Clinical Oncology Week articles from May 2004

Clinical Oncology Week archives from May 2004

Frozen section and permanent analysis of sentinel nodes are equivalent.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Using frozen section (FS) or permanent section (PS) analysis of sentinel node biopsies in breast cancer does not affect patient quality of life, researchers report. According to published research...

Locoregional recurrence is lower in recent years after breast-conserving surgery.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Improved patient selection may be partly responsible for lower rates of recurrence after breast-conserving surgery, researchers say. "The aim of our study was to compare the locoregional recurrence...

Longevity gene may also predict better outcome for breast cancer patients.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- A gene known to promote longevity in animals has now been discovered to encode a tumor suppressor - a protein that helps prevent cancer, according to a study by a team of scientists from The University...

Local chemotherapy preserves eyeballs with vitreous seeding.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Local chemotherapy is able to preserve eyeballs that have vitreous seeding. "Retinoblastoma with vitreous seeding has been one of the most challenging conditions for eye-preservation therapy....

Glut-1 expression in oral cancer indicates need for chemoradiotherapy.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Results of EORTC Translational Research Fund studies demonstrate that Glut-1 expression in oral squamous cell carcinomas treated by surgical resection indicates a need for neoadjuvant chemoradiotherapy....

EGCG inhibits radiation-induced apoptosis by inactivating capase pathway.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Polyphenol EGCG inhibits radiation-induced apoptosis by inactivating the capase pathway in HaCaT cells. "Green tea is a rich source of polyphenols, and (-)-epigallocatechin-3-gallate (EGCG) is a...

Cognitive function can decline in patients with brain tumors.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Declining cognitive function is often the sign of progressive disease, researchers say. "Cognitive function, with survival and response on brain imaging, is increasingly regarded as an important...

Proton magnetic resonance spectroscopy can monitor glioma response to treatment.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Monitoring low-grade glioma response to temozolomide can be accomplished using proton magnetic resonance spectroscopy (H-1-MRS), researchers say. "Assessment of low-grade glioma treatment response...

Sentinel node biopsy should be standardized.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Researchers urge standardization of sentinel node biopsy (SNB) and pathological examination, in order to improve diagnostic and therapeutic strategies for breast and gastrointestinal cancer patients....

Breast cancer patients self-participation depends on length of consultation.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Study finds that patient-physician communication interactions can be evaluated by perceptual and behavioral measures. "This study examines correlations between observable communicative behaviors...

Certain characteristics of tumor in vessels and lymph nodes predict progression.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Certain characteristics of tumor in vessels and lymph nodes predict progression. According to published research from Japan, "Invasive ductal carcinomas of the breast are composed of primary...

HCCR-2 related to breast cancer development and p53 tumor suppressor regulation.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Oncoprotein HCCR-2 is related to breast cancer development and p53 tumor suppressor regulation. "Transgenic mice containing novel oncogene HCCR-2 were generated to analyze the phenotype and to...

Lymphatic mapping suggested when invasive breast cancer is suspected.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Lymphatic mapping is suggested any time invasive breast cancer in suspected. "The concept of lymphatic mapping has helped to redefine the clinical significance of lymph nodes with respect to breast...

Malignant breast cancer cells revert to normal with manipulation.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Manipulation of the extracellular matrix of non-malignant breast cells can lead to genomic instability via oxidative damage, study findings show. The extracellular matrix (ECM) is a network of...

Million Women Study: Hormone replacement therapy increases breast cancer risk.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Researchers believe the increased risk of invasive breast cancer as reported in the Million Women Study (MWS) was was not justifiable. "MWS published in the summer of 2003, has suggested unexpected...

Sentinel node biopsy in breast cancer patients avoids axillary dissection.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Sentinel node biopsy in breast cancer patients avoids axillary dissection. According to recent research from Netherlands, "Since its introduction in the early 1990s, the sentinel node (SN) concept...

Stromal infiltration may predict tumor invasion in breast FNA biopsy.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Stromal infiltration may predict tumor invasion in breast fine-needle aspiration biopsy. According to a study from the United States, "Clinical management of in situ carcinoma of the breast is...

