Cancer Vaccine Week articles from January 2004

Cancer Vaccine Week archives from January 2004

Tumor growth inhibited by vaccination with Her-2/neu peptides.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Tumor cell growth was inhibited by antibodies induced after vaccination with peptides derived from the extracellular domain of Her-2/neu. According to a study from Austria, "The anti Her-2/neu...

Vaccines for leukemia therapy reviewed.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Researchers have reviewed progress in the development of leukemia vaccines in a recent issue of the journal Acta Haematologica. According to a study from Germany, "Evidence that immunological...

Shc proteins are prognostic markers for primary breast cancer.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Shc proteins are strong, independent prognostic markers for both node-negative and node-positive primary breast cancer. "Activated Shc signaling proteins are implicated in many pathways associated...

Inhibiting DNA replication-initiation protein induces apoptosis.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Inhibiting the expression of DNA replication-initiation proteins induces apoptosis in human cancer cells. According to a study from China, "DNA replication-initiation proteins are expressed in...

A3 adenosine receptor agonist inhibits colon cancer growth.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- The A3 adenosine receptor agonist CF101 inhibits primary colon carcinoma growth and liver metastasis. According to recent research published in the British Journal of Cancer, "Adenosine is a purine...

Data from Theratope Vaccine trial presented.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Biomira, Inc., (BIOM, BRA) and Merck KGaA of Darmstadt, Germany, announced that data from the final analysis of their Theratope Vaccine phase III clinical trial in women with metastatic breast cancer...

SAFB1 and SAFB2 may be novel breast tumor suppressor genes.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Scaffold attachment factor B1 (SAFB1) and Scaffold attachment factor B2 (SAFB2) may be novel breast tumor suppressor genes, researchers say. "SAFB1 and SAFB2 are large, multifunctional proteins that...

Requirement discussed for Arf6 in cell adhesion, migration, cancer cell invasion.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Researchers discuss the possible roles of a small GTP-binding protein, Arf6, in epithelial cell adhesion and migration, and in cancer cell invasion. According to published research from Japan, "Cell...

Researchers analyze model of a virus that replicates selectively in tumor cells.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Researchers analyze a model in which viruses infect tumor cells, replicate inside them, and eventually cause their death. According to a study from the United States, "We consider a procedure for...

Multiple mechanisms contribute to the carcinogenicity of cadmium.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Multiple mechanisms contribute to the carcinogenicity of cadmium, researchers say. "Cadmium is a heavy metal, which is widely used in industry, affecting human health through occupational and...

Activation of PPAR gamma in colon tumor cell lines.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Oxidation products of linoleic acid are metabolically produced endogenous ligands for PPAR gamma and that PPAR gamma plays an important role in the differentiation of intestinal cells. According to...

Dendritic cell vaccine to be used in trial for new cancer treatment.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Aastrom Biosciences, Inc., (ASTM) announced the initiation of a phase I clinical trial in collaboration with investigators at Duke University Medical Center (Duke). The clinical trial will evaluate...

15-Hydroxy-eicosatetraenoic acid arrests growth of colorectal cancer.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Treating colon cancer cells with 15S-HETE inhibits cell proliferation and induces apoptosis in a PPARgamma-dependent pathway, researchers report. "Peroxisome proliferator-activated receptor gamma...

Knudson's theory can explain diverse experimental situations.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Knudson's two-hit theory can explain diverse experimental situations and guide specific predictions, including some directly relevant to cancer prevention, researchers report. "The multistep model...

Cancer vaccine company reports $10M net loss; provides clinical update.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- CancerVax Corporation (CNVX) announced financial results for the third quarter of 2003. For the 3 months ended September 30, 2003, the company reported a net loss of $10.0 million, as compared to a...

Human MutY genetic mutations detected in cancer.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Mutations in the human MutY gene and defective activity of the human MutY protein have been detected in cancer, researchers say. According to recent research published in the journal Cellular and...

Proteomics is the newest, most promising direction for gynecologic cancer.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Proteomic technology is the newest and most promising direction for translational developments in gynecologic cancers, researchers report. "Diagnosis and management of cancer requires tools with...

Data reported in trials of heat shock protein-based cancer vaccines.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Antigenics, Inc., (AGEN) announced updated results from clinical trials of HSPPC-70 (previously referred to as AG-858) and Oncophage (HSPPC-96) personalized cancer vaccines, both of which are based on...

Interim data reported from phase II trial of GVAX vaccine.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Cell Genesys, Inc., (CEGE) reported interim clinical data from a phase II trial of GVAX cancer vaccine for acute myelogenous leukemia (AML). Patients with newly diagnosed leukemia were treated with...

Qualitative methods in environmental health research.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Researchers describe the legacy of qualitative research in environmental health. According to published research from the United States, "Public health researchers increasingly turn to qualitative...

