Clinical Oncology Week articles from May 2003

Clinical Oncology Week archives from May 2003

Red meat doneness and panfrying are associated most with risk.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Red meat doneness and panfrying were associated with colon cancer, and a particular heterocyclic amine tested most responsible, regardless of cooking method. "The authors examined the association...

Genetic inactivation of ACVR2 gene may indicate it is a tumor suppressor.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Genetic inactivation of the activin A type II receptor (ACVR2) gene in gastrointestinal and pancreatic cancer points to the gene as being a tumor suppressor. "The activin signaling pathway parallels...

New approaches to cervical screening may lead to clinical benefit.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- New approaches to cervical screening may lead to clinical benefit. "Screening programs for cervical cancer using the current test - the Pap smear - have markedly reduced the incidence of the...

A significant diffuse component is a predictor for lowered survival.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Grade 3 follicular lymphomal survival does not depend on the WHO cytologic subtypes, but on the level of diffuse component present. According to published research from the United States, "Grade 3...

IFN-alpha, verpamil, and dacarbazine combination can be effective.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Metastatic malignant melanoma may be treatable with a combination therapy of dacarbazine, verapamil, and IFN-alpha. According to recent research published in the journal Melanoma Research,...

Interactions of PDT with chemotherapy studied.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- According to recent research from Switzerland, "Although photodynamic therapy (PDT) is becoming an additional cancer therapy, only little is known about its interactions with other drugs and treatment...

The P54-cleaved tyrosine kinase Lyn stops B cell receptor induced apoptosis.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- B cell receptor engagement and cell death of B lymphoma is self limiting due to the caspase-generated cleavage of Lyn which then acts as a negative regulator on the process. According to a study...

MUC-1 mucin protein expression is common in any state of disease.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- MUC-1 mucin expression is correlated only with lymphoma, and not a particular cell type or disease status, nor was there a correlation with the rearrangement of the gene. "We have recently shown...

Metaplasia and carcinogenesis may result from increased metallothionein.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Increased metallothionein expression protects cells from apoptosis, leading to progression of Barrett metaplasia. According to a study from the United States, "Barrett esophagus is the...

A comparison of drug therapies based on toxicity and efficacy has been developed.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- A mathematical method for comparing two treatments in which toxicity and drug concentrations are taken into account has been developed to analyze clinical trials. "The primary goal of anticancer...

Adamantinoma was found with discrete osteofibrous dysplasia in an ulna.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Evidence of concurrent adamantinoma and osteofibrous dysplasia in an ulna further shows the lesions may be related. "An adamantinoma is a rare, low-grade malignant, osteolytic bone tumor occurring...

Donor T cell-derived TNF is required for graft-versus-host disease.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Donor T cell-derived TNF is required for graft-versus-host disease after bone marrow transplantation. According to published research from the United States, "Previous studies in murine bone marrow...

Isoliquiritigenin in licorice has estrogenic and antiproliferative activities.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- At lower levels, licorice root's isoliquiritigenin is an estrogenic agonist and at higher levels it is cytotoxic. According to a study from Italy, "Licorice root contains chemically diverse...

Organized mammography screening does not result in overdiagnosis of cancer.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Organized mammography screening does not result in overdiagnosis of breast cancer. "Mammography screening may lead to overdiagnosis of asymptomatic breast cancers, that would otherwise not have...

Percutaneous 4OHTam may be a useful alternative to tamoxifen.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Percutaneous 4OHTam may be a useful alternative to tamoxifen in breast cancer prevention. "In the search for a breast cancer prevention strategy which would avoid undesirable effects of orally...

Peroxisome receptor gamma agonists reduce estrogen receptor alpha.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- The mode of action of peroxisome proliferator activated receptor gamma agonists is to induce degradation of cyclin D1 and estrogen receptor alpha and thus decrease breast cancer cell proliferation. ...

Tumor suppressors p16INK4a and p14ARF are linked and not inactivated by mutation.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Two tumor suppressor proteins involved in cell cycle control in breast cancer are linked, and their inactivation is due to hypermethylation or deletion. "The INK4a/ARF locus encodes 2 tumor...

