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Gene therapy for retinopathy of prematurity: the eye is a window to the future.
August 1, 2001... The eye is the window to the brain, the soul, and now perhaps even the future, with the exciting publication by Chowers et al in this month's issue of the BJO (p 991). The authors give us a view of the future as they elegantly demonstrate...
Optic disc changes following trabeculectomy.(Brief Article)
August 1, 2001... The reversal of optic disc cupping following pressure reduction by medical or surgical means has long been recognised, particularly in congenital and juvenile glaucoma. Less clear cut is whether this reversal is accompanied by any improvement...
Getting our journals to developing countries.(Brief Article)
August 1, 2001... For some years now it has been our policy to give free subscriptions to our journals to applicants from countries in the developing world. However, in practice this has had its difficulties. Many developing countries have either poor or...
"Don't worry my good man--you won't understand our medical talk" [1]: consent to treatment today.
August 1, 2001... Patient: " Do you really think this operation will make me see better, doctor?"
Doctor" Oh yes--it is a very good operation with a 98% success rate!"
Patient "Oh good! What does that mean doctor?"
Doctor: "Well... er...How long...
Blindness in Africa: present situation and future needs.
August 1, 2001... Abstract
Aim--To review the prevalence and causes of blindness in sub-Saharan Africa, the existing services and limitations, and the Vision 2020 goals for the future.
Methods--Methodologically sound population based surveys published...
Eyes in the back of your head.(visual field of American woodcock)
August 1, 2001... The American woodcock (Scolopax minor, although the older name, Philohela minor from the Greek meaning "loving marsh" seems much more appropriate) is a shy upland game bird, which is a member of the sandpiper family. This species and its...
Amniotic membrane grafts, "fresh" or frozen? A clinical and in vitro comparison.
August 1, 2001... Abstract
Backgroundlaims--The use of "fresh" (hypothermically stored) and frozen amniotic membrane (AM) was compared in a patient with cicatricial pemphigoid with stem cell failure. The viability of both "fresh" and frozen AM epithelial...
Combined phototherapeutic keratectomy and therapeutic contact lens for recurrent erosions in bullous keratopathy.
August 1, 2001... Abstract
Aims--To evaluate the therapeutic effects of excimer laser phototherapeutic keratectomy (PTK) combined with therapeutic contact lens for painful recurrent corneal erosions (RCE) secondary to bullous keratopathy (BK) not suitable...
A comparison of different depth ablations in the treatment of painful bullous keratopathy with phototherapeutic keratectomy.(Statistical Data Included)
August 1, 2001... Abstract
Aim--To study the efficacy of phototherapeutic keratectomy (PTK) for pain relief for patients with painful bullous keratopathy and poor visual potential.
Methods--Patients with painful bullous keratopathy and poor visual...
The cornea in young myopic adults.(Statistical Data Included)
August 1, 2001... Abstract
Aims--To further understand the effect of refractive error on the corneal dimensions and function.
Methods--Corneal curvature, corneal thickness, and axial length measurements were performed, as well as specular microscopy...
Ocular hypotensive efficacy and safety of once daily carteolol alginate.(Statistical Data Included)
August 1, 2001... for the Once-daily Carteolol Study Group
Abstract
Backgroundlaim--Carteolol is a [beta] adrenoceptor antagonist used topically to reduce intraocular pressure, typically twice daily. In an effort to provide a once daily dosing...
Is the pulse rate useful in assessing risk of diabetic retinopathy and macular oedema? The Wisconsin Epidemiological Study of Diabetic Retinopathy.(Statistical Data Included)
August 1, 2001... Abstract
Aim--To describe the relation between pulse rate and incident diabetic retinopathy.
Methods--Population based cohort study of people with diabetes. Resting pulse rate was measured in 30 second intervals. Diabetic...
Electrophysiological changes after 360[degrees] retinotomy and macular translocation for subfoveal choroidal neovascularisation in age related macular degeneration.(Statistical Data Included)
August 1, 2001... Abstract
Aim--To evaluate electrophysiological changes after 3600 retinotomy and macular translocation for subfoveal choroidal neovascularisation in patients with age related macular degeneration (AMD).
Methods--A consecutive series...
Reduced incidence of retinopathy of prematurity.(Statistical Data Included)
August 1, 2001... Abstract
Aim--To audit the prevalence of retinopathy of prematurity (ROP) in a level 2 status neonatal unit.
Methods--Data were collected prospectively over 9 years from September 1989 to September 1998. Preterm infants were examined...
Outcome of cataract surgery in patients with retinitis pigmentosa.(Statistical Data Included)
August 1, 2001... Abstract
Aim--To determine the visual benefit of cataract extraction in patients with retinitis pigmentosa and to identify risk factors for poor outcome.
Methods--A retrospective analysis was undertaken of a continuous series of 142...
Accuracy of intraocular lens power calculation in paediatric cataract surgery.(Statistical Data Included)
August 1, 2001... Abstract
Aims--To determine the accuracy of intraocular lens (IOL) power calculation in a group of pseudophakic children.
Methods--A retrospective analysis of biometric and refractive data was performed on 52 eyes of 40 infants and...
