Cancer Vaccine Week articles from June 2003

Cancer Vaccine Week archives from June 2003

Antibody mimic CO17-1A elicits immune response in colorectal cancer patients.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- An antibody mimicking the gastrointestinal carcinoma-associated epitope CO17-1A elicited an immune response in colorectal cancer patients. According to published research from the United States,...

Lipopolysaccharide not needed for T-cell response to DNA vaccination.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- Lipopolysaccharide was not needed to induce T-cell responses to a DNA vaccine. According to a study from the United States, "Bacterial products, including lipopolysaccharide (LPS), are potential...

Costimulatory molecule vaccine effective against B-cell lymphoma in mice.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - A vaccine containing recombinant fowlpox virus encoding B7-1, intercellular adhesion molecule-1, and leukocyte function-associated antigen-3 elicited...

Immune cells may help deliver cancer vaccines for children.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- In a finding that could lay the groundwork for future cancer vaccines for children, cancer researchers working in cell culture have shown that modified immune cells can efficiently deliver genetic...

Combinatorial IL-12 and IL-18 gene therapy strikes out at distant tumors.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- Combinatorial IL-12 and IL-18 gene therapy strikes out at distant tumors. According to a study from Japan, "the immune response is modulated by genetic adjuvants using plasmid vectors expressing...

TLC ELL-12 in rats is well tolerated and may be therapeutically active.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- TLC ELL-12 in rats is well tolerated and may be therapeutically active. "TLC ELL-12 is a liposomal formulation of the antineoplastic L-O-octadecyl-2-O-methyl-sn-glycero-3-phosphocholine...

1100delC may be the only CHEK2 allele that contributes to breast cancer.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- 1100delC may be the only CHEK2 allele that contributes to breast cancer. According to a study from England, "We recently reported that a sequence variant in the cell-cycle-checkpoint kinase CHEK2...

CYP19 Arg(264)Cys polymorphism modifies breast cancer risk, more with alcohol.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- CYP19 Arg(264)Cys polymorphism modifies breast cancer risk, more with alcohol consumption. "A case-control study was performed to assess the potential influence of CYP19 Arg(264)Cys and CYP1B1...

Overexpression of KCNK9 in cell lines promotes tumor formation.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- Overexpression of KCNK9 in cell lines promotes tumor formation. "Representational difference analysis (RDA) of human breast cancer was used to discover a novel amplicon located at chromosomal...

DNA methylation markers are promising future tools in the clinic.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- DNA methylation markers are promising future tools in the clinic. According to recent research published in the journal Nature Reviews Cancer, "The past few years have seen an explosion of interest...

p53 Protein is a mechanism of resistance to amifostine-induced apoptosis.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- p53 Protein is a mechanism of resistance to amifostine-induced apoptosis. According to a study from the United States, "To determine the role of p53 protein on the cellular effects of amifostine, we...

CA 72-4 antigen can be considered the marker of choice in patient follow-up.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- CA 72-4 antigen can be considered the marker of choice in patient follow-up. "To date no general agreement has been reached regarding the prognostic significance of CEA, CA 19-9 and CA 72-4 as serum...

Homozygous deletion scanning reveals alternative pathways for carcinogenesis.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- Homozygous deletion scanning reveals alternative pathways for carcinogenesis. "Despite high rates of loss of heterozygosity affecting various chromosomes, the number of tumor suppressor genes (TSGs)...

Experts examine global progress in vaccines.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- Many of the world's vaccine scientists met at the National Foundation for Infectious Diseases' (NFID) Sixth Annual Conference on Vaccine Research to present the latest research on vaccines against...

PTEN protein may be absent in B-CLL with a normal PTEN genotype.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- PTEN protein may be absent in B-CLL with a normal PTEN genotype. According to a study from Switzerland, "One fifth of B-cell chronic lymphocytic leukemia (B-CLL) patients exhibit loss of...

Richard L. Jackson joins board of cancer vaccine company.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- Biomira, Inc., (BIOM) and its chairman, Eric Baker, announced the appointment of Richard L. Jackson, PhD, to its board of directors. Jackson is the principal of Jackson Associates, Inc., a...