Rituximab leads to substantial but transient down-modulation of CD20 expression.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Rituximab therapy leads to a substantial but transient down-modulation of CD20 expression, researchers report. "Lymphoid cells in most patients with chronic lymphocytic leukemia (CLL), when treated...

Risk model with intermediate endpoints needed for new lung cancer chemo studies.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Development of a risk model with intermediate endpoints is necessary to conduct future chemoprevention studies of lung cancer, researchers say. "Lung cancer is a major cause of mortality and...

RTK classes, known to be expressed on normal hematopoietic tissue, summarized.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Researchers summarize the RTK classes that are known to be expressed on normal hematopoietic tissue. "Hematopoiesis is controlled by a number of growth factors and cytokines, a number of which act...

Fibroblasts may control melanoma cell invasion after start of tumor progression.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Researchers say fibroblasts may influence melanoma cell invasion after the beginning of tumor progression through the dermis. According to published research from France, "The dermis is the main...

MyVax Personalized Immunotherapy shows promise in mantle cell lymphoma.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Genitope Corp. (GTOP) announced results of a phase II clinical trial evaluating MyVax Personalized Immunotherapy for the treatment of aggressive non-Hodgkin lymphoma, including mantle cell lymphoma...

Interventional strategies that decreasing rate of clonal expansion preferred.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Intervention strategies that decrease the rate of clonal expansion of partially altered cells are preferred to strategies that decrease the rate of early mutational events, researchers say. "We...

Alpha-methylacyl-coenzyme A racemase may be an important prostate cancer marker.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Alpha-methylacyl-coenzyme A racemase (AMACR) may be an important new marker of prostate cancer. According to a study from the United States, "Prostate cancer is among the most common malignancies....

Biology of prostate-specific antigen reviewed.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Data are emerging that show that active hK2, hK4, and hK15 may be important to convert pro-PSA to the active PSA enzyme, researchers report. "The human kallikrein (hk) family, located on chromosome...

Heavy metal-metabolizing proteins involved in human prostate homeostasis.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Heavy metal-metabolizing proteins were involved in human prostate homeostasis, and that the metal metabolizing system might be different in malignant tissues," researchers say. According to recent...

Improved tools for analyzing prostate cancer genes are needed.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Improved tools for analyzing prostate cancer genes are needed, researchers say. "The molecular genetics of prostate cancer, the second most common cause of cancer-related death in men, is poorly...

New targets for therapy in prostate cancer discussed.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- A quantitative assay for DD3(PCA3) could have important implications for the earlier diagnosis and molecular staging of prostate cancer. "Identification of new markers for diagnosis and new targets...

Multiple roles of the tuberous sclerosis complex genes reviewed.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Researchers summarize some current concepts in the understanding of the biological and biochemical function of the TSC genes. According to recent research from the United States, "Soon after...

New eco-evolutionary model of tumor dynamics described.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Researchers describe a new eco-evolutionary model of tumor dynamics that incorporates stoichiometric mechanisms. According to a study from the United States, "Biological stoichiometry is the study...

Haploinsufficient genes requiring inactivation of only one allele.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Haploinsufficient genes requiring inactivation of only one allele, and genes inactivated not by mutation but rather epigenetic hypermethylation do not adhere to the two-hit model, researchers say. ...

Model for the early growth of DCIS of the breast is formulated.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Researchers formulate a nutrient-limited growth model in which a Stokes flow constitutive relation describes cell movement. "The growth of a tumor in a rigid walled cylindrical duct is examined in...

BLA filed for Arilvax vaccine.
January 5, 2004... 2004 JAN 5 - (NewsRx.com & NewsRx.net) -- Acambis plc (ACAM) announced that it has filed a Biologics License Application (BLA) with the CBER vaccine division of the U.S. Food and Drug Administration (FDA) to seek registration in the U.S. of its...

Broadly applicable heat shock protein-mediated tumor vaccine developed.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Researchers have developed a broadly applicable, personalized heat shock protein-mediated oncolytic tumor vaccine. According to recent research from the United States, "Each tumor harbors unique...

Positive results reported for telomerase cancer vaccine clinical trial.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Geron Corp. (GERN) announced the presentation of additional positive preliminary results from a phase I/II clinical trial of a telomerase therapeutic vaccine for metastatic prostate cancer at Duke...

PI3-K pathway may be major pathway for trastuzumab-mediated radiosensitization.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Researchers say the PI3-K pathway might be the major pathway for trastuzumab-mediated radiosensitization of breast cancer cells. According to published research from the United States, "HER2, a...

Oncolytic viruses used as vectors for treatment of malignant gliomas.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Oncolytic viruses have been used as vectors for the treatment of malignant gliomas. "Gene therapy using viral vectors for the treatment of primary brain tumors has proven to be a promising novel...

Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Loosening-up the chromatin structure by histone acetylation can increase the efficiency of several anticancer drugs targeting DNA. "Several anticancer drugs target DNA or enzymes acting on the...

Some CpG G:C-A:T transitions may be caused by smoking.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Some CpG G:C-A:T transitions may be caused by smoking and other environmental mutagens, researchers say. "According to a study from the United States, "Bladder cancer is associated with smoking,...

Liposomal delivery offers clinical gene therapy for brain tumors.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Liposomal delivery of anticancer molecules to gliomas offers clinical gene therapy for brain tumors. "Liposomes are one of the most promising delivery systems for genes, proteins, and other...

Epigenetic silencing of HIC-1 may play role in most medulloblastomas.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Researchers say that epigenetic silencing of HIC-1 may well contribute to the pathogenesis in the majority of medulloblastomas (MBs). "The HIC-1 (hypermethylated in cancer) candidate tumor...

TRAIL triggers apoptosis in human malignant glioma cells.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- TRAIL may be an effective therapeutic agent for malignant gliomas. "Many malignant glioma cells express death receptors for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), yet some...

In situ, invasive lobular breast carcinoma share common methylation patterns.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- In situ and lobular breast carcinomas share many common methylation patterns and some molecular differences. According to a study from the United States, "Little is known about epigenetic...

Most in situ breast cancers represent focal lesions derived from single clone.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- The vast majority of in situ breast cancers represent focal lesions all derived from a single clone and requiring local treatment alone, researchers report. "We focused our attention on rare cases...

Prognostic value of cathepsin D recognized, but clinical use unclear.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- The prognostic value of cathepsin D has been recently recognized, researchers say. "But as many quantitative tumor markers, its clinical use remains unclear partly because of methodological issues...

TOP2A aberration testing may help identify targeted breast cancer therapies.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Testing for TOP2A aberrations may be useful in the search for individually tailored treatment regimes for breast cancer, researchers report. According to recent research from Norway, "The TOP2A...

TOP2A gene copy number aberration screening important with topoII-inhibitors.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- It is important to screen for TOP2A gene copy number aberrations when topoII-inhibitors are considered either alone or in combination of other chemotherapeutic drugs in treating cancer patients,...

Coping strategies help healthy women face breast, ovarian cancer risk.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Women used various coping strategies in order to 'get on with their lives' in the face of cancer risk. According to a study from the United States, "This paper investigates how healthy women with...

Cancer cells are characterized by having aberrant chromosomes.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Cancer cells are characterized by having aberrant chromosomes, researchers say. "The number of aberrations and the specific chromosomes affected are correlated with tumor progression. We show that...

Birt-Hogg-Dube in activation occurs in some renal cell, colorectal cancers.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Researchers suggest that Birt-Hogg-Dube (BHD) inactivation occurs in a subset of clear cell renal cell carcinoma (RCC) and colorectal cancer (CRC). According to recent research published in the...

Gadd45a contributes to p53 stabilization in response to DNA damage.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Gadd45a, a conventional downstream gene of p53, may play a role as an upstream effector in p53 stabilization following DNA damage, researchers say. "p53 is an important molecule in cellular...

BRAF mutations do not seem to be involved in gastric cancer development.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- BRAF mutations do not seem to be involved in gastric cancer development. According to recent research published in the journal Human Genetics, "Recently, BRAF mutations were found in a variety of...

Promoter methylation of cyclin D2 gene may be involved in gastric carcinoma.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Demethylation of cyclin D2 may be involved in development and progression of gastric carcinoma, researchers say. "Methylation of CpG island in the promoter has been recognized as an important...

Soluble factors role in glioma invasion may lead to new therapies.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Understanding the mechanisms by which soluble factors modulate glioma cell invasion will lead to the development of novel therapeutic strategies in the management of gliomas, researchers say. ...

Activation of Galectin-1 gene in human hepatocellular carcinoma examined.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Researchers say the specific interaction of methylation-sensitive factors to the upstream and downstream elements may be essential for the activation of the Gal-1 gene in hepatocellular carcinoma (HCC)...

Caspase-8 activation is an indispensable process in TRAIL-induced apoptosis.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Down-regulation of X-linked inhibitor of apoptosis (XIAP) may be responsible for enhancing or restoring TRAIL sensitivity after CHX treatment in B-lymphocytic leukemia cells. According to recent...

MAPK pathway may be a potential therapeutic target in ALL.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- The MAPK pathway may be a potential therapeutic target in acute lymphocytic leukemia (ALL). According to recent research published in the Journal of Biological Chemistry, "Because the MAPK pathway...

Reduced transcription of the RB2/p130 gene in human lung cancer analyzed.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Reduction in RB2/p130 gene expression may be due to histone deacetylation, altered mRNA stability, and/or other forms of transcriptional regulation, researchers say. "Reduced expression of the...

