Cancer Vaccine Week articles from May 2003

Cancer Vaccine Week archives from May 2003

CD4+ cells play critical role in tumor immunity against simian virus 40 antigen.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- CD4+ T lymphocytes played a critical role in antibody production and tumor immunity against simian virus 40 large tumor antigen. According to recent research published in the journal Cancer...

Tumor therapy with epidermal growth factor receptor vaccine investigated.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Immunogene therapy of tumors was investigated with a vaccine based on xenogeneic epidermal growth factor receptor. "The breaking of immune tolerance against self epidermal growth factor receptor...

Roadblocks to tumor vaccines could be overcome with interleukin-2.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Roadblocks to tumor vaccines could be overcome with interleukin-2. "Transforming growth factor-beta (TGF-beta), found at the site of most tumors, has been recognized as one of the mechanisms...

Transdermal gene delivery eradicates tumors expressing hepatitis C proteins.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer-A series of research experiments has demonstrated that hepatitis C virus (HCV) DNA vaccine can suppress tumor growth. The vaccine, developed by researchers at...

Endogenous dendritic cells required for T cell response by DC vaccines in vivo.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Endogenous dendritic cells are required for amplification of T cell responses induced by dendritic cell vaccines in vivo. According to recent research published in the Journal of Immunology,...

Mast cell-derived exosomes induce maturation of dendritic cells.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Mast cell-derived exosomes induced phenotypic and functional maturation of dendritic cells and elicited specific immune responses in vivo. "Mast cells (MCs) are considered major players in...

Compound triggers release of nitric oxide to fight leukemia and tumors.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Researchers from the University of Utah and the National Cancer Institute (NCI) have developed an experimental drug that reacts with a substance inside cancer cells, releasing nitric oxide to kill the...

A novel atypical retinoid is endowed with proapoptotic and antitumor activity.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- A novel atypical retinoid is endowed with proapoptotic and antitumor activity. According to recent research published in the Journal of Medicinal Chemistry, "The novel atypical retinoid...

Spike, a novel BH3-only protein, mediates proapoptotic signals.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Spike, a novel BH3-only protein, mediates proapoptotic signals. According to a study from Germany, "We have isolated Spike, a novel and evolutionary conserved BH3-only protein. BH3-only proteins...

Vaccine elicits tumor-specific antibodies in patients with breast cancer.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Researchers have identified tumor-specific antibodies in patients with breast cancer vaccinated with gene-modified allogeneic tumor cells. "Thirty HLA-A2+ women with metastatic breast cancer...

Researchers demonstrate broad use of Ciphergen's SELDI ProteinChip Technology.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Ciphergen Biosystems, Inc., (CIPH) announced that more than 45 studies highlighting the use of its SELDI ProteinChip platform in cancer research were published in the Proceedings of the American...

Angiogenesis targeting is one way that immunotherapy could fight cancer.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Angiogenesis targeting is one way that immunotherapy could fight cancer. According to a study from Australia, "one of the most controversial issues in immunology for over a century has been whether...

Lung cancer study combines gene expression and protein expression.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Ciphergen Biosystems, Inc., (CIPH) announced that Dr. Lin Ji from the University of Texas M. D. Anderson Cancer Center published work in the Proceedings of the American Association for Cancer Research's...

p53(15)Ant peptide induces necrotic cell death.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- p53(15)Ant peptide induces necrotic cell death, which is uncommon in traditional cancer therapy. According to recent research from the United States, "p53 is the most frequently altered gene in...

CTLA-4 blockade enhances effect of poxvirus vaccine targeting p53 in tumor model.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- A CTLA-4 blockade enhanced the therapeutic effect of an attenuated poxvirus vaccine targeting p53 in an established murine tumor model. "p53 is overexpressed by half of all cancers, and is an...

Efficient gene transfer into dendritic cells accomplished by electroporation.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Researchers have achieved efficient gene transfer into human monocyte-derived dendritic cells by electroporation. According to recent research published in the journal FEBS Letters, "Dendritic...

Inhibition of the PI3K-Akt/PKB survival pathway may contribute to apoptosis.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Inhibition of the PI3K-Akt/PKB survival pathway may contribute to apoptosis. "Synthetic alkyl-lysophospholipids (ALPs) represent a new class of anti-tumor agents that target cell membranes and...

Tumor-derived suppressor molecules impede host antitumor immune activity.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Tumor-derived suppressor molecules impede host antitumor immune activity. According to recent research published in the journal Experimental Biology and Medicine, "Tumors can evade immune responses...

