Cancer Vaccine Week articles from March 2003

Cancer Vaccine Week archives from March 2003

Protein can exert effects on cell survival depending on apoptosis trigger.
March 3, 2003... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- According to recent research from Sweden, "Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) is required for viral transformation and has been shown to protect lymphocytes from...

Maturity allows migration of dendritic cells to lymph nodes in melanoma patients.
March 3, 2003... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- According to recent research from The Netherlands, "Dendritic cells are the professional antigen-presenting cells of the immune system. To induce an effective immune response, these cells should not...

Vaccine development company gains experienced board member.
March 3, 2003... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- VaxGen, Inc. (NASDAQ:VXGN) announced that Michel Greco, former deputy CEO and board member of Aventis Pasteur, has joined VaxGen's Board of Directors. As one of the world's most experienced vaccine...

Company increases focus on cancer, eliminates broad-based gene therapy research.
March 3, 2003... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- Cell Genesys, Inc. (NASDAQ:CEGE) announced its decision to decrease further resource investment in broad-based gene therapy programs in order to increase the focus on the company's clinical programs...

Cancer vaccine one step closer.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- Andreea Ioan-Facsinay from Leiden University Medical Center has attached proteins from tumor cells to antibodies. With these she treated immune cells from a mouse. These treated cells were used to...

Vaccine technique shows potential.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- In a demonstration of vaccine therapy's potential for treating lung cancer, Dana-Farber Cancer Institute scientists and their associates report that a prototype vaccine boosted the natural immune...

Clinical trials expanded with novel vaccine.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- Several additional cancer centers in the United States and Canada are enrolling patients in a clinical trial evaluating the use of a therapeutic cancer vaccine in patients with first-line metastatic...

Intra-tumoral injection of CpG inhibits tumor growth in murine colon tumors.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- Intra-tumoral injection of CpG results in the inhibition of tumor growth in murine colon-26 and B-16 tumors. "Direct tumor injections of CpG (ODN #1826) into murine tumors markedly suppressed the...

Dendritic cells act as natural adjuvants and modulate immune response.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- Dendritic cells can act as natural adjuvants and modulate immune response. According to recent research from India, "Dendritic cells (DCs) are potent antigen presenting cells. Mature DCs activate...

Peptides trap HIV-1 envelope glycoprotein fusion intermediate at two sites.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- Peptides trap the human immunodeficiency virus type 1 envelope glycoprotein fusion intermediate at two sites. According to recent research from the United States, "Human immunodeficiency virus...

Encouraging update reported from trial of GVAX vaccine.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- Cell Genesys, Inc., (CEGE) reported updated data from the initial phase I/II clinical trial of GVAX lung cancer vaccine, a patient-specific vaccine made directly from patient tumor biopsies. Data...

Immunotherapeutics companies announce plans to merge.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- Epimmune, Inc., (EPMN), and Anosys, Inc., announced that they have preliminarily agreed to merge their operations to create a combined company focused on the field of immunotherapeutics and products...

Dendritic cell ability to direct T helper cells dependent on microbial signals.
March 17, 2003... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- The ability of murine dendritic cell subsets to direct T helper cell differentiation is dependent on microbial signals. According to recent research from England, "Dendritic cells (DC) initiate T...

Myelocytes prevent proliferation of cytolytic T cells.
March 17, 2003... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- c-kit+ FcR+ myelocytes are increased in cancer and prevent the proliferation of fully cytolytic T cells in the presence of immune serum. According to a study from the United States, "Immunogenic...

Tumor vaccine produces remission in patients with advanced cancer.
March 17, 2003... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Cancer cells made to secrete lymphotactin and interleukin (IL-2) have generated complete or partial remission in patients diagnosed with advanced...

Flt3 ligand performs poorly as adjuvant for prostate cancer vaccine.
March 17, 2003... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - The number of dendritic cells stimulated by an MHC class I peptide vaccine consisting of the E75 HLA-A2 epitope from HER-2/neu were increased when...

