Cancer Vaccine Week articles from October 2003

Cancer Vaccine Week archives from October 2003

Phase II study demonstrates vaccine effectiveness in half of patients.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- A Phase II clinical study reports that administration of a prototype vaccine, developed by Therion Biologics Corp., administered in combination with interleukin-2 (IL-2), generated objective tumor...

Cdc37 is necessary for normal human prostate epithelial cell survival.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Cdc37 is necessary for normal human prostate epithelial cell survival. According to published research from the United States, "Cdc37 is a co-chaperone protein that recruits several immature client...

PBR-specific ligands cause apoptosis and cell-cycle arrest.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- PBR-specific ligands cause apoptosis and cell-cycle arrest. "Specific ligands of the peripheral benzodiazepine receptor (PBR) are known to induce apoptosis and cell cycle arrest in esophageal...

Low levels of chromium(VI) selectively activates Src family kinases, JNK.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Low levels of chromium(VI) selectively activate Src family kinases and JNK. According to published research from the United States, "Inhaled hexavalent chromium (Cr(VI)) promotes pulmonary disease...

Lung cancer vaccines yield promising results in clinical trials.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Lung cancer vaccines are yielding promising results in clinical trials. "A number of cancer vaccine and gene therapy approaches are being evaluated in patients with lung cancer. Cancer vaccine...

Immunotherapeutic approaches in ovarian cancer reviewed.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Immunologic principles and immunotherapeutic approaches in ovarian cancer have been reviewed in a recent issue of Hematology - Oncology Clinics of North America. According to researchers in the...

Functional FAS promoter polymorphisms are associated with increased risk of AML.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Functional FAS promoter polymorphisms are associated with increased risk of AML. "The FAS (TNFRSF6/CD95/APO-1) gene is silenced in many tumor types, resulting in an inability to respond to...

Novel mechanisms of apoptosis induced by histone deacetylase inhibitors.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Novel mechanisms of apoptosis can be induced by histone deacetylase inhibitors. "Histone deacetylase inhibitors (HDACIs) are a new class of chemotherapeutic drugs able to induce tumor cell apoptosis...

PS-341 enhances TRAIL-induced apoptosis by increasing the cleavage of caspase 8.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- PS-341 enhances TRAIL-induced apoptosis by increasing the cleavage of caspase 8. "We demonstrate that PS-341, a small molecule inhibitor of the proteasome, markedly sensitizes resistant prostate,...

Pifithrin-alpha promotes p53-mediated apoptosis in JB6 cells.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Pifithrin-alpha promotes p53-mediated apoptosis in JB6 cells. According to recent research from the United States, "Recently, blockage of p53-dependent transcriptional activation and apoptosis by...

Brk promotes breast carcinoma cell proliferation.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Brk promotes breast carcinoma cell proliferation. "Brk (PTK6) is a nonreceptor protein tyrosine kinase, which is expressed in over 60% of breast carcinoma tissue samples and breast tumor cell...

Malathion alters cell adhesion of cultured breast carcinoma cells.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Malathion alters cell adhesion of cultured breast carcinoma cells. "We have studied the effects of the organophosphorous pesticide malathion on cell viability, actin cytoskeleton, cell adhesion...

cDNA microarray profiling identifies 5-fluorouracil-inducible target genes.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- cDNA microarray profiling identifies 5-fluorouracil-inducible target genes. According to a study from Northern Ireland, "The fluoropyrimidine 5-Fluorouracil (5-FU) is widely used in the treatment...

Sodium salicylate may be used to protect cells against deleterious stressors.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Sodium salicylate may be used to protect cells against deleterious stressors. According to recent research published in the European Journal of Biochemistry, "As heat shock proteins (Hsps) are...

GeneMax Corp. announces agreement for the production of TAP cancer vaccine.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- GeneMax Corp. (GMXX) announced an amended contractual agreement with Molecular Medicine BioServices, Inc., of San Diego, California, for the production of its clinical vector for delivery of the TAP...

Chromosomal instability is an early driving force of cancer progression.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Chromosomal instability is an early driving force of cancer progression. According to published research from the United States, "In this paper, we derive analytic solutions of stochastic...

