant transformation of a recurrent vestibular schwannoma.(Postscript)
January 1, 2004... Malignant nerve sheath tumours are uncommon tumours, particularly those that affect cranial nerves. They are most frequently seen within the context of neurofibromatosis type II. Malignant transformation of benign cranial nerve sheath tumours...

Best practice guideline on microbiological investigation of infertility requires further review.(Postscript)
January 1, 2004... The best practice guideline on the investigation of infertility briefly comments on appropriate microbiological investigations. (1) However, there are several issues that we feel merit further consideration. The need to check the rubella...

Pathology of the Pancreas, Gallbladder, Extrahepatic Biliary Tract and Ampullary Region.
January 1, 2004... Pathology of the Pancreas, Gallbladder, Extrahepatic Biliary Tract and Ampullary Region Lack E. ([pounds sterling]145.00.) Oxford University Press, 2003. ISBN 0 19 5133927. Superb! The author has succeeded in producing an excellent...

Worms and Human Disease--Second Edition.
January 1, 2004... Worms and Human Disease--Second Edition Muller R. ([pounds sterling]35.00.) Cabi Publishing, 2002. ISBN 0 85199 516 0. This book is the second edition of Worms and disease: a manual of medical helminthology first published in 1975....

Cancer Cytogenetics: Methods and Protocols.
January 1, 2004... Cancer Cytogenetics: Methods and Protocols Swansbury J, ed. ($89.50.) Humana Press, 2003. ISBN 1588290808. The discovery of the Philadelphia chromosome by Nowell and Hungerford in 1960 greatly stimulated interest in cancer...

Manual of Clinical Microbiology, 8th Edition.
January 1, 2004... Manual of Clinical Microbiology, 8th Edition Murray P R, Baron E J, Jorgensen J H, et al, eds. ($189.95.) ASM Press, 2003. 1 55581 255 4. The manual of clinical microbiology, published by ASM Press, is a favourite of mine because of...

Cytokines and Chemokines in Infectious Diseases Handbook.
January 1, 2004... Cytokines and Chemokines in Infectious Diseases Handbook Kotb M, Calandra T. ($145.00.) Humana Press, 2003. ISBN 0 89603 908 0. Cytokines are soluble protein molecules that facilitate communication between cells of the immune system,...

Differential Diagnosis by Laboratory Medicine.
January 1, 2004... Differential Diagnosis by Laboratory Medicine Mesko D. ed. ([pounds sterling]35.00): Springer-Verlag, 2003. ISBN 3 540 43057 1. What do you do when you get phoned in your laboratory office by a clinical colleague asking you what...

Calendar of events.(Calendar)
January 1, 2004... Surgical Pathology for the Practising Pathologist 16-19 January 2004, Doubletree La Posada Resort, Scottsdale, Arizona, USA Further details: Department of Continuing Education, Harvard Medical School, PO Box 825, Boston, MA...

Correction.(Correction Notice)
January 1, 2004... The Scotland and Newcastle epidemiological study of Hodgkin's disease: impact on histopathological review and EBV status on incidence estimates. Jarrett RF, Krajewski AS, Angus B, et al. J Clin Pathol 2003;56:811-6. In the key to fig 3A EBV-...