The prodomain of IL-1 alpha interacts with RNA processing elements.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Selective apoptosis of a wide range of tumor cells is obtained with the IL-1alpha precursors' leftover component, the "prodomain"; this component interacts with RNA splicing and processing elements. ...

Hue-Saturation-Intensity (HSI) works better than the gold standard.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Histochemical staining of lung cancer tissue by hue saturation density for levels of proliferating cells with Ki-67 worked better than the gold standard. "We tested a recently developed flexible...

Better directions and practice screens would improve PAINReportIt questionnaire.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Better directions and practice screens would improve PAINReportIt questionnaire. "We examined usability (completion time, acceptability, and completeness of information) of a computerized format for...

ELF-electromagnetic fields induce apoptosis.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- ELF-electromagnetic fields induce apoptosis and may be a first step for a noninvasive treatment of cancer tissue. According to a study from Germany, "Weak and low-frequency pulsating...

Therapy-related myelodysplastic syndrome can occur by rearrangement of MOZ gene.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Therapy-related myelodysplastic syndrome can occur by rearrangement of the MOZ gene. "In this study, we examined a pediatric case of therapy related myelodysplastic syndrome (tMDS). The symptoms...

Chronic osteomyelitis mimics a soft tissue sarcoma.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Chronic osteomyelitis mimics a soft tissue sarcoma. According to published research from Ireland, "This report describes a rare case of chronic osteomyelitis in a 60-year-old man mimicking a soft...

Intestinal lymphomas should be diagnosed following universal standards.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Intestinal lymphomas should now be classified worldwide by the same universal means, the WHO standards. According to recent research from Austria, "Intestinal lymphomas are almost exclusively...

Colorectal cancer prognosis has improved.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Colorectal cancer prognosis has improved because of chemotherapeutic agents and earlier diagnosis. "In the last two decades the prognosis of colorectal cancer has improved for two reasons: (I) the...

TP53 mutation status may make a difference in chemotherapeutic outcome.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- P53 status of colorectal cancer patients needs to be incorporated into chemotherapeutic outcome studies, as there may be differences in effectiveness of therapy depending on that status. According...

Human cancer cell lines have tissue type specific patterns.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- DNA methylation in human cancer cell lines does differ slightly from primary tumors, but the common patterns can be used to determine tissue origin. According to published research from Spain,...

A score test can determine non-inferiority with respect to long-term survival.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- A score test can determine non-inferiority of a new treatment with respect to long-term survival. "In recent years randomized trials designed to establish non-inferiority of a new treatment as...

Temozolomide can induce apoptosis, but resistance occurs if given in low doses.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Temozolomide can induce apoptosis in glioma cells, or eventual resistance if given in low doses. According to published research from Germany, "Temozolomide is an alkylating cytostatic drug that...

Radiation causes cytotoxic conditioning of the culture medium of hepatoma cells.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Radiation causes cytotoxic conditioning of the culture medium of hepatoma cells. According to published research from the Netherlands, "Cultured H35 hepatoma cells release a cytotoxic factor in response...

Patients have inactivated E-cadherin due to missense mutations in CDH1.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Hereditary diffuse gastric cancer patients have inactivated E-cadherin due to missense mutations in CDH1. "E-cadherin is involved in the formation of cell-junctions and the maintenance of...

The ZSDS single-item screen has poor sensitivity and specificity.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- The Zung Self-Rating Depression Scale (ZSDS) single-item screen has poor sensitivity and specificity for detecting insomnia in cancer patients. "The focus of this pilot study was to examine issues...

Multiple leiomyosarcomas develop after hereditary retinoblastoma.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Multiple leiomyosarcomas can develop after hereditary retinoblastoma. "This report describes two patients who developed leiomyosarcomas, one involving the subcutaneous tissue of the thigh and the...

Bilateral femoral aseptic necrosis is the first symptom of CML.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Bilateral femoral aseptic necrosis is the first symptom of chronic myelogenous leukemia (CML). According to a study from Germany, "Chronic myelogenous leukemia (CML) is a disease of the elderly; in...

