Gut articles from March 2001

Gut archives from March 2001

Retractions in Gut 10 years after publication.(retractions of "Experimental non-steroidal anti-inflammatory drug induced enteropathy in the rat--similarities to inflammatory bowel disease and effect of thromboxane synthetase inhibitors" in issue 1990;31:1358-64 and "Sulphasalazine reduces indomethacin induced changes in small intestinal permeability in man" (Banerjee A, Sherwood R, Rennie JA, Peters TJ) in issue 1990;31:A593)
March 1, 2001... It is with great regret that I include in this issue of the journal a retraction order for a paper authored by Dr Anjan Banerjee and Professor Tim Peters, which was published in Gut in 1990 when they were employed by King's College Hospital....

Blood, urine, stool, breath, money, and Helicobacter pylori.(non-invasive testing methods for Helicobacter pylori infection diagnosis)
March 1, 2001... Helicobacter pylori infection can be diagnosed by invasive (that is, endoscopy and biopsy) and non-invasive techniques. The choice of a diagnostic test should depend on the clinical circumstances, the pre-test probability of infection,...

Helicobacter pylori associated gastric B cell MALT lymphoma: predictive factors for regression.
March 1, 2001... Experimental data have extended the knowledge of the mere association of gastric mucosa associated lymphoid tissue (MALT) lymphoma and infection with Helicobacter pylori. The acquisition of MALT in the stomach is a direct consequence of the...

Interaction of trefoil family factors with mucins: clues to their mechanism of action?
March 1, 2001... Tomasetto C, Masson R, Linaires J-L, et al. pS2/TFF1 interacts directly with the VWFC cysteine-rich domains of mucins. Gastroenterology 2000;118:70-80 Abstract The trefoil peptides or trefoil factor family (TFFs) are a group of...

Lack of effect of intravenous azathioprine on time to respond for steroid treated Crohn's disease.
March 1, 2001... Sandborn WJ, Tremaine WJ, Wolf DC, et al. Lack of effect of intravenous administration on time to respond to azathioprine for steroid-treated Crohn's disease. Gastroenterology 1999;117:527-35. Aim To assess whether intravenous...

Predictive factors for regression of gastric MALT lymphoma after anti-Helicobacter pylori treatment.(Abstract)
March 1, 2001... A Ruskone-Fourmestraux, A Lavergne, P H Aegerter, F Megraud, L Palazzo, A de Mascarel, T Molina, J-C L Rambaud, the Groupe d'Etude des Lymphomes Digestifs (GELD) Abstract Background and aims--Discrepant remission rates (41-100%) have...

Secular trends in the epidemiology and outcome of Barrett's oesophagus in Olmsted County, Minnesota.(Statistical Data Included)
March 1, 2001... Abstract Background--The incidence of oesophageal adenocarcinoma has increased greatly. Barrett's oesophagus is a known risk factor. Aims--To identify changes in the incidence, prevalence, and outcome of Barrett's oesophagus in a...

Correlation of oesophageal acid exposure with Barrett's oesophagus length.
March 1, 2001... Abstract Background--Gastro-oesophageal reflux disease (GORD) plays a major role in th development of Barrett's oesophagus However, it has yet to be elucidated what factors determine the length of Barrett' mucosa in each individual...

Endoscopic fluorescence detection of low and high grade dysplasia in Barrett's oesophagus using systemic or local 5-aminolaevulinic acid sensitisation.
March 1, 2001... Abstract Background and aims--Barrett's oesophagus is associated with an increased risk of cancer. As dysplasia is not visible during routine endoscopy, random biopsies in the four quadrants every 1-2 cm are recommended. Endoscopic...

Genetically related Escherichia coli strains associated with Crohn's disease.
March 1, 2001... Abstract Escherichia coli strains isolated from patients with Crohn's disease (CD) with chronic ileal lesions (n=14), early endoscopic recurrent lesions (n=20), without endoscopic recurrence (n=7), and controls (n=21) were compared by...

Increased expression of IL-16 in inflammatory bowel disease.
March 1, 2001... Abstract Background--Inflammatory bowel disease (IBD) is characterised by infiltration of inflamed mucosal regions with [CD4.sup.+] T lymphocytes and other mononuclear cells. Interleukin (IL)-16 exerts a strong chemoattractant activity...

