Cardiovascular Week articles from October 2003

Cardiovascular Week archives from October 2003

High blood pressure, fatty deposits are "bit players" in bulging arteries.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Contrary to long-accepted conventional wisdom and to current theories, high blood pressure and other risk factors for plaque buildup are not major factors in the dangerous ballooning of blood vessels...

Hypothermia - good for both brain and heart?
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Sudden death from cardiac arrest is a major health problem that still receives too little publicity. Current therapy after cardiac arrest concentrates on resuscitation efforts; until now, no specific...

Chest pain units improve the treatment of heart attacks.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Chest pain accounts for a considerable number of consultations in emergency departments. Among several other causes of chest pain, heart attacks need to be ruled out promptly since a fast diagnosis...

Discovery points to new way to control atherosclerosis.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Howard Hughes Medical Institute researchers have discovered a genetic switch that can drastically reduce fatty deposits in the coronary arteries of mice. According to the researchers, the switch is...

Researchers link vision change to patients diagnosed with high blood pressure.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- A new study conducted by researchers at Oregon Health & Science University found subtle visual changes among middle-aged people diagnosed with high blood pressure. The study found that certain...

Women with family history of early heart death at greater risk of having small babies.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Women with a family history of early death from coronary artery disease may be at increased risk of having an underweight baby, suggests new research. Low birth weight is itself a risk factor for...

Antibiotics don't help heart in study.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Antibiotics failed to ward off heart trouble in the biggest study yet to test the theory that low-level infections play a major role in triggering heart attacks. But researchers said they are not yet...

Heart may heal with help from oxygen-sensitive genes, new study suggests.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Researchers have uncovered a mechanism that the heart may use to repair tissue damaged during a heart attack. A new study reveals that oxygen is the trigger that helps specific genes in...

Alcohol drinking patterns differentially affect central adiposity.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Alcohol drinking patterns differentially affect central adiposity as measured by abdominal height. "Alcohol drinking in light-to-moderate amounts has been associated with reduced coronary heart...

Bypass surgery may relieve chest pain better than angioplasty plus stent.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Bypass surgery is better than stent-assisted angioplasty at relieving chest pain and improving quality of life in the year after the procedure, researchers report. The study is the first randomized...

Heart patients may benefit from VEGF gene transfer.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Heart patients may benefit from VEGF gene transfer. According to a study from the United States, "this phase I open label, dose-escalating study shows that gene transfer of vascular endothelial...

Fibrinolytic factors are not useful in predicting risk of thromboembolism.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Fibrinolytic factors are not useful in predicting risk of venous thromboembolism. According to recent research from the United States, "Prior research has conflicted on whether increased levels of...

Fucoidan and heparin enhance growth factor-induced tube formation.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- According to a study from France, "basic fibroblast growth factor (FGF-2) activates its high-affinity receptors (FGFRs) but also acts through interaction with heparan sulfate proteoglycans (HSPG)....

Basis of lisinopril-binding specificity in human ACE reported.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Scientists present the structural basis of the lisinopril-binding specificity in N- and C-domains of human somatic angiotensin I-converting enzyme (ACE)in a recent issue of Biochemical and Biophysical...

Clarithromycin has no effect on inflammatory markers in atherosclerosis.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Clarithromycin has no effect on inflammatory markers in atherosclerotic, coronary artery disease patients. "Atherosclerosis can, to a certain extent, be regarded as an inflammatory disease. Also,...

Invasive arterial catheter use reduced due to blood pressure monitoring systems.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Medwave Inc. (MDWV), developer of sensor-based, noninvasive blood pressure measuring solutions, reported that anesthesiologists at Northwest Medical Center of Tucson, Arizona, recently informed Medwave...

New insight offered into the genetics of congenital heart disease.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Using a sophisticated approach to alter gene activity in the embryo, scientists have identified a potential culprit for one of the most common human congenital heart malformations, AVCD...

Folkman honored for hypertension research.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Judah Folkman, MD, is the winner of this year's Novartis Award for Hypertension Research. He is a pioneer in the field of angiogenesis. His work has led to a better understanding of how angiogenesis is...

