Cancer Vaccine Week articles from May 2004

Cancer Vaccine Week archives from May 2004

P-glycoprotein-derived peptides inhibited multidrug resistance of tumors.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Immunization with synthetic P-glycoprotein-derived peptides inhibited multidrug resistance of tumors. "Overexpression of the membrane glycoprotein (P170) represents the most common multidrug...

6-Nitro-7-hdroxycoumarin novel therapeutic agent for renal cell carcinoma.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- 6-Nitro-7-hdroxycoumarin may be a novel therapeutic agent for renal cell carcinoma. "Previously, 7-hydroxycoumarin (7-OHC) and 6-nitro-7-hydroxycoumarin (6-NO2-7-OHC) have been shown to be potent...

Researchers describe how cancer neutralizes T cell attack.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- It has long been recognized that the immune system is able to recognize and destroy cancer cells, but although the immunological battle might slow the progression or spread of cancer, it's usually the...

Generex reports advance in cancer immunotherapy.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Generex Biotechnology Corp. (GNBT) announced its recent report at the American Association for Cancer Research in Orlando, Florida, on a novel approach to cancer vaccination developed by scientists and...

Dendritic cell vaccine generates specific antipancreatic cancer T cells.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Dendritic cells pulsed with pancreatic cancer total tumor RNA generate specific antipancreatic cancer T cells. According to a study from the United States, "RNA-based dendritic cell immunotherapy...

EGCG inhibits radiation-induced apoptosis by inactivating capase pathway.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Polyphenol EGCG inhibits radiation-induced apoptosis by inactivating the capase pathway in HaCaT cells. "Green tea is a rich source of polyphenols, and (-)-epigallocatechin-3-gallate (EGCG) is a...

FGFR3 and P53 are often seen in bladder cancer.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Factor growth receptor 3 and P53 mutation may be two separate genetic pathways in the pathogenesis of bladder cancer, researchers say. According to published research from Netherlands, "Fibroblast...

Perillyl alcohol inhibits human breast cancer cell growth in mice.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Researchers report that monoterpene perillyl alcohol (POH) administered to nude mice inhibited breast cancer cell growth. According to a study from Japan, "The effect of POH on cell growth, cell...

Proteomic approaches in cancer risk and response assessment described.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Researchers describe proteomic approaches in cancer risk and response assessment in a recent issue of Trends in Molecular Medicine. "Proteomics is more than just a list-generating exercise where...

Company reports advancements in several pipeline programs at AACR meeting.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- ImClone Systems Inc. (IMCL) presented preclinical data highlighting progress made in the development of several pipeline programs at the 95th annual meeting of the American Association for Cancer...

Phase I healthy volunteer trial of HYB2055 completed.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Hybridon, Inc., (HBY) has completed a phase I trial of HYB2055 in healthy volunteer subjects. In this trial, this drug candidate was safe and biologically active. HYB2055 is a second-generation...

DNA vaccines encoding ras epitopes and B7.1 reduced tumor burden in rats.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- DNA vaccines encoding mutated ras epitopes and the costimulatory molecule B7.1 reduced adenocarcinoma tumor burden in rats. "1-Methyl-1-nitrosourea (MNU), a well characterized carcinogen, was used...

Dendritic cell subsets induce antigen-specific cytotoxic T cell responses.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Dendritic cell subsets generated from CD34+ hematopoietic progenitors can be transfected with mRNA and induce antigen-specific cytotoxic T cell responses. "Human dendritic cells (DCs) generated in...

Dendritic cell tumoristatic and tumoricidal activities are distinct.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Distinct mechanisms are involved in tumoristatic and tumoricidal activities of monocyte-derived dendritic cells. According to recent research from Belgium, "Monocyte-derived dendritic cells (DC)...

RNA-transfected cells induce responses against viral and tumor antigens.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- RNA-transfected CD40-activated B cells induce functional T-cell responses against viral and tumor antigen targets. "Vaccination with antigen-presenting cells (APCs) engineered to mimic mechanisms...

gONC increases conformational stability and toxicity for cancer cells.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Glycosylation of onconase increases its conformational stability and toxicity for cancer cells. "Onconase (ONC) is currently in Phase III clinical trials as a cancer chemotherapeutic agent. Despite...

Thyroglobulin polymorphic variation increases non-medullary thyroid cancer risk.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Polymorphic variation in thyroglobulin increases risk for non-medullary thyroid cancer. "Benign thyroid disorders are strong risk factors for non-medullary thyroid cancer (NMTC). Germline variation...