Cryptogenetic multifocal ulcerous stenosing enteritis: an atypical type of vasculitis or a disease mimicking vasculitis.
March 1, 2001... Abstract Backgroundlaims--Crypto genetic multi-focal ulcerous stenosing enteritis (OMUSE) is a rare disease whose origin is unknown. The aim of this study was to describe the clinical spectrum of GMUSE, to determine the origin and...

Selective inhibition of COX-2 in humans is associated with less gastrointestinal injury: a comparison of nimesulide and naproxen.
March 1, 2001... Abstract Background--Selective inhibitors of cyclooxygenase (COX)-2 may provoke less gastric damage and platelet inhibition than conventional non-steroidal anti-inflammatory drugs. Aims--We compared the biochemical and...

Role of duodenal lipid and cholecystokinin A receptors in the pathophysiology of functional dyspepsia.
March 1, 2001... Abstract Background/aims--We aimed to evaluate the role of fat and cholecystokinin (CCK) in the pathophysiology of functional dyspepsia (FD) by investigating symptoms and plasma CCK levels following increasing doses of duodenal lipid...

Topical phenylephrine increases anal canal resting pressure in patients with faecal incontinence.
March 1, 2001... Abstract Introduction--The internal anal sphincter receives a stimulatory [alpha.sub.1] adrenergic innervation. Use of an adrenergic agonist may therefore have a role in treating patients with faecal incontinence. Methods--Ten...

Tumour infiltrating lymphocytes and apoptosis are independent features in colorectal cancer stratified according to microsatellite instability status.
March 1, 2001... Abstract Background--The presence of high level DNA microsatellite instability (MSI-H) in colorectal cancer is associated with an improved prognosis, as is the presence of tumour infiltrating lymphocytes (TILs). It is not clear if TILs...

Hypermethylation of the promoter region of the E-cadherin gene (CDH1) in sporadic and ulcerative colitis associated colorectal cancer.
March 1, 2001... Abstract Background--Ulcerative colitis associated colorectal cancer (UCACRC) has several distinctive clinicopathological and genetic features which differ from sporadic colorectal cancer (SCRC). Hypermethylation of the E-cadherin gene...

Detection of hypermethylation of the [p16.sup.INK4A] gene promoter in chronic hepatitis and cirrhosis associated with hepatitis B or C virus.
March 1, 2001... Abstract Backgroundlaim--Inactivation of the [p16.sup.INK4A] (p16) tumour suppressor gene by promoter region hypermethylation has been demostrated not only in many types of tumours, including hepatocellular carcinoma (HCC), but also in...

Induction of autoantibodies to the adrenal cortex and pancreatic islet cells by interferon alpha therapy for chronic hepatitis C.
March 1, 2001... Abstract Backgroundlaims--Interferon alpha (IFN-[alpha]) therapy for chronic hepatitis C may trigger induction of autoixnmunity against several organs. Immune reactions against distinct adrenocortical protein antigens involved in adrenal...

Abdominal decompression plays a major role in early postparacentesis haemodynamic changes in cirrhotic patients with tense ascites.
March 1, 2001... Abstract Background--Some cirrhotic patients with tense ascites who undergo paracentesis develop a circulatory dysfunction syndrome, manifested by an increase in plasma renin activity. Recently, a significant inverse correlation between...

Transjugular intrahepatic portosystemic shunt (TIPS) versus endoscopic variceal ligation in the prevention of variceal rebleeding in patients with cirrhosis: a randomised trial.
March 1, 2001... Abstract Background and aims--The transjugular intrahepatic portosystemic shunt (TIPS) is a new therapeutic modality for variceal bleeding. In this study we compared the two year survival and rebleeding rates in cirrhotic patients...

HLA and interleukin 1 gene polymorphisms in primary biliary cirrhosis: associations with disease progression and disease susceptibility.
March 1, 2001... Abstract Background and aims--Twin and family studies suggest that there is a genetic component to primary biliary cirrhosis (PBC) but the genetic associations which have been described are weak with marked variations between centres....

K-ras mutations in the bile of patients with primary sclerosing cholangitis.
March 1, 2001... Abstract Background and aims--The development of cholangiocarcinoma (CCC) is a complication of primary sclerosing cholangitis (PSC). To date, no reliable factors have been described which can define those PSC patients at high risk for...

The causes of obvious jaundice in South West Wales: perceptions versus reality.
March 1, 2001... Abstract Aims--(1) A prospective analysis of clinically obvious jaundice (bilirubin [greater than]120 [micro]mol/l in South Wales to determine accuracy of diagnosis, referral pattern, treatment, and outcome. (2) To compare British...

