Cancer Vaccine Week articles from June 2004

Cancer Vaccine Week archives from June 2004

Dendritic cell vaccine shows promise for tumors expressing CEA.
June 7, 2004... 2004 JUN 7 - (NewsRx.com & NewsRx.net) -- A dendritic cell-based vaccine was beneficial for some patients with metastatic gastrointestinal or lung adenocarcinomas expressing carcinoembryonic antigen (CEA). According to published research...

Dendritic cell vaccine for prostate cancer immunotherapy possible.
June 7, 2004... 2004 JUN 7 - (NewsRx.com & NewsRx.net) -- Effective antigen cross-presentation by prostate cancer patients' dendritic cells has implications for prostate cancer immunotherapy. According to recent research published in the journal Prostate...

CTLs to breast tumor-associated protein lyse breast cancer cells.
June 7, 2004... 2004 JUN 7 - (NewsRx.com & NewsRx.net) -- Human cytotoxic T lymphocytes to wild-type and enhanced epitopes of a novel prostate and breast tumor-associated protein, TARP, lyse human breast cancer cells. "Vaccine therapy for prostate and...

New guide compiles information on colorectal cancer research.
June 7, 2004... 2004 JUN 7 - (NewsRx.com & NewsRx.net) -- Research and Markets, a research reports organization, has announced a new compendium of information on colorectal cancer. Entitled, Analysis of Colorectal Cancer R&D - the Complete Guide, the...

Scientists link gene family mutation to colon cancer.
June 7, 2004... 2004 JUN 7 - (NewsRx.com & NewsRx.net) -- Research published in the May 21 issue of Science shows mutations in a family of genes linked to more than a quarter of colon cancers, as well as other cancers. Scientists from the Johns Hopkins...

Immature dendritic cells in irradiated tumors induce antitumor immunity.
June 7, 2004... 2004 JUN 7 - (NewsRx.com & NewsRx.net) -- Direct injection of immature dendritic cells into irradiated tumor induces efficient antitumor immunity. "Although there are several ways to load tumor antigens to dendritic cells (DCs), in vitro...

Protection against MUC1-expressing mouse tumors requires T cells.
June 7, 2004... 2004 JUN 7 - (NewsRx.com & NewsRx.net) -- Protection against MUC1-expressing mouse tumors by intramuscular injection of MUC1 cDNA requires functional CD8+ and CD4+ T cells but does not require the MUC1 tandem repeat domain. According to...

HPV vaccines and cervical cancer reviewed.
June 7, 2004... 2004 JUN 7 - (NewsRx.com & NewsRx.net) -- Scientists review human papillomavirus (HPV) vaccine and cervical cancer in a recent issue of Nature Reviews Microbiology. According to researchers in the Unites States, "Human papillomavirus (HPV)...

Juvaris collaborates with RNA-based gene-inhibition technology company.
June 7, 2004... 2004 JUN 7 - (NewsRx.com & NewsRx.net) -- Juvaris BioTherapeutics, Inc., and SomaGenics, Inc., both private biotechnology companies, announced that they have entered into a collaboration to develop products combining their technologies. ...

Streptococcal-derived OK-432 effective for ascites from gastric cancer.
June 7, 2004... 2004 JUN 7 - (NewsRx.com & NewsRx.net) -- DTH-oriented doses of the streptococcal preparation OK-432 was effective for treating malignant ascites from gastric cancer. "Locoregional administration of the streptococcal preparation OK-432 is...

Cytokine gene therapy reverts melanoma growth in mice.
June 7, 2004... 2004 JUN 7 - (NewsRx.com & NewsRx.net) -- Cytokine gene therapy reverts melanoma growth in mice. "In the present study, interleukin (IL)-12 gene-transduced B78-H1 melanoma cells (B78/IL-12) were used in combination with IL-15 to treat...

TAP-1 technology corroborated in models of skin cancer.
June 7, 2004... 2004 JUN 7 - (NewsRx.com & NewsRx.net) -- GeneMax Corp. (GMXX) announced its patented TAP-1 (transporters associated with antigen processing) anticancer technology is effective in generating immune responses against melanoma in mice. A...

Special protocol assessment granted from FDA for trial of GVAX vaccine.
June 7, 2004... 2004 JUN 7 - (NewsRx.com & NewsRx.net) -- Cell Genesys, Inc., (CEGE) announced that it has received a Special Protocol Assessment (SPA) from the U.S. Food and Drug Administration (FDA) for its upcoming phase III clinical trial of GVAX prostate...