BMP-2 modulates proliferation and differentiation of gastric cancer cells.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- BMP-2 modulates the proliferation and differentiation of gastric cancer cells. "Bone morphogenetic protein 2 (BMP-2), a member of the transforming growth factor beta super-family, has been shown to...

Cyclin-dependent kinase inhibitor p21 induces Flt3-ITD leukemogenesis.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Cyclin-dependent kinase inhibitor p21 induces Flt3-ITD leukemogenesis. "Flt3 is a type III RTK and approximately 30% of AML patients harbor an internal tandem duplication (ITD) of the juxta-membrane...

Notch1 gene involved in ATRA-modulated differentiation process in APL.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- The notch1 gene may be involved in the ATRA-modulated differentiation process in acute promyelocytic leukemia. "The effect of all-trans retinoid acid (ATRA) on the expression of Notch1 gene by...

P73 A4T14 genotype associated with cervical cancer risk.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- P73 A4T14 genotype is associated with risk of cervical cancer. A "possible association between cervical cancer and p73 G4C14-to-A4T14 in exon 2 and p53 Arg72Pro polymorphisms" was examined in an...

Ptc acts as a tumor suppressor gene in bladder cancer.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Ptc acts as a tumor suppressor gene in bladder cancer. "The PATCHED (PTC) gene is recognized as a tumor suppressor in basal cell carcinoma. Mapping of a minimal region of deletion at 9q22.3 and...

Eurya emarginata extracts inhibit leukemia cell growth via apoptosis induction.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Eurya emarginata extracts inhibit leukemia cell growth via induction of apoptosis. The "inhibitory effect of Eurya emarginata extracts on the growth of cancer cells" was examined. "The ethylacetate...

DNA vaccine expressing L1 protein protects against papillomavirus challenge.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- A single vaccination with a vesicular stomatitis virus vector expressing high levels of L1 protein provided complete protection from papillomavirus challenge. "We generated an attenuated,...

CpG-A and CpG-B oligonucleotides stimulate CD8+ T-cell responses in vitro.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- CpG-A and CpG-B oligonucleotides stimulate CD8+ T-cell responses in vitro. According to a study from Germany, "two distinct types of CpG oligodeoxynucleotide (ODN) have been identified that differ...

ATRA and TSA therapy useful in acute leukemia displaying MLL-AF9 fusion gene.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- ATRA and TSA are therapeutically useful in patients with acute leukemia displaying the MLL-AF9 fusion gene. In acute "leukemia patients with MLL (mixed linage leukemia), rearrangements tend to...

Genetic factors regulate 3'-azido-3'-deoxythymidine-induced cytogenetic damage.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Genetic factors regulate 3'-azido-3'-deoxythymidine-induced cytogenetic damage. "The activation of telomerase in phytohemagglutinin-stimulated peripheral lymphocytes is thought to play a role in...

Oncogenesis from single base mutation in IRES of Epstein-Barr nuclear antigen 1.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Oncogenesis develops from a single base mutation in the internal ribosome entry site of Epstein-Barr nuclear antigen 1. Recently published data show that "the U leader exon located within the 5'...

MLL gene rearrangement not pathogenic mechanism in de novo MDS.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Mixed lineage leukemia gene rearrangement is not a pathogenic mechanism in de novo myelodysplastic syndromes. "The mixed lineage leukemia (MLL) gene has been identified in 11q23 translocations. The...

PML tumor suppressor gene mutations indicate poor APL prognosis.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Promyelocytic leukemia tumor suppressor gene mutations indicate a poor acute promyelocytic leukemia prognosis. "The promyelocytic leukemia (PML) tumor suppressor of acute promyelocytic leukemia...

Metastasis-associated protein analysis indicates different metastasis roles.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Metastasis-associated protein analysis indicates different roles they may play in metastasis. "Metastasis is the most insidious and life threatening aspect of cancers. However little is known about...

PKC delta tumor-suppressing effects mediated by p53 transcription activation.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- PKC delta tumor-suppressing effects are mediated through p53 transcription activation. "In response to DNA damage, signal transduction pathways are activated that result in the increase of p53...

NY-ESO-1 shows promise as antigen for breast cancer vaccine development.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- NY-ESO-1 shows promise as an antigen for vaccine development to treat breast cancer patients with a poor prognosis. According to recent research published in the journal Cancer Research, "NY-ESO-1...