Study shows there's a learning curve in performing sentinel node biopsy.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Proctored training of surgeons learning to perform sentinel node biopsy results in acceptable skills after performing 40 procedures, study finds. According to recent research published in the...

Stromal composition helps diagnosis of biphasic lesions of the breast.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Phyllodes tumor is a possibility when a biphasic breast tumor has cellular stroma, researchers report. According to recent research from the United States, "Biphasic lesions of the breast are...

There may be a link between Internet use and cancer outcomes.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Research identifies that a high percentage of cancer patients use the internet for a variety of reasons related to their disease. According to recent research published in the Ca - A Cancer Journal...

Predicting cancer patient survival with gene-expression data.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Cancer specialists often talk about cancer as an umbrella term for more than 200 different diseases, each having unique characteristics. But even these categories are too broad, as the same type of...

Deficiency in alpha 1-antitrypsin increases risk of certain cancers.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Imbalances of neutrophil elastase and alpha1-antitrypsin can increase the risk of developing certain cancers and of cancer progression, researchers say. "Neutrophil elastase and alpha1-antitrypsin...

Certain antitumor agents can suppress cutaneous radiation syndrome.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Inhibiting histone deacetylase (HDAC) inhibitors may protect normal skin during radiation therapy, researchers say. "Radiotherapy is an effective treatment for head and neck, skin, anogenital, and...

Matrikines form the basis for new types of antiangiogenesis therapy.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Matrikines form the basis for new types of antiangiogenesis therapy. According to recent research published in the journal Critical Reviews in Oncology/Hematology, "neoangiogenesis, the formation of...

Microwaves regress colorectal tumor tissue in mice.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Microwaves regress colorectal tumor tissue in mice. "The human LoVo and WI-38 cells were exposed to high power non-invasive microwaves. The apoptotic effect of the microwaves on the cells was...

Radiolanthanides show promise in targeted cancer immunotherapy.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- A series of radiolanthanides have significant antitumor effects in mice. "[superscript]149Pm, [superscript]166Ho, and [superscript]177Lu possess a range of half-lives and...

Therapy combining cisplatin and overexpressed CAD promotes tumor destruction.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Therapy combining cisplatin and overexpressed CAD promotes tumor destruction. "Recent studies have demonstrated that a caspase-activated deoxyribonuclease (CAD) causes DNA degradation in nuclei...

Bendamustine plus mitoxantrone effective treatment for advanced CLL.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Bendamustine plus mitoxantrone is an effective treatment for advanced chronic lymphocytic leukemia. "The toxicity and efficacy of the combination bendamustine plus mitoxantrone (BM) was evaluated...

gONC increases conformational stability and toxicity for cancer cells.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Glycosylation of onconase increases its conformational stability and toxicity for cancer cells. "Onconase (ONC) is currently in Phase III clinical trials as a cancer chemotherapeutic agent. Despite...

Oral contraceptives increase colon cancer risk.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Oral contraceptives increase colon cancer risk; tubal ligation and abortion decrease risk. "267,400 female textile workers in Shanghai, who were administered a questionnaire at enrollment into a...

Short course of Tibetan yoga improves sleep in cancer patients.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- The first study to look at the use of Tibetan yoga by cancer patients found the combination of movement and meditation led to a significant sleep benefit, say researchers at the University of Texas M.D....

Noninvasive imaging of skin tumors is becoming diagnostically reliable.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- A variety of skin tumors can be diagnosed using noninvasive imaging modalities, researchers say. "In this article, the authors review different approaches to the diagnosis of skin tumors using...

Early FAMM diagnosis and prophylaxis decreases neoplastic transformation risk.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Early FAMM diagnosis and prophylaxis decreases risk of neoplastic transformation of melanocytes. "Familial atypical multiple mole melanoma (FAMMM) syndrome is an autosomal dominant disorder with...

Multislice CT angiography can image mesenteric vasculature.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Multislice CT (MSCT) is capable of providing excellent imaging of mesenteric vessels, researchers say. "Due to several distinct advantages over conventional angiography (including minimal...

