Cancer Vaccine Week articles from November 2003

Cancer Vaccine Week archives from November 2003

Dendritic cell vaccine induces T-cell immunity in stage IV melanoma patients.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Single injection of CD34+ progenitor-derived dendritic cell vaccine can lead to induction of T-cell immunity in patients with stage IV melanoma. According to a study from the United States, "There...

New cancer vaccine trial to begin.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- The first patient has been vaccinated in a New York University (NYU) Medical Center clinical trial of a new cancer vaccine. The vaccine is designed to prevent patients who have already had a kind...

Antigen-specific immunotherapy and cancer vaccines reviewed.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Scientists have published a review of antigen-specific immunotherapy and cancer vaccines in a recent issue of the International Journal of Cancer. "The specific activation of the immune system to...

Clinical studies of vaccines targeting breast cancer reviewed.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Investigators have published a review of clinical studies of vaccines targeting breast cancer in a recent issue of the journal Clinical Cancer Research. "Many clinical studies have been undertaken...

Heat shock protein from a non-autologous tumor used as anti-tumor vaccine.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Heat shock protein derived from a non-autologous tumor can be used as an anti-tumor vaccine. According to published research from Ireland, "Antigenic cross-reactivity between certain tumors has...

Immunogene vaccine improves outcome after combination therapy for myeloma.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Immunogene vaccination improved the outcome after combination therapy for myeloma murine myeloma. According to a study from Canada, "Increasing evidence suggests a role for immunologic vaccination...

Clinical and molecular aspects of adrenocortical tumorigenesis reviewed.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Clinical and molecular aspects of adrenocortical tumorigenesis is reviewed. "Adrenal masses are a common problem affecting 3-7% of the population. The majority turn out to be benign adrenocortical...

Virus delivered nitroreductase/CB1954 acts synergistically with 5-FU on cancer.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- The enzyme-prodrug combination nitroreductase/CB1954 creates cancer cell apoptosis by the caspase pathway, and acts synergistically with 5-fluorouracil. According to published research from England,...

Passive immunotherapy appears to be an effective way to treat melanoma.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Passive immunotherapy should soon be a recognized way of effectively treating melanoma. According to recent research published in the journal Bulletin du Cancer, "The protocols of tumor...

Abnormal methylation of tumor suppressor genes occurs in sporadic breast cancer.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Abnormal methylation of several tumor suppressor genes occurs in sporadic breast cancer. "Multiplex methylation-sensitive PCR was employed in studying the methylation of CpG islands in the RB1,...

Acetylated Sp3 is a transcriptional activator.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Acetylated Sp3 is a transcriptional activator. According to a study from the United States, "Sp3 transcription factor can either activate or repress target gene expression. "However, the...

Circulating tumor DNA may not be accurate reflection of breast cancer status.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Circulating tumor DNA may not be a sufficiently accurate reflection of breast cancer clinical status or tumor activity. "We evaluated the potential utility of occult circulating tumor DNA as a...

Endo180 is a link between uPA-uPAR and setting the internal cellular compass.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Endo180 is a link between uPA-uPAR and setting the internal cellular compass in breast cancer. "Urokinase-type plasminogen activator (uPA) and its receptor (uPAR) play an important role in cell...

Interactions between breast cancer, osteoblastic cells induce osteoclastogenesis.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Direct interactions between breast cancer and stromal or osteoblastic cells induce osteoclastogenesis through modulating RANKL expression. "Bone destruction is primarily mediated by osteoclastic...

Her-2/neu is potential vaccine target for acute lymphoblastic leukemias.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- The Her-2/neu antigen is a potential vaccine target for acute lymphoblastic leukemias. "Her-2/neu is a tumor-associated antigen that is expressed on several adenocarcinomas and correlates with poor...

In vitro method of culturing cells useful in carcinogenesis studies.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- An in vitro method of culturing cells is useful in carcinogenesis studies. According to a study from the United States, "Mouse mammary epithelial cell cultures previously described bring about...

Akt/mTOR pathway involved in EGF-induced cell transformation.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Akt/mTOR pathway is involved in EGF-induced cell transformation. According to a study from the United States, "Our previous study demonstrated that phosphatidylinositol 3-kinase (PI3K) is necessary...