High-speed images show how cells mobilize for immune response.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- New high-speed imaging techniques are allowing scientists to show how a single cell mobilizes its resources to activate its immune response, a new research study shows. Howard R. Petty, PhD,...

Vgamma1Vdelta1+ T cells can lyse tumor cells.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Vgamma1Vdelta1 T cells can be induced to lyse leukemia and other malignant cells. "The T-cell subset expressing Vdelta2 paired primarily with Vgamma2 comprises a majority of gammadelta T cells in...

RXL peptide-treated tumors undergo apoptosis.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- RXL peptide-treated tumors undergo apoptosis and may provide selective antiproliferative agents. According to published research from the United States, "A central function of the tumor suppressor...

Molecular targets for cell cycle inhibition are promising for cancer therapy.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Molecular targets for cell cycle inhibition are promising for cancer therapy. "Cell cycle dysregulation is a critical feature of tumor cells. Numerous cell cycle regulators act either as oncogenes...

Recombinant antigenized secretory IgA recovered for use as vaccine vector.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Researchers have developed a simplified procedure to recover recombinant antigenized secretory IgA for use as a vaccine vector. "Induced protection mechanisms at mucosal surfaces involve secretory...

Cancer patients experience tumor regression despite low T cell levels.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Cancer patients can experience tumor regression despite low titers of antigen-specific T cells. According to a study from Belgium, "Following vaccination with defined tumor antigens that are...

Advancements in dendritic cell vaccines for cancer therapy expected.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Advancements in dendritic cell vaccine technology for the treatment of cancer are expected. According to a study from Germany and the United States, "A novel approach to vaccination against cancer...

Evidence of efficacy of adenovirally delivered 4-1BBL provided.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Strong evidence supporting efficacy of adenovirally delivered 4-1BBL for genetic immunotherapy of cancer is provided. According to a study from Japan, "4-1BB ligand (4-1BBL), a member of the tumor...

Vaccines prolong survival of colorectal cancer patients.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - A vaccine containing autologous tumor cells and one made with the Newcastle disease virus (NDV) prolonged the survival of patients with colorectal...

Variety of cancer vaccines available to combat malignancies.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- A variety of cancer vaccines are available to combat malignancies. "There is clear evidence that certain forms of immunotherapy can be successful against certain cancers. However, it would appear...

The interleukin-21 gene generates systemic immunity against colon cancer cells.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- The interleukin-21 gene generates systemic immunity against colon cancer cells. "Interleukin-21 (IL-21) is a novel cytokine that can induce proliferation of activated T cells and maturation of...

p15 methylation was an early event in the evolution of some AML patients.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- p15 methylation was an early event in the evolution of some AML patients. "Seventeen patients with therapy-related myelodysplastic syndrome/acute myeloid leukemia (t-MDS/AML) were examined for...

Bis(Acridinylthiourea)platinum(II) compounds can mediate cytotoxicity.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Bis(Acridinylthiourea)platinum(II) compounds can mediate cytotoxicity. According to a study from the United States, "The preparation of two novel bis(acridine)platinum(II) complexes is reported....

Defects in TACC2 expression may contribute to the pathogenesis of some tumors.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Defects in TACC2 expression may contribute to the pathogenesis of some tumors. According to recent research published in the journal Genomics, "The human transforming acidic coiled-coil 2 (TACC2)...

Gene company expands to new headquarters, gets NIH contract.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Althea Technologies, Inc., announced that it has relocated its operations to a state-of-the-art facility at 11040 Roselle Street, San Diego, California, and received a U.S. National Institutes of...

Grant awarded for tumor growth inhibition research.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Northwest Biotherapeutics, Inc. (Bulletin Board: NWBT.OB) announced it has received notification from the U.S. National Institutes of Health (NIH) that the company will receive a National Cancer...

Ceramides with acyl groups larger than C6 might act as tumor promoters.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Ceramides with acyl groups larger than C6 might act as tumor promoters. According to a study from the United States, "The inhibition of apoptosis and gap junctional intercellular communication...

Up-regulation of survivin may be involved in typical CML evolution.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Up-regulation of survivin may be involved in typical CML evolution. "Survivin, a unique member of the inhibitor of the apoptosis protein (IAPs) family, is over-expressed in many cancers but not in...

Subtractive immunization identifies a cell surface phosphorylated glycoprotein antigen.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen. According to a study from the United...