Hydroxynorleucine used to introduce amino acid group into carbohydrates.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Hydroxynorleucine as a glycosyl acceptor was an efficient means for introducing amino acid functionality into complex carbohydrates. "A new approach to the synthesis of biologically relevant...

Removing CD4+ T cells overcomes suppression of anti-HER2 immune responses.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Elimination of CD4+ T cells may overcome suppression of anti-HER2 immune responses in tumor-bearing hosts. "In this study, we analyzed specific anti-tumor immune responses in tumor-bearing hosts by...

Interleukin 12 is promising adjuvant for cancer vaccination.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Interleukin 12 offers promise as an adjuvant for cancer vaccines. "The clinical development of interleukin 12 (IL-12) as a single agent for systemic cancer therapy has been hindered by its...

Progenipoietin plus melanoma tumor antigen vaccine stimulates immune response.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Results from a phase I clinical trial indicate that administration of progenipoietin and a vaccine containing melanoma tumor antigens stimulated in a...

Vaccine trial launched for previously untreated metastatic disease.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Cancer can be difficult to treat because it tricks the immune system into thinking it's not a threat. Researchers at the Columbia Presbyterian Medical Center at New York-Presbyterian Hospital are...

Host absence of CCR5 potentiates dendritic cell vaccination.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- The absence of CCR5 in the host potentiated dendritic cell vaccination. According to a study from the United States, "Previous work has shown that dendritic cells (DCs) express specific chemokine...

Inactivation of MMR genes is responsible for MSI in breast cancer cell lines.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Inactivation of MMR genes is responsible for MSI in breast cancer cell lines. According to a study from Germany, "At present, there is conflicting evidence whether microsatellite instability (MSI)...

Bi-213-PAI2 shows promise in preclinical studies of metastatic cancers.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Bi-213-PAI2 shows promise in preclinical studies of metastatic cancers. According to a study from Australia, "the control of micrometastatic breast cancer remains problematic. To this end, we are...

Researchers isolate the first fusion RTK protein from a human astrocytoma.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Researchers isolate the first fusion RTK protein from a human astrocytoma. According to a study from the United States, "The transmembrane proto-oncogene receptor tyrosine kinase (RTK) ROS is an...

Clinical development program reports progress.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Transgene (NASDAQ: TRGNY; Nouveau Marche: TRANSGENE) has reported progress and plans for its cancer vaccines and immunotherapy programs. The update describes the progress of several Phase II trials...

Therapeutic vaccine effective against EBV-associated cancers.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- A therapeutic LMP1 polyepitope vaccine has been developed for Epstein-Barr virus (EBV)-associated Hodgkin's disease and nasopharyngeal carcinoma. According to a study from Australia, "Development of...

Gen-17.1A significantly inhibited colon cancer cell growth in vitro and in vivo.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Gen-17.1A significantly inhibited colon cancer cell growth in vitro and in vivo. According to recent research published in the International Journal of Oncology, "We have shown that genistein, a...

Small interfering RNAs directed against beta-catenin inhibit cancer cell growth.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Small interfering RNAs directed against beta-catenin inhibit cancer cell growth. According to a study from the United States, "The beta-catenin and APC genes are key components of the Wnt signaling...

The ASPP family of proteins directs cells toward death after p53 upregulation.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- The ASPP family of proteins directs cells toward death after p53 upregulation. "It is well established that p53 is a primary target for mutation in human cancer. p53 carries out the important task...

Cell therapy company reports net loss of $.04 per share for first quarter.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Aastrom Biosciences, Inc., (ASTM) announced financial results and operational progress for the third quarter ended March 31, 2003. Quarterly highlights included several significant business...

A new fusion gene uses vaccine mechanisms to halt kidney cancer.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Researchers at the University of California at Los Angeles have developed a fusion gene that shows promise as a new kidney cancer vaccine. Laboratory...

Systemic combined low-dose chemotherapy had favorable response.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Systemic combined low-dose chemotherapy had favorable response in hepatocellular carcinoma. According to recent research published in the journal Digestive Diseases and Sciences, "The purpose of...

INI-1, a partner gene of ALL-1, is highly conserved in human acute leukemia.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- INI-1, a partner gene of ALL-1, is highly conserved in human acute leukemia. According to a study from Japan, "Recently, much interest has been focused on the role of INI-1, a partner gene of...