Chronobiology will result in more active treatment schedules for many diseases.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Chronobiology will result in more active treatment schedules for many diseases. According to recent research published in the journal Pathologie Biologie, "The medical applications of chronobiology...

Nitric oxide-mediated protection of apoptosis is p53-dependent.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Nitric oxide-mediated protection of apoptosis is p53-dependent. "Ser-46 of p53 is phosphorylated in response to DNA-damage in vivo, and it plays a pivotal role for apoptotic signaling by p53 through...

Anti-infective ability of DC should be studied to apply to anticancer efforts.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Dendritic cell based anticancer immunotherapy research should encompass anti-infectious response research. "Dendritic cells (DC) are the most potent antigen-presenting cells (APC) that initiate T...

Cancer vaccine company completes UKP 17M financing.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- BioVex, Ltd., announced the completion of a UKP 17 million (U.S. $28 million) private placement. The placement was led by Scottish Equity Partners (U.K.). Other new investors participating in the...

5-FU chemoresistance is overcome by inhibition of inducible NF-kappaB activation.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- 5-Fluorouracil chemoresistance is overcome by inhibition of inducible NF-kappaB activation. "5-Fluorouracil (5-FU) is used for the treatment of stomach and colon cancer, but many tumors are...

Failure of Mn-SOD mRNA induction may be predictive of gastric cancer.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Failure of Mn-SOD mRNA induction may be predictive of gastric cancer. "Reactive oxygen species (ROS) cause macromolecular damage and may play an important role in tumor development," researchers in...

Researchers study global analysis of G-protein-coupled receptor signaling.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Researchers study global analysis of G-protein-coupled receptor signaling in human tissues. "The G-protein-coupled receptor (GPCR) family mediates a host of cell-cell communications upon activation...

Chemical biology applied on genomic scale may speed translation to therapeutics.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Small-molecule chemical biology applied on a genomic scale promises to speed translation to novel therapeutics. "The recently completed human genome sequence represents an enormous opportunity to...

Cytogenetic characterization of tumors of the vulva and vagina evaluated.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Cytogenetic characterization of tumors of the vulva and vagina is evaluated. According to recent research from Norway, "Neoplasms of the vulva and vagina account for less than 5% of all female...

A single VH domain intrabody to RAS stops transformation in vitro.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- A new way of generating intrabodies yields an intrabody to RAS that could inhibit related oncogenic transformation in vitro. According to recent research from England, "There is a major need in...

Introducing mutant p53 into MOLT-4 partially increases cell survival.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Introducing mutant p53 into MOLT-4 partially increases cell survival. According to published research from Japan, "The effects of X-rays on cell survival, apoptosis, and long-term response in the...

Small and large cells differ molecularly in patients with CLL.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Small and large cells differ molecularly in patients with chronic lymphocytic leukemia (CLL). "The genetic events involved in the transformation of chronic lymphocytic leukemia (CLL) to Richter's...

Proteomics analysis of lung cancer valuable for further study.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Comparative proteomics analysis of human lung squamous carcinoma can be valuable for further study. According to recent research from People's Republic of China, "Two-dimensional polyacrylamide gel...

WNT7a induces E-cadherin in lung cancer cells.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- WNT7a induces E-cadherin in lung cancer cells. "E-cadherin loss in cancer is associated with de-differentiation, invasion, and metastasis. Drosophila DE-cadherin is regulated by Wnt/beta-catenin...

Human MUC1 carcinoma antigen regulates intracellular oxidant levels.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Human MUC1 carcinoma antigen regulates intracellular oxidant levels. According to a study from the United States, "The DF3/MUC1 transmembrane oncoprotein is aberrantly overexpressed by most human...

Effects of all-trans retinoic acid (ATRA) on human myeloma cells presented.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Effects of all-trans retinoic acid (ATRA) on human myeloma cells are presented. According to a study from Japan, "All-trans retinoic acid (ATRA) is a natural oxidative metabolite of vitamin A...