CpG island methylation is a common finding in a genetic survey of cell lines.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Colorectal cancer cell lines are similar to colorectal cancer in that methylation is generally high, but there are other differences that may be important when using cell lines to conduct cancer...

There may be an important role for HIP in colorectal cancer metastasis.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- There may be an important role for heparin/heparan sulfate interacting protein (HIP) in colorectal cancer metastasis. According to a study from Singapore, "Heparin/heparan sulfate interacting...

Recent review of DNA vaccines published.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- A review of DNA vaccines has been recently published in the Journal of Internal Medicine. According to a study from France, "The DNA vaccines are simple rings of DNA containing a gene encoding an...

St. Jude to manufacture investigative drugs and vaccines.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- St. Jude Children's Research Hospital has become the only pediatric cancer research center in the United States to open a Good Manufacturing Practices (GMP) facility for producing vaccines, drugs,...

Investment allows for development of cancer vaccine.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Biovest International, Inc., announced that it has entered into an investment agreement with Accentia, Inc., one of the Hopkins Capital Group portfolio companies. Accentia is a privately held...

Phase II study results of vaccine combination released.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Xenova Group plc (NASDAQ: XNVA; London Stock Exchange: XEN) has announced the results of an open label, physician-sponsored Phase II "prime-boost" study, targeting the treatment of human papillomavirus...

CRG-L2 is an excellent candidate as a new marker of hepatocellular carcinoma.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- CRG-L2 is an excellent candidate as a new marker of hepatocellular carcinoma. "Liver cancer is very common worldwide and the rates of hepatocellular carcinoma (HCC) have increased by over 70% in...

p53-Abs could be a potential biomarker for the study of lung cancer.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- p53-Abs could be a potential biomarker for the study of lung cancer. According to a study from Thailand, "Abnormalities of p53 gene can lead to the production of p53 antibodies (p53-Abs) in the...

Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis. According to published research from the United States, "Mdm2 harnesses the p53 tumor suppressor, yet loss of one Mdm2...

Interdisciplinary team should be sought for medullary thyroid cancer patients.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Interdisciplinary team should be sought for medullary thyroid cancer patients. "Medullary thyroid cancer is a rare endocrine neoplasm that arises from the parafollicular C cells. Sporadic and...

Clinical results reported for heat shock protein-based immunotherapy.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- A presentation by Mojave Therapeutics, Inc., at The Future of Vaccines Conference in Semmering, Austria, included an update on the company's melanoma clinical trial and results from recent pre-clinical...

ERK may play a major role in the oncogenic behavior of malignant melanoma.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- ERK may play a major role in the oncogenic behavior of malignant melanoma. According to recent research published in the International Journal of Cancer, "During the process of oncogenic...

Intratumoral interferon-gamma immunotherapy appears safe and well tolerated.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - The results of a phase I clinical trial suggest intratumoral interferon-gamma immunotherapy is safe and well tolerated by patients with advanced melanoma. ...

PAX genes may be involved in the increased metastatic potential of some tumors.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- PAX genes may be involved in the increased metastatic potential of some tumors. "Transcription factors encoded by PAX3 and PAX7 are among the first expressed in the embryo, being principal...

Activated mutant epidermal growth factor receptor and RAS result in cancer.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Brain cancers appear to result from the combination of activated Ras and overexpression of mutant epidermal growth factor receptor (EGFR) in transgenic mouse models. According to recent research...

Cell-cycle regulatory proteins Rb, p21(WAF1), and cyclin E are altered.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Strong retinoblastoma protein and cyclin E expression and weak p21 are linked with poor prognosis in ovarian cancer. According to a study from Germany, "To investigate the role of cell-cycle...

Warner named chief scientific officer.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Juvaris BioTherapeutics, Inc., announced the appointment of John F. Warner, PhD, as chief scientific officer and vice president of Research and Development effective April 1, 2003. Warner, most...

Risk is related to overexpression of hMTH in peripheral blood lymphocytes.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Overexpression of a specific repair gene involved in oxidative stress was correlated to the risk for prostate cancer. "Oxidative damage is an important factor in prostate carcinogenesis, and...

Interleukin-4 receptor-targeted therapy effective against prostate cancer.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Interleukin-4 receptor-targeted cytotoxin therapy was effective for treating refractory prostate carcinoma in xenograft models. "Prostate cancer is the most commonly diagnosed solid tumors in...