Company receives marketing clearance for Quantix/OR in United States.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Neoprobe Corp. (NEOP) announced that it has received clearance from the U.S. Food and Drug Administration (FDA) to begin commercial marketing of the Quantix/OR system for the intraoperative measurement...

Hemodilution with hemoglobin vesicle solutions can improve ischemic tissue oxygenation.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Hemodilution with HbV solutions can improve oxygen delivery to ischemic tissues. Scientists in Switzerland conducted a study "to test the influence of oxygen affinity of Hb vesicles (HbVs) and level...

Defibrillators save lives also in lay volunteers' hands.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Researchers in Piacenza, Italy, have found that when defibrillator devices are broadly disseminated throughout the community, early intervention by lay volunteers trained to use semiautonamic...

FDA grants approval to start atrial fibrillation study.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- CryoCath Technologies, Inc., (CYT), announced that is has received Investigational Device Exemption (IDE) conditional approval from the U.S. Food and Drug Administration (FDA) to initiate a study to...

Patient enrollment completed in cryoblation study.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- CryoCor, Inc., a development stage medical technology company, announced the completion of U.S. patient enrollment of the first phase of the feasibility trial for paroxysmal atrial fibrillation and the...

Intravascular MRI catheter for coronary arteries set for clinical trial.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- TopSpin Medical has developed a technology for a miniature, portable imaging probe containing all the magnetic field sources to perform local magnetic resonance imaging (MRI) with no external magnets,...

Pharmaceutical company spends $1.5M in cardiac safety monitoring for studies.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- eResearchTechnology, Inc. (eRT) (ERES), a provider of centralized electrocardiographic (ECG) collection and interpretation services, has received agreements for approximately $1.5 million in cardiac...

U.K. nurses may be best choice to advise patients about driving restrictions.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- After admission to the hospital with a wide range of illnesses, the law in the United Kingdom puts a restriction on driving in many cases. These regulations often affect previously fit people and may...

DNA microarray enables cardiac myocyte transcriptome study during heart failure.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- A DNA microarray enables cardiac myocyte transcriptome study during heart failure. "Dahl salt-sensitive rats are genetically hypersensitive to sodium intake. When fed a high sodium diet, they...

Targeted enzyme deletion attenuates left ventricular rupture after infarction.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Targeted enzyme deletion attenuates left ventricular rupture after infarction. "Matrix metalloproteinase-2 (MMP-2) is prominently overexpressed both after myocardial infarction (MI) and in heart...

Agreements signed for cardiac safety monitoring, information distribution services.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- eResearchTechnology, Inc., (eRT, ERES), a provider of centralized electrocardiographic (ECG) collection and interpretation services, announced that it has received agreements for more than $1.4 million...

Alliance with CryoVascular Systems for cardiology device technology.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Boston Scientific Corporation (BSX) announced that it has entered into a series of agreements with CryoVascular Systems, Inc., a privately held company located in Los Gatos, California. ...

Babies of diabetic mothers have fivefold increase in structural heart defects.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Babies born to mothers with diabetes are five times as likely to have structural heart defects as other babies, suggests a new study. Structural abnormalities of the heart are the most common kind...

Cardiac neuropathy contributes to high mortality in diabetic patients.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Cardiac autonomic neuropathy contributes to the high mortality rate seen in diabetic patients after a heart attack. "Diabetic patients have substantially greater long-term mortality after acute...

Losartan protects against sudden cardiac death in people with diabetes.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Data from the LIFE study suggest that losartan is better than atenolol in protecting against sudden cardiac death in people with diabetes. According to a study from Sweden, "In the Losartan...

Angiotensin II blockers useful for treatment of diabetic nephropathy.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Angiotensin II blockers are beneficial for the treatment of diabetic nephropathy. "The increased activity of the renin-angiotensin-aldosterone system (RAAS) is an important pathogenetic factor in...

Net sales up 34% for cardiothoracic surgery device manufacturer.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- MedicalCV, Inc., (MDCVU), a Minnesota-based cardiothoracic surgery device manufacturer, reported results for its first fiscal quarter ended July 31, 2003. Net sales for the quarter rose 34% to $1.1...

