Cancer Vaccine Week articles from September 2004

Cancer Vaccine Week archives from September 2004

Binding patterns reveal tumor-specific epitope of epithelial mucin.
September 6, 2004... 2004 SEP 6 - (NewsRx.com & NewsRx.net) -- Binding patterns of DTR-specific antibodies reveal a glycosylation-conditioned tumor-specific epitope of the epithelial mucin (MUC1). "Glycosylation determines essential biological functions of...

Dendritic cell and fibroblast fusions possess antitumor effects.
September 6, 2004... 2004 SEP 6 - (NewsRx.com & NewsRx.net) -- Fusions composed of dendritic cells and fibroblasts transfected with genomic DNA from tumor cells possess antitumor effects. According to a study from Japan and the United States, "Based on several...

Epigenetically altered tumor cell vaccine developed.
September 6, 2004... 2004 SEP 6 - (NewsRx.com & NewsRx.net) -- An epigenetically altered tumor cell vaccine has been developed. According to a study from the United States, "Functional inactivation of genes critical to immunity may occur by mutation and/or by...

Pemetrexed (ALIMTA) is novel multitargeted antineoplastic agent.
September 6, 2004... 2004 SEP 6 - (NewsRx.com & NewsRx.net) -- Pemetrexed (ALIMTA) is a novel multitargeted antineoplastic agent. "Pemetrexed (ALIMTA, LY231514, MTA) is a novel antimetabolite that inhibits at least three enzymes involved in the folate pathway....

Dendritic cells and Langerhans cells both cross-prime T cells.
September 6, 2004... 2004 SEP 6 - (NewsRx.com & NewsRx.net) -- Despite differences between dendritic cells and Langerhans cells in the mechanism of papillomavirus-like particle antigen uptake, both cells cross-prime T cells. According to a study from...

Mesenchymal stem cells have antitumor effect in rat glioma model.
September 6, 2004... 2004 SEP 6 - (NewsRx.com & NewsRx.net) -- Genetically engineered mesenchymal stem cells have an antitumor effect in a rat glioma model. "The prognosis of patients with malignant glioma is extremely poor, despite the extensive surgical...

Pharmaceutical company reports second quarter, clinical development results.
September 6, 2004... 2004 SEP 6 - (NewsRx.com & NewsRx.net) -- Progenics Pharmaceuticals, Inc., (NASDAQ: PGNX) announced its results of operations for the second quarter ended June 30, 2004, and first half of 2004. The company also provided an update of its...

Dendritic cell vaccine induces tumoricidal CD8+ cytotoxic lymphocytes.
September 6, 2004... 2004 SEP 6 - (NewsRx.com & NewsRx.net) -- Vaccination with dendritic cells pulsed in vitro with tumor antigen conjugated to cholera toxin efficiently induces specific tumoricidal CD8+ cytotoxic lymphocytes dependent on cyclic AMP activation of...

Genetic adjuvants enhance efficacy of vaccine against Her-2/neu tumor antigen.
September 6, 2004... 2004 SEP 6 - (NewsRx.com & NewsRx.net) -- Genetic adjuvants enhance the efficacy of DNA vaccination against Her-2/neu tumor antigen. According to published research from South Korea, "Certain types of malignant tumors overexpress Her-2/neu,...

IL-18-secreting fibroblasts prolong survival of tumor-bearing mice.
September 6, 2004... 2004 SEP 6 - (NewsRx.com & NewsRx.net) -- Interleukin-18-secreting fibroblasts loaded with an epitope peptide generated tumor-specific cytotoxic T lymphocyte and prolongation of the survival of tumor-bearing mice. "There is currently much...

Immunotherapy of cancer reviewed.
September 6, 2004... 2004 SEP 6 - (NewsRx.com & NewsRx.net) -- Scientists review the immunotherapy of cancer in a recent issue of the Journal of Cancer Research and Clinical Oncology. "Until the end of the 19th century the possibility that a tumor could be...

Non-CpG motif oligonucleotides for cancer vaccination developed.
September 6, 2004... 2004 SEP 6 - (NewsRx.com & NewsRx.net) -- Scientists have developed immunomodulatory six base-length non-CpG motif oligonucleotides for cancer vaccination. According to recent research from Canada, "We have previously described a novel...

Plasmid DNA in microparticles stimulates durable T cell responses.
September 6, 2004... 2004 SEP 6 - (NewsRx.com & NewsRx.net) -- Repeated immunization with plasmid DNA formulated in poly(lactide-co-glycolide) microparticles is well tolerated and stimulates durable T cell responses to the tumor-associated antigen cytochrome...

