Cancer Vaccine Week articles from July 2004

Cancer Vaccine Week archives from July 2004

Folate-mediated targeting of T cells to tumors reviewed.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Scientists review folate-mediated targeting of T cells to tumors in a recent issue of Advanced Drug Delivery Reviews. According to recent research from the United States, "Recently various...

Immunological therapies in lymphoproliferative disorders reviewed.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- A scientist reviews the accomplishments and perspectives of immunological interventions in lymphoproliferative disorders in a recent issue of the Journal of Experimental and Clinical Cancer Research....

Toll-like receptor signals needed to reverse regulatory CD8 tolerance.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance. According to a study from the United States, "One chief barrier to cancer immunotherapy...

Tumor suppressor candidate protein in PTEN turnover identified.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Scientists have identified a tumor suppressor candidate protein in phosphatase and tensin homologue deleted on chromosome 10 (PTEN) turnover. According to published research from Japan, "The turnout...

Positive results reported for telomerase cancer vaccine clinical trial.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Geron Corp. (GERN) announced the presentation of new positive results from a phase I/II clinical trial of its telomerase therapeutic vaccine in metastatic prostate cancer. The presentation was...

Significant survival advantage reported in phase III trial of Theratope.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Biomira, Inc., (BIOM, BRA) of Edmonton, Alberta, Canada, announced that an exploratory analysis showed a statistically significant survival advantage for women in the hormonal therapy subset of patients...

FDA grants fast track designation for MedPulser Electroporation Therapy System.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Genetronics Biomedical Corp. (GEB) has been granted a fast track designation by the U.S. Food and Drug Administration for its MedPulser Electroporation System clinical development program for patients...

T cells primed by DCs pulsed with hepatoma acid-eluted substances.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Natural killer T cells can be primed in vivo by dendritic cells (DCs) pulsed with hepatoma-derived acid-eluted substances. "Many murine tumor cells express not only individual haplotype-matched...

CTL precursor-oriented peptide vaccine promising for colorectal cancer.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Results from a phase I trial indicate some benefit from cytotoxic T-lymphocyte (CTL) precursor-oriented peptide vaccines for colorectal carcinoma patients. According to recent research from Japan,...

PELP1 expression modulated by E2-ER pathway and PELP1 is an ER target gene.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- PELP1 expression is modulated by the E2-ER pathway and PELP1 is an ER target gene. "Proline-, glutamic acid- and leucine-rich protein 1 (PELP1)/modulator of nongenomic activity of estrogen receptor...

iTopia Epitope Discovery System launched for immune response prediction.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Beckman Coulter, Inc., (BEC) announced the commercial availability of its new iTopia Epitope Discovery System, which incorporates a proprietary technology announced last year at the World Vaccine...

Trial launched for new kidney-cancer vaccine.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Merix Bioscience, a company pioneering therapeutic cancer vaccines, announced its first corporate-sponsored clinical trial, a trial with potential significant impact on the future treatment of kidney...

Data from trial of EP-2101 released at ASCO.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Epimmune, Inc., (EPMN) provided preliminary data from ongoing phase I/II clinical trials of its EP-2101 therapeutic vaccine in non-small cell lung (NSCL) cancer and colorectal cancer patients in a...

MDX-010 receives orphan drug designation.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Medarex, Inc., (MEDX) announced that under the U.S. Orphan Drug Act, the U.S Food and Drug Administration (FDA) has granted orphan drug designation to Medarex's fully human anti-CTLA-4 antibody,...

U.S. perspective on toxicology approaches for oncology drugs reviewed.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- A scientist describes the U.S. perspective on multi-species toxicology approaches for oncology drugs in a recent issue of the European Journal of Cancer. According to a study from the United States,...

Vaccine shows promise in advanced pancreatic cancer, data shows.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Therion Biologics Corporation presented data supporting the safety profile of the company's therapeutic cancer vaccines and suggesting early evidence of extended overall survival in patients with...

Final results of phase I/II trial of CG7870 reported.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Cell Genesys, Inc., (CEGE) reported final clinical data from its phase I/II clinical trial of CG7870 oncolytic (cancer cell-killing) virus therapy for prostate cancer. The trial enrolled 23...

Tumor-associated antigens show promise for prostate cancer vaccines.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Scientists have identified potential tumor-associated antigens for the development of prostate cancer vaccines. According to published research from Norway, "Serological cloning of tumor-associated...

Vaccine benefits some prostate cancer patients in biochemical relapse.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Vaccination with autologous dendritic cells pulsed with recombinant human PSA benefits some prostatectomized prostate cancer patients in biochemical relapse. "This study was conducted in prostate...