Skin substitute manufacturer emerges from Chapter 11 protection.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Organogenesis Inc. announced the completion of its court-approved reorganization plan, allowing the company to emerge from Chapter 11 protection and continue manufacturing and supplying Apligraf, its...

Tampa-based pharmaceutical company reports second quarter revenue of $84,049.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Nanobac Pharmaceuticals, Inc., (PNNBP) announced the filing of its 10Q for the period ending June 30, 2003, as well as an 8K/A required by the company's acquisition of NanobacLabs Pharmaceuticals. ...

$4M financing advances antithrombotic agent into clinical development.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Targeted Molecules Corp. (TMC) announced the completion of a $4 million financing by a group of investors that will be used to advance TMC's lead compound, TMC-2001, into clinical development and to...

Poor fitness increases risk of death in women more than in men.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Physical fitness level predicts death in women more than in men, Chicago researchers report. Findings from the St. James Women Take Heart Project (WTH) could influence how doctors test and treat women...

CYP3A5 genotype predicts renal CYP3A activity and blood pressure in healthy adults.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- CYP3A5 genotype is a strong predictor of renal CYP3A activity and blood pressure in healthy adults - which may help explain African-Americans' heightened hypertension risk. "A single-nucleotide...

Antioxidant treatment may do more harm than good.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Antioxidant treatment may do more harm than good for patients with HIV-associated lipodystrophy. In a recent study from the United States, "ten HIV-infected nucleoside reverse transcriptase...

Leptin replacement can ameliorate protease inhibitor-induced lipid abnormalities.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Leptin replacement therapy can ameliorate the lipid dysfunction triggered by some anti-HIV drugs. "A major complication associated with the use of protease inhibitors (PIs) in treatment of...

Japanese government expands use of automated external defibrillators.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Cardiac Science, Inc., (DFIB) announced that the Japanese Ministry of Health, Labor, and Welfare (MHLW) has for the first time approved the use of automated external defibrillators (AEDs) by non-medical...

Acetaminophen may be best for patients on cardioprotective aspirin therapy.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Heart specialists say acetaminophen, the medicine in Tylenol, may be the best choice over-the-counter pain reliever for the millions of Americans taking aspirin to protect against cardiovascular...

DECREASE-HF study to find best cardiac resynchronization therapy.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Approved by the U.S. Food and Drug Administration (FDA) in 2001, cardiac resynchronization therapy (CRT) has been hailed as the first major therapeutic breakthrough for people with serious congestive...

Hemostatic risk factors predict thrombosis during pregnancy and the puerperium.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Hemostatic risk factors predict thrombosis during pregnancy and the puerperium. "In a retrospective study of 190 women with a first history of venous thromboembolism during pregnancy and the....

Old drug works new tricks for iron overload heart disease.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Researchers at the University of Toronto (U of T) and Toronto General Hospital have made a discovery that could prevent damage to the heart, pancreas, and pituitary gland from excess iron with a simple...

New technology permits bedside assessment of cerebral hemodynamics.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Neoprobe Corporation (NEOP) announced that the results of a clinical evaluation using its proprietary blood flow measurement technology support the implementation of new technology in the bedside...

Benicar HCT now available in U.S.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Sankyo Pharma, Inc., and Forest Laboratories, Inc., (FRX) announced that Benicar HCT (olmesartan medoxomil-hydrochlorothiazide) is now available via prescription in the United States. Benicar HCT...

Hypotension-related liver disease clears upon hemodynamic support.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Hypotension-related liver disease clears upon hemodynamic support. "Ischemic hepatitis or shock liver is defined as an extensive hepatocellular necrosis associated with a decrease in hepatic...

Amgen submits NDA for cinacalcet HCL.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- NPS Pharmaceuticals, Inc., (NPSP) announced that its licensee, Amgen, Inc., of Thousand Oaks, California, has submitted a new drug application (NDA) to the U.S. Food and Drug Administration seeking...