New company launched for development of therapeutic DNA vaccines.
June 14, 2004... 2004 JUN 14 - (NewsRx.com & NewsRx.net) -- PowderMed Ltd, a new company focusing on the development of therapeutic DNA vaccines, has launched. The company has been created through a spin out of the powder injection DNA Vaccines technology...

Vector of membrane fusogenic liposomes used for melanoma vaccine.
June 14, 2004... 2004 JUN 14 - (NewsRx.com & NewsRx.net) -- Scientists have developed a melanoma vaccine based on the vector of membrane fusogenic liposomes. "Membrane fusogenic liposomes can deliver encapsulated contents into the cytoplasm directly in a...

Combinatorial gene therapy offers antitumor protection to leukemia models.
June 14, 2004... 2004 JUN 14 - (NewsRx.com & NewsRx.net) -- Combinatorial gene therapy offers antitumor protection to leukemia models. "We report in a murine model of acute lymphoid leukemia L1210 the potent antitumor efficiency of a combinatorial delivery...

Company reaches full enrollment in phase II non-small cell lung cancer trial.
June 14, 2004... 2004 JUN 14 - (NewsRx.com & NewsRx.net) -- NovaRx Corp. has successfully achieved full enrollment more than a year ahead of schedule in its multicenter phase II clinical trial treating individuals with advanced stages of lung cancer. The...

Dendritic cells loaded with antigen enhance antitumor immunity.
June 14, 2004... 2004 JUN 14 - (NewsRx.com & NewsRx.net) -- Dendritic cells loaded with exogenous antigen by electroporation can enhance MHC class I-mediated antitumor immunity. "To develop an efficient antitumor immunotherapy, we have examined if...

Heated tumor cells elicit anti-tumor immunity.
June 14, 2004... 2004 JUN 14 - (NewsRx.com & NewsRx.net) -- Heated tumor cells of autologous and allogeneic origin elicit anti-tumor immunity. "Vaccination with established tumor cell lines may circumvent the problem of obtaining autologous tumor cells from...

Plant viruses have potential to deliver anti-HPV vaccine.
June 14, 2004... 2004 JUN 14 - (NewsRx.com & NewsRx.net) -- Plant viruses are showing promise as carriers for new, low-cost, antiviral vaccinations against human papillomaviruses (HPVs) that cause benign and malignant tumors. A consortium of researchers...

HLA-DR T cell epitopes of CEA identified colorectal cancer patients.
June 14, 2004... 2004 JUN 14 - (NewsRx.com & NewsRx.net) -- Researchers have identified functional HLA-DR T cell epitopes of CEA in patients with colorectal carcinoma immunized with the recombinant protein CEA. "A baculovirus-produced recombinant CEA (rCEA)...

Apoptosis increases efficacy of alphaviral replicase-based DNA vaccines.
June 14, 2004... 2004 JUN 14 - (NewsRx.com & NewsRx.net) -- Apoptosis is essential for the increased efficacy of alphaviral replicase-based DNA vaccines. "Alphaviral replicons can increase the efficacy and immunogenicity of naked nucleic acid vaccines. To...

Nup88 mRNA overexpression associated with high aggressiveness of breast cancer.
June 14, 2004... 2004 JUN 14 - (NewsRx.com & NewsRx.net) -- Nup88 mRNA overexpression is associated with high aggressiveness of breast cancer "The nuclear pore complex protein Nup88 is overexpressed in tumor cells. Immunohistochemical studies have shown...

Enhanced tumor response to dendritic cells without CD8+ cells reported.
June 14, 2004... 2004 JUN 14 - (NewsRx.com & NewsRx.net) -- Researchers report an enhanced tumor response to dendritic cells in the absence of CD8+ cells. According to a study from the United States, "Wild-type mice immunized with MART-1 melanoma...

Protein synthesis is necessary for oncogenic cellular transformation.
June 14, 2004... 2004 JUN 14 - (NewsRx.com & NewsRx.net) -- Researchers explore the roles of PI 3-kinase signaling pathway and the mRNA-binding protein YB-1 in protein synthesis and oncogenic cell transformation. According to recent research from the United...

Prostate tissue-specific vaccine candidate identified.
June 14, 2004... 2004 JUN 14 - (NewsRx.com & NewsRx.net) -- Scientists have identified naturally processed CD8 T cell epitopes from prostein, a prostate tissue-specific vaccine candidate. "Prostein is a prostate tissue-specific protein that is uniquely and...

Method to load antigen-presenting protein with glycolipids developed.
June 14, 2004... 2004 JUN 14 - (NewsRx.com & NewsRx.net) -- Scientists have developed a method to load the antigen-presenting protein CD1d with synthetic glycolipids. "CD1 proteins present mammalian and microbial lipid and glycolipid antigens to different...