Increased sphincter of Oddi basal pressure in patients affected by gall stone disease: a role for biliary stasis and colicky pain?
March 1, 2001... Abstract Background and aims--Even if the motor activity of the gall bladder and sphincter of Oddi (SO) are integrated, it is not known if the presence of stones in the gall bladder affects SO function. The aim of the study was to...

FAS engagement drives apoptosis of enterocytes of coeliac patients.
March 1, 2001... Abstract Background--Villus atrophy is the most distinctive sign of untreated coeliac disease (CD) and epithelial apoptosis is considered to be involved in this stage of the coeliac lesion. The extent of villus atrophy is, however, not...

Role of interferon [alpha] in promoting T helper cell type 1 responses in the small intestine in coeliac disease.
March 1, 2001... Abstract Coeliac disease (CD) is caused by a CD4 T helper cell type 1 (Th1) response in the small intestinal mucosa to dietary gluten. As the major Thi inducing cytokine, interleukin 12, is undetectable in CD gut mucosa, the mechanism by...

Increased colorectal neoplasia in chronic ulcerative colitis complicated by primary sclerosing cholangitis: fact or fiction?
March 1, 2001... Summary It is well accepted that patients with ulcerative colitis (UC) are at increased risk of developing colorectal carcinoma. Since 1992, several studies have examined the hypothesis that patients with concomitant primary sclerosing...

Potential benefits and hazards of physical activity and exercise on the gastrointestinal tract.
March 1, 2001... Summary This review describes the current state of knowledge on the hazards of exercise and the potential benefits of physical activity on the gastrointestinal tract. In particular, acute strenuous exercise may provoke gastrointestinal...

CORRECTION.(title in Abstract A277 in 200;47(supplIII) should read "Disposable versus reusable endoscopic biopsy forceps: comparison of costs and histological quality")(Correction Notice)
March 1, 2001... Abstract A277 in Gut 2000;47(suppl III) contained errors. The title should read "Disposable versus reusable endoscopic biopsy forceps: comparison of costs and histological quality", and the complete author list is C Lejeune, P Prost, C...

USE OF THE SIMPLE CLINICAL COLITIS ACTIVITY INDEX (SCCAI) TO DEFINE RELAPSE OF ULCERATIVE OLITIS (UC).(Abstract)
March 1, 2001... C.J. Seal [1] Newcastle University at North Tyneside Hospital, North Shields NE29 8NH, UK; (1.) Dept of Biological & Nutritional Sciences, Newcastle University NE1 7RU, UK Background: Several tools exist to assess disease activity in...

A RANDOMISED TRIAL OF INTRAVENOUS PAMIDRONATE AND CALCIUM & VITAMIN D IN THE TREATMENT OF OSTEOPOROSIS ASSOCIATED WITH CROHN'S DISEASE.(Abstract)
March 1, 2001... S.A. Bartram [1] R.M. Francis [1] N.P. Thompson [2] (1.) Musculoskeletal Unit, (2.) Dept of Gastroenterology, Freeman Hospital, Newcastle-upon-Tyne NEI9 2HP, UK Introduction: Osteoporosis is recognised as a common...

CAN LEFT-SIDED ULCERATIVE COLITIS BE TREATED WITH EPIDERMAL GROWTH FACTOR ENEMAS?(Abstract)
March 1, 2001... A. Sinha [1] J.M.D. Nightingale [1] K.P. West [1] J. Berlanga-Acosta [3] R.J. Playford [4] (1.) University Hospitals, Leicester, Leicester University; (3.) CIGB, Havana, Cuba; (4.) Imperial College School of Medicine,...

DIETS CAN MODULATE THE INFLAMMATORY RESPONSE IN VIVO AND IN VITRO.(Abstract)
March 1, 2001... Adult and Paediatric Gastroenterology, Queen Mary, University of London, London ECIA 7BE, UK Nutritional therapy is recognised as a useful therapeutic modality in IBD. It is as successful as corticosteroids in producing clinical...

ANTI-INFLAMMATORY EFFECT OF ELEMENTAL DIET IN VITRO DEPENDS ON FATTY ACID COMPOSITION.(Abstract)
March 1, 2001... D. Meister [1] M. C. Aldhous [1] J. Bode [1] A. Shand [1] W. Johnson [2] S. Giffen [2] S. Ghosh [1] (1.) GI Laboratory, Dept of Medical Sciences, University of Edinburgh, Western General Hospital, Edinburgh;...