F11782 topoisomerase inhibitor induces apoptosis through Bax and caspase action.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- F11782 is a dual topoisomerase inhibitor that can induce Bax and caspase activation resulting in apoptosis of leukemia cells. "F11782 (2'',3''...

Fludarabine accumulation in CLL is mostly mediated by ENT-type transporters.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Fludarabine accumulation in chronic lymphocytic leukemia (CLL) is mostly mediated by ENT-type transporters. According to recent research published in the journal Blood, "Nucleoside derivatives are...

Lung ossification may be due to metastatic spread of colorectal adenocarcinomas.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Lung ossification may be due to metastatic spread of colorectal adenocarcinomas. "Ossification of lung tissue is a rare phenomenon, which can be found in association with carcinoid tumors of the...

The density of hair is inversely related to pigmented lesion count.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Malignant melanoma patients demonstrated an inverse relationship between areas of hair density and number of lesions. According to published research from the United States, "The aim of this study...

A rare case of sclerosing hemangioma is isolated to the mediastinum.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- A rare case of sclerosing hemangioma is isolated to the mediastinum. According to a study from Japan, "Sclerosing hemangioma is an uncommon tumor of unknown histogenesis that generally develops in...

Glucocorticoid hormone resistance may be due to increased STAT3 and PI-3 kinase.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Melanomal resistance to hormone treatment appears to be due to increases of STAT3 and PI-3 kinase. "STAT proteins act as signal transducers and activators of transcription in cells treated with...

Increasing oxygen and acidity by glucose/iodobenzylguanidine may improve outcome.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Induction of hyperglycemia and meta-iodo-benzylguanidine treatment can increase oxygen and acidification in melanoma such that other therapies may be enhanced. "Tumor oxygen tension and...

Fotemustine plus whole brain irradiation works better than fotemustine alone.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Fotemustine and radiation works better than fotemustine alone for brain metastasis of malignant melanoma. "The main objective of this prospective multicenter randomized phase III study is to...

Osteoprotegerin is a decoy receptor for TRAIL ligand, protecting from apoptosis.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Osteoprotegerin can function as a survival factor for human myeloma cells, since it inhibits apoptosis by TRAIL. "Myeloma cells grow only in the bone marrow closely associated with bone, suggesting...

Nasopharyngeal cancer pain during radiation therapy is often undertreated.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Nasopharyngeal carcinoma pain during radiation therapy is often undertreated. According to recent research from the United States, "The purpose of this study was to describe the characteristics and...

TP53 mutations may act as fingerprints for exposure to specific carcinogens.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- There is the possibility that fingerprints may exist with specific p53 mutations being produced by specific occupational carcinogens. According to recent research from Finland, "In some cases,...

Height, more than body mass, is positively associated with ovarian cancer risk.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Height, more than body mass, is positively associated with ovarian cancer risk. According to a study from Netherlands, "Although many studies have been conducted to investigate the relation between...

Endometriosis doesn't appear premalignancy-based when tested for clonality.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Endometriotic foci do not appear to be premalignant when tested for clonality. According to recent research published in the FASEB Journal, "Since 1925, epidemiological and histological evidence for...

No chromosomal instability was found in radiation exposed normal fibroblasts.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- No chromosomal instability in descendants was found in normal fibroblasts exposed to low or high LET radiation. "Radiation induced genomic instability has been proposed as a very early, if not an...

Cytokine activation sensitizes hematopoietic cells to cisplatin-induced death.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Cytokine activation sensitizes hematopoietic cells to cisplatin-induced death. "Cytokine growth factors regulate the normal proliferation of hematopoietic cells but can also override...

UVA radiation produces apoptosis of immortalized human keratinocytes.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- UVA radiation treated immortalized keratinocytes creates GSH efflux, increasing intracellular oxidative stress and apoptosis. "We have investigated the role played by GSH efflux in apoptosis of...

HTLV-1 Tax oncoprotein binds to a PDZ domain of the IL-16 precursor.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- It is the HTLV-1 protein Tax that can produce T cell malignancy, due to its binding to a PDZ domain on pro-IL-16. "HTLV-1 Tax oncoprotein interacts with various cellular factors and modulates...