Delayed reactivation of p53 may occur in the progeny of radiation survivors.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Genomic alterations due to ionizing radiation may occur in cell progeny as a result of delayed reactivation of p53. "Ionizing radiation induces genomic instability, which is transmitted through...

Gates Foundation gives $70 million for genome research.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- The University of Washington, already known for human genome research, is getting $70 million to bolster the program from the Bill & Melinda Gates Foundation. A formal announcement of the grant,...

The p53 network should be an important target for head and neck cancer therapy.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Squamous cell carcinoma tends to have inactivated p53, and the pathways involved should be the focus of new treatment development. "Head and neck squamous cell carcinoma (HNSCC) is the sixth most...

pH-responsive polymers used for intracellular delivery of biomolecular drugs.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Bio-inspired pH-responsive polymers have been developed for the intracellular delivery of biomolecular drugs. "The biotechnology and pharmaceutical industries have developed a wide variety of...

Therapeutic vaccines firm raises UKP15 million in international funding round.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Oxxon Pharmaccines Ltd., a biotechnology company developing innovative immunotherapeutics, specifically therapeutic vaccines (pharmaccines), has raised UKP15 million pounds ($23 million) in a private...

Many young adults fear vaccine injections.
May 12, 2003... 2003 MAY 12 - (NewsRx.com & NewsRx.net) -- Almost a quarter of the young adult patients visiting a travel health clinic admitted being afraid of injections. "Fear of injections may interfere with receipt of vaccines. The frequency,...

Vaccines for acute lymphoblastic leukemia available.
May 19, 2003... 2003 MAY 19 - (NewsRx.com & NewsRx.net) -- Vaccines are available for the treatment of acute lymphoblastic leukemia. "Acute lymphoblastic leukemia (ALL) represents the most frequent malignant disease in childhood and adolescence and offers...

Tumor-derived TGF-beta reduces efficacy of dendritic cell/tumor fusion vaccine.
May 19, 2003... 2003 MAY 19 - (NewsRx.com & NewsRx.net) -- Tumor-derived TGF-beta reduced the efficacy of a dendritic cell/tumor fusion vaccine. According to a study from the United States, "Dendritic cell (DC)-based antitumor vaccine is a novel cancer...

Novel bacillus Calmette-Guerin-MUC1-based breast cancer vaccine developed.
May 19, 2003... 2003 MAY 19 - (NewsRx.com & NewsRx.net) -- A novel bacillus Calmette-Guerin-MUC1-based breast cancer vaccine has been developed and tested. "Due to the high incidence of breast cancer and associated mortality rate, the development of an...

Researchers review value of anticancer antibodies.
May 19, 2003... 2003 MAY 19 - (NewsRx.com & NewsRx.net) -- A recent review of anticancer antibodies has been published in the American Journal of Clinical Pathology. According to a study from the United States, "The recent clinical and commercial success...

The tumor suppressor gene ECRG2 has a bifunctional role in the esophagus.
May 19, 2003... 2003 MAY 19 - (NewsRx.com & NewsRx.net) -- The tumor suppressor gene ECRG2 has a bifunctional role in the esophagus. According to a study from Peoples Republic of China, "esophageal cancer related gene 2 (ECRG2) is a novel candidate of the...

Herpes simplex virus G47 Delta may be a better anticancer vaccine.
May 19, 2003... 2003 MAY 19 - (NewsRx.com & NewsRx.net) -- A new anticancer herpes vector has enhanced tumor cell killing and MHC I expression. According to recent research from Japan, "The use of replication-competent viruses that can selectively...

Telomerase activity was decreased by RNA interference in cancer cells.
May 19, 2003... 2003 MAY 19 - (NewsRx.com & NewsRx.net) -- RNA was able to interfere with telomerase activity in the nucleus of human cancer cells, albeit transiently. "Telomerase is an attractive molecular target toward which to direct cancer therapeutic...

Actinomycin D (Act D) induces time-and dose-dependent apoptosis in K562 cells.
May 19, 2003... 2003 MAY 19 - (NewsRx.com & NewsRx.net) -- Actinomycin D (Act D) induces time-and dose-dependent apoptosis in K562 cells. According to published research from Canada, "K562 cells express the fusion protein BCR-ABL and have been shown to be...

Elucidating family history of breast cancer patients is important.
May 19, 2003... 2003 MAY 19 - (NewsRx.com & NewsRx.net) -- Elucidating family history from breast cancer patients is important. According to a study from England, "We aimed to assess frequency and penetrance of BRCA1, BRCA2, and TP53 mutations in women...