Electroporated DNA vaccine clears breast cancer in transgenic mice.
June 21, 2004... 2004 JUN 21 - (NewsRx.com & NewsRx.net) -- Electroporated DNA vaccine clears away multifocal mammary carcinomas in Her-2/neu transgenic mice. "The transforming rat Her-2/neu oncogene embedded into the genome of virgin transgenic BALB/c...

Melanoma cells expressing CD83 induce antitumor immunity.
June 21, 2004... 2004 JUN 21 - (NewsRx.com & NewsRx.net) -- Melanoma cells transfected to express CD83 induce antitumor immunity that can be increased by engaging CD137. According to a study from the United States and China, "Interactions between CD83 and...

Researchers turn tumor cells in situ into tumor epitope-presenters.
June 21, 2004... 2004 JUN 21 - (NewsRx.com & NewsRx.net) -- Researchers turn tumor cells in situ into tumor epitope-presenters. "Immunological control or cure of tumors depends on initiating a robust T helper cell response to MHC class II epitopes of...

Melanoma vaccine based on vector of membrane fusogenic liposomes.
June 21, 2004... 2004 JUN 21 - (NewsRx.com & NewsRx.net) -- Scientists have developed a melanoma vaccine based on the vector of membrane fusogenic liposomes. "Membrane fusogenic liposomes can deliver encapsulated contents into the cytoplasm directly in a...

Cell death induced by vaccine adjuvants containing surfactants.
June 21, 2004... 2004 JUN 21 - (NewsRx.com & NewsRx.net) -- Cell death was induced by vaccine adjuvants containing surfactants. According to a study from Taiwan, "Many vaccine adjuvants contain surface-active agents, but the immunological roles played by...

NY-ESO-1 protein protects against NY-ESO-1+ tumors.
June 21, 2004... 2004 JUN 21 - (NewsRx.com & NewsRx.net) -- NY-ESO-1 protein formulated in ISCOMATRIX adjuvant is a potent anticancer vaccine inducing both humoral and CD8+ T-cell-mediated immunity and protection against NY-ESO-1+ tumors. According to a...

Results of phase II study of G17DT vaccine reported.
June 21, 2004... 2004 JUN 21 - (NewsRx.com & NewsRx.net) -- Aphton Corporation (APHT) announced that the results from a phase II dose-ranging study of G17DT vaccine in gastric carcinoma were published in the European Journal of Surgical Oncology. The study...

Reproductive death delayed in progeny of irradiated melanoma cells.
June 21, 2004... 2004 JUN 21 - (NewsRx.com & NewsRx.net) -- Researchers have investigated delayed reproductive death and reactive oxygen species (ROS) levels in the progeny of irradiated melanoma cells. "The cell death and survival of proliferating...

Anti-tumor responses induced by ovarian cancer protein characterized.
June 21, 2004... 2004 JUN 21 - (NewsRx.com & NewsRx.net) -- Researchers have characterized the anti-tumor immune responses induced by a fusion protein of ovarian carcinoma anti-idiotypic antibody 6B11ScFv and murine GM-CSF in BALB/c mice. According to...

Clinical trial to study Panvac-VF in advanced pancreatic cancer.
June 21, 2004... 2004 JUN 21 - (NewsRx.com & NewsRx.net) -- Therion Biologics Corporation obtained agreement from the U.S. Food and Drug Administration (FDA) to initiate a phase III trial of its lead vaccine candidate, Panvac-VF, for the treatment of metastatic...

Tumor necrosis factor autovaccination eliminates melanoma metastasis.
June 21, 2004... 2004 JUN 21 - (NewsRx.com & NewsRx.net) -- Tumor necrosis factor autovaccination eliminates melanoma metastasis. According to recent research published in the British Journal of Cancer, "tumor necrosis factor (TNF) is a proinflammatory...

Follow-up data presented on autologous hemoderivative vaccine.
June 28, 2004... 2004 JUN 28 - (NewsRx.com & NewsRx.net) -- A team of researchers from France and the U.S. presented at the 2004 annual meeting of the American Society of Clinical Oncology follow-up data on an autologous hemoderivative vaccine administered to...

Vaccine containing multiple antigens generates higher immune response.
June 28, 2004... 2004 JUN 28 - (NewsRx.com & NewsRx.net) -- A breast cancer vaccine containing multiple antigens may boost a patient's clinical response rate because this strategy increases the chances that the immune system will respond to at least one...

B7-2 expression elicits anti-tumor immunity in B-cell lymphoma.
June 28, 2004... 2004 JUN 28 - (NewsRx.com & NewsRx.net) -- B7-2 expression above a threshold elicits anti-tumor immunity as effective as interleukin-12 and prolongs survival in murine B-cell lymphoma. According to a study from the United States, "The...