Increased CD26/dipeptidyl pepticlase IV on cell membrane increases sensitivity.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Increased CD26/dipeptidyl pepticlase IV on cancer cells increases sensitivity to topoisomerase II inhibitors. "CD26/dipeptidyl peptidase IV (DPPIV) is a surface antigen with multiple functions,...

Higher CD44 or lower E-cadherin can increase tumor spread.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Upregulation of CD44 or downregulation of E-cadherin or both can increase a tumor's invasive properties. According to a study from the United States, "CD44 is a principal cell-surface receptor for...

Epidermal growth factor signaling pathway is impaired by oxidative stress.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Epidermal growth factor signaling pathway is impaired by oxidative stress induced by UVA, and vitamin E prevented much of the related effects. According to a study from France, "Ultraviolet A (UVA)...

Sporadic adenoma and intraepithelial neoplasia are difficult to distinguish.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Differential diagnosis between sporadic adenoma and intraepithelial neoplasia in ulcerative colitis patients is difficult, and should be attempted in the remission phase. "The differential...

Two parameters need to be estimated in validity/reliability studies.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- The correlation between the mismeasured and true exposure and differential bias need to be estimated in validity/reliability studies. "Differential exposure measurement error can have more adverse...

Caffeine diminishes cytotoxic effects of paclitaxel.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Caffeine diminishes cytotoxic effects of paclitaxel on human lung carcinoma cell line. "This study was performed to investigate how caffeine modifies the cytotoxic effects of paclitaxel on a human...

New treatment studied at MCG.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- An agent that stimulates the immune system to identify and eliminate abnormal cells may give women with the most common type of ovarian cancer new hope, says a Medical College of Georgia (MCG)...

Screening for malignancy is best done by way of a rapid access clinic.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Lymph node risk of malignancy and diagnosis can be assessed most effectively through specialized screening clinics. "Lymphadenopathy is common, affecting patients of all ages. The current referral...

Betel quid chewing and tobacco use, but not alcohol, increases risk.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- There is increased risk from betel quid chewing and tobacco use but not alcohol consumption in the development of oral leukoplakia and oral submucous fibrosis. According to a study from Taiwan, "In...

Monitoring tests may prompt patients to pick more aggressive treatment.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Some men who are diagnosed with prostate cancer choose to monitor the disease's progress instead of beginning aggressive treatment right away. This is called "watchful waiting." The relatively new...

Risk is related to overexpression of hMTH in peripheral blood lymphocytes.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Overexpression of a specific repair gene involved in oxidative stress was correlated to the risk for prostate cancer. "Oxidative damage is an important factor in prostate carcinogenesis, and...

Translocation t(9;11) appears to be related to a damage-repair mechanism.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- The characteristic translocation t(9;11) in acute myeloid leukemia appears to be related to a damage-repair mechanism, and usually involves MLL fusion to different parts of AF9. "The translocation...

Nasal-type NK/T cell lymphoma of the orbit can occur.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Nasal-type NK/T cell lymphoma of the orbit can occur and may progress/metastasize rapidly, even to the heart. "A case of a nasal-type NK/T cell lymphoma of the orbit with distant metastases is...

Cisplatin induces reticulum stress and nucleus-independent apoptotic signaling.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling. According to a study from Sweden, "DNA damage is believed to be the main cause of the antiproliferative...

2-(4-aminophenyl)benzothiazoles create DNA adducts in human tumor cells.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- The 2-(4-aminophenyl)benzothiazoles and a related prodrug generate DNA adducts in sensitive, but not resistant, ovarian and breast cancer cells. "2-(4-Aminophenyl)benzothiazoles represent a potent...

Sigma receptor agonists upregulate IL-10 and increase lung tumor growth.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Sigma receptor agonists, including cocaine, can upregulate IL-10 and increase lung tumor growth. According to recent research from the United States, "Sigma receptors are unique endoplasmic...