T-cell responses in patients vaccinated with melanoma vaccine reported.
September 6, 2004... 2004 SEP 6 - (NewsRx.com & NewsRx.net) -- Researchers report the results of an analysis of T-cell responses in metastatic melanoma patients vaccinated with dendritic cells pulsed with tumor lysates in a recent issue of Cancer Immunology...

New DNA vaccine targets proteins expressed in cervical cancer cells.
September 6, 2004... 2004 SEP 6 - (NewsRx.com & NewsRx.net) -- Johns Hopkins Medical Institutions pathologists have developed a new DNA vaccine that targets proteins expressed in cervical cancer cells. Their work was described in the August 2004 issue of the...

Local planners approve Vermont cancer center.
September 6, 2004... 2004 SEP 6 - (NewsRx.com & NewsRx.net) -- Local planners have given their approval for a proposed $8 million cancer center located in the former Ames department store building. The North Country Oncology Center is a joint venture between...

Telomerase technology company reports Q2 loss of $8.9 million.
September 6, 2004... 2004 SEP 6 - (NewsRx.com & NewsRx.net) -- Geron Corp. (GERN) reported financial results for the three and six months ended June 30, 2004. For the second quarter of 2004, the company reported a net loss of $8.9 million or $0.20 per share...

Cells engineered to secrete soluble CD70 boost antitumor immunity.
September 6, 2004... 2004 SEP 6 - (NewsRx.com & NewsRx.net) -- Cells engineered to secrete soluble CD70 boost antitumor immunity. According to a study from France, "one of the strategies to promote an antitumor response is the genetic modification of tumor...

Novel diffuse large B-cell lymphoma cancer testis antigen identified.
September 6, 2004... 2004 SEP 6 - (NewsRx.com & NewsRx.net) -- Scientists have identified a novel diffuse large B-cell lymphoma-associated cancer testis antigen encoding a PAS domain protein. According to published research from England, "Here we report that...

Alkaloid riddelliine induces mutations in liver cII gene of Big Blue rats.
September 6, 2004... 2004 SEP 6 - (NewsRx.com & NewsRx.net) -- The carcinogenic pyrrolizidine alkaloid riddelliine induces mutations in the liver cII gene of transgenic Big Blue rats. According to published research from the United States, "Riddelliine is a...

Cell-therapy company announces executive appointments.
September 6, 2004... 2004 SEP 6 - (NewsRx.com & NewsRx.net) -- Chromos Molecular Systems, Inc., (CHR) announced the appointments of Dr. Phillip B. Maples as vice president, clinical development and manufacturing; Dr. Alan Hardwick as vice president, process...

Riaz Bandali joins board of electroporation company.
September 6, 2004... 2004 SEP 6 - (NewsRx.com & NewsRx.net) -- Genetronics Biomedical Corp. (GEB) announced that the company's board of directors has appointed Riaz Bandali as a director of the company. Bandali is currently senior vice president of business...

Immunobiology of Tomatine adjuvant reviewed.
September 6, 2004... 2004 SEP 6 - (NewsRx.com & NewsRx.net) -- Researchers review the immunobiology of the Tomatine adjuvant in a recent issue of the journal Vaccine. According to recent research from the United States, "Soluble or sub-unit protein vaccines...

Individual cancer, virus vaccines promote healthy future for biotechnology company.
September 6, 2004... 2004 SEP 6 - (NewsRx.com & NewsRx.net) -- Merix Bioscience wants to give patients a dose of their own medicine. To that end, the Durham biotechnology firm is creating personalized vaccines that signal patients' immune systems to attack...

Anti-parathyroid immunotherapy reduced metastatic tumor size.
September 13, 2004... 2004 SEP 13 - (NewsRx.com & NewsRx.net) -- Anti-parathyroid hormone immunotherapy reduced tumor size in a patient with metastatic parathyroid carcinoma. According to a study from Belgium, "Parathyroid carcinoma is a rare cause of primary...

Dendritic cell-tumor cell hybrids generated by electrofusion.
September 13, 2004... 2004 SEP 13 - (NewsRx.com & NewsRx.net) -- Scientists have generated dendritic cell-tumor cell hybrids by electrofusion for clinical vaccine application. According to a study from the United States and France, "Vaccination with hybrids...

Naked RNA vaccine controls tumors with down-regulated MHC expression.
September 13, 2004... 2004 SEP 13 - (NewsRx.com & NewsRx.net) -- A naked RNA vaccine controls tumors with down-regulated MHC class I expression through NK cells and perforin-dependent pathways. According to recent research from Taiwan, "One of the major issues...

