Annals of the Rheumatic Diseases articles from May 2001

Annals of the Rheumatic Diseases archives from May 2001

Cancer and autoimmunity: autoimmune and rheumatic features in patients with malignancies.
May 1, 2001... Abstract Objectives,--To review the autoimmune and rheumatic manifestations of patients with malignancy. Methods--A Medline search of all published papers using keywords related to malignancies, autoimmunity, rheumatic diseases, and...

Free Radicals and Inflammation.(Review)
May 1, 2001... Free radicals and inflammation. P G Winyard, D R Blake, C H Evans. (Pp 272; DM238.) Basle: Birkhauser Verlag AG, 2000. ISBN 3-7643-5851-3. Understanding the genesis, propagation, and persistence of the inflammatory process in arthritis is...

Principles of Molecular Rheumatology.(Review)
May 1, 2001... Principles of molecular rheumatology. Ed G C Tsokos. (Pp545; $145) Totowa, New Jersey: Humana Press, 2000. ISBN 0-89603-773-8. During the past decade enormous progress has been made in understanding the pathophysiology of the rheumatic...

Incidence of clinically manifest ulcers and their complications in patients with rheumatoid arthritis.
May 1, 2001... Abstract Background--Non-steroidal anti-inflammatory drugs (NSAIDs) are often prescribed in patients with rheumatoid arthritis (RA). Because of its frequency and severity, NSAID gastropathy is the most important side effect. The clinical...

Outcome of cervical spine surgery in patients with rheumatoid arthritis.
May 1, 2001... Abstract Objectives--Cervical spine instability in patients with rheumatoid arthritis (RA) may lead to cervical myelopathy or occipital neuralgia, or both. Morbidity and mortality in patients with RA treated with cervical spine surgery...

Treatment strategy, disease activity, and outcome in four cohorts of patients with early rheumatoid arthritis.
May 1, 2001... Abstract Objective--To compare four different inception cohorts of patients with early rheumatoid arthritis (RA) with respect to treatment strategies, disease activity, and outcome during a five year follow up period. Method--Data...

Prevalence and clinical significance of antikeratin antibodies and other serological markers in Lithuanian patients with rheumatoid arthritis.
May 1, 2001... Abstract Objectives--To assess the clinical value of several serological markers in Lithuanian patients with rheumatoid arthritis (RA) compared with control patients with rheumatic disease and age matched healthy controls. ...

A longitudinal cohort study of Finnish patients with primary Sjogren's syndrome: clinical, immunological, and epidemiological aspects.
May 1, 2001... Abstract Objective--To evaluate outcome in a cohort of Finnish patients with primary Sjogren's syndrome (pSS). Methods--Clinical and laboratory data from the time of diagnosis and follow up were collected from 110 patients with pSS...

Glandular and extraglandular expression of costimulatory molecules in patients with Sjogren's syndrome.
May 1, 2001... Abstract Objectives--To investigate the expression and regulation of CD80, CD86, and CD28 costimulatory molecules in sialoadenitis and interstitial nephritis in patients with Sjogren's syndrome (SS). Methods--Expression of CD80,...

Polymorphisms of the mannose binding lectin gene in patients with Sjogren's syndrome.
May 1, 2001... Abstract Objective--To investigate polymorphisms of both codon 54 allele and promoter variants of the mannose binding lectin (MBL) gene in patients with primary Sjogren's syndrome (SS). Methods--Polymorphisms of codon 54 allele and...

Nerve growth factor and neuropeptides circulating levels in systemic sclerosis (scleroderma).
May 1, 2001... Abstract Objective--To determine the circulating levels of nerve growth factor (NGF), neuropeptide Y (NPY), and vasoactive intestinal peptide (VIP) in systemic sclerosis (SSc), and to correlate these levels with clinical and laboratory...

Flow cytometric analysis of gut mucosal lymphocytes supports an impaired Th1 cytokine profile in spondyloarthropathy.
May 1, 2001... Abstract Objective--To quantify the fraction of gut mucosal lymphocytes expressing the T helper type 1 (Th1) cytokines, interferon [Gamma] (IFN[Gamma]) and interleukin (IL)2, and the Th2 cytokines, IL4 and IL10, at the single cell level...

Cofactor dependence and isotype distribution of anticardiolipin antibodies in viral infections.
May 1, 2001... Abstract Background--Antibodies to cardiolipin (aCLs) are often detected in patients with autoimmune disorders or infectious diseases. Objective--To investigate the distribution of aCL isotypes and requirement of protein cofactor in...