A RANDOMISED CONTROLLED TRIAL OF HIGH VERSUS LOW LONG CHAIN TRIGLYCERIDE WHOLE PROTEIN FEED IN ACTIVE CROHN'S DISEASE.(Abstract)
March 1, 2001... K. Leiper [1] J. Woolner [2] M. M. C. Mullan [2] T. Parker [2] M. van der Vleit [1] S. Fear [1] J. M. Rhodes [1] J. O. Hunter [2] (1.) Gastroenterology Research Group, Dept of Medicine, University of...

LONGTERM OUTCOME OF U.C. PATIENTS WITH AND WITHOUT LOW GRADE DYSPLASIA (LGD).(Abstract)
March 1, 2001... C. H. Lim [1] M. F. Dixon [2] A. Vail [3] D. Forman [4] D. A. F. Lynch [5] A. T. R. Axon [1] (1.) Centre for Digestive Diseases, Leeds General Infirmary; (2.) Academic Unit of Pathology, University of Leeds;...

IMPACT OF THE TWO WEEK WAITING TIME STANDARD ON THE GASTROENTEROLOGY SERVICE OF A DISTRICT GENERAL HOSPITAL (DGH).(Abstract)
March 1, 2001... Combined Gastroenterology Services, Scarborough Hospital, Woodlands Drive, Scarborough Y012 6QL, UK The two week waiting time standard for suspected gastrointestinal cancers came into effect in July 2000. There are concerns that this may...

MOLECULAR GENETIC TESTS IN FAMILIAL ADENOMATOUS POLYPOSIS MAY GUIDE MANAGEMENT DECISIONS.(Abstract)
March 1, 2001... The Polyposis Registry, ICRF Colorectal Cancer Unit, St Marie's Hospital, Harrow, UK Introduction: Familial adenomatous polyposis (FAP) is caused by a germline mutation on the APC gene. Management usually involves a prophylactic...

DUODENAL CANCER IN FAMILIAL ADENOMATOUS POLYPOSIS.(Abstract)
March 1, 2001... C.J. Groves [1] B.P. Saunders [1] A.D. Spigelman [2] R.K.S. Phillips [1] (1.) St Mark's Hospital, Harrow, Middlesex, UK; (2.) University of Newcastle, New, Australia Background: Prophylactic colectomy in familial...

HYPERPLASTIC POLYPOSIS: PREVALENCE AND CANCER RISK.(Abstract)
March 1, 2001... ICRF Colorectal Cancer Unit, St Mark's Hospital, London, United Kingdom Background: WHO defines hyperplastic polyposis (HPP) as [greater than or equal to]30 hyperplastic polyps (HP) throughout the colon and/or 5 histologically diagnosed...

FEELING THE BLUES IN FUNCTIONAL GUT PAIN: MANIPULATING MOOD STATE INFLUENCES THE THRESHOLD FOR OESOPHAGEAL PAIN.(Abstract)
March 1, 2001... E. Watkins [1] R. Howard [1] A. Hobson [2] Q. Aziz [2] (1.) Institute of Psychiatry, De Crespigny Park, Denmark Hill, London; (2.) Dept of Gastroenterology, Hope Hospital, Stott Lane, Salford, UK Since functional...

DOES IRRITABLE BOWEL SYNDROME (IBS) PRECEDE OR FOLLOW INFECTIOUS DIARRHOEA (ID)?(Abstract)
March 1, 2001... Dept of Gastroenterology, Regional School of Medicine, North Tyneside Hospital, Rake Lane, North Shields NE29 8NH, UK Introduction: Irritable bowel syndrome (IBS) has been reported to follow infectious diarrhoea (ID) [1,2,3]. ID affects...

WIND-UP IN THE HUMAN VISCERA: CENTRAL SENSITIZATION CONTRIBUTES TO VISCERAL PAIN.(Abstract)
March 1, 2001... C.J. Woolf [1] (1.)Dept of Gastrointestinal Science, Hope Hospital, Salford, UK; (1.) Dept of Anaesthesia and Critical Care, Massachusetts General Hospital, Boston, MA, USA Background: Perceptual wind-up is the progressive increase...

PROSTAGLANDIN [E.sub.2] RECRUITS SENSORY NEURONS TO RESPOND TO ACID.(Abstract)
March 1, 2001... J.I.W. Jones [1] J.L. Brough [1] P. Milns [2] D. Kendall [2] C.J. Hawkey [1] (1.) Division of Gastroenternoloy (2.) School of Biomedical Sciences, University Hospital, Nottingham NG7 2UH, UK Introduction:...