BRCA1 mutations are frequent in Polish women with ovarian cancer.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- BRCA1 mutations are frequent in Polish women with ovarian cancer. According to published research from Poland, "There is increasing evidence that hereditary factors play a greater role in ovarian...

Vaccine developer receives patent for delivery platform.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- BioVex Limited announced that it has received a Notice of Allowance from the U.S. Patent and Trademark Office in relation to one of its core patents. The patent relates to the use of herpes simplex...

Manufacturing agreement met for phase II cancer vaccine.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Prima Biomed Limited announced that its subsidiary Cancer Vac has entered into an agreement with Progen Industries Ltd (PGLAF) to commence the scale up manufacture for the therapeutic vaccine in its...

E2F3 loss has opposing effects on different pRB-deficient tumors.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- E2F3 loss has opposing effects on different pRB-deficient tumors. According to recent research from the United States, "The E2F transcription factors are key downstream targets of the retinoblastoma...

Epigallocatechin-3-gallate selectively induces apoptosis in prostate cancer cells.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Epigallocatechin-3-gallate selectively induces apoptosis in prostate cancer cells. "Chemical inhibitors of fatty acid synthase (FAS) inhibit growth and induce apoptosis in several cancer cell lines...

Researchers review recent advances in pediatric renal neoplasia.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Researchers review recent advances in pediatric renal neoplasia. According to a study from the United States, "Over the past 6 years, molecular genetic studies have significantly advanced our...

Retinoblastoma inactivation is achieved by different kinase cascades.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Retinoblastoma inactivation is achieved by different kinase cascades. "Inactivation of the retinoblastoma (Rb) tumor suppressor protein is essential for the G[subscript]1/S transition during...

Gene rearranged by 2p21 aberrations in thyroid adenomas is identified.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Gene rearranged by 2p21 aberrations in thyroid adenomas is identified. "Thyroid adenomas belong to the cytogenetically best investigated human epithelial tumors. Cytogenetic studies of about 450...

Bcl-2 inhibits TNF-alpha-mediated increase of glycolytic enzyme activities.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Bcl-2 inhibits TNF-alpha-mediated increase of glycolytic enzyme activities. According to recent research published in the journal Molecules and Cells, "To understand the effects of bcl-2 on glucose...

Hsp27 plays a negative role in down-regulating IKK signaling.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Hsp27 plays a negative role in down-regulating IKK signaling. According to recent research published in the Journal of Biological Chemistry, "Heat shock protein 27 (Hsp27) is a ubiquitously...

YB1 is a potential negative regulator of the p53 tumor suppressor.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- YB1 is a potential negative regulator of the p53 tumor suppressor. "The p53 tumor suppressor plays a major role in preventing tumor development by transactivating genes to remove or repair...

The Simpson-Golabi-Behmel gene is not involved in sporadic Wilms tumorigenesis.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- The Simpson-Golabi-Behmel gene is not involved in sporadic Wilms tumorigenesis. "Many genes have been implicated in Wilms tumor; however, only one gene, WT1, has a proven role in the development of...

Promise, pitfalls of genotype versus gene products are discussed.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Promise, pitfalls of genotype versus gene products are discussed. "We present a critical assessment of the promise and pitfalls of genotype versus gene function measures in cancer epidemiology...

European research project focused on optimizing a cancer vaccine.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- IDM (Immuno-Designed Molecules), a biopharmaceutical company specializing in the field of cellular immunotherapy, announced that it will coordinate a European research project entitled "Dendritophages,...

CD38 is a signaling molecule in B-cell chronic lymphocytic leukemia cells.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- CD38 is a signaling molecule in B-cell chronic lymphocytic leukemia cells. "The prognosis for patients with B-cell chronic lymphocytic leukemia (B-CLL) is generally less favorable for those...

Gene expression profiles in human non-small, small cell lung cancers analyzed.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Gene expression profiles in human non-small and small-cell lung cancers are analyzed in this study. According to recent research published in the European Journal of Cancer, "Suppression...

History of anticancer drug development at the U.S. NCI reviewed.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- History of anticancer drug development at the U.S. National Cancer Institute has been summarized. "Anticancer drug discovery and development is a rapidly evolving field. Recent advances in...