Oncophage cancer vaccine clinical findings announced.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Antigenics Inc. (AGEN) announced findings from two clinical trials of the company's investigational cancer vaccine Oncophage (HSPPC-96). Demographic data from the company's phase III trial of...

IMC-BEC2 cancer vaccine trial did not meet primary endpoint.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- ImClone Systems, Inc., (IMCL) and Merck, KGaA, of Darmstadt, Germany (MRK), announced that the international, randomized, phase III, clinical trial of the companies' IMC-BEC2 cancer vaccine did not meet...

Flagellin fusion proteins induce specific immune responses.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Flagellin fusion proteins as adjuvants or vaccines induce specific immune responses. "Vaccination is the most efficient prophylaxis against a variety of infectious diseases. New vaccination...

Epicutaneous CpG oligodeoxynucleotides with antigen promotes CTL.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Epicutaneous application of CpG oligodeoxynucleotides with peptide or protein antigen promotes the generation of cytotoxic T lymphocytes (CTL). According to recent research published in the Journal...

Merck, KGaA, returns Theratope rights.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Biomira, Inc., (BIOM) and Merck, KGaA, of Darmstadt, Germany, announced that development and commercialization rights to the therapeutic cancer vaccine, Theratope, will be returned to Biomira. The...

pH-sensitive toxins find application in vaccines and drug delivery.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- pH-sensitive toxins are finding application in vaccines and drug delivery. "pH-sensitive toxins are secreted by bacteria and reach the cytosol of eukaryotic target cells by complex mechanisms...

Dendritic cell vaccines show promise for breast cancer therapy.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Dendritic cell vaccines show promise for breast cancer therapy. According to published research from Australia, "The long-held belief that breast cancer is a weakly immunogenic tumor and a poor...

Novel cancer compound targets EGFR pathway; demonstrates positive trial results.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- CancerVax Corp. (CNVX) announced data from phase I/II clinical trials of an investigational specific active immunotherapeutic product candidate (SAI-EGF) that targets the epidermal growth factor...

Adenovirus encoding HCA661 targets hepatoma cells.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Transduction of dendritic cells with recombinant adenovirus encoding HCA661 activates autologous cytotoxic T lymphocytes to target hepatoma cells. According to recent research from China,...

CTLA-4 blockade plus DNA vaccine enhances tumor immunity.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- A CTLA-4 blockade in combination with xenogeneic DNA vaccines enhances T-cell responses, tumor immunity, and autoimmunity to self-antigens in animal and cellular model systems. According to recent...

DNA vaccines suppress angiogenesis to inhibit tumor growth.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- DNA vaccines suppress angiogenesis to inhibit tumor growth. "Four novel oral DNA vaccines provide long-lived protection against melanoma, colon, breast, and non-small cell lung carcinoma in mouse...

CuraGen licenses Seattle Genetic technology for $2 million.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- CuraGen Corp. said that it licensed Seattle Genetics Inc.'s proprietary ADC technology for use with CuraGen's antibodies for the treatment of cancer. CuraGen will pay an upfront fee of $2 million...

GADD34 up-regulation mediates activity of mitomycin C and herpesvirus.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Up-regulation of GADD34 mediates the synergistic anticancer activity of mitomycin C and a gamma[subscript]134.5-deleted oncolytic herpes virus (G207). According to recent research published in the...

Gene transfer of OX40 ligand to tumor cells enhances antitumor immunity.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Adenovirus vector-mediated in vivo gene transfer of OX40 ligand to tumor cells enhances antitumor immunity of tumor-bearing hosts. According to recent research published in the journal Cancer...

Peptides immunogenic for HLA-A2+ cancer patients identified.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Scientists have identified epidermal growth factor receptor-derived peptides immunogenic for HLA-A2+ cancer patients. According to published research from Japan, "Epidermal growth factor receptor...

Antigen loading of dendritic cells with antigen reviewed.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Researchers review antigen loading of dendritic cells (DCs) with antigen in a recent issue of Cytotherapy. According to published research from Australia, "Understanding the biology of the...

Current issues in delivering dendritic cells for immunotherapy reviewed.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Researchers review current issues in delivering dendritic cells for immunotherapy in a recent issue of Cytotherapy. "Dendritic cell (DC)-based immunotherapy has shown early promise in clinical...

Dendritic cell immunotherapy reviewed.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Scientists review dendritic cell immunotherapy in a recent issue of Nature Medicine. "Dendritic cells (DCs) are the professional antigen-presenting cells of the immune system, with the potential to...