INFLAMMATORY BOWEL DISEASE IN THE COMMUNITY: DISEASE PROFILE, HEALTHCARE UTILIZATION, IMPACT ON LIFESTYLE AND PRODUCTIVITY.(Abstract)
March 1, 2001... Dept of Gastroenterology, Bromley Hospital, Kent, UK Aim: To ascertain demographic and clinical characteristics, healthcare utilisation and impact of disease on lifestyle/productivity in community patients with inflammatory bowel disease...

AN ANALYSIS OF THE HOSPITAL COSTS OF INFLAMMATORY BOWEL DISEASE IN UK.(Abstract)
March 1, 2001... Liver Unit, St Jame's University Hospital, Beckett Street, Leeds, UK The economic burden of inflammatory bowel disease (IBD) on society and health care systems is high due their occurrence during the economically productive years and...

DOES BETTER DISEASE RELATED EDUCATION IMPROVE QUALITY OF LIFE? A SURVEY OF IBD PATIENTS.(Abstract)
March 1, 2001... Dept of Gastroenterology, Hull Royal Infirmary, Anlaby Road, Hull HU13 OEL, UK Background and aims: The importance of Health Related Quality of Life (HRQOL) assessment in patients with chronic disorders such as inflammatory bowel disease...

HELICOBACTER PYLORI INFECTION REDUCES SYSTEMIC AVAILABILITY OF DIETARY VITAMIN C.(Abstract)
March 1, 2001... Dept of Medicine & Therapeutics, Western Infirmary, Glasgow, Scotland, UK H. pylori infection is recognized to lower the concentration of vitamin C in gastric juice. The objective of this study was to assess whether this effect of the...

ADAM17 AND TIMP3 mRNA EXPRESSION IN GASTRIC MUCOSA INFECTED WITH H. PYLORI AND IN GASTRIC CANCER.(Abstract)
March 1, 2001... M.F. Dixon [1] A.T.R. Axon [1] Molecular Medicine Unit, St. James's University Hospital; (1.)Leeds General Infirmary, Leeds, UK Introduction: ADAM17 (a disintegrin and metalloproteinase) protein is implicated in the shedding...

HELICOBACTER PYLORI LEADS TO DECREASED SURFACE EXPRESSION OF [beta]-CATENIN IN EPITHELIAL CELLS.(Abstract)
March 1, 2001... J.R. Bebb [1] L. Leach [2] J.C. Atherton [1] (1.) Division of Gastroenterology & Institute of Infections and Immunity and (2.) School of Biomedical Sciences, University Hospital, Nottingham, UK Background: H.pylori is...

"TWO WEEK WAIT" GUIDELINES FOR UPPER GASTROINTESTINAL CANCER - DO THEY WORK?(Abstract)
March 1, 2001... (introduced by S.A. Riley). Dept of Gastroenterology, Northern General Hospital, Sheffield S5 7AU, UK Introduction: National guidelines have recently been introduced with the aim of facilitating the earlier diagnosis and treatment of...

QUALITY OF LIFE AFTER HELICOBACTER PYLORI ERADICATION: A LARGE PROSPECTIVE STUDY IN PRIMARY CARE.(Abstract)
March 1, 2001... Dept of Gastroenterology, Hull Royal Infirmary, Anlaby Road, Hull, HU13 OEL, UK Introduction: Eradication of Helicobacter pylori (HP) and amelio ration of dyspeptic symptoms may improve quality of life (QOL) of patients with various...

BENEFIT OF HELICOBACTER PYLORI ERADICATION IN THE TREATMENT OF ULCER-LIKE DYSPEPSIA IN PRIMARY CARE.(Abstract)
March 1, 2001... G. Baxter [1] (1.) Wyeth Laboratories, Taplow, UK Background: The role of Helieobacter pylon (Hp) eradication in patients without confirmed ulcer is unclear. The majority of studies have been conducted in secondary care on patients...

HYPNOTHERAPY IS EFFECTIVE IN THE LONG-TERM TREATMENT OF FUNCTIONAL DYSPEPSIA.(Abstract)
March 1, 2001... Dept of Medicine, University Hospital of South Manchester, M20 2LR, UK We have shown hypnotherapy (HT) to be highly effective in the treatment of irritable bowel syndrome (IBS), with long term improvements in both symptoms and quality of...

