Journal of Clinical Pathology articles from February 2003

Journal of Clinical Pathology archives from February 2003

Evidence based pathology: squamous carcinoma of the hypopharynx. (Best Practice No 169).
February 1, 2003... This best practice article reviews the published evidence on the pathology and patterns of spread of carcinomas of the hypopharynx, and the relevance of pathological features to prognosis. Medline (1966-200]) was searched using a combination...

Micropurification techniques in the analysis of amyloid proteins. (Review).
February 1, 2003... This review describes the different microtechniques developed for the extraction and purification of amyloid proteins from small specimens of fresh and formalin fixed tissues. These procedures differ with respect to solvent type, extraction...

Classification and grading of the non-invasive urothelial neoplasms: recent advances and controversies. (Review).
February 1, 2003... The classification and grading of the non-invasive, intraepithelial neoplasms of the urothelium are based on the morphological pattern of growth--that is, papillary or flat (and endophytic)--and on their degree of architectural and...

Ewing's sarcoma: diagnostic, prognostic, and therapeutic implications of molecular abnormalities. (Review).
February 1, 2003... The identification of the non-random chromosome rearrangements between the EWS gene on chromosome 22q 12 and members of the ETS gene family in Ewing's sarcoma, peripheral primitive neuroectodermal tumour, Askin tumour, and neuroepithelioma...

Chymase expressing bone marrow mast cells in mastocytosis and myelodysplastic syndromes: an immunohistochemical and morphometric study. (Original Article).
February 1, 2003... Background: Two cell specific neutral proteases, tryptase and chymase, are produced by human mast cells (MC). Tryptase is constitutively expressed by all MC, whereas chymase is found only in an MC subset. Very little is known about chymase...

Expression and prognostic relevance of vascular endothelial growth factor (VEGF) and its receptor (FLT-1) in nephroblastoma. (Original Article).
February 1, 2003... Aims: To investigate the prognostic relevance of vascular endothelial growth factor (VEGF) and its receptor Flt-1 in nephroblastoma and whether tumour microvessel density (MVD) immunoreactivity, determined by the CD31 antigen, is related to...

European Concerted Action on Anticoagulation (ECAA). An assessment of lyophilised plasmas for ISI calibration of CoaguChek and TAS whole blood prothrombin time monitors. (Original Article).
February 1, 2003... Aims: The recommended method for the international sensitivity index {ISI} calibration of whole blood point of care testing (POCT) prothrombin time (PT) systems was originally described by Tripodi et al in 1993 but is too complex and...

Genetic characterisation of adenovirus type 8 isolated in Hiroshima city over a 15 year period. (Original Article).
February 1, 2003... Aims: To investigate the genetic differences among the strains of adenovirus type 8 (Ad8) circulating in Hiroshima city, Japan, and to study their circulation pattern. Methods: One hundred and twenty nine strains of adenovirus type 8...

The effects of storage conditions on viability of Clostridium difficile vegetative cells and spores and toxin activity in human faeces. (Original Article).
February 1, 2003... Aims: Clostridium difficile is a common nosocomial pathogen and as such diagnostic and research methods may necessitate storage of faecal specimens for long periods, followed by subsequent re-examination. This study investigated the effects...

A comparison of flow cytometry, bone marrow biopsy, and bone marrow aspirates in the detection of lymphoid infiltration in B cell disorders. (Original Article).
February 1, 2003... Aims: To evaluate the diagnostic value of bone marrow aspirates, trephine biopsies (BMB), and flow cytometry (FC) in the assessment of bone marrow infiltration in chronic lymphoid disorders. Methods: Investigations were carried out in 110...

Will the spectrum of lesions prompting a "B3" breast core biopsy increase the benign biopsy rate? (Original Article).
February 1, 2003... Aim: To audit the benign surgical biopsies in women screened, assessed, and referred by the Leeds/Wakefield Breast Screening Unit for the year 1999-2000 with a view to determining any association with a preoperative B3 core biopsy...