Impaired catecholaminergic signalling of B lymphocytes in patients with chronic rheumatic diseases.
May 1, 2001... Abstract Objective--To investigate further the influence of the autonomic nervous system on chronic rheumatic diseases. Methods--The density and affinity of [[Beta].sub.2] adrenergic receptors ([Beta]2R) on CD19+ lymphocytes in...

Reversibility of histological and immunohistological abnormalities in sublabial salivary gland biopsy specimens following treatment with corticosteroids in Sjogren's syndrome.
May 1, 2001... Abstract Sjogren's syndrome (SS) is a chronic autoimmune disease characterised by specific lesions in exocrine glands, so sublabial minor salivary gland biopsy (SLGB) plays an important part in its diagnosis. The extent and composition...

Treatment with cyclosporin switching to hydroxychloroquine in patients with rheumatoid arthritis.
May 1, 2001... Abstract Objective--To investigate the therapeutic benefit of cyclosporin A (CSA) switching to hydroxychloroquine (HCQ) in patients with rheumatoid arthritis (RA). Methods--Thirty four patients with RA who displayed residual...

Acute arthritis after intra-articular hyaluronate injection: onset of effusions without crystal.
May 1, 2001... Abstract Side effects of intra-articular hyaluronate injection include aseptic acute arthritis, which develops within hours after injection. Based on standard crystal analysis, calcium crystal shedding has been postulated to explain this...

Threefold increased risk of hip fractures with rheumatoid arthritis in Central Finland.
May 1, 2001... Abstract Objectives--To evaluate the impact of rheumatoid arthritis (RA) on the incidence of hip fractures. Methods--All patients with acute hip fractures admitted to Jyvaskyla Central Hospital in 1991-93 (n=517) were selected from...

Expression of costimulatory molecules on peripheral blood lymphocytes of patients with systemic lupus erythematosus.
May 1, 2001... Abstract Objective--In systemic lupus erythematosus (SLE) autoantibody production is T cell dependent. For a proper T and B cell interaction, signalling of costimulatory molecules on these cells is necessary. The expression of...

Characteristics of patients with antiphospholipid syndrome with major bleeding after oral anticoagulant treatment.
May 1, 2001... Abstract Objective--To study the demographic and clinical characteristics of patients with antiphospholipid syndrome (APS) with serious haemorrhagic complications of anticoagulant treatment in an attempt to establish risk factors for...

HLA-DRB1 genes and patients with late onset rheumatoid arthritis.
May 1, 2001... Abstract Objective--To determine the influence of HLA-DRB*1 genes on susceptibility to and severity of rheumatoid arthritis (RA) in patients with late onset compared with younger onset disease. Methods--The clinical, biological, and...

Reversible posterior leucoencephalopathy syndrome in systemic lupus and vasculitis.
May 1, 2001... Abstract Objectives--Reversible posterior leucoencephalopathy syndrome (RPLS) may develop in patients with renal insufficiency, hypertension, and immunosuppression, and is managed by prompt antihypertensive and anticonvulsant treatment....

Isolated digital vasculitis in a patient with rheumatoid arthritis: good response to tumour necrosis factor [Alpha] blocking treatment.
May 1, 2001... Abstract Tumour necrosis factor a (TNF[Alpha]) blocking agents are among the most promising new treatments for rheumatoid arthritis (RA). However, no data exist about the effect of these agents on extra-articular manifestations of RA. A...

Polyarteritis nodosa complicated by thrombotic thrombocytopenic purpura.
May 1, 2001... A 56 year old woman was diagnosed with polyarteritis nodosa (PAN) in June 1998 based on the presence of fibrinoid necrosis and infiltration of polymorphonuclear cells into medium and small sized arteries on a skin biopsy specimen. She...

Placement of intra-articular injections verified by ultrasonography and injected air as contrast medium.
May 1, 2001... Intra-articular injection of long acting corticosteroid is a corner stone in rheumatological treatment. The injected intra-articular corticoid is more effective when correctly placed.[1 2] Injection of radiographic contrast material has shown...

HLA class II alleles and synovial fluid cytology in RA.(Rheumatoid arthritis )
May 1, 2001... Rheumatoid arthritis (RA) is associated with HLA-DR4, which is encoded by the DRB1 gene. This genetic predisposition has been shown to lie within the sequence motif present in the third hypervariable region of the DRB1 gene.[1] This sequence...