IV PROTON PUMP INHIBITORS (PPI) WITH OR WITHOUT ENDOSCOPIC THERAPY PREVENT REBLEEDING AND SURGERY IN PATIENTS WITH PEPTIC ULCER HAEMORRHAGE (PUH)--A META-ANALYSIS OF RANDOMISED CONTROLLED TRIALS (RCTS).(Abstract)
March 1, 2001... V.K. Sharma [1] G.I. Leontiadis [2] C.W. Howden [3] (1.) University of Arkansas for Medical Sciences, Little Rock, AR, USA; (2.) "G. Papanikolaou" Hospital, Thessaloniki, Greece; (3.) Northwestern University, Chicago,...

REBOUND MAXIMAL ACID HYPERSECRETION AFTER OMEPRAZOLE PERSISTS TO AT LEAST 11 MONTHS AFTER TREATMENT.(Abstract)
March 1, 2001... Dept of Medicine & Therapeutics, Western Infirmary, Glasgow, Scotland, UK Introduction: We have previously reported that there is significant rebound maximal acid hypersecretion in H. pylon negative healthy subjects at 1 to 8 weeks after...

OESOPHAGITIS, A RISK FACTOR FOR OESOPHAGEAL CANCER.(Abstract)
March 1, 2001... JA Todd [1] T Weston [2] D Steinke [2] DA Johnston [2] JF Dillon [2] (1.) Peterborough District Hospital, Peterborough, PE3 6DA; (2.) Ninewells Hospital & Medical School, Dundee, DD1 9SY, UK Background:...

ONE YEAR FOLLOW-UP OF ARGON PLASMA COAGULATION (APC) ABLATION OF BARRETT'S EPITHELIUM (BE).(Abstract)
March 1, 2001... University Hospitals of Leicester NHS Trust, Leicester, UK Introduction: The aim of BE ablation is to reduce malignant potential which is related to BE extent. APC is effective for ablation but the long-term effects are unclear. Aim:...

CLINICAL OUTCOME AND LONG-TERM SURVIVAL FOLLOWING RADICAL OESOPHAGECTOMY IN THE ELDERLY.(Abstract)
March 1, 2001... Northern Oesophago-Gastric Cancer Unit, Ward 36 Office, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK Background: Oesophagectomy is considered an especially high-risk procedure in elderly patients. The aim of this study was...

A NEW APPROACH TO THE TREATMENT OF INOPERABLE CARCINOMA OF THE OESOPHAGUS: LASER AND RADICAL CHEMORADlATION THERAPY.(Abstract)
March 1, 2001... L.B. Lovat [1] C.H. Bridgewater [2] T. Evans [2] S.M. Thorpe [1] G.M. Blackman [2] S.G. Bown [1] J. Tobias [2] (1.)National Medical Laser Centre, Royal Free and University College School of Medicine,...

WHAT HAPPENS TO ENDOSCOPIC ULTRASOUND (EUS) STAGE T4 OESOPHAGEAL CANCERS? A COMPARISON WITH STAGE T3 TUMOURS.(Abstract)
March 1, 2001... I. Ahmad [1] R. Kerwat [2] R.H. Hardwick [2] J. Manson [3] D. Richards [4] A.B. Hawthorne [1] S.A. Roberts [4] (1.) Depts of Gastroenterology (2.) General Surgery, University Hospital of Wales, Cardiff;...

WHAT IS THE ROLE OF ENDOSCOPIC ULTRASOUND (EUS) FOLLOWING CHEMOTHERAPY FOR OESOPHAGAL CARCINOMA: ARE WE ASKING THE RIGHT QUESTIONS?(Abstract)
March 1, 2001... A. Antoniou [1] Endosonography Centre, Guy's and St. Thomas' Hospital, London; (1.) Dept of Surgery, Queen Mary's Hospital, Sidcup, UK Background: EUS is superior to CT for T/N staging of oesophageal tumours, however like all...

DO GASTRIC "ULCER-CANCERS" PRESENT DIFFERENTLY TO "MASS-CANCERS"?(Abstract)
March 1, 2001... S.J. Panter [1] H. O'Flanagan [2] M.G. Bramble [1] (1.) Endoscopy Centre, South Cleveland Hospital, Middlesbrough and Centre for Health Studies, University of Durham; (2.) NoReN Middlesbrough, Teesside, UK Aims: The aim...