Company reports positive results from evaluation of new solid tumor treatment.
May 19, 2003... 2003 MAY 19 - (NewsRx.com & NewsRx.net) -- Northwest Biotherapeutics, Inc., (NWBT) announced positive findings from a recently completed preclinical mouse tumor evaluation of its new product candidate, DCVax-Direct Adjuvant Cancer Therapy,...

Early growth response 1 is an upstream gatekeeper of the p53 tumor suppressor.
May 19, 2003... 2003 MAY 19 - (NewsRx.com & NewsRx.net) -- Early growth response 1 is an upstream gatekeeper of the p53 tumor suppressor. "The proliferation of most primary cells in culture is limited by replicative senescence and crisis, p53-dependent...

A primitive neuroectodermal tumor by histology had isochromosome 17q.
May 19, 2003... 2003 MAY 19 - (NewsRx.com & NewsRx.net) -- A medulloblastoma of the cerebellum was found to have neuroectodermal histology and isochrome 17q within cells. According to a study from Poland, "An unusual posterior fossa neoplasm in a 26 yr...

APC has multiple additional roles in colorectal carcinogenesis.
May 19, 2003... 2003 MAY 19 - (NewsRx.com & NewsRx.net) -- APC has multiple additional roles in colorectal carcinogenesis. According to published research from England, "Mutations in APC have been identified in up to 80% of 'classic' sporadic colorectal...

Three single nucleotide polymorphisms within the NOTCH4 gene were found.
May 19, 2003... 2003 MAY 19 - (NewsRx.com & NewsRx.net) -- The NOTCH4 gene was found to have 3 single nucleotide polymorphisms. "Mapping of disease susceptibility loci within the MHC has been partly hampered by the high degree of polymorphism of the HLA...

Microgel polymer beads may provide general vehicle for vaccines, gene therapy.
May 19, 2003... 2003 MAY 19 - (NewsRx.com & NewsRx.net) -- A simple method of shuttling proteins into cells via microscopic polymer beads shows promise as a general way of carrying vaccines or bits of DNA for gene therapy, according to chemists at the...

The phosphatidylinositol metabolic pathway may be linked to DNA repair.
May 19, 2003... 2003 MAY 19 - (NewsRx.com & NewsRx.net) -- By genomic screening with wortmannin, a PI kinase inhibitor, a new way to possibly overcome genome instability was found. According to published research from the United States, "We report a novel...

Underexpression of a new RhoGAP protein, the tumor suppressor DLC2, is found.
May 19, 2003... 2003 MAY 19 - (NewsRx.com & NewsRx.net) -- The DLC2 encodes a RhoGAP protein which can suppress Ras-induced transformation and Rho-induced actin stress fibers; it was found deleted in 18% of liver cancers, appearing to contribute in these ways...

Deleted region at 17p13.3 may correspond to candidate tumor suppressors.
May 19, 2003... 2003 MAY 19 - (NewsRx.com & NewsRx.net) -- The LOST1 gene and other possible tumor suppressor genes appear to be disabled at 17p13.3 in some human lung cancer. "17p13.3 is one of the chromosomal regions most frequently affected by allelic...

Neuroendocrine marker increases and semaphorin 313 decreases in lung carcinoma.
May 19, 2003... 2003 MAY 19 - (NewsRx.com & NewsRx.net) -- A large cell lung tumor line with enhanced metastasis tested for higher mRNA levels for some neuroendocrine markers and reduced semaphorin 313. According to published research from Germany, "We...

Company reports 48% increase in biopharmaceutical product sales.
May 19, 2003... 2003 MAY 19 - (NewsRx.com & NewsRx.net) -- Nabi Biopharmaceuticals (NABI) announced its financial results for the first quarter ended March 29, 2003. For the quarter, the company reported net income of $0.5 million, or $0.01 per share on a...

Phase II study population expanded for cancer vaccine.
May 19, 2003... 2003 MAY 19 - (NewsRx.com & NewsRx.net) -- Favrille, Inc., announced that it has expanded its current phase II clinical trial (FavId-04) with the company's investigational agent FavId in combination with Rituxan, to include patients who have...

Gab proteins are crucial in controlling cell growth.
May 19, 2003... 2003 MAY 19 - (NewsRx.com & NewsRx.net) -- Gab proteins are crucial in controlling cell growth. "Tyrosine phosphorylation plays an important role in controlling cellular growth, differentiation and function. Abnormal regulation of tyrosine...