Dendritic cells made to overexpress CCL21 stimulate tumor immunity.
June 28, 2004... 2004 JUN 28 - (NewsRx.com & NewsRx.net) -- Dendritic cells made to overexpress CCL21 stimulate tumor immunity. According to published research from the United States, "to achieve in situ tumor antigen uptake and presentation, intratumoral...

Multicenter melanoma vaccine study demonstrates promising results.
June 28, 2004... 2004 JUN 28 - (NewsRx.com & NewsRx.net) -- Results from the largest multisite study conducted to date, evaluating a peptide-derived therapeutic vaccine for melanoma, were released by the Eastern Cooperative Oncology Group (ECOG) at the 40th...

Antitumor immunity determined by the tumor not vaccine.
June 28, 2004... 2004 JUN 28 - (NewsRx.com & NewsRx.net) -- CTL-dependent and -independent antitumor immunity is determined by the tumor not the vaccine. "Previously, we compared the efficiency of direct injection with an adenovirus (Ad) expressing human...

Cross-talk between dendritic and NK cells examined.
June 28, 2004... 2004 JUN 28 - (NewsRx.com & NewsRx.net) -- Investigators examine the role of cross-talk between IFN-alpha-induced monocyte-derived dendritic cells and NK cells in priming CD8+ T cell responses against human tumor antigens in a recent issue of...

Cancer vaccine maker reports $1M net loss.
June 28, 2004... 2004 JUN 28 - (NewsRx.com & NewsRx.net) -- Avax Technologies, Inc., (AVXT) announced financial results for the first quarter ended March 31, 2004. Net loss decreased for the 3-month period ended March 31, 2004, to $1,081,600 from...

Administration route shapes the effects of IL-12-expressing dendritic cells.
June 28, 2004... 2004 JUN 28 - (NewsRx.com & NewsRx.net) -- Administration route shapes the effects of IL-12-expressing dendritic cells. According to published research from the United States, "gene-modified dendritic cells (DC) provide unique therapeutic...

Pharmacogenomic profiling of PI3K/PTEN-AKT-mTOR pathway in tumors elucidated.
June 28, 2004... 2004 JUN 28 - (NewsRx.com & NewsRx.net) -- Pharmacogenomic profiling of the PI3K/PTEN-AKT-mTOR pathway in common tumors has been elucidated. "The protein synthetic machinery is activated by a variety of genetic alterations during tumor...

CD28 costimulation triggers tumor recognition by modified T cells.
June 28, 2004... 2004 JUN 28 - (NewsRx.com & NewsRx.net) -- CD28 costimulation triggers tumor recognition by modified T cells. "T cells engineered to express single-chain antibody receptors that incorporate TCR-zeta and cluster designation (CD)28 signaling...

Results on electroporation-enhanced DNA vaccine delivery presented at meeting.
June 28, 2004... 2004 JUN 28 - (NewsRx.com & NewsRx.net) -- Genetronics Biomedical Corp. (GEB), a company focused on cancer and other medical therapies based on electroporation-enhanced delivery of drugs, DNA vaccines, and genes, presented a poster in...

Targeting melanoma inhibitor of apoptosis protein destroys tumors.
June 28, 2004... 2004 JUN 28 - (NewsRx.com & NewsRx.net) -- Targeting the melanoma inhibitor of apoptosis protein results in immune-mediated tumor destruction. "Aberrantly expressed or mutated proteins in cancer cells evoke immune recognition, but host...

Nasopharyngeal carcinomas and Epstein-Barr virus reviewed.
June 28, 2004... 2004 JUN 28 - (NewsRx.com & NewsRx.net) -- Researchers review nasopharyngeal carcinomas and the Epstein-Barr virus in a recent issue of MS-Medecine Sciences. "Nasopharyngeal carcinomas (NPC) challenge clinicians and biologists in various...

Generex prepares for trials in patients with Her-2/neu positive ovarian cancer.
June 28, 2004... 2004 JUN 28 - (NewsRx.com & NewsRx.net) -- Generex Biotechnology Corp.'s (GNBT) wholly owned subsidiary, Antigen Express, has established a collaboration with Saint Savas Cancer Center in Athens, Greece, to use modified peptide antigens to...

Dr. Michael Fons tapped as executive director, corporate development.
June 28, 2004... 2004 JUN 28 - (NewsRx.com & NewsRx.net) -- Genetronics Biomedical Corp. (GEB) has appointed Michael Fons, PhD, MBA, as executive director, corporate development. Fons has extensive business development experience relating particularly to...