Combined phacoemulsification and transpupillary drainage of silicone oil: results and complications.(Statistical Data Included)
August 1, 2001... Abstract
Aim--To review retrospectively 74 consecutive cases of combined phacoemulsification and transpupillary drainage of silicone oil.
Methods--Candidate patients for intraocular silicone oil removal and cataract extraction...
The suitability of the ultrasound biomicroscope for establishing texture in giant cell arteritis.
August 1, 2001... Abstract
Aim--To establish whether ultrasound biomicroscope (UBM) is a helpful tool in locating the arterial segment responsible in patients with segmental attacks in giant cell arteritis
Methods--The superficial temporal arteries of...
Palisaded encapsulated neuroma (solitary circumscribed neuroma of skin) of the eyelid: report of two cases and review of the literature.
August 1, 2001... Abstract
Backgroundlaims--Palisaded encapsulated neuroma of the skin (PEN) is an uncommon benign neural tumour that occurs on the head and neck, including the eyelid, but is unfamiliar to many ophthalmic clinicians. For the first time in...
The use of a newspaper insertion to promote DIY testing of vision in India.
August 1, 2001... Abstract
Background--The mass media have the potential to motivate people to participate in self appraisal of their own health status. An innovative communication package was designed to help people to examine vision at home. The impact...
Optic disc changes following trabeculectomy: longitudinal and localisation of change.(Statistical Data Included)
August 1, 2001... Abstract
Aims--To determine whether there were any changes in the optic disc at 2 years after trabeculectomy. To determine the factors that most influenced change and whether change was localised to any region of the optic disc.
...
A 7 year prospective comparative study of three topical [beta] blockers in the management of primary open angle glaucoma.(Statistical Data Included)
August 1, 2001... Abstract
Aim--To determine the long term efficacy of monotherapy with topically applied [beta] blocking agents and to determine whether selective [beta] blockers were able to preserve the visual field more effectively than non-selective...
Evaluation of the G protein coupled receptor-75 (GPR75) in age related macular degeneration.(Statistical Data Included)
August 1, 2001... Abstract
Background--A long term project was initiated to identify and to characterise genes that are expressed exclusively or preferentially in the retina as candidates for a genetic susceptibility to age related macular degeneration...
Ultrasound biomicroscopy of the peripheral retina and the ciliary body in degenerative retinoschisis associated with pars plana cysts.(Statistical Data Included)
August 1, 2001... Abstract
Aim--To evaluate the ciliary body and peripheral retina in degenerative retinoschisis associated with pars plana cysts using ultrasound biomicroscopy (UBM).
Methods--18 eyes of 12 patients with degenerative retinoschisis...
Meta-analysis of randomised controlled trials comparing latanoprost with timolol in the treatment of patients with open angle glaucoma or ocular hypertension.(Statistical Data Included)
August 1, 2001... Abstract
Aim--To evaluate the comparative efficacy and tolerance of latanoprost versus timolol through a meta-analysis of randomised controlled trials (RCTs).
Methods--Systematic retrieval of RCTs of latanoprost versus timolol to...
Gene transfer by viral vectors into blood vessels in a rat model of retinopathy of prematurity.
August 1, 2001... Abstract
Aims--To test the feasibility of gene transfer into hyaloid blood vessels and into preretinal neovascularisation in a rat model of retinopathy of prematurity (ROP), using different viral vectors.
Methods--Newborn rats were...
In situ immunohistochemical study of Bcl-2 and heat shock proteins in human corneal endothelial cells during corneal storage.
August 1, 2001... Abstract
Aim--To investigate the expression of Bcl-2 and heat shock proteins (HSPs), which are known to increase cell survival, in human corneal endothelial cells (HCECs) of corneas stored in organ culture.
Methods--32 paired corneas...
Single dose intranasal administration of retinal autoantigen generates a rapid accumulation and cell activation in draining lymph node and spleen: implications for tolerance therapy.
August 1, 2001... Abstract
Backgroundlaims--A single intranasal delivery of retinal autoantigen suppresses effectively experimental autoimmune uveoretinitis (EAU). To further unravel underlying mechanisms the authors wished to determine, firstly, the...
The Eye Book. Eyes and Eye Problems Explained.(Review)
August 1, 2001... The Eye Book. Eyes and Eye Problems Explained. By Ian Grierson. [pound]12.95; pp 218.
Liverpool: Liverpool University Press, 2000. ISBN 0-85323-755-7.
The cover of The Eye Book states that it is written for anyone needing to wear...
Fundamentals of Clinical Ophthalmology: Scleritis.(Review)
August 1, 2001... Fundamentals of Clinical Ophthalmology: Scleritis. By Peter McCluskey. (Series editor: Susan Lightman.) [pound]40; pp 130. London: BMJ Books, 2001. ISBN 072791586X.
Seleritis is part of a book series Fundamentals of Clinical...
Electrophysiologic Testing in Disorders of the Retina, Optic Nerve, and Visual Pathway.(Review)
August 1, 2001... Electrophysiologic Testing in Disorders of the Retina, Optic Nerve, and Visual Pathway. 2nd ed. By Gerald A Fishman, David G Birch, Graham E Holder, Mitchell G Brigell. Pp 308;$95. San Francisco: American Academy of Ophthalmology, 2001. ISBN...