Paper describes novel in situ cancer vaccine to cure recurrent cancer.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Generex Biotechnology Corp. (GNBT) announced the publication of an invited review in Cancer Treatment Reviews. This paper, by Antigen Express scientists and collaborators, describes their...

Tumor rejection antigen carbohydrate mimic elicits antitumor response.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Mimic of tumor rejection antigen-associated carbohydrates mediates an antitumor cellular response. According to recent research from the United States, "Tumor-associated carbohydrate antigens are...

IL-2 improves metastatic malignant melanoma response to vaccine.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Interleukin-2 improves tumor response to DNP-modified autologous vaccine for the treatment of metastatic malignant melanoma. According to recent research published in the British Journal of...

Her-2 and EGFR are osteosarcoma vaccine targets.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Her-2 and epidermal growth factor receptor (EGFR) are candidate targets for vaccines against primary osteosarcoma. According to published research from the United States, "There is controversy...

Steroidogenic acute regulatory therapy useful for adrenocortical cancer.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Steroidogenic acute regulatory (StAR)-directed immunotherapy protects against tumor growth of StAR-expressing Sp2-0 cells in a rodent adrenocortical carcinoma model. According to a study from...

In vivo expression technology identifies virulence genes in H. pylori.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- In vivo expression technology identifies virulence genes in H. pylori. "Some pathogenic factors of Helicobacter pylori, a bacterium involved in peptic ulcer and gastric cancer, have already been...

Human alpha-lactalbumin made lethal to tumor cells kills glioblastomas.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Human alpha-lactalbumin made lethal to tumor cells (HAMLET) kills human glioblastoma cells in brain xenografts by an apoptosis-like mechanism and prolongs survival. "Malignant brain tumors present...

Estrogen receptor-alpha mutation K303R not found in Japanese breast carcinomas.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Estrogen receptor-alpha mutation K303R was not found in Japanese breast carcinomas. A "common somatic mutation, A-to-G transition at nucleotide 908, in the estrogen receptor-alpha (ERalpha) gene...

Perillyl alcohol suppresses breast cancer cell growth in vitro and in vivo.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Perillyl alcohol suppresses breast cancer cell growth in vitro and in vivo. "The effect of monoterpene perillyl alcohol (POH) on cell growth, cell cycle progression, and expression of cell...

Ring finger protein RNF11 important target for novel cancer therapies.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Ring finger protein RNF11 may be an important target for novel cancer therapies. "The identification of novel tumor-associated genes represents an important area of cancer research. To that end," a...

Prodrugs becoming an integral part of the drug discovery paradigm.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Prodrugs are becoming an integral part of the drug discovery paradigm. "Prodrugs are bioreversible derivatives of drug molecules used to overcome some barriers to the utility of the parent drug...

CD8+ T cells against Her-2/neu antigens possess antitumor activity.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- The CD8+ T cell repertoire against Her-2/neu antigens in neu transgenic mice is of low avidity with antitumor activity. According to a study from the United States, "The majority of...

Biallelic MYH mutations confer susceptibility to colorectal cancer.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Biallelic MYH mutations confer susceptibility to colorectal cancer. "Mutations in the base excision repair gene MYH have recently been shown to confer recessive susceptibility to colorectal...

Flavenoids from Scutellaria plants inhibit cancer cell proliferation in vitro.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Flavenoids from Scutellaria plants inhibit cancer cell proliferation in vitro. "The effects of 17 favonoids, isolated from two favonoid-rich Scutellaria species (Scutellaria baicalensis Georgi and...

Challenges of virtual screening for kinase targets demystified.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Challenges of virtual screening for kinase targets are demystified. "Kinases have become a major area of drug discovery and structure-based design. Hundreds of 3D structures for more than thirty...

Biopharma company offers up to 4,000,000 shares of common stock.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- GenVec, Inc., (GNVC) announced that it is offering, through Stonegate Securities, Inc., as placement agent, to sell up to 4,000,000 shares of its common stock for $3.15 per share, prior to commissions,...

Telomerase inhibitor PinX1 not involved in gastrointestinal tract carcinoma.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Telomerase inhibitor PinX1 is not involved in gastrointestinal tract carcinoma. "PinX1 was isolated as a Pin2/TRF1 binding protein that also binds to the telomerase catalytic subunit hTERT. The...