Positron-emitting tracers show potential for tumor imaging.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Positron-emitting tracers show potential for tumor imaging. The "potential of O-[[superscript]11C]methyl-L-tyrosine and O[superscript]18F]fluoromethyl-L-tyrosine as positron-emitting tracers for...

Researchers develop polarized reflectance spectroscopy for precancer detection.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- A new noninvasive optical technique can potentially detect early precancers, thereby improving greater survival and patient quality of life, researchers report. "Early detection of cancer and its...

Abietane diterpenes from Aegiphila lhotzkyana has antitumor effects.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Abietane diterpenes from Aegiphila lhotzkyana has antitumor effects. "Five abietane diterpenes were isolated from a hexane extract obtained from the roots of Aegiphila lhotzkyana and identified as...

Diacid hemiester completely inhibits tumor growth in mice.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- A diacid hemiester completely inhibited tumor growth in mice. "A series of cis-1,2-dihydroxy-1,2-dihydrobenzo[b] acronycine diacid hemiesters and dicarbamates were prepared by acylation of...

Novel ribonuclease has antimicrobial and antiproliferative activities.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- A novel ribonuclease derived from an edible mushroom has demonstrated antimicrobial, antifungal and antitumor activities. In a recent study from China, a "12 kDa ribonuclease preferential for poly...

Gossypol MOA via oxidative stress, reactive oxygen species and DNA scission.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- The mechanism of action of gossypol is via oxidative stress, reactive oxygen species and DNA scission. "Gossypol, a constituent of cottonseeds, displays various drug properties, including...

Adequate analgesia is important for patients with advanced disease.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Researchers discuss the management of pain for patients with advanced malignant and nonmalignant diseases. According to a study from England, "This series of two articles explores the challenge of...

Hormone replacement therapy after melanoma does not adversely affect prognosis.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Hormone replacement therapy after melanoma does not adversely affect prognosis. "A total of 206 women were followed for a minimum of 5 years after primary melanoma surgery to establish if hormone...

Thyroglobulin polymorphic variation increases non-medullary thyroid cancer risk.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Polymorphic variation in thyroglobulin increases risk for non-medullary thyroid cancer. "Benign thyroid disorders are strong risk factors for non-medullary thyroid cancer (NMTC). Germline variation...

COX-2 may be a target for prevention and treatment of esophageal cancer.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Researchers report early evidence that the cyclooxygenase-2 (COX-2) enzyme may be helpful in preventing and treating esophageal cancer. According to published research from the United States,...

BMP-2 modulates proliferation and differentiation of gastric cancer cells.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- BMP-2 modulates the proliferation and differentiation of gastric cancer cells. "Bone morphogenetic protein 2 (BMP-2), a member of the transforming growth factor beta super-family, has been shown to...

Diagnosis and treatment options for gastric cancer reviewed.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Scientists review the diagnosis and treatment options for gastric cancer in a recent issue of American Family Physician. "Although the overall incidence of gastric cancer has steadily declined in...

Extended lymph node dissection fails to increase survival.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Extended lymph node dissection - a treatment for gastric cancer involving the surgical removal of lymph nodes near the tumor, in distant areas of the stomach, and in some cases, in combination with the...

Lymphatic mapping aims to increase staging accuracy in GI cancer.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Sentinel lymph node mapping (SLNM)in gastrointestinal malignancies is accurate, researchers say. According to recent research published in the journal Annals of Surgical Oncology, "The advent of...

Malignant lesions can be managed by endoscopic resection.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Pre-malignant and malignant lesions can be managed by endoscopic resection. "Endoscopic resection (ER) has gained more and more importance in the treatment of early gastrointestinal neoplasia over...

Genetic cancer alterations seen between ethnic populations.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Genetic cancer alterations exist between ethnic populations. "The cancer spectrum and genetic pathways underlying tumorigenesis vary among different ethnic populations due to genetic background...

Cyclin-dependent kinase inhibitor p21 induces Flt3-ITD leukemogenesis.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Cyclin-dependent kinase inhibitor p21 induces Flt3-ITD leukemogenesis. "Flt3 is a type III RTK and approximately 30% of AML patients harbor an internal tandem duplication (ITD) of the juxta-membrane...