Thymidylate synthase inhibitors may have promise as anticancer agents.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Thymidylate synthase inhibitors may have promise as anticancer agents. According to a study from the United States, "Thymidylate synthase (TS) is a folate-dependent enzyme that catalyzes the...

A panel of human cancer cell lines provides valuable database for drug discovery.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- A panel of human cancer cell lines provides valuable database for drug discovery. According to recent research from Japan, "Studies conducted at the U.S. National Cancer Institute (NCI) and in our...

Vaccine shows promise.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- After five major surgeries for a particularly aggressive form of breast cancer, Patricia Thomas called the little pinprick she received in a government study the simplest procedure she's undergone. ...

Synergy between systemic toxicity and genotoxicity is relevant to cancer risk.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Synergy between systemic toxicity and genotoxicity is relevant to cancer risk "The health risk manager and policy analyst must frequently make recommendations based upon incomplete toxicity data....

CA-RP VIII plays a role in the process of invasion in colorectal cancer.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- CA-RP VIII plays a role in the process of invasion in colorectal cancer. "Carbonic anhydrase-related protein (CA-RP) VIII, which is a member of the CA gene family, has been shown to have no...

Autoimmune disease drug maker secures $10.6M in private placement.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Favrille, Inc., a biotechnology company developing patient-specific treatments for cancer and autoimmune diseases, announced that it has raised $10.6 million in a Series B-2 as an extension of the...

Cancer susceptibility testing among PCPs may be influenced by patient inquiry.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Cancer susceptibility testing among PCPs may be influenced by patient inquiry. According to published research from the United States, "Primary care physicians (PCPs) are assuming greater roles in...

CCND1 G/A polymorphism is associated with the early onset of lung cancer in men.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- CCND1 G/A polymorphism is associated with the early onset of lung cancer in men. "The objective was to study the relationship between cyclin D1 gene (CCND1) polymorphism and lung cancer in the...

Researchers identify small molecules that can reactivate mutant p53.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Researchers identify small molecules that can reactivate mutant p53. According to a study from Sweden, "Around half of all human tumors carry mutant p53. "This allows escape from p53-induced...

Capital investment to be used in part for cancer vaccine development.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Biovest International announced the completion of $5 million of capital investment under its April 10, 2003, investment agreement with Accentia, Inc., a Hopkins Capital Group portfolio company. ...

Ghrelin promotes pancreatic adenocarcinoma cell proliferation and invasiveness.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Ghrelin promotes pancreatic adenocarcinoma cell proliferation and invasiveness. "Ghrelin, a newly described potent orexigenic peptide, may have therapeutic potential in patients with cachexia. We...

8p22 deletion was the strongest parameter to predict prostate cancer progression.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- 8p22 deletion was the strongest parameter to predict prostate cancer progression. According to recent research published in the journal Aktuelle Urologie, "The natural course of human prostate...

LIM kinase 1 is essential for the invasive growth of prostate epithelial cells.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- LIM kinase 1 is essential for the invasive growth of prostate epithelial cells. "Mammalian LIM kinase 1 (LIMK1) is involved in reorganization of actin cytoskeleton through inactivating...

Researchers present comprehensive evaluation of pathogenesis of thyroid cancer.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Researchers present comprehensive evaluation of pathogenesis of thyroid cancer. "A number of molecular abnormalities have been described in association with the progression from normal thyroid...

PTEN is involved in the regulation of several basic cellular functions.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- PTEN is involved in the regulation of several basic cellular functions. According to recent research published in the journal Trends in Cell Biology, "The PTEN tumor suppressor gene is mutated...

GMCSF gene modified tumor vaccine shows promise in advanced lung cancer.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- A GMCSF gene modified tumor vaccine has shown promise for the treatment of advanced stage non-small cell lung cancer. According to a study from the United States, "Treatment for advanced stage...

Individualized human scFv vaccines produced in plants.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- Scientists have produced individualized human scFv vaccines in plants. "We have developed a method for rapidly producing in plants the idiotype regions of the tumor-specific Ig as single-chain Fv...