Drug-eluting stents improve outcomes in heart stent procedures.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- ECRI's technology assessment of published studies on the implantation of drug-eluting stents after angioplasty concluded that the rate of coronary artery restenosis (reblockage or renarrowing of the...

Novel mAb may aid glycoprotein VI research.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- A novel monoclonal antibody may aid research on the platelet collagen receptor glycoprotein VI (GVPI). "The newly identified platelet collagen receptor glycoprotein A binds to fibrous collagen,...

Fungal infection can cause aneurysm of the extracranial internal carotid artery.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Fungal infection can cause an aneurysm in the carotid artery of immunosuppressed persons. According to a study from Belgium, "Extracranial internal carotid artery aneurysm is rare. "They...

Hypoxia-inducible VEGF gene delivery may treat ischemic heart disease.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Hypoxia-inducible VEGF gene delivery may treat ischemic heart disease. "Therapeutic angiogenesis with gene encoding vascular endothelial growth factor (VEGF) is a new potential treatment in...

PACAP is coexpressed with CGRP in rat, VIP in human tooth pulp nerve fibers.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Pituitary adenylate cyclase-activating polypeptide is coexpressed with calcitonin gene-related protein in rat, and vasoactive intestinal polypeptide in human tooth pulp nerve fibers. According to a...

Study: Multivitamins linked with reduced risk of heart attack.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Multivitamin/mineral supplement users may have a lower risk for myocardial infarction (MI) according to an observational study, reports the organization Vitamin Nutrition Information Service (VINS). ...

Oat bran product available to consumers.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- OatVantage, an all-natural, highly concentrated source of oat bran, is now available as a nutritional supplement in U.S. health food stores and provides a convenient, new option to help supply the...

Family history of early death from heart disease increases risk of LBW babies.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Women with a family history of early death from coronary artery disease may be at increased risk of having an underweight baby, suggests research in the journal Heart. Low birthweight is itself a...

Melatonin supplements may make standing hazardous for some.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- For insomniacs and jet-lagged travelers, melatonin supplements may enable a good night's sleep. However, a study by Chester A. Ray, PhD, associate professor of medicine, Penn State College of...

CardioWrap pericardial film wins FDA approval.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- MacroPore Biosurgery, Inc., (XMP) announced that it has received U.S. Food and Drug Administration (FDA) clearance for MacroPore CardioWrap, a bioresorbable film indicated for the repair of the...

Phase II drug shows promise for treating peripheral arterial obstructive disease.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- NicOx S.A. (NICOX) announced positive results from a clinical endoscopy study with NCX 4016 after 21 days of administration, both as monotherapy and in co-administration with aspirin, for the treatment...

Fendley named VP of operations at cardio-diagnostics company.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Atherotech, Inc., developer of the VAP (Vertical Auto Profile) Cholesterol Test, announced the appointment of Ted W. Fendley, PhD, as vice president of operations. Fendley will focus on ensuring the...

Gennevois named VP of medical affairs at cardiovascular device company.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Corgentech, Inc., a privately-held biotechnology company, announced that Daniel Gennevois, MD, has been appointed vice president of medical affairs. Gennevois has held a number of top clinical...

Martin B. Leon, MD, interventional cardiologist, joins scientific advisory board.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Light Sciences announced that Martin B. Leon, MD, president and CEO of Cardiovascular Research Foundation associated with Lenox Hill Hospital, was appointed to the company's scientific advisory board....

PDE2 and PDE4 inhibitors reduce VEGF-inspired cell growth and migration.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- PDE2 and PDE4 inhibitors reduce VEGF-inspired cell growth and migration. According to researchers from France, "migration and proliferation of endothelial cells in response to VEGF play an important...

Women satisfied in their marriage appear to reap health benefit.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Women who are in satisfying marriages have a health advantage over unmarried women or those in unsatisfying marriages, according to a study published in the September 2003 issue of Health Psychology....

Emergency rooms can rule out pulmonary embolism rapidly by following protocol.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Emergency rooms can rule out pulmonary embolism rapidly with protocol. "We propose an emergency department (ED) pulmonary embolism rule-out protocol based on pretest probability assessment coupled...