Dendritic cells are attractive targets for vaccine design.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Dendritic cells are attractive targets for vaccine design. According to published research from Australia, "The increasingly stringent requirements laid down by regulatory authorities have brought...

Dopamine[subscript]2 receptor expressed in 80% of corticotroph pituitary tumors.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Dopamine[subscript]2 receptors are expressed in approximately 80% of corticotroph pituitary tumors. According to a study from Italy, "The role of dopamine agonist treatment in corticotroph...

Molecular alterations associated with cyclin D1 overexpression in cancer.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Molecular alterations are associated with cyclin D1 overexpression in endometrial cancer. According to recent research from Spain, "Cyclin DI is frequently overexpressed in human neoplasias by...

In vitro system produces infectious HPV16 in keratinocytes for research.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Penn State University scientists have found a way to produce infectious human papillomavirus 16 (HPV16) in the laboratory. "Despite the prevalence of HPV16 in invasive cervical cancers, an in...

SEC sues Florida pharmaceutical company over securities offer.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- The Securities and Exchange Commission (SEC) sued a Florida company that touted a breakthrough cancer treatment, claiming the company raised more than $3 million in a fraudulent, unregistered...

Imatinib mesylate plus dendritic cell vaccine is effective for leukemia.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Imatinib mesylate effectively combines with chaperone-rich cell lysate-loaded dendritic cells to treat bcr-abl+ murine leukemia. "Imatinib mesylate has become an effective agent for the treatment...

Dendritic cells loaded with microspheres used for immunotherapy.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Human monocyte-derived dendritic cells loaded with biodegradable poly(Lactide-co-glycolide) microspheres can be used for immunotherapy. According to published research from Switzerland, "Dendritic...

Dendritic cells used for multiple myeloma immunotherapy.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Dendritic cells show promise for multiple myeloma immunotherapy. According to a study from Australia, "Therapy for patients with multiple myeloma (MM) is currently unsatisfactory and most patients...

MMP-9 modulation may have therapeutic potential in advanced CLL.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- MMP-9 modulation may have therapeutic potential in advanced CLL. According to a study from England, "Matrix metalloproteinases (MMPs) are important for the pathogenesis and progression of different...

Synthetic retinoids induce apoptosis in ovarian carcinoma cells.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Synthetic retinoids induce apoptosis in ovarian carcinoma cells. "Apoptosis is also known as programmed cell death. Apoptosis plays an essential role in maintaining normal tissue and cell...

Vaccine-development company appoints Edward C. Farrauto as CFO.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- GeneMax Corp. (GMXX) has named Edward C. Farrauto as its CFO, treasurer, and secretary. Farrauto's responsibilities will encompass the company's accounting functions that involve the preparation of...

Retinoid-related molecule potently induces apoptosis in prostate cancer cells.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Retinoid-related molecule potently induces apoptosis in prostate cancer cells. "Synthetic retinoid-related molecules, such as N-(4-hydroxyphenyl)retinamide (fenretinide) and...

MTI-MMP plays critical role in esophageal squamous cell carcinoma progression.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- MTI-MMP plays critical role in esophageal squamous cell carcinoma progression. According to a study from Japan, "Matrix metalloproteinase (MMP) is critical for carcinoma progression. In our study,...

New cytokine-dependent AML cell line with novel features established.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- A new cytokine-dependent acute myeloid leukemia cell line with novel features has been established. According to recent research from Germany, "Continuous human leukemia-lymphoma (LL) cell lines...

Multiple antigens recognized by lymphocytes identified from individual.
July 19, 2004... 2004 JUL 19 - (NewsRx.com & NewsRx.net) -- Researchers have identified multiple antigens recognized by tumor-infiltrating lymphocytes from a single patient. According to published research from the United States, "The authors describe a...

mRNA-transfected dendritic cells used for cancer immunotherapy.
July 19, 2004... 2004 JUL 19 - (NewsRx.com & NewsRx.net) -- Cancer immunotherapy was accomplished with mRNA-transfected dendritic cells. "Bone marrow-derived dendritic cells (DCs) are the most potent antigen-presenting cells capable of activating naive T...

Processing of antigens delivered as DNA vaccines reviewed.
July 19, 2004... 2004 JUL 19 - (NewsRx.com & NewsRx.net) -- Scientists review the processing of antigens delivered as DNA vaccines in a recent issue of Immunological Reviews. According to a study from England, "The ability of DNA vaccines to provide...

Dendritic cell vaccine needs IL-2 for melanoma metastasis efficacy.
July 19, 2004... 2004 JUL 19 - (NewsRx.com & NewsRx.net) -- Dendritic cell vaccines require IL-2 for effectiveness against melanoma metastases. "IL-2 has been approved for treatment of patients with cancer. Moreover, it has been used as a component of...