Additional data from phase I trial of GVAX pancreatic cancer vaccine reported.
September 13, 2004... 2004 SEP 13 - (NewsRx.com & NewsRx.net) -- Cell Genesys, Inc., (CEGE) announced the publication of encouraging immunologic data for GVAX pancreatic cancer vaccine, a non-patient-specific vaccine which is being developed as an "off-the-shelf"...

Company reaches clinical milestone related to IL-9 antibody alliance.
September 13, 2004... 2004 SEP 13 - (NewsRx.com & NewsRx.net) -- Genaera Corp. (GENR) announced achievement of a $500,000 milestone payment from MedImmune, Inc., related to the initiation of phase I clinical trials with a neutralizing interleukin-9 (IL-9) antibody....

Biopharmaceutical company announce milestones in StaphVAX development.
September 13, 2004... 2004 SEP 13 - (NewsRx.com & NewsRx.net) -- Nabi Biopharmaceuticals (NASDAQ:NABI) announced the completion of two of its three major milestones in 2004 for the development of its lead program StaphVAX [Staphylococcus aureus Polysaccharide...

Recombinant xenogeneic endoglin boosts immune system response to tumors.
September 13, 2004... 2004 SEP 13 - (NewsRx.com & NewsRx.net) -- Recombinant xenogeneic endoglin boosts immune system response to tumors. "Angiogenesis plays a critical role in tumor growth and metastasis. Increasing evidence suggests that endoglin is a powerful...

Biopharmaceutical company hosts conference to discuss liposomes.
September 13, 2004... 2004 SEP 13 - (NewsRx.com & NewsRx.net) -- NeoPharm, Inc, (Nasdaq:NEOL) announced that it will sponsor a conference, entitled "Advances in Liposomes: New Technologies and New Therapies," in Lincolnshire, Illinois, a suburb of Chicago. ...

Study supports electroporation-mediated DNA delivery without anesthesia.
September 13, 2004... 2004 SEP 13 - (NewsRx.com & NewsRx.net) -- Genetronics Biomedical Corp. (AMEX), a late-stage developer of cancer and other therapies using electroporation-enabled delivery of drugs, DNA vaccines, and genes, announced that a study assessing the...

Electroporation-focused company report Q2 net loss of $2.2 million.
September 13, 2004... 2004 SEP 13 - (NewsRx.com & NewsRx.net) -- Genetronics Biomedical Corp. (GEB), a late-stage developer of cancer and other therapies using electroporation-enabled delivery of drugs, DNA vaccines, and genes, announced its results for the quarter...

Peptide variants of viral epitopes promote antigen-specific thymocytes.
September 20, 2004... 2004 SEP 20 - (NewsRx.com & NewsRx.net) -- Peptide variants of viral CTL epitopes mediate positive selection and emigration of antigen-specific thymocytes in vivo. "During development, thymocytes carrying TCRs mediating low-affinity...

Vaccine and antibody-directed T cell tumor immunotherapy reviewed.
September 20, 2004... 2004 SEP 20 - (NewsRx.com & NewsRx.net) -- Scientists review vaccine and antibody-directed T cell tumor immunotherapy in a recent issue of Biochimica Et Biophysica Acta - Reviews on Cancer. According to a study from England, "Clearer...

Vaccine targeting carbohydrate antigen induces tumor-specific antibody.
September 20, 2004... 2004 SEP 20 - (NewsRx.com & NewsRx.net) -- A fully synthetic therapeutic vaccine candidate targeting carcinoma-associated Tn carbohydrate antigen induces tumor-specific antibodies in nonhuman primates. "We recently developed an efficient...

p63 gene plays role in esophageal squamous cell carcinoma development.
September 20, 2004... 2004 SEP 20 - (NewsRx.com & NewsRx.net) -- The p63 gene plays role in human esophageal squamous cell carcinoma. According to a study from Japan, "p63, a recently identified member of the p53 gene family, plays an important role in human...

CpG motifs are efficient adjuvants for DNA cancer vaccines.
September 20, 2004... 2004 SEP 20 - (NewsRx.com & NewsRx.net) -- CpG motifs are efficient adjuvants for DNA cancer vaccines. According to recent research from Austria, "DNA vaccines can induce impressive specific cellular immune response (IR) when taking...

Dendritic cell vaccine safe for children with brain cancer.
September 20, 2004... 2004 SEP 20 - (NewsRx.com & NewsRx.net) -- Researchers report the results of a phase 1 study utilizing monocyte-derived dendritic cells pulsed with tumor RNA in children and young adults with brain cancer in a recent issue of the journal...

Wyoming to begin developing cancer control plan.
September 20, 2004... 2004 SEP 20 - (NewsRx.com & NewsRx.net) -- Wyoming health officials and others will gather in Casper to begin developing a plan to control and reduce cancer rates in Wyoming. On September 1, 2004, at the Holiday Inn in Casper, up to 125...