An animal model is found for Q fever endocarditis.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- An animal model is found for Q fever endocarditis, with calcifications and bacteria filled macrophages, as in humans. According to a study from Japan, "Q fever, a worldwide zoonosis caused by...

Physicians don't follow guidelines for women's heart care, study finds.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Women often miss out on cholesterol screening and nutrition counseling because their physicians do a poor job of following the recommended guidelines for cardiovascular care in women, according to a...

Angioplasty device company starts clinical studies of catheter.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- AngioScore, Inc., a developer of novel angioplasty tools, announced the successful initiation of the ACE (AngioSculpt Catheter Evaluation) clinical study of the company's AngioSculpt scoring catheter,...

Restenosis rates drop to 5.1% in sirolimus-eluting coronary stent trials.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Results of Cypher Sirolimus-eluting Coronary Stent trials in Canada and Europe demonstrate a reduction of restenosis rates to 5.1%, surpassing those of Sirius, the precedent-setting U.S. clinical trial....

Therapy to combat septic shock mortality is based on limiting immune reactivity.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- The pathophysiology of sepsis should eventually be overcome by an understanding of the immune mechanisms involved. "Severe sepsis leading to shock is the principal cause of death in non-cardiac...

Distribution agreement announced for sudden cardiac death risk stratifier.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Quinton Cardiology Systems, Inc., (QUIN) and Cambridge Heart, Inc., (CAMH), the developer of the Microvolt T-Wave Alternans test (MTWA) for the risk assessment of sudden cardiac death, jointly announced...

New drug therapies improve outcomes.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Sudden cardiac death is mostly due to coronary artery disease, and it is one of the major killers in our industrialized world. If someone who is suffering from sudden cardiac death is very lucky,...

Home care trial planned for heart failure patients.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- American TeleCare, Inc., (ATI) announced a partnership to launch a home telemonitoring 9-month clinical trial with Partners Home Care and Partners Telemedicine. The purpose of this study is to see...

Deep vein thrombosis may be related to acute cytomegalovirus infection.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Deep vein thrombosis may be related to an acute cytomegalovirus infection, according to a recent report in Blood Coagulation and Fibrinolysis. "We report the case of a 17-year-old girl with...

Thrombin upregulates ICAM-1 in human monocytes, THP-1 cells, and in pregnancy.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Thrombin upregulates ICAM-1 in human monocytes, THP-1 cells, and in pregnancy. "Monocytes play a pivotal role in both the inflammatory and coagulation responses, which may be mediated through a...

Gene transfer of IkappaBalpha limits infarct size in a murine model.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Gene transfer of IkappaBalpha limits infarct size in a murine model. "Nuclear factor-kappaB (NF-kappaB) plays a central role in myocardial ischemia-reperfusion (MI/R) injury. The inhibitory protein...

Can heart failure impair thinking?
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- High sympathetic and decreased parasympathetic activities are characteristic of heart failure (HF) and are manifested as blunted baroreceptor activity, diminished parasympathetic effects on the...

Study: Early use of antiplatelet therapy reduces incidence of death.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Treating high-risk acute coronary syndrome (ACS) patients with an antiplatelet medicine, known as a glycoprotein (GP) IIb-IIIa inhibitor, before interventional procedures such as angioplasty,...

Aspirin reduces risk of first heart attack by one-third.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Aspirin reduces the risk of a first heart attack by 32%, according to a report by researchers at Mount Sinai Medical Center & Miami Heart Institute (MSMC-MHI). The paper, which is based on a...

Homeobox transcription factors may hold the key to groundbreaking therapies.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Homeobox transcription factors may hold the key to groundbreaking therapies. "Homeobox genes are a family of transcription factors with a highly conserved DNA-binding domain that regulate cell...

New risk factor first identified in Illinois family by SLU cardiologist.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- A cardiologist at St. Louis University School of Medicine was the first to identify a new hereditary condition that increases the risk of sudden cardiac death. The risk factor - a dramatic, short...