There is a direct role of Cajal body components in leukemogenesis.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- There is a direct role of Cajal body components in leukemogenesis. According to a study from the United States, "The (11;19)(q23;p13.1) translocation in acute leukemia results in the formation of a...

DAS inhibits DES metabolism thus preventing the formation of DNA adducts.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- DAS inhibits DES metabolism thus preventing the formation of DNA adducts. "According to recent research published in the journal Oncology Reports, "Diethylstilbesterol (DES) is known to cause...

Cumulative cigarette smoking plays an important role lung cancer risk.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Cumulative cigarette smoking plays an important role lung cancer risk. According to a study from the United States, "XRCC1 (X-ray cross-complementing group 1) and ERCC2 (excision repair...

GSTP1 exon 6 polymorphism is associated with lung cancer.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- GSTP1 exon 6 polymorphism is associated with lung cancer. "Glutathione transferases (GSTs), a multiple gene family of phase II enzymes, catalyze detoxifying endogenous reactions with glutathione...

Genetic alterations are detected on chromosomes 13 and 14.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Genetic alterations are detected on chromosomes 13 and 14. "Genetic alterations in 28 non-small cell lung carcinoma patients were detected on chromosomes 13q and 14q with microsatellite markers by...

BCL6 deregulation is involved in DLBCL pathogenesis.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- BCL6 deregulation is involved in DLBCL pathogenesis. According to a study from the United States, "The BCL6 proto-oncogene encodes a transcriptional repressor whose expression is deregulated by...

Functional loss of the NF2 protein may be involved in mesothelioma formation.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Functional loss of the NF2 protein may be involved in mesothelioma formation. "Fourteen primary human malignant mesothelioma (HMM) samples obtained from 14 patients were screened for point mutations...

Loss of heterozygosity and p53 polymorphism Pro72Arg led to aggressive therapy.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Loss of heterozygosity and p53 polymorphism Pro72Arg can lead to aggressive therapy. According to a study from Italy, "Differently from conventional primary neuroectodermal tumors (PNETs),...

TNF-alpha magnifies the biological activity of CXC-chemokines in melanocytes.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- TNF-alpha magnifies the biological activity of CXC-chemokines in melanocytes. "The CXC-chemokines Groa and interleukin-8 (IL-8) are ligands for two different G protein-coupled receptors, named...

DNA repair capacity is reduced in young patients suffering from multiple cancers.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- DNA repair capacity is reduced in young patients suffering from multiple cancers. "Young patients less than 45 years old suffering from multiple cancers but lacking typical risk factors were...

Common BRG1 mutations are excluded in prostate cancer.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Common BRG1 mutations are excluded in prostate cancer. According to recent research published in the International Journal of Oncology, "Previous studies in hereditary and sporadic prostate cancer...

There may be a link between the IFN and E2F1 pathways in regulating apoptosis.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- There may be a link between the IFN and E2F1 pathways in regulating apoptosis. According to a study from the United States, "p202, an interferon (IFN) inducible protein, is a phosphonuclear protein...

E2F plays a pivotal role in cell cycle control.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- E2F plays a pivotal role in cell cycle control. "The E2F family of transcription factors plays a central role in regulating cellular proliferation by controlling the expression of both the genes...

Activating BRAF mutations may be important in papillary thyroid carcinoma.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Activating BRAF mutations may be important in papillary thyroid carcinoma. "The BRAF gene has been found to be activated by mutation in human cancers, predominantly in malignant melanoma,"...

MTIG and CRABPI are likely involved in the pathogenesis of sporadic PTC.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- MTIG and CRABPI are likely involved in the pathogenesis of sporadic papillary thyroid carcinoma (PTC). According to published research from the United States, "We previously obtained gene...

PP2 inhibits RET/papillary thyroid carcinoma oncogenic kinases.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- PP2 inhibits RET/papillary thyroid carcinoma oncogenic kinases. "Inappropriate activation of the RET receptor tyrosine kinase causes development of papillary and medullary thyroid cancer,"...

Bfl-1 gene coexpression enhances response to HSV-thymidine kinase gene therapy.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Bfl-1 gene coexpression enhances response to HSV-thymidine kinase gene therapy systems. "Anticancer suicide gene therapy using herpes simplex virus-thymidine kinase (HSV-tk) and ganciclovir (GCV)...