Breast tumor cell destruction by herpesvirus induces antitumor immunity.
July 19, 2004... 2004 JUL 19 - (NewsRx.com & NewsRx.net) -- Destruction of nonimmunogenic mammary tumor cells by a fusogenic oncolytic herpes simplex virus induces potent antitumor immunity. "In principle, destruction of tumor cells in vivo by oncolytic...

Adoptive transfer of anti-idiotypic T cells cure B cell lymphoma.
July 19, 2004... 2004 JUL 19 - (NewsRx.com & NewsRx.net) -- Adoptive transfer of anti-idiotypic T cells cure mice of disseminated B cell lymphoma. "There is extensive interest in idiotypic vaccination as a treatment of lymphoma. An alternative approach is...

Dendritic cell vaccine prevents GI tumors based on mutation.
July 19, 2004... 2004 JUL 19 - (NewsRx.com & NewsRx.net) -- A dendritic cell vaccine prevents gastrointestinal (GI) tumors based on adenomatous polyposis coli gene mutation. "Here we describe the effect of immunization with dendritic cells loaded with...

Companies to develop personalized dendritic-cell vaccines.
July 19, 2004... 2004 JUL 19 - (NewsRx.com & NewsRx.net) -- Merix Bioscience, a company pioneering therapeutic immunotherapy vaccines, and Kirin Brewery's pharmaceutical division, which is developing therapeutic products for renal disease, cancer, and...

Dendritic cells and immunity to cellular antigens reviewed.
July 19, 2004... 2004 JUL 19 - (NewsRx.com & NewsRx.net) -- Scientists review the cross-presentation, dendritic cell subsets, and generation of immunity to cellular antigens in a recent issue of Immunological Reviews. According to a study from Australia,...

Ets gene PEA3 assists beta-catenin-Lef-1/c-Jun in OPN transcription regulation.
July 19, 2004... 2004 JUL 19 - (NewsRx.com & NewsRx.net) -- Ets gene PEA3 assists beta-catenin-Lef-1/c-Jun in osteopontin transcription regulation. According to recent research from North Ireland, "Osteopontin (OPN) is a multifunctional protein implicated...

Potential uses of RapidMist technology in transmucosal vaccines discussed.
July 19, 2004... 2004 JUL 19 - (NewsRx.com & NewsRx.net) -- Generex Biotechnology Corp. (GNBT) announced the presentation of a research abstract by Robert Humphreys, the chief scientific officer of its Antigen Express immunomedicines subsidiary, at the...

Two patents awarded for applications of electroporation therapy.
July 19, 2004... 2004 JUL 19 - (NewsRx.com & NewsRx.net) -- Genetronics Biomedical Corp. (GEB), a company focused on the electroporation-enhanced delivery of drugs, DNA vaccines, and gene therapies intended to treat cancer, infectious diseases, and other...

Phase II trial of GVAX lung cancer vaccine begins.
July 26, 2004... 2004 JUL 26 - (NewsRx.com & NewsRx.net) -- Cell Genesys, Inc., (CEGE) announced enrollment has been initiated for a multicenter, phase II, clinical trial of GVAX lung cancer vaccine in patients with advanced-stage bronchoalveolar carcinoma...

Immunofluorescence test to detect varicella-zoster IgG developed.
July 26, 2004... 2004 JUL 26 - (NewsRx.com & NewsRx.net) -- Researchers have developed an immunofluorescence test for sensitive detection of varicella-zoster virus-specific IgG. According to a study from Germany, "A highly sensitive indirect fluorescence...

Poxvirus vaccine plus celecoxib elicits antitumor immunity.
July 26, 2004... 2004 JUL 26 - (NewsRx.com & NewsRx.net) -- The combination of a poxvirus-based vaccine with a cyclooxygenase-2 inhibitor (celecoxib) elicits antitumor immunity and long-term survival in mice. "The present study was designed to determine...

Tumor cell-based vaccines are potent activators of CD4+ T lymphocytes.
July 26, 2004... 2004 JUL 26 - (NewsRx.com & NewsRx.net) -- MHC class II and CD80 tumor cell-based vaccines are potent activators of type 1 CD4+ T lymphocytes provided they do not coexpress invariant chain. According to a study from the United States, "We...

HPV vaccine targeting women age 24-45 is under study.
July 26, 2004... 2004 JUL 26 - (NewsRx.com & NewsRx.net) -- A vaccine that appears to protect against four common strains of human papillomavirus (HPV) - two that cause cervical cancer and two that cause genital warts - is under study at the Medical College of...