Tyrosine kinase inhibitors are in clinical development as anticancer agents.
March 17, 2003... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Tyrosine kinase inhibitors are in clinical development as anticancer agents. According to a study from the United States, "Numerous small molecule synthetic tyrosine kinase inhibitors are in...

Weekly paclitaxel is suited to combined modality therapy.
March 17, 2003... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Weekly paclitaxel is suited to combined modality therapy. "Weekly paclitaxel was initially used to exploit the radio sensitizing properties of the drug," researchers in Spain report. "However,...

Anti-CD28 has potent adjuvant effect on antibody response.
March 17, 2003... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Anti-CD28 exerts a potent adjuvant effect on the antibody response to soluble antigens mediated through the CTLA-4 by-pass. "With the surge in potential new vaccines produced as recombinant...

Occult orbital neuroblastoma detected after antitumor vaccine.
March 17, 2003... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- An occult orbital neuroblastoma was detected after administration of an antitumor vaccine. According to a study from the United States, "A 6-year-old girl with neuroblastoma developed swelling and...

Dendritic cells induce antitumor CD8 cells in chronic lymphocytic leukemia.
March 24, 2003... 2003 MAR 24 - (NewsRx.com & NewsRx.net) -- Idiotype-pulsed dendritic cells are able to induce antitumoral cytotoxic CD8 cells in chronic lymphocytic leukemia. According to recent research from France and the United States, "Idiotypic...

Adenovirus with MnSOD plus BCNU can shrink oral cancers.
March 24, 2003... 2003 MAR 24 - (NewsRx.com & NewsRx.net) -- Adenovirus with MnSOD plus BCNU treatment was reported to shrink oral cancers. "We hypothesized that inhibitors of peroxide removal, such as BCNU, an indirect inhibitor of glutathione peroxidase...

Researchers explore turning on immune system to attack tumor cells.
March 24, 2003... 2003 MAR 24 - (NewsRx.com & NewsRx.net) -- Researchers at Cedars-Sinai's Maxine Dunitz Neurosurgical Institute are working to develop a nonsurgical approach to brain cancer that uses radiation and the injection of specially cultured bone marrow...

Growing knowledge and advanced techniques will yield successful cancer vaccines.
March 24, 2003... 2003 MAR 24 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - The discovery of highly antigenic proteins, the ability to produce large amounts of antigens and other vaccine components by recombinant techniques,...

UCN-01 may be useful against gastric and colorectal cancers.
March 24, 2003... 2003 MAR 24 - (NewsRx.com & NewsRx.net) -- UCN-01 may be useful against gastric and colorectal cancers. According to recent research from Japan, "To evaluate the clinical usefulness of 7-hydroxystaurosporine (UCN-01), we compared the...

Design and analysis of non-inferiority mortality trials in oncology.
March 24, 2003... 2003 MAR 24 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "The recent revision of the Declaration of Helsinki and the existence of many new therapies that affect survival or serious morbidity, and that...

Cancer treated using vaccines in mixed allogeneic bone marrow chimeras.
March 31, 2003... 2003 MAR 31 - (NewsRx.com & NewsRx.net) -- Successful therapy of metastatic cancer was achieved using tumor vaccines in mixed allogeneic bone marrow chimeras. According to a study from the United States, "A frequent outcome of allogeneic...

Dendritic cell vaccine shows promise against cervical cancer.
March 31, 2003... 2003 MAR 31 - (NewsRx.com & NewsRx.net) -- Vaccination with dendritic cells pulsed with tumor lysate and matured with a novel synthetic clinically nontoxic, double-stranded RNA analogue poly [I]:poly[C[subscript]12U] (Ampligen) induced a strong...

CD40-directed gene therapy shows prospects for treating human cancers.
March 31, 2003... 2003 MAR 31 - (NewsRx.com & NewsRx.net) -- CD40-directed gene therapy shows prospects for treating human cancers. According to a study from the United States, "CD40, a member of the tumor necrosis factor receptor (TNF-R) family, is a...