Nitric oxide evoked p53-accumulation and apoptosis.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Nitric oxide evoked p53-accumulation and apoptosis. According to published research from Germany, "The tumor suppressor p53 accumulates under conditions of cellular stress and affects cell cycle...

Tight regulation of p53 activation is imperative for preventing tumorigenesis.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Tight regulation of p53 activation is imperative for preventing tumorigenesis. According to recent research from the United States, "The p53 tumor suppressor exerts anti-proliferative effects,...

TauT may represent a downstream target gene of WT1 during renal development.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- TauT may represent a downstream target gene of WT1 during renal development. According to recent research published in the journal FEBS Letters, "In the present study we have demonstrated that WT1...

Allovectin-7 shows promise against metastatic melanoma.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- HLA-B7/beta-2 microglobulin plasmid DNA/lipid complex (Allovectin-7) shows promise for treating metastatic melanoma. "Human leukocyte antigen (HLA)-B7/beta-2 microglobulin plasmid DNA/lipid...

Antigen silencing in melanomas induced by oncostatin M.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Antigen silencing in melanoma tumors is induced by oncostatin M. "We previously reported that antigen expression in melanoma cell lines is down-regulated by proteins secreted by antigen-negative...

RNA-binding protein L523S is potential therapeutic target for lung cancer.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- L523S, an RNA-binding protein, is a potential therapeutic target for vaccines against lung cancer. According to recent research published in the British Journal of Cancer, "Approaches to...

Xenogenized vaccine cells persist in vivo, preventing tumor attack.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Investigators have released evidence that xenogenized vaccine cells persist in vivo, inducing tumor immunity. "Trioma cell vaccination is a potent new immunotherapeutic strategy for the treatment...

Transforming growth factor beta inhibits action of dendritic cell vaccines.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Transforming growth factor beta inhibited the antigen-presenting functions and antitumor activity of dendritic cell vaccines. "Dendritic cell (DC)-based vaccines have exhibited minimal...

HPV vaccines reviewed from basic science to clinical trials.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- The history of human papillomavirus vaccines, from basic science to clinical trials, has been published in a recent issue of Frontiers in Bioscience. According to researchers in the United States,...

Papillary serous adenocarcinoma was less likely to express vimentin.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Papillary serous adenocarcinoma was less likely to express vimentin. "Adenocarcinomas of the uterine cervix show a wide range of morphological features, and can be confused with endometrial...

Regulatory RNA: B16 RNA provides antimelanoma activity, upregulating NF-kappa B.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- B16 RNA treatment appears to provide anti-melanoma effect, as that RNA appears to be a regulatory RNA. "Regulatory RNAs are noncoding RNAs that can regulate gene expression. Our previous results...

Hh inhibitors could be a valid therapeutic approach for treating BCC.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Hh inhibitors could be a valid therapeutic approach for treating BCC. "The link between basal cell carcinoma (BCC) and aberrant activation of the Hedgehog (Hh) signaling pathway has been well...

Increased cancer risk and BLMAsh mutation are not related.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Increased cancer risk and BLMAsh mutation are not related in Bloom syndrome. According to a study from Canada, "Bloom syndrome is an autosomal recessive disorder whose characteristics include an...

SCH58500 provides measurable efficacy in preclinical brain tumor models.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- SCH58500 provides measurable efficacy in preclinical brain tumor models. "Malignant gliomas remain incurable entities that provide fertile ground for experimental therapy," researchers in the...

Akt may be a target for enhancing radiotherapy response.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Akt may be a potential target for enhancing the response to radiotherapy. "The phosphatidylinositol 3-kinase (PI-3K)/Akt pathway, regulated by its upstream growth factor receptor tyrosine kinases,...

BRCA1 helps to mediate the resistance to both radiation and paclitaxel.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- BRCA1 helps to mediate the resistance to both radiation and paclitaxel. "BRCA1, the gene responsible for approximately half of all cases of hereditary breast cancer and almost all cases of combined...