Company focuses on therapeutic vaccines, slashes workforce to cut expenses.
July 26, 2004... 2004 JUL 26 - (NewsRx.com & NewsRx.net) -- Cerus Corp. (CERS) announced the company is realigning its operations to focus more intensively on its program to develop therapeutic vaccines against cancer and infectious disease. As a result of...

Potent vaccine-induced anti-tumor T cell response characterized.
July 26, 2004... 2004 JUL 26 - (NewsRx.com & NewsRx.net) -- Scientists have characterized a potent tumor vaccine-induced secondary anti-tumor T cell response. "This study describes a tumor vaccine-induced secondary in vivo T cell response to an...

SSX-2-derived epitope recognized by CD4+ T cells along with HLA-DR.
July 26, 2004... 2004 JUL 26 - (NewsRx.com & NewsRx.net) -- An immunodominant SSX-2-derived epitope is recognized by CD4+ T cells in association with HLA-DR. "Ectopic gene expression in tumors versus normal somatic tissues provides opportunities for the...

Biopharma signs agreement to manufacture Coley's Toxin cancer vaccine.
July 26, 2004... 2004 JUL 26 - (NewsRx.com & NewsRx.net) -- Cobra Biomanufacturing, Plc, an international manufacturer of biopharmaceuticals, announced an agreement between the Ludwig Institute for Cancer Research and its collaborator, the Cancer Research...

Heat-shock protein as dendritic cell target enhances vaccine potency.
July 26, 2004... 2004 JUL 26 - (NewsRx.com & NewsRx.net) -- Using secretory heat-shock protein as a dendritic cell-targeting molecule provides a new strategy to enhance the potency of genetic vaccines. According to published research from the United States,...

Dendritic cells expressing HPV16-E7 inhibited by co-expression of IL12.
July 26, 2004... 2004 JUL 26 - (NewsRx.com & NewsRx.net) -- The adjuvant effect of dendritic cells transduced with recombinant vaccinia virus expressing HPV16-E7 is inhibited by co-expression of IL-12. "Dendritic cells (DC) enhanced the immunogenicity of...

Hypervariable epitopes induce immune responses against papillomaviruses.
July 26, 2004... 2004 JUL 26 - (NewsRx.com & NewsRx.net) -- Hypervariable epitope constructs induced immune responses against human papillomaviruses. "An ideal prophylactic vaccine against human papillomaviruses (HPV) would be one that can induce broadly...

Presentation system improves cellular immunity against papillomavirus.
July 26, 2004... 2004 JUL 26 - (NewsRx.com & NewsRx.net) -- An inducible surface presentation system improves cellular immunity against human papillomavirus type 16 E7 antigen in mice after nasal administration with recombinant lactococci. According to...

CD40 ligand gene therapy halts Th2-mediated tumor escape.
July 26, 2004... 2004 JUL 26 - (NewsRx.com & NewsRx.net) -- CD40 ligand gene therapy halts Th2-mediated tumor escape. "Tumors exhibit immune escape properties that promote their survival. These properties include modulation of Ag presentation, secretion of...

Initial clinical data from GVAX pancreatic cancer vaccine program.
July 26, 2004... 2004 JUL 26 - (NewsRx.com & NewsRx.net) -- Cell Genesys, Inc., (CEGE) presented clinical data from an exploratory phase II clinical trial of GVAX pancreatic cancer vaccine in patients with inoperable, metastatic pancreatic cancer. The...

Melanoma peptide cocktail generates T cells against malignant melanoma.
July 26, 2004... 2004 JUL 26 - (NewsRx.com & NewsRx.net) -- An HLA-A24-restricted melanoma peptide cocktail generated cytotoxic T cells against human malignant melanoma cells. According to a study from Japan, "Many human leukocyte antigen (HLA)-class 1...

L3MBTL implications for pathogenesis of myeloid malignancy 20q deletions.
July 26, 2004... 2004 JUL 26 - (NewsRx.com & NewsRx.net) -- L3MBTL implications for pathogenesis of myeloid malignancies associated with 20q deletions. "L3MBTL encodes a member of the Polycomb family of proteins, which, together with Trithorax group...

Scalable production platform for oncolytic adenoviral vectors developed.
July 26, 2004... 2004 JUL 26 - (NewsRx.com & NewsRx.net) -- Researchers have developed a scalable production platform for oncolytic adenoviral vectors. "This study demonstrates the novel use of the HeLaS3 human tumor cell line for propagating ONYX-411, a...