P-cadherin as a marker in the differential diagnosis of breast lesions. (Short Report).
February 1, 2003... Aims: To assess the value of the calcium dependent cell adhesion molecule P-cadherin as a myoepithelial marker in the differential diagnosis of benign and malignant breast lesions. Methods: Immunohistochemical analysis of normal breast,...

TGF-[beta] and transglutaminase 2 work together to cause cataracts. (Echo).
February 1, 2003... A molecular study has shown for the first time that transglutaminase 2 (TGase 2) overexpression induced by transforming growth factor [beta] (TGF-[beta]) is a key step in the development of some cataracts. The investigators showed TGase...

Differential expression of galectin 3 in solid cell nests and C cells of human thyroid. (Short Report).
February 1, 2003... J Clin Pathol 2003;56:142-143 Aims: To provide new insights into characterising solid cell nests and gain information that might help distinguish between solid cell nests and C cells. Methods: Thyroid tissue specimens from patients...

A simple method for the construction of small format tissue arrays. (Short Report).
February 1, 2003... Tissue arrays can evaluate molecular targets in high numbers of samples in parallel. Array construction presents technical difficulties and tissue arrayers are expensive, particularly for small and medium sized laboratories. This report...

Mitochondrial disruption and apoptosis in lymphocytes of an HIV infected patient affected by lactic acidosis after treatment with highly active antiretroviral therapy. (Case Report).
February 1, 2003... Aims: Highly active antiretroviral therapy (HAART) can induce an increase in lactic acid concentrations that seems to be caused by mitochondrial dysfunction induced by the interaction of nucleoside reverse transcriptase inhibitors (NRTIs)...

Urachal adenocarcinoma in situ with pseudomyxoma peritonei: a case report. (Case Report).
February 1, 2003... J Clin Pathol 2003;56:152-153 A 54 year old man presented with a six month history of abdominal pain. A computerised tomography scan showed a well defined intra-abdominal unilocular mass with a calcified wall just superior to the...

Myelofibrosis presenting as spinal cord compression. (Case Report).
February 1, 2003... This report describes a case of myelofibrosis presenting as spinal cord compression on account of extramedullary haemopoietic tissue encroaching upon the spinal cord from a large pelvic mass. Extramedullary haemopoiesis is a recognised...

Molten gold was poured down his throat until his bowels burst. (Historical Perspectives).
February 1, 2003... In 1599, a Spanish governor in early colonial Ecuador suffered this fate. Native Indians of the Jivaro tribe, unscrupulously taxed in their gold trade, attacked the settlement of Logrono and executed the gold hungry governor by pouring molten...

Correspondence.
February 1, 2003... If you have a burning desire to respond to a paper published in Journal of Clinical Pathology, why not make use of our "rapid response" option? Log on to our website (www.jclinpath.com), find the paper that interests you, and send your...

Cytopathology of Bone and Soft Tissue Tumours. (Book Reviews).(Book Review)
February 1, 2003... Layfield W. ([pounds sterling]115.00.) Oxford University Press, 2002. ISBN 0 19 513236 X. "Fine needle aspiration (FNA) is only now gaining acceptance as a primary modality for the study of musculoskeletal lesions." So opens the preface...

The Hospital Autopsy, 2nd ed. (Book Reviews).(Book Review)
February 1, 2003... Burton J, Rutty R, eds. ([pounds sterling]255.00.) Arnold, 2001. ISBN 034076420 1. Didactic information in a textbook cannot substitute for practical experience in gaining skill and dexterity in the performance of autopsies. However, the...

Handbook of Toxicologic Pathology, 2nd ed. (Book Reviews).(Book Review)
February 1, 2003... Haschek WM, Rousseaux CG, Wallig MA, eds. ([pounds sterling]330.00.) Academic Press, 2001 ISBN 0 123302153. My first impression on being asked to review this "hand book" was that I would need big hands to hold it for long! I found this a...