The collagen alpha2(I) gene is methylated in multiple cancer cell lines.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- The collagen alpha2(I) gene is methylated in multiple cancer cell lines. "Collagen production plays a significant role in tumor development, especially in breast cancer, hepatocarcinomas, and...

Cytokine gene therapy combinations could become viable anticancer agents.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Combinations of interferon-alpha and interleukin-12 gene therapy could be refined so that their feasibility for treating human cancers would be enhanced. ...

CTLA-4 antibody blockade increases tumor immunity in cancer patients.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- A CTLA-4 antibody blockade increased tumor immunity in some previously vaccinated cancer patients. "A large number of cancer-associated gene products evoke immune recognition, but host reactions...

Tumor-derived ER chaperone grp170 reduces pulmonary metastatic disease.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Immunization with tumor-derived endoplasmic reticulum chaperone grp170 elicited a tumor-specific CD8+ T-cell response and reduced pulmonary metastatic disease. "Glucose-regulated protein (grp) 170...

Inflammation should be treated appropriately for chemoprevention of cancers.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Inflammation should be treated appropriately for chemoprevention of cancers. According to recent research published in the journal Toxicology Letters, "Chronic infection and inflammation are...

Gene overexpression increased from low- to high-grade lesions to cancer.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Gene overexpression increased from low- to high-grade lesions to cervical cancer. "The Pap test has effectively reduced the incidence and mortality of cervical cancer," investigators in the United...

CEP-6800 could be used as a chemopotentiating agent.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- CEP-6800 could be used as a chemopotentiating agent. According to a study from the United States, "Poly(ADP-ribose) polymerase 1 (PARP-1) is a nuclear zinc finger DNA-binding protein that is...

Inhibition of HDAC is an early event in cells treated with CI-994.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Inhibition of HDAC is an early event in cells treated with CI-994. "CI-994 or N-acetyldinaline [4-(acetylamino)-N-(2-amino-phenyl) benzamide] is an antitumor cytostatic agent currently undergoing...

FLIP and BCL-XL expression may reduce sensitivity of cancer cells to therapies.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- FLIP and BCL-XL expression may reduce sensitivity of cancer cells to therapies. "The extrinsic cell death pathway is initiated upon ligand-receptor interactions at the cell surface including FAS...

Tumor-suppressor genes show a gene-type specific methylation profile.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Tumor-suppressor genes show a gene-type specific methylation profile. "The stomach is one of the organs whose epithelia] cells frequently undergo aberrant methylation of CpG islands. To date,...

Delivery technology licensed for therapeutic vaccines.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Valentis, Inc., (NASDAQ:VLTSC) and Juvaris BioTherapeutics announced that they have entered into a broad, non-exclusive licensing agreement in which Juvaris will use Valentis' proprietary plasmid...

(MAsO)-O-III should be considered in treating other hematologic malignancies.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- (MAsO)-O-III should be considered in treating other hematologic malignancies. According to recent research from the United States, "Treatment with arsenic trioxide (As[superscript]2O[superscript]3)...

Apoptosis inhibitors cIAP1 and cIAP2 are overexpressed and may be oncogenes.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Many lung cancers overexpress cIAP1 and 2, with or without high genetic copy numbers, thus these apoptosis inhibitors may be oncogenes. "Amplification of oncogenes is an important mechanism that...

EGFRvIII is a potential therapeutic target in non-small cell lung cancer.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- EGFRvIII is a potential therapeutic target in non-small cell lung cancer. According to recent research from the United States, "The epidermal growth factor receptor (EGFR) variant type III...

High expression of Skp2 and Cks1 may be involved in the pathogenesis of NSCLCs.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- High expression of Skp2 and Cks1 may be involved in the pathogenesis of NSCLCs. According to a study from Japan, "Enhanced degradation of cyclin-dependent kinase (CDK) inhibitor p27(Kip1) is known...

A change in phenotype can occur in long-term tumor cultures.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- A change in phenotype can occur in long-term tumor cultures of melanoma. "We employed G-banding cytogenetic analysis to follow the clonal constitution of short-term cultures of metastatic malignant...

SCH66336 has good in vitro antitumor activity in both human and mouse melanoma.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- SCH66336 has good in vitro antitumor activity in both human and mouse melanoma. According to a study from the United States, "The constitutive activity of a number of growth and cell survival...