Lysophosphatidic acid signaling has role in cancer progression.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Lysophosphatidic acid signaling has role in cancer progression. According to a study from the United States, "Lysophosphatidic acid (LPA) promotes growth, differentiation, survival and motility in...

Epimmune earns milestone payment under cancer epitope license.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Epimmune, Inc., (EPMN) announced that it has earned and received a milestone payment from Anosys, Inc., as a result of Anosys' filing of an IND for a product incorporating Epimmune technology under a...

Ethics of phase 1 oncology studies examined.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- The ethics of phase 1 oncology studies have been examined in a recent issue of the Journal of the American Medical Association. "Phase 1 oncology trials are critical to improving the treatment of...

P16 inactivation may be associated with development of uterine cervical cancers.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- P16 inactivation may be associated with development of uterine cervical cancers. According to recent research from India, "In our analysis, alterations in the P16 tumor suppressor gene were seen in...

A low but significant number of colorectal carcinomas are positive for EMR2.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- A low but significant number of colorectal carcinomas are positive for EMR2. "EMR2 and CD97, members of the epidermal growth factor (EGF)-TM7 family, show a very high homology. CD97, whose...

Detection of hepatic disseminated tumor cells is a powerful prognostic factor.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Detection of hepatic disseminated tumor cells is a powerful prognostic factor. According to a study from Germany, "Approximately 30-50% of all colorectal cancer patients with a resectable primary...

Function of APC may be regulation of caspase activity, other apoptotic proteins.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- One of the functions of adenomatous polyposis coli (APC) may be the regulation of caspase activity and other apoptotic proteins. "The adenomatous polyposis coli gene, a member of the WNT pathway,...

PEITC may play an important role in cancer cell killing.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- PEITC may play an important role in the killing of cancerous cells. According to a study from the United States, "Phenethyl isothiocyanate (PEITC) is a potential chemopreventive agent that is...

CRAC1 is unlikely to be implicated in the development of colorectal cancer.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- CRAC1 is unlikely to be implicated in the development of colorectal cancer. "A susceptibility gene to colorectal adenomas and carcinoma (CRAC1) on chromosome region 15q14 similar to q22 has been...

FDA approves clinical trial to test therapeutic vaccine Collidem.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- IDM (Immuno-Designed Molecules), a biopharmaceutical company in the field of cellular immunotherapy, announced that it has received approval from the U.S. Food and Drug Administration (FDA) to launch a...

Peptide mass signature genotyping can detect TP53 mutations in tumor DNA.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Peptide mass signature genotyping can detect TP53 mutations in tumor DNA. According to a study from the United States, "This report describes the application of a new approach to tumor genotyping...

Biotechnology and pharmaceutical companies co-developing new anticancer drug.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- OncoGenex Technologies, Inc., and Isis Pharmaceuticals, Inc., (ISIS) have expanded their antisense drug development partnership to include the development of the second-generation antisense anticancer...

Akt may have a pivotal role in regulating endometrial cancer cell survival.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Akt may have a pivotal role in regulating endometrial cancer cell survival. "In a number of different cancers including endometrial cancers, tumor suppressor phosphatase tensin homologue (PTEN, a...

Insensitivity to growth suppression signals might be a mechanism of cell immortality.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Insensitivity to the usual growth suppression signals induced by activin A might be one of the mechanisms of immortality of human endometrial adenocarcinoma cells. "Menstrual cycle-dependent...

H. pylori increases proteasome-mediated degradation of p27(Kip1).
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- H. pylori increases proteasome-mediated degradation of p27(Kip1). According to published research from the United States, "Helicobacter pylori infection is associated with increased gastric...

Activation of transcription factors may contribute to stomach cancer development.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Inappropriate activation of intestine-specific transcription factors could contribute to the occurrence of the intestinal-type cancer of the stomach. According to recent research from Japan,...

Telomere dysfunction could contribute to genomic instability in human tumors.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Telomere dysfunction could contribute to genomic instability in human tumors. According to recent research from the United States, "Tumor growth is an evolutionary process that is characterized by...

PEITC potently induces apoptosis and cell-cycle arrest in HepG2 cells.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Beta-phenylethyl isothiocyanate (PEITC) potently induces apoptosis and cell-cycle arrest in HepG2 cells. "Beta-phenylethyl isothiocyanate (PEITC) is a promising chemoprotective compound that is...