Notch1 gene involved in ATRA-modulated differentiation process in APL.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- The notch1 gene may be involved in the ATRA-modulated differentiation process in acute promyelocytic leukemia. "The effect of all-trans retinoid acid (ATRA) on the expression of Notch1 gene by...

P73 A4T14 genotype associated with cervical cancer risk.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- P73 A4T14 genotype is associated with risk of cervical cancer. A "possible association between cervical cancer and p73 G4C14-to-A4T14 in exon 2 and p53 Arg72Pro polymorphisms" was examined in an...

Ptc acts as a tumor suppressor gene in bladder cancer.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Ptc acts as a tumor suppressor gene in bladder cancer. "The PATCHED (PTC) gene is recognized as a tumor suppressor in basal cell carcinoma. Mapping of a minimal region of deletion at 9q22.3 and...

Women with uterine fibroids may lack CCN5 gene functionality.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Women with uterine fibroids may lack CCN5 gene functionality. According to recent research from the United States, "uterine fibroids (leiomyomas) are a major women's health problem. Currently, the...

Early anti-EBV cytotoxic immune response impaired in HIV patients.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- The early cytotoxic response to Epstein-Barr virus (EBV) is impaired in HIV patients. According to recent research from France, "[i]mmunodeficiency related to HIV may increase the incidence of...

Intralesional chemotherapy may improve prognosis for head and neck carcinoma.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Researchers discuss the use of locally delivered chemotherapy in patients with head and neck cancer. "In the last decade, chemotherapy has gained widespread acceptance in the treatment of oral and...

Sentinel lymphadenectomy for head and neck cancer may be helpful.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Careful evaluation of sentinel node lymphadenectomy in the region of the head and neck is necessary and indications for its use need to be determined, researchers say. According to published...

Eurya emarginata extracts inhibit leukemia cell growth via apoptosis induction.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Eurya emarginata extracts inhibit leukemia cell growth via induction of apoptosis. The "inhibitory effect of Eurya emarginata extracts on the growth of cancer cells" was examined. "The ethylacetate...

CD30 mediates T-cell inhibition by Hodgkin Reed-Sternberg cells.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Suppression of T-cell proliferation by Hodgkin disease tumor cells is mediated by CD30. This molecule "is expressed on Hodgkin Reed-Sternberg (H-RS) cells, the tumor cells in Hodgkin disease,"...

Researchers describe how cancer neutralizes T cell attack.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- It has long been recognized that the immune system is able to recognize and destroy cancer cells, but although the immunological battle might slow the progression or spread of cancer, it's usually the...

TGF-beta plays role in immune escape by AK-5 tumor cells.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Transforming growth factor (TGF)-beta is involved in immune escape by AK-5 tumor cells. TGF-beta1, "a multifunctional cytokine secreted by various cell types has been implicated in diverse...

Utility of intravenous immunoglobulin therapy reviewed.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- The utility of intravenous immunoglobulin therapy has been reviewed. IVIG "is generated from the plasma of more than 10,000 healthy subjects," scientists in Israel explained. "Originally IVIG was...

Nitrotyrosine-induced oxidative DNA damage may be biomarker of inflammation.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Nitrotyrosine-induced oxidative DNA damage may be a biomarker of inflammation. "Inflammation has been postulated as a risk factor for several cancers. 3-Nitrotyrosine is a biochemical marker for...

Researchers identify virus gene involved in tumor cell growth, spread.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- In studying a virus that causes the skin cancer Kaposi sarcoma, University of North Carolina (UNC) at Chapel Hill scientists have identified a viral gene that switches on cellular genes involved in...

ATRA and TSA therapy useful in acute leukemia displaying MLL-AF9 fusion gene.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- ATRA and TSA are therapeutically useful in patients with acute leukemia displaying the MLL-AF9 fusion gene. In acute "leukemia patients with MLL (mixed linage leukemia), rearrangements tend to...