Beta-1,3-glucans enhance tumoricidal activity of antitumor antibodies.
September 20, 2004... 2004 SEP 20 - (NewsRx.com & NewsRx.net) -- Researchers have determined the mechanism by which orally administered beta-1,3-glucans enhance the tumoricidal activity of antitumor monoclonal antibodies in murine tumor models. According to...

DNA vaccine plus vaccinia virus infection induce anti-cancer response.
September 20, 2004... 2004 SEP 20 - (NewsRx.com & NewsRx.net) -- DNA vaccination followed by vaccinia virus infection induced a cytotoxic T-cell response against steroidogenic acute regulatory protein in a mouse adrenal carcinoma model. "Adrenocortical...

Dendritic cell vaccine elicits antigen-specific T-cells against glioma.
September 20, 2004... 2004 SEP 20 - (NewsRx.com & NewsRx.net) -- Vaccination with tumor lysate-pulsed dendritic cells elicits antigen-specific, cytotoxic T-cells in patients with malignant glioma. "The primary goal of this Phase I study was to assess the safety...

Dendritic cells loaded with liver cancer cells suppress liver tumors.
September 20, 2004... 2004 SEP 20 - (NewsRx.com & NewsRx.net) -- Inoculation with dendritic cells loaded with hepatocellular carcinoma cells inhibited spontaneous development of liver tumors in C3H/HeNCRJ mice. "We attempted to prevent spontaneous development of...

Multimodal cell therapy reasonable to treat advanced gastric cancer.
September 20, 2004... 2004 SEP 20 - (NewsRx.com & NewsRx.net) -- Researchers report the effects of a multimodal cell therapy approach with PBSCs to treat advanced gastric cancer. "The EAP combination of etoposide (ETP), doxorubicin (ADM) and cisplatin (CDDP)...

Vaccine induces antitumor immunity in CEA transgenic mice.
September 20, 2004... 2004 SEP 20 - (NewsRx.com & NewsRx.net) -- Dendritic cells pulsed with an anti-idiotype antibody mimicking carcinoembryonic antigen (CEA) can reverse immunological tolerance to CEA and induce antitumor immunity in CEA transgenic mice. ...

Immunomodulators aid maturation of dendritic cells.
September 20, 2004... 2004 SEP 20 - (NewsRx.com & NewsRx.net) -- Immunomodulators aid the maturation of dendritic cells. "Biological response modifiers (BRMs) augment the cytotoxic activity of various effector cells by the induction of multiple cytokines and...

Vaccinating and screening for human papillomavirus reviewed.
September 20, 2004... 2004 SEP 20 - (NewsRx.com & NewsRx.net) -- Researchers present an international perspective on screening and vaccination for human papillomavirus in a recent issue of the International Journal of Cancer. According to a study from Spain, "At...

BLP25 liposome vaccine phase IIb data to be subject of presentation.
September 27, 2004... 2004 SEP 27 - (NewsRx.com & NewsRx.net) -- Biomira, Inc., (BIOM, BRA) and its collaborator, Merck KGaA of Darmstadt, Germany, announced that data from the companies' phase IIb BLP25 Liposome vaccine (L-BLP25) trial has been accepted as the...

Immunotherapy of ovarian cancer with antibodies reviewed.
September 27, 2004... 2004 SEP 27 - (NewsRx.com & NewsRx.net) -- A researcher reviews immunotherapy of ovarian cancer with antibodies in a recent issue of Expert Opinion on Biological Therapy. "Recent advances in the molecular and cellular biology of malignancy...

NY-ESO-1 protein with ISCOMATRIX adjuvant induces broad immune response.
September 27, 2004... 2004 SEP 27 - (NewsRx.com & NewsRx.net) -- Recombinant NY-ESO-1 protein with ISCOMATRIX adjuvant induces broad integrated antibody and CD4+ and CD8+ T cell responses in humans. According to published research from Australia and the United...

Response to melanoma dendritic cell vaccine provides therapy insights.
September 27, 2004... 2004 SEP 27 - (NewsRx.com & NewsRx.net) -- The response to vaccination with monocyte-derived dendritic cells can provide insight into melanoma vaccine efficacy. According to published research from Germany and Denmark, "Anticancer immune...

Cancer-vaccine maker appoints Konstantine Sarafis as COO.
September 27, 2004... 2004 SEP 27 - (NewsRx.com & NewsRx.net) -- GeneMax Corp. (GMXX) announced that Konstantine Sarafis was appointed its COO, effective August 30, 2004. Sarafis will be responsible for the development, coordination, and execution of the...