Membrane type-1 matrix metalloproteinase acts to self-cleave into multiple forms.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- There is a sequence of cleavages done by membrane type-1 matrix metalloproteinase, thus it is a proprotein self-convertase. According to recent research published in the Journal of Biological...

Metastasis to the ovaries is rare but possible.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Bladder adenocarcinoma was found to metastasize to the ovaries and bone. According to published research from Japan, "We report a urachal adenocarcinoma metastatic to both ovaries in a 50-year-old...

Workers exposed to beta-napthylamine are screened annually.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Workers exposed to beta-napthylamine are screened annually for bladder cancer. According to a study from the United States, "Approximately 1800 workers in pipe manufacturing plants in the United...

Neurotrophin receptor p75 acts as a tumor suppressor, inhibiting proliferation.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Neurotrophin receptor p75 levels in bladder tumor cells determine the levels of cell proliferation: the higher the amount of receptor, the lower the amount of proliferation. "The neurotrophin...

Highly malignant osteosarcoma is juxtaposed to areas of benign giant cell tumor.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Highly malignant osteosarcoma may be juxtaposed to areas of benign giant cell tumor. According to recent research from Italy, "Malignant giant cell tumor is a confusing term that in the past has...

Diagnosis of cerebral ischemia in less than 1% of patients did not prove harmful.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- In patients sent for screening (by computed stereotactic biopsy) for brain cancer, a very small percentage had other types of cerebral insults, most commonly ischemic insults, but biopsy was not...

A chiasmatic pilocytic astrocytoma undergoes malignant transformation.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- A chiasmatic pilocytic astrocytoma can undergo malignant transformation. "Chiasmatic gliomas with metastatic spread are rare in children and are usually associated with diencephalic syndrome,"...

Primary osteosarcoma can occur in the breast.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Primary osteosarcoma of the breast can occur, and clinically it was indistinguishable from a calcified fibroadenoma, although diagnosis was reached through histology. According to published...

An extract of Nigerian Vernonia amygdalina is an active anticancer agent.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Physiologically relevant concentrations of extract from Vernonia amygdalina inhibit DNA synthesis in a breast cancer cell line. According to recent research published in the journal Experimental...

Basement membrane invasion is preceded by type XV and XIX collagen loss.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Loss of types XV and XIX collagen precedes basement membrane invasion by ductal breast carcinoma. According to a study from the United States, "Ductal and lobular carcinomas comprise most...

Breakthrough in mammographic technology announced.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Planmed Inc., a manufacturer of mammography systems, announced its breakthrough development in mammography that enables radiologists and technologists to capture up to 30% more breast tissue than other...

Capecitabine treatment results in increased volume of red blood cells.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Treatment of patients with advanced solid cancer with capecitabine produced increased volume of red blood cells. "Capecitabine is a novel fluoropyrimidine carbamate which is selectively activated...

Thyroid and breast cancer are confined in their pattern of lymphatic spread.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Thyroid and breast cancer are confined in their pattern of lymphatic spread. "We previously showed that advanced visceral cancers (58 rectum cancers) are confined in their pattern of lymphatic...

Inactivation by methylation of the 3p21.3 gene BLU allows cancer growth.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- BLU appears to be a suppressor gene that is hypermethylated (inactivated) in a variety of human cancers. According to recent research from England, "Many distinct regions of 3p show frequent...

5-lipoxygenase in epithelial cells may contribute to diseases like cancer.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- 5-lipoxygenase in epithelial cells may contribute to diseases like cancer. According to recent research published in the journal Histology and Histopathology, "Leukotrienes (LTs) are intercellular...

Autofluorescence spectroscopy of malpighian epithelial cells may detect cancer.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Autofluorescence spectroscopy of malpighian epithelial cells may detect cervical cancer. "A spectroscopic analysis of autofluorescence was investigated within the cell cytoplasm from cervical...

Experts applaud FDA approval of new screening option.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- The following is a statement released by the Society of Gynecologic Oncologists and the Gynecologic Cancer Foundation: The Society of Gynecologic Oncologists (SGO) and the Gynecologic Cancer...