INTERCOLLEGIATE NATIONAL-BSG COLONOSCOPY (IBNC) AUDIT: IDENTIFICATION AND MANAGEMENT OF POLYPS DIAGNOSED AT COLONOSCOPY.(Abstract)
March 1, 2001... C.J.A. Bowles [1] R. Leicester [2] E. Swarbrick [3] C.B. Williams [4] C. Romaya [5] O. Epstein [1] (1.) Royal Free Hospital, London; (2.) St George's Hospital, London; (3.) New Cross Hospital,...

A PROSPECTIVE AUDIT OF COLONOSCOPY IN A LARGE DGH--FACTORS EFFECTING CAECAL INTUBATION RATES.(Abstract)
March 1, 2001... J. Robinson [1] P. Small [1] G.D. Bell [2] I. Crighton [1] J. Corson [1] J. Hancock [1] D. Nylander [2] H. Mitchison [2] (1.) Depts of Surgery and (2.) Gastroenterology, Sunderland Royal Hospital,...

INTERCOLLEGIATE-BSG NATIONAL COLONOSCOPY (IBNC) AUDIT: METHODS USED TO IDENTIFY THE CAECUM AND CAECAL INTUBATION RATE.(Abstract)
March 1, 2001... C.J.A. Bowles [1] R. Leicester [2] E. Swarbrick [3] C.B. Williams [4] C. Romaya [5] O. Epstein [1] (1.) Royal Free Hospital, London; (2.) St George's Hospital, London; (3.) New Cross Hospital,...

SILENT MYOCARDIAL ISCHAEMIA DURING ENDOSCOPIC RETROGRADE CHOLANGIO-PANCREATOGRAPHY (ERCP).(Abstract)
March 1, 2001... Division of Gastroenterology, Ulster Hospital Dundonald, Belfast, N. Ireland, UK Background: Myocardial ischaemia (defined as ST depression [greater than] 1mm) may predispose patients to ischaemic complications, for example, arrhythmias...

ENDOSCOPY IN PRIMARY CARE: A SURVEY OF STRUCTURES, SERVICES AND STANDARDS.(Abstract)
March 1, 2001... Endoscopy Subcommittee PCSG Background: Long hospital waiting lists and savings from fundholding have contributed to an increase in endoscopy services in primary care. Concerns about safety, supervision and cost effectiveness have been...

"WAITING LIST INITIATIVE" COLONOSCOPY LISTS; ARE THEY VALUE FOR MONEY? A REVIEW OF THE INITIAL 12 MONTHS EXPERIENCE.(Abstract)
March 1, 2001... South Cleveland Hospital Endoscopy Unit, Middlesbrough, UK Trusts have been under increasing pressure to reduce waiting times for all specialities. In Gastroenterology, one solution has been to provide extra 'out of hours' sessions, which...

WORKLAND AND DYNAMICS OF A DGH OUTPATIENT CLINIC: BALANCING THE BOOKS.(Abstract)
March 1, 2001... Dept of Gastroenterology, Sunderland Royal Hospital, Sunderland, UK Background: Maintaining GI outpatient (GOP) targets and keeping clinic size manageable, requires the number of new patients (NP) plus follow up patients (FUP) to be...

IS AGE 45 AN APPROPRIATE CUT OFF POINT FOR OPEN ACCESS ENDOSCOPY?(Abstract)
March 1, 2001... This retrospective study looks at cumulative experience from a district general hospital in the south east of England in order to determine if the present age cut off for open access endoscopy in patients with dyspepsia of 45 could reasonably...

ENDOSCOPIC ULTRASOUND IN THE MANAGEMENT OF GASTROINTESTINAL SUBMUCOSAL TUMOURS.(Abstract)
March 1, 2001... E.F. Shen [1] J. Plevris [2] I.D. Penman [1] (1.) Western General Hospital (2.) Royal Infirmary, Edinburgh, UK Introduction: "Submucosal" tumours (SMT) in the upper gastrointestinal tract (UGI) maybe hard to evaluate....

SUBSTITUTION OF ENDOSCOPIC ULTRASOUND (EUS) FOR ERCP: IMPLICATIONS FOR SERVICE DEVELOPMENT AND TRAINING.(Abstract)
March 1, 2001... Endosonography Centre, Guys' and St. Thomas' Hospital, London, UK Background: Endoscopic ultrasound (EUS) provides an accurate, safe and rapid method for visualizing the biliary tract, EUS obviates the risks of pancreatitis and...

