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Intestinal B cell hyperactivity in AIDS is controlled by highly active antiretroviral therapy.(Intestinal Immunology)
April 1, 2004... Gut 2004;53:487-493. doi: 10.1136/gut.2003.027854 Background: It is well documented that highly active antiretroviral therapy (HAART) restores systemic immunity to human immunodeficiency virus (HIV) but the effect of this treatment on the mucosal immune system is less clear. Aims:...
Impairment of intestinal intraepithelial lymphocytes in Id2 deficient mice.(Intestinal Immunology)
April 1, 2004... Gut 2004;53:480-486. doi: 10.1136/gut.2003.022293 Background: Id2, an inhibitor of basic helix-loop-helix transcription factors, regulates cell differentiation. Id[2.sup.-/-] mice exhibit a variety of phenotypes in the immune system. Aims: In this study we investigated whether Id2...
Gene transfer: Bax to the future for cancer therapy.(Commentary)
April 1, 2004... The Bax gene as a competitor in the marathon towards licensed cancer gene therapy ********** Intraperitoneal spread of gastrointestinal malignancies is a significant clinical problem and contributes to an incidence of distant relapse as high as 30% in gastric cancer. Local...
Management of swallowed razor blades--retrieve or wait and see?(GI Snapshot)
April 1, 2004... Question A 16 year old boy with a long history of self harm was admitted for the third time in four weeks with a history of ingestion of a number of shaving blades (fig 1). On previous occasions, endoscopic intervention with the use of an overtube under general anaesthesia had been...
Fatigue in chronic cholestasis.(Leading Article)
April 1, 2004... Gut 2004;53:475-477, doi: 10.1136/gut.2003.025155 Fatigue is probably the most intriguing symptom affecting patients with chronic cholestatic disorders, in particular those with primary biliary cirrhosis. It is postulated that fatigue in patients with primary biliary cirrhosis may be...