Oncogenic transformation by BK virus may lead to human tumors.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Oncogenic transformation by BK virus may lead to human tumors. According to a study from Italy, "BK virus (BKV), a human polyomavirus closely related to JC virus and Simian Virus 40, is ubiquitous...

Corixa Corp. signs research, development, and license agreement.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- InNexus Biotechnology, Inc., (IXS), a monoclonal antibody-development company, and Corixa Corp. (CRXA), a developer of immunotherapeutic products, announced that the companies have entered into an...

Anthocyanidins induce apoptosis in human promyelocytic leukemia cells.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Anthocyanidins induce apoptosis in human promyelocytic leukemia cells. According to recent research published in the International Journal of Oncology, "Anthocyanidins are the aglycon nucleuses of...

p15 Methylation has a poor prognostic impact on disease-free survival.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- p15 Methylation has a poor prognostic impact on disease-free survival in leukemia. According to recent research from the People's Republic of China, "Acute promyelocytic leukemia (APL) has distinct...

Loss of PDCD4 expression correlates with tumor progression and prognosis.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Loss of PDCD4 expression correlates with tumor progression and prognosis. According to recent research from Germany, "The programmed cell death 4 gene (PDCD4), a newly identified transformation...

Zinc adequacy appears to be necessary for maintaining DNA integrity.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Zinc adequacy appears to be necessary for maintaining DNA integrity. "Poor zinc nutrition may be an important risk factor in oxidant release and the development of DNA damage and cancer,"...

Mutation of the BIK gene is a frequent feature of B-cell lymphomas.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Mutation of the BIK gene is a frequent feature of B-cell lymphomas. According to recent research published in the journal Genes Chromosomes & Cancer, "BIK, a BH (Bcl2 homology domain)3-only...

Oncolytic adenovirus may accelerate radiation-induced tumor fibrosis.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Oncolytic adenovirus may accelerate radiation-induced tumor fibrosis. According to a study from France, "In spite of aggressive surgery, irradiation and/or chemotherapy, treatment of malignant...

Imatinib may inhibit the growth-promoting role of wild-type ckit.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Imatinib may inhibit the growth-promoting role of wild-type ckit. "Imatinib has shown to be effective against malignant disease driven by ckit," scientists writing in the journal Lancet report. ...

Both products of the mouse Ink4a/Arf locus suppress melanoma formation in vivo.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Both products of the mouse Ink4a/Arf locus suppress melanoma formation in vivo. "Deletion of the INK4a/ARF locus at 9p21 is detected with high frequency in human melanoma. Within a short genomic...

Knowledge of genetics has generated optimism for prevention program development.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- The ability to validate pathogenetic relevance of mutations in the mouse has generated optimism for development of effective prevention programs, diagnostic measures and targeted therapeutics. ...

Wnt signaling plays a role in the pathogenesis of mesothelioma.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Wnt signaling plays a role in the pathogenesis of mesothelioma. "Malignant pleural mesothelioma is a relatively uncommon and yet incurable tumor. The pathogenesis of mesothelioma remains poorly...

TRAF2 controls cell sensitivity to apoptosis.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- TRAF2 controls cell sensitivity to apoptosis. According to recent research published in the journal Molecular and Cellular Biology, "Tumor necrosis factor receptor (TNFR)-associated factor 2...

Financing secured for the development of cancer vaccines.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Therion Biologics Corporation has successfully secured private equity financing totaling $39 million for the advanced clinical development of Panvac-VF and Prostvac-VF, its lead vaccine candidates to...

Bombesin may act as a mitogen in prostate cancer.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Bombesin may act as a mitogen in prostate cancer. "Bombesin and its mammalian homologue gastrin-releasing peptide have been shown to be highly expressed and secreted by neuroendocrine cells in...

Grape seed extract may be an effective therapeutic agent for prostate cancer.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Grape seed extract may be an effective therapeutic agent in prostate cancer. According to a study from the United States, "The alarmingly high rate of prostate cancer (PCA) mortality as well as the...