ENDOSCOPIC MRI IN SUSPECTED OESOPHAGEAL CANCER.(Abstract)
March 1, 2001... U. Dave [1] Z. Amin [2] M.R. Thursz [1] S. Taylor-Robinson [1] Robert Steiner MR Unit, Hammersmith Hospital; (1.) Depts of Medicine and (2.) Radiology, Imperial College School of Medicine, London, UK ...

DETECTION OF SMALL BOWEL NEOPLASIA AT PUSH ENTEROSCOPY.(Abstract)
March 1, 2001... Dept of Gastroenterology, Glasgow Royal Infirmary, Glasgow, UK Introduction: Push enteroscopy is of proven value in detecting proximal small bowel disease. The diagnostic yield for small bowel neoplasia, in an unselected population...

THE WIRELESS ENDOSCOPE: FIRST CLINICAL TRIALS IN PATIENTS GI BLEEDING.(Abstract)
March 1, 2001... M. Appleyard [1] A. Glukhovsky [2] S. Gan [2] P. Swain [1] (1.) Royal London Hospital, London, UK; (2.) Given Imaging, Yoqneam, Israel Background: Current endoscopic methods to image the small bowel are limited in...

ENDOSCOPIC MANAGEMENT OF BLEEDING PEPTIC ULCERS IN A LARGE UK TEACHING HOSPITAL.(Abstract)
March 1, 2001... Division of Gastroenterology, St. James's University Hospital, Leeds, UK Background and methods: Single centre RCTs suggest that endoscopic haemostasis (EH) can reduce rebleeding, surgery and mortality in patients with bleeding peptic...

A NOVEL METHOD FOR STUDYING THE CORTICAL PROCESSING OF HUMAN SWALLOWING USING SYNTHETIC APERTURE MAGNETOMETRY (SAM).(Abstract)
March 1, 2001... S. Handy [1] A. Hobson [1] D. Thompson [1] P. Furlong [2] (1.) Dept of GI Sciences, Hope Hospital, Salford; (2.) the Wellcome Trust MEG Institute of Neuroscience, Aston University, Birmingham, UK Background/Aims:...

GASTRIC ACID IN THE CARDIA ESCAPES BUFFERING BY FOOD AND REMAINS HIGHLY ACIDIC AFTER MEALS.(Abstract)
March 1, 2001... Dept of Medicine & Therapeutics, Western Infirmary, Glasgow, Scotland, UK Background: Gastroesophageal reflux typically occurs after meals. Previously we have shown that this postprandial refluxate is often more acidic than the contents...

PATTERNS OF PRESCRIBING LONG-TERM [H.sub.2] RECEPTOR ANTAGONISTS IN PRIMARY CARE: ROLE OF HELICOBACTER PYLORI INFECTION. A CROSS SECTIONAL SURVEY.(Abstract)
March 1, 2001... Dept of Gastroenterology, Hull Royal Infirmary, Anlaby Road, Hull HUI3 OEL, UK Background: Dyspepsia is a common problem in the community requiring patients to be maintained on long-term acid suppression. Nonetheless the prevalence of...

NON-INVASIVE HP TESTING VERSUS ENDOSCOPY WITH HP TESTING FOR DYSPEPSIA.(Abstract)
March 1, 2001... Western Infirmary, Scotland, UK Introduction: There is interest in using non-invasive H. pylori (H.P.) testing in place of endoscopy for investigating dyspepsia. Aim: To compare by prospective randomised trial HP breath test versus...

GASTRIC SECRETION OF AMOXICILLIN AND METRONIDAZOLE IS INCREASED BY PRONASE, A LUMINAL MUCOLYTIC.(Abstract)
March 1, 2001... P.V. Sherwood [1] J.I.D. Wibawa [2] N. Jordan [3] D.A. Barrett [2] P.N. Shaw [2] R.C. Spiller [1] Depts of (1.) Gastroenterology and (2.) Pharmaceutical Sciences University Hospital, Nottingham; (3.) Dept...

VALIDATION OF A RISK STRATIFICATION IN ACUTE UPPER GASTROINTESTINAL HAEMORRHAGE.(Abstract)
March 1, 2001... Dept of Gastroenterology, Addenbrooke's Hospital, Cambridge, UK Aim: Acute upper gastrointestinal haemorrhage has an incidence of approximately 100 per 100,000 per year and an event related mortality of up to 14%. Accurate identification...