Collaboration with p53 and p63, p73 responds to cell genotoxic damage.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- A collaboration exists between p53 and p63 and p73 in response to cell genotoxic damage. "Homologies in sequence and gene organization of p53 and their relatives, p73 and p63, suggest similar...

LCR promotes beta-globin transcription repression in committed cells.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- LCR promotes beta-globin transcription repression in committed cells. "During erythroid differentiation, beta-globin gene expression is regulated by the locus control region (LCR). The...

Molecular footprints may gives clues about human lung cancer progression.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- The identification of environmental as well as genetic factors inducing or suppressing the occurrence of such alterations would be a clue to find novel ways of preventing lung cancer, researchers say....

Patients with multiple primary melanoma have INK4A mutations.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Researchers say the risk of melanoma can be shown by INK4A mutations. According to a study from the United States, "Estimation of the relative risk of cancer due to rare germline mutations using...

Production of melanoma gp100 antigen and polyclonal antibodies reported.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Scientists report the production and purification of the melanoma gp100 antigen and polyclonal antibodies. According to a study from Israel, "gp100 is a melanoma-associated antigen found to carry...

Promoter activity of AVL-A LTR region related to induction of glial neoplasm.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- The promoter activity of the avian leukosis virus subgroup A LTR region may be related to the induction of glial neoplasm. "So-called fowl glioma is a retroviral infectious disease caused by avian...

FGFR3 and P53 mutations affect pathogenesis of urothelial cell carcinoma.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- FGFR3 and P53 mutations affect the pathogenesis of urothelial cell carcinoma. "Fibroblast growth factor receptor 3 (FGFR3) and P53 mutations are frequently observed in bladder cancer. The...

CHEK2*1100delC mutation has no major contribution in esophageal carcinogenesis.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- The CHEK2*1100delC mutation has no major contribution in esophageal carcinogenesis. "In response to DNA damage, the cell cycle checkpoint kinase 2 (CHEK2) may phosphorylate p53, Cdc25A and Cdc25C,...

Cancer testis antigens show promise for pancreatic carcinoma treatment.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Cancer testis antigens show promise for pancreatic carcinoma treatment. According to published research from Germany, "In order to define antigens that might be suitable as vaccines for pancreatic...

Novel cooperation up-regulate vitamin D receptor protein.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Genistein and 1,25-dihydroxyvitamin D[subscript]3 up-regulate the vitamin D receptor protein. The "mechanisms by which genistein and 1,25-dihydroxyvitamin D[subscript]3...

The androgen receptor may be a target for prostate caner therapy.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Researchers review the functions of the androgen receptor and its role in the development of prostate cancer. According to recent research published in the journal Steroids, "The androgen receptor...

Autocrine stimulation by osteopontin sustains carcinoma proliferation in vitro.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Autocrine stimulation by osteopontin sustains carcinoma proliferation in vitro. "Papillary thyroid carcinomas are characterized by rearrangements of the RET receptor tyrosine kinase generating...

Acetylation of Ku70 by CBP and PCAF controls Bax-mediated apoptosis.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Acetylation of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. "Apoptosis is a key tumor suppression mechanism that can be initiated by activation of the proapoptotic factor Bax. The Ku70 DNA...

Fbw7 essential in controlling cyclin E and Notch signaling pathways.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Fbw7 is essential in controlling cyclin E and Notch signaling pathways in the mouse. "The mammalian F-box protein Fbw7 and its Caenorhabditis elegans counterpart Sel-10 have been implicated in the...

MedImmune to codevelop therapeutic vaccine for cancer.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- MedImmune, Inc., (MEDI) and Cerus Corp. (CERS) announced an agreement to develop and commercialize a novel therapeutic vaccine designed to treat cancers of the breast, prostate, and colon, as well as...

Heat shock protein 70-pulsed dendritic cells elicit tumor immunity.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- Tumor-derived heat shock protein 70-pulsed dendritic cells elicit tumor-specific cytotoxic T lymphocytes (CTLs) and tumor immunity. "Vaccination with autologous tumor-derived heat shock proteins...

Peptide-based vaccine effective for prostate cancer.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- A synthetic luteinizing hormone releasing hormone (LHRH) vaccine was effective for the treatment of prostate cancer. "We have designed a peptide-based immunotherapeutic vaccine for treatment of...