Treatment delivers radioactive isotope directly into the liver with embolization.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Treatment options for patients with hepatocellular carcinoma, a type of liver cancer, are limited, and up to 90% of patients are not candidates for surgery. Although surgery offers the best chance...

CT detection of hepatocellular carcinoma is difficult in severely cirrhotic livers.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Computed tomographic imaging is necessary for liver transplant recipients preoperatively, but small hepatocellular carcinomas are difficult to detect. "Computed tomography (CT) is being used as the...

Age itself is not a factor in determining the management of lung cancer.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Although most patients with lung cancer are over 65 at diagnosis, management should be determined by the selection process used for patients of all ages. According to recent research published in...

Alarming rise in incidence of lung cancer and death seen in women.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- In the past 50 years, there has been a 600% increase in the number of women who will be diagnosed with lung cancer and die of the disease. However, the death rate for men has decreased slightly over the...

Lung-tumor therapies improved by combining CT and PET scans.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Physicians targeting lung tumors for radiation therapy can substantially improve their aim by combining data from two scanning techniques, according to Washington University researchers at Siteman...

Noninvasive lung cancer staging is currently under development.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Molecular staging of lung cancer promises to be extremely accurate, researchers say. "The staging of lung cancer is a continuously progressing field, with advances in technology not only improving...

Allo-PBSCT with RIC feasible for children with refractory Hodgkin disease.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Allogeneic PBSCT with reduced intensity conditioning is feasible and effective for children with treatment-resistant HD. "Despite high-dose chemotherapy and autografting, the outcome for patients...

Anterior mediastinal masses can be resected via figure-L mini-sternotomy.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Less invasive mini-sternotomy can be used when removing anterior mediastinal tumors, researchers say. "We performed a figure-L unilateral mini-sternotomy for anterior mediastinal tumor resection in...

Locoregional recurrence of malignant melanoma has various treatment options.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Locoregional metastatic melanoma results from incomplete excision of the primary melanoma, researchers report. According to a study from Austria, "The correct classification of locoregional...

Researchers discuss future applications of sentinel node technology.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- New approaches for the role of sentinel node technology in solid tumors are emerging, researchers say. According to a study from Japan, "The sentinel node (SN) concept was originally proposed by...

Sentinel lymph node dissection and mapping may be useful for recurrent melanoma.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Lymphatic mapping and sentinel lymph node dissection (LM/SLND) may be applied to local recurrent melanoma management, researchers say. According to published research from Australia, "Lymphatic...

Sentinel lymph node tumor status is important for staging melanoma.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- The best predictor of recurrence of and survival from melanoma is the relative tumor area of the sentinel node, researchers say. "Correct identification of the sentinel node (SN) and accurate...

Sentinel node biopsy for melanoma has a high false-negative rate.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Researchers report that sentinel node (SN) biopsy for melanoma must be evaluated in randomized clinical trials to determine its clinical efficacy. According to a study from Australia, "The SN...

t translocation predicts poor auto-SCT outcome in multiple myeloma patients.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- The t(4;14) translocation predicts poor outcome in multiple myeloma (MM) patients undergoing stem-cell autotransplantation. In a study from Canada, the "frequency and prognostic relevance of...

Role of mtDNA mutations in MDS-leukemia transition determined.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Mutations in mtDNA may be involved in the transition from myelodysplastic syndromes (MDS) to leukemia. According to researchers in the United States, MDS "are clonal myeloid disorders characterized...

Tumor irradiation poses risk of bystander effect.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Tumor irradiation poses risks of a bystander effect. "The bystander effect post radionuclide decay describes the biologic response(s) of cells not directly targeted by the radiation insult," wrote...

Fly with brain tumor may shed light on cancer-causing genes.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- A new study shows how the expression of genes changes when the brain tissue of fruit flies becomes cancerous. As the function of many of these genes is conserved across evolution, the researchers expect...

Gene plays major role in formation of stem cells and cancer.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Researchers from The Netherlands Cancer Institute in Amsterdam have discovered a common link between cancer cells and stem cells. Together with colleagues from the University of Zurich, Merel...