U19 suppresses prostate tumor growth.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- U19 suppresses prostate tumor growth. According to recent research published in the journal Cancer Research, "Androgens control prostate homeostasis and regulate androgen response genes. ...

SUMO-1/Ubc9 promotes nuclear accumulation and metabolic stability Smad4.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- SUMO-1/Ubc9 promotes nuclear accumulation and metabolic stability Smad4. According to a study from the United States, "Tumor suppressor Smad4/DPC4 is a central intracellular signal transducer for...

Analysis of differentiation therapy might provide targeted molecules for therapy.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Analysis of molecular mechanisms of tumor differentiation therapy by vesnarinone might provide selective and targeted molecules for novel tumor dormancy therapy. According to a study from Japan,...

Carbohydrate-specific antibodies make potential cancer vaccine for human use.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Induction of carbohydrate-specific antibodies in HLA-DR transgenic mice by a synthetic glycopeptide is a potential cancer vaccine in humans. "Over the last few years, anticancer immunotherapy has...

A single vaccine could benefit most women.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- The risk of developing cervical cancer by women infected with the human papillomavirus (HPV) is essentially the same no matter which type of virus is involved, provided it belongs to the group of 15 or...

Glycosylamino acids with tumor-associated carbohydrate antigens synthesized.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Researchers have synthesized non-natural glycosylamino acids containing tumor-associated carbohydrate antigens. "The glycosylation reaction of a monosaccharide tri-chloroacetimidate donor with...

Dendritic cells respond to antigens through heat shock protein receptor.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Disease-associated dendritic cells respond to disease-specific antigens through the common heat shock protein receptor. According to recent research published in the journal Blood, "The most...

HPV type 16 E5 protein is potential vaccine target.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- The human papillomavirus type 16 E5 protein is a potential vaccine target. According to a study from Taiwan, "Human papillomavirus type 16 (HPV-16) E5 protein, along with the more publicized E6 and...

Phase I trial initiated for lung cancer vaccine.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Corixa Corp. (CRXA), a developer of immunotherapeutics, announced the initiation of a phase I clinical study to test safety and immune response activity of an investigational vaccine for patients with...

TRF-1 expression level may have prognostic value in adrenal tumors.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- The level of TRF-1 expression may have prognostic value in adrenal tumors. According to a study from the United States, "It is often difficult to distinguish histologically between an adrenal...

Xenogeneic proteins may lead the way to effective cancer vaccines.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Xenogeneic proteins may lead the way to effective cancer vaccines. "The breaking of immune tolerance of 'self-antigens' associated with angiogenesis is an attractive approach to cancer therapy by...

Polymerase chain reaction has use in urinary diagnosis of bladder cancer.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Polymerase chain reaction has use in the urinary diagnosis of bladder cancer. According to a study from Germany, "The polymerase chain reaction (PCR) is a highly sensitive and specific method for...

FTI and tamoxifen may increase the antitumor effect of either drug alone.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- FTI and tamoxifen may increase the antitumor effect of either drug alone. According to recent research published in the International Journal of Cancer, "The efficacy of tamoxifen in the hormonal...

Low levels of PPARgamma and PGC-I are associated with poor clinical outcomes.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Low levels of PPARgamma and PGC-I are associated with poor clinical outcomes. "Peroxisome-proliferator activated receptor-gamma (PPARgamma) belongs to a family of nuclear receptors and acts as...

Novel taxane analogs could effectively kill MDR1-positive breast cancer cells.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Novel taxane analogs could effectively kill MDR1-positive breast cancer cells. According to published research from the United States, "This study aimed to investigate the apoptotic effects of...

Women with mutated BRCA 1 or 2 should avoid repeated x-ray use.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Women with mutated BRCA 1 or 2 should avoid repeated x-ray use. According to recent research from Germany, "It is generally assumed that the radiation risk from mass screening for breast cancer...

The roles of BRCA1 alternative splicing are emerging.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- The roles of BRCA1 alternative splicing are emerging. "Germline mutations of the BRCA1 gene predispose individuals mainly to the development of breast and/or ovarian cancer," scientists in Hungary...

COX-2 inhibitors may be used as radiosensitizing agents for cancer therapy.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- COX-2 inhibitors may be used as radiosensitizing agents for cancer therapy. "Prostaglandins have long been known to impact the radiosensitivity of cells and tissues, and many studies have centered...