Magnaese superoxide dismutase mutant has potent antitumor effects.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- Magnaese superoxide dismutase mutant has potent antitumor effects. "Mn-SOD serves as the primary cellular defense against oxidative damage by converting superoxide radicals (O[subscript]2(radical...

Gastrin aids progression of Barrett metaplasia via antiapoptotic pathways.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- Gastrin aids progression of Barrett metaplasia via antiapoptotic pathways. "Mechanisms by which premalignant Barrett's metaplasia (BM) progresses to esophageal adenocarcinoma are currently being...

Hedgehog-interacting protein prevents basal cell carcinoma.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- Recombinant hedgehog-interacting protein provides immunoprevention of basal cell carcinomas. "Basal cell carcinomas (BCCs) are driven by abnormal hedgehog signaling and highly overexpress several...

Epigenetic downregulation of CTMP transcription common in glioblastomas.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- Epigenetic downregulation of CTMP transcription is common in glioblastomas. "The carboxyl-terminal modulator protein (CTMP) has been identified as a negative regulator of protein kinase B/Akt....

540 protein inhibitors promising treatments for postmenopausal breast cancer.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- 540 protein inhibitors are promising treatments for postmenopausal breast cancer. "The P450 family of proteins has more than 1000 representatives, which despite sometimes relatively low sequence...

Bcl-2 overexpression prevents Tc-99m-MIBI uptake in breast cancer cells.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- Bcl-2 overexpression prevents Tc-99m-MIBI uptake in breast cancer cells in vitro. A "correlation between the absence of technetium-99m methoxyisobutylisonitrile (Tc-99m-MIBI) uptake and...

Brk protein tyrosine kinase therapeutic cancer target.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- Brk protein tyrosine kinase is a therapeutic cancer target. "Brk is an intracellular protein tyrosine kinase that is significantly overexpressed in a majority of breast tumors, while being...

Novel systemic therapies for breast cancer reviewed.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- Researchers review novel systemic therapies for breast cancer in a recent issue of Surgical Oncology - Oxford. According to published research from England, "The rapid expansion in our knowledge...

Immunotherapy company opens cGMP production center in the United States.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- IDM (Immuno-Designed Molecules), a biopharmaceutical company specializing in immunotherapy for the treatment of cancer, announced the opening of its first cGMP (current good manufacturing practices)...

Nanobac Pharmaceuticals changes name.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- Nanobac Pharmaceuticals, Inc., announced that it has renamed the company Nanobac Life Sciences, Inc. The revised name reflects Nanobac's mission to fully exploit its portfolio of nanobacteria...

Upregulated heat shock protein 70 protects against tumor growth in mice.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- Upregulated heat shock protein 70 protects against tumor growth in mice. "Although heat-shock protein 70 (Hsp70) has been considered an intracellular protein, we report that Hsp70 is secreted under...

L-myc gene polymorphism not associated with lung ADCA risk and prognosis.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- L-myc gene polymorphism is not associated with lung adenocarcinoma risk and prognosis. "The non-coding variation in the second intron of the L-myc gene, generating an EcoRI polymorphism, is...

Dacogen and Taxotere show synergistic activity against human carcinoma cells.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- Dacogen and Taxotere show synergistic activity against human carcinoma cells in vitro. "The antineoplastic activity of 5-aza-2-deoxycytidine (5-AZA-CdR) and docetaxel (Taxotere, Taxo) alone or in...

Novel 2-nitroimidazole-tethered tricyclic quinoline compounds cytotoxic.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- Novel 2-nitroimidazole-tethered tricyclic quinoline compounds are cytotoxic. "Two novel nitroimidazole-based bioreductive compounds,...

Novel drug wrenchnolol impairs transcription of Her2 oncogene.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- A novel drug, wrenchnolol, impairs transcription of the Her2 oncogene. "Development of synthetic molecules that provide external control over the transcription of a given gene represents a...

Complement function in antibody-mediated cancer immunotherapy described.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- Researchers describe complement function in monoclonal-antibody-mediated cancer immunotherapy in a recent issue of Trends in Immunology. "Complement activation by monoclonal antibodies can cause...

Plasmids costimulate DNA vaccine against carcinoembryonic antigen.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- Plasmids encoding membrane-bound IL-4 or IL-12 strongly costimulate DNA vaccination against carcinoembryonic antigen (CEA). "Vaccination with plasmids encoding an antigen of interest (DNA...