Immunotherapy and antiangiogenic therapy combine to reject tumors.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- Immunotherapy and antiangiogenic therapy combine to reject tumors. According to recent research from the United States, "immunotherapy is an attractive strategy for cancer treatment. However,...

Clinical application of dendritic cells in cancer vaccines reviewed.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- Researchers have reviewed the clinical application of dendritic cells in cancer vaccination therapy in a recent issue of the journal APMIS. According to scientists in Denmark, "During the last...

Interleukins 21 and 23 genes produce an antitumor effect in pancreatic cancer.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- Interleukins 21 and 23 genes produce an antitumor effect in pancreatic cancer "We examined whether novel cytokines, interleukin (IL)-21 and IL-23, that were expressed in tumors could produce...

Interleukin-2 gene therapy shows early signs of diminishing prostate cancer.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- Interleukin-2 gene therapy shows early signs of diminishing prostate cancer. According to research from Canada, "preclinical studies demonstrate that intratumoral delivery of adenovirus expressing...

Bisdioxopiperazines target ATP-bound topoisomerase II.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- Bisdioxopiperazines target ATP-bound topoisomerase II. According to recent research from the United States, "Type IIA topoisomerases both manage the topological state of chromosomal DNA and are...

Barrett esophagus is excellent model to study early neoplastic progression.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- Barrett esophagus is an excellent model in which to study the early events of neoplastic progression. According to recent research published in the World Journal of Surgery, "Human cancer...

A neural survival factor is a candidate oncogene in breast cancer.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- A neural survival factor is a candidate oncogene in breast cancer. According to recent research published in the journal Proceedings of the National Academy of Sciences USA, "Using serial analysis...

An RNA molecule functions as a tumor suppressor in human breast cancer.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- An RNA molecule functions as a tumor suppressor in human breast cancer. According to published research from the United States, "Prohibitin is a candidate tumor suppressor gene located on human...

BRC repeat, RAD51 sequence conservation shows import of BRCA2-RAD51 interactions.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- Conservation of BRC repeat, RAD51 sequence substantiates functional significance of BRCA2-RAD51 interactions. According to a study from England, "In humans, the interactions between the breast...

BRCA1 might function as a molecular scaffold for p53 response.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- BRCA1 might function as a molecular scaffold for p53 response. According to published research from Netherlands, "The tumor suppressor gene p53, mutated in approximately 50% of all human cancers,...

Genetic polymorphisms in ER-alpha gene may play role in breast cancer etiology.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- Genetic polymorphisms in ER-alpha gene may play role in breast cancer etiology. "Estrogen receptor (ER) is a ligand-activated transcription factor that mediates estrogen actions in target tissues....

Human breast tumors aberrantly express lipoxygenases and cyclooxygenase-2.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- human breast tumors aberrantly express lipoxygenases and cyclooxygenase-2. "Lipoxygenases and cyclooxygenase are key mediators of arachidonic acid metabolism. The eicosanoids metabolites from these...

Short trinucleotide repeat genotypes of AR gene protect against breast cancer.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- Short trinucleotide repeat genotypes of the AR gene protect against breast cancer. "Up to one-third of women with breast cancer have a family history of breast cancer, and approximately 5% of cases...

Tamoxifen can induce, support changes that lead to altered ERalpha expression.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- Tamoxifen can induce and/or support certain cellular changes that lead to altered ERalpha expression. According to published research from the United States, "MCF-7 breast tumor cells form...

Two companies collaborating on breast cancer vaccine.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- Bavarian Nordic and Pharmexa have entered into a collaborative agreement that will test the use of Bavarian Nordic's proprietary MVA-BN vector technology in combination with Pharmexa's HER-2 DNA...

Nutrition's role in cancer prevention still needs more study.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- Nutrition's role in cancer prevention still needs more study. "Cancer is the major cause of death in the UK, and the Government has set a target to reduce death rate from cancer in individuals ...

Dendritic cell vaccine generates anti-B16BL6 melanoma immunity in mice.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- Dendritic cells transduced with gp100 gene by RGD fiber-mutant adenovirus vectors are highly efficacious in generating anti-B16BL6 melanoma immunity in mice. "Dendritic cells (DCs) are the most...