Clusterin may be a biomarker in murine and human intestinal neoplasia.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Clusterin may be a biomarker in murine and human intestinal neoplasia. According to published research from the United States, "Early detection of colorectal cancer is critical for the management...

Dysregulated RNA-binding of TIA-1 promotes COX-2 expression in neoplasia.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Dysregulated RNA-binding of TIA-1 promotes COX-2 expression in neoplasia. "The cyclooxygenase-2 (COX-2) enzyme catalyzes the rate-limiting step of prostaglandin formation in inflammatory states,...

Nemo-like kinase induces apoptosis in DLD-1 human colon cancer cells.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Nemo-like kinase induces apoptosis in DLD-1 human colon cancer cells. According to a study from Japan, "Deregulation of Wnt/beta-catenin signaling is thought to play a critical role in human...

Stomach cancer cells in vivo may need Omi/HtrA2 expression for apoptosis.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Stomach cancer cells in vivo may need Omi/HtrA2 expression for apoptosis. "The serine protease Omi/HtrA2 is released from mitochondria into the cytosol after apoptosis stimuli, inducing apoptosis...

There is a high degree of overexpression of COX-2 in upper GI cancers.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- There is a high degree of overexpression of COX-2 in upper GI cancers. According to a study from the United States, "Cancers of the esophagus, stomach, and pancreas have been successfully treated...

P19ARF inhibits the functions of the HPV16 E7 oncoprotein.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- P19ARF inhibits the functions of the HPV16 E7 oncoprotein. "The E7 oncoprotein encoded by high-risk types of human papillomavirus (HPV) plays a significant role in the development of HPV-related...

Genetically reduced mEH activity may be protective against lung cancer.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Genetically reduced mEH activity may be protective against lung cancer. According to recent research from Austria, "Microsomal epoxide hydrolase (mEH) plays a dual role in the detoxification and...

IL-10 is one of the cytokines up-regulating the GM-CSF expression in NSCLC.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- IL-10 is one of the cytokines up-regulating the GM-CSF expression in NSCLC According to recent research published in the journal Anticancer Research, "It is unclear how the cytokine network...

Outcome of MFH is associated with the genetic profiles of the primary tumors.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Outcome of malignant fibrous histiocytomas (MFH) is associated with the genetic profiles of the primary tumors. "In this study, a panel of 39 primary malignant fibrous histiocytomas (MFH) of high...

SBIR award to aid development of melanoma peptide vaccine.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Generex Biotechnology Corp. (GNBT) announced that the National Cancer Institute has awarded a small business innovative research (SBIR) grant to support development of a novel vaccine for T-helper...

Anti-GD2 monoclonal antibody immunotherapy may prevent neuroblastoma relapse.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Anti-GD2 monoclonal antibody immunotherapy may prevent neuroblastoma relapse. "In spite of the satisfactory frequency of clinical response to first-line therapy in neuroblastoma (NB), complete...

CASP8 defects represent an independent event in neuroblastoma.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- CASP8 defects represent an independent event in neuroblastoma. "Neuroblastomas are characterized by defects in tumor necrosis factor-related apoptosis inducing ligand (TRAIL)-induced apoptosis,...

Familial neuroblastoma is a complex heritable disease.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Familial neuroblastoma is a complex heritable disease. According to a study from Italy, "Genomic surveys carried out over the years have revealed a great heterogeneity in the pattern of genetic...

Gene expression patterns differ between metastatic and nonmetastatic tumors.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Gene expression patterns differ between metastatic and nonmetastatic neuroblastoma tumors. According to a study from Spain, "The striking differences in the natural history of clinical subgroups...

Understanding genetics known to be involved SNS development may be key.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Understanding genetic components known to be involved in the control of sympathetic nervous system (SNS) development may provide the key in neuroblastoma. "Genetic investigation of neuroblastoma...

p53 inactivation via mutation, MDM2 amplification may occur at relapse.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- p53 inactivation via mutation, MDM2 amplification may occur at relapse in neuroblastoma. "Early studies of p53 in neuroblastoma reported infrequent mutations in tumors and cell lines," scientists...