Journal of Clinical Pathology articles from January 2003

Journal of Clinical Pathology archives from January 2003

Diagnostic role of tests for T cell receptor (TCR) genes. (Review).
January 1, 2003... Rapid advances in molecular biological techniques have made it possible to study disease pathogenesis at a genomic level. T cell receptor (TCR) gene rearrangement is an important event in T cell ontogeny that enables T cells to recognise...

Tumour suppressor genes do not regulate the cell cycle. (Echo).(Brief Article)
January 1, 2003... A study of thc effects of hamartin and tuberin on cell growth suggests that tuber in acts as a tumour suppressor gene--but not by regulating the cell cycle. The researchers induced transient overexpression of hamartin and tuberin in cell...

What is Good's syndrome? Immunological abnormalities in patients with thymoma. (Review).
January 1, 2003... Good's syndrome (thymoma with immunodeficiency) is a rare cause of combined B and T cell immunodeficiency in adults. The clinical characteristics of Good's syndrome are increased susceptibility to bacterial infections with encapsulated...

The investigation and management of obesity. (Best Practice No 168).
January 1, 2003... Obesity is a chronic condition characterised by an excess of body fat. It is a complex disorder of appetite regulation and energy metabolism controlled by specific biological factors. In the past 10 years, great progress has been made in the...

Comparative genomic hybridisation divides retinoblastomas into a high and a low level chromosomal instability group. (Original Article).
January 1, 2003... Background: Retinoblastoma is the most common intraocular malignancy in childhood and is responsible for approximately 1% of all deaths caused by childhood cancer. Aims/methods: Comparative genomic hybridisation was performed on 13...

Detection of telomerase, its components, and human papillomavirus in cervical scrapings as a tool for triage in women with cervical dysplasia. (Original Article).
January 1, 2003... Aim: To examine whether the detection of either telomerase and its components or high risk human papillomavirus (HPV) are of value in predicting the presence of cervical intraepithelial neoplasia (CIN) grade II/III in women referred because...

Serum Ro52 antibody denotes connective tissue disease. (Echo).(Brief Article)
January 1, 2003... Ahitherto unrecognised subgroup of patients can now be identified, since the discovery of another, independent, serum marker for connective tissue diseases. Eighteen serum samples among more than 1700 tested routinely for antinuclear...

Chromosomal translocation t(11;18)(q21;q21) in gastrointestinal mucosa associated lymphoid tissue lymphoma. (Original Article).
January 1, 2003... Aims: To evaluate the chromosomal translocation 1(1l;18)(q21;q21) in gastrointestinal lymphomas. Methods: A possible AP12--MLT fusion transcript specific to t(1l;l8)(q21;q21) was examined by means of reverse transcription-polymerase...

Corridor consultations and the medical microbiological record: is patient safety at risk? (Original Article).
January 1, 2003... The performance procedures of the General Medical Council are aimed at identifying seriously deficient performance in a doctor. The performance procedures require the medical record to be of a standard that enables the next doctor seeing the...

A systematic review of outcome measures reported for the therapeutic effectiveness of oral anticoagulation. (Original Article).
January 1, 2003... Aims: To evaluate the evidence of therapeutic international normalised ratio (INR) control reporting and to provide recommendations for future reporting, particularly for research and audit purposes. Methods: A systematic review of...

Myopathy and an unusual serum antibody point to a defined syndrome. (Echo).(Brief Article)
January 1, 2003... A study of patients presenting over three years with syndromes affecting skeletal muscles has found that those with serum antibody to the signal recognition particle (SRP) represent a defined syndrome. Empirical evidence suggests that early...

Endothelin B receptor gene hypermethylation in prostate adenocarcinoma. (Original Article).
January 1, 2003... Background: Alterations in the methylation patterns of promoter CpG islands have been associated with the transcriptional inhibition of genes in many human cancers. These epigenetic alterations could be used as molecular markers for the early...

PCR plus phylogenetics pin down group A coxsackievirus infections. (Echo).(Brief Article)
January 1, 2003... A study from Japan has confirmed the potential of PCR and phylogenetic analysis to enable identification of group A coxsackieviruses and diagnosis of illnesses they cause in children. Throat swabs cultured from 246 children with acute...

[p16.sup.INK4A] as a marker for cervical dyskaryosis: CIN and cGIN in cervical biopsies and ThinPrep smears. (Original Article).
January 1, 2003... Aim: To examine the potential of [p16.sup.INK4A] as a biomarker for dysplastic squamous and glandular cells of the cervix in tissue sections and ThinPrep[TM] smears. Methods: Immunocytochemical analysis of [p16.sup.INK4A] expression was...

Clinical, biochemical, and immunohistochemical features of necrobiotic xanthogranulomatosis. (Original Article).
January 1, 2003... Aims: To describe the clinical features of two patients with paraproteinaemia and necrobiotic xanthogranulomatosis together with detailed immunohistochemistry of the lesions in one. Methods: The clinical history and results of biochemical...

APC mutation and tumour budding in colorectal cancer. (Original Article).
January 1, 2003... Aim: To determine the frequency of tumour budding and somatic APC mutation in a series of colorectal cancers stratified according to DNA microsatellite instability (MSI) status. Material/Methods: Ninety five colorectal cancers were...

Low grade marginal zone B cell lymphoma of the breast associated with localised amyloidosis and corpora amylacea in a woman with long standing primary Sjogren's syndrome. (Case Report).
January 1, 2003... Primary low grade marginal zone B cell lymphoma (MZL) of the breast and localised mammary amyloidosis are exceedingly rare entities. This report describes the case of a woman with long standing Sjogren's syndrome presenting with asymptomatic...

New chemokines may have a role in vernal keratoconjunctivitis. (Echo).(Brief Article)
January 1, 2003... New attractants of T lymphocytes and several activation factors contribute to inflammation in vernal keratoconjunctivitis (VKC), a molecular study has found. The findings may help to explain how T lymphocytes are recruited to the conjunctiva....

Correspondence.
January 1, 2003... If you have a burning desire to respond to a paper published in Journal of Clinical Pathology, why not make use of our "rapid response" option? Log on to our website (www.jclinpath.com], find the paper that interests you, and send your...

Essentials of Anatomic Pathology. (Book Reviews).(Book Review)
January 1, 2003... Cheng L, Bostwick DG, eds. ($175.00.) Humana Press, 2002. ISBN 1 58829 118 9. What is the best format to store and transmit information? With the development of electronic storage media and the Internet, paper is not always the first...

Leucocyte Typing VII. (Book Reviews).(Book Review)
January 1, 2003... Mason D, ed. ([pounds sterling]225.00.) Oxford University Press, 2001. ISBN 019 263 25223. This book is the edited proceedings of the seventh conference or international workshop on white cell differentiation antigens held in Harrogate...

Biochemical Investigations in Laboratory Medicine. (Book Reviews).(Book Review)
January 1, 2003... Barth JH, Butler GE, Hammond P, eds. (324.00.) ACB Ventura Publications, 2001. ISBN 0 902429 34 5 I was considering buying this book but to my delight a gratis copy arrived on my desk to review. But would it have been worth purchasing?...