TR3 induces both proliferation and apoptosis.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Researchers find that TR3 induces both proliferation and apoptosis in the same cells depending on the stimuli and its cellular localization. According to published research from the United States,...

p63 Amplification, overexpression occurs early in developing lung cancer.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- There is early and frequent genomic amplification of p63 in the development of squamous carcinoma of the lung. According to recent research published in the journal Cancer Research, "The fight...

p27(KIP1) has a novel role in down-regulation of telomerase activity.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- p27(KIP1) has a novel role in down-regulation of telomerase activity, researchers report. According to a study from the United States, "The cyclin-dependent kinase inhibitor p27(KIP1) is...

Drug resistance remains a major clinical challenge in multiple myeloma.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Researchers discuss emerging therapeutic approaches to induce apoptosis According to a study from the United States, "Drug resistance remains a major clinical challenge for cancer treatment. ...

Oral cytology differs between smokers and nonsmokers.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Flow cytometric evaluation of oral cytology harvested keratinocytes can measure exposure to tobacco carcinogens, and possibly establish a link to premalignant and malignant transformation before a...

Overexpression of TSC2 may exert the antitumor effect on oral cancer cells.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Overexpression of tuberous sclerosis complex (TSC) 2 may exert the antitumor effect on oral cancer cells. According to published research from Japan, "Tuberous sclerosis is caused by mutations in...

MSI-low is a real phenomenon that varies in frequency among cancer types.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- MSI-L is rare in breast carcinomas, but does occur in colorectal, endometrial, and ovarian carcinomas, which are all part of the hereditary non-polyposis colon cancer (HNPCC) syndrome, researchers say....

New adenoviral vector technology wins patent; Introgen gets license.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Introgen Therapeutics (INGN) announced that a patent directed to classes of adenoviral vectors has been awarded to the board of regents of the University of Texas System and is exclusively licensed to...

AMACR is essential for optimal growth of prostate cancer cells in vitro.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- alpha-Methylacyl-CoA racemase (AMACR) is essential for optimal growth of prostate cancer (PCa) cells in vitro and may be a complementary target with androgen ablation in PCa treatment, researchers...

Elevated PSA in prostate cancer cells may indicate tumor metastasis.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- p53 Mutations directly contribute to increased levels of serum PSA, and are associated with more aggressive tumors, researchers report. "The underlying basis for rising levels of prostate-specific...

Lycopene inhibits the growth of normal human prostate epithelial cells in vitro.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Researchers hypothesize that lycopene might inhibit the growth of prostatic epithelial cells in vivo. According to a study from the United States, "Lycopene has repeatedly been shown to inhibit...

Wild-type p53 in prostate tumor cells may reduce the effectiveness of radiation.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Wild-type p53 is associated with increased survival of prostate carcinoma cells after fractionated exposure to radiation. According to recent research published in the journal Cancer Research,...

Chromosomal imbalances indicate tumor relapse in cutaneous CD30+ T-cell lymphoma.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Analysis demonstrates chromosomal imbalances that may be involved in the pathogenesis of relapsing CD30+ CTCL, researchers say. "Primary cutaneous CD30+ large T-cell lymphoma (CD30+ CTCL) is a...

T-plastin shows potential as Sezary cell-specific marker.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- T-plastin has the potential to be a Sezary cell-specific marker valuable for diagnostic and treatment of Sezary syndrome (SS). According to a study from Canada, "Mycosis fungoides (MF) and its...

Microarray analysis should prove useful for identifying tumor markers.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Microarray analysis should prove useful for identifying genes whose products might serve as molecular targets for treatment of testicular germ cell tumors (TGCTs). According to a study from Japan,...

Genetics research could spawn further creation of targeted, nontoxic therapies.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Understanding the molecular events that lead to cancer should allow the future development of targeted, nontoxic therapeutics similar to modern-day antibiotics, researchers say. According to...

Arsenic trioxide increases the thermosensitivity of tumors.
January 12, 2004... 2004 JAN 12 - (NewsRx.com & NewsRx.net) -- Researchers say that the clinical use of arsenic trioxide (ATO) to increase tumor thermosensitivity via direct cellular and vascular effects appears feasible. According to a study from the United...

Reengineered dendritic cells readies cytotoxic T cells for select epitopes.
January 19, 2004... 2004 JAN 19 - (NewsRx.com & NewsRx.net) -- Reengineered dendritic cells readies cytotoxic T cells for select epitopes. According to a study from the United States, "the ability of two plasmid DNA vaccines to stimulate lymphocytes from...

Tumor cell vaccines containing nonviral vectors offer cancer prevention.
January 19, 2004... 2004 JAN 19 - (NewsRx.com & NewsRx.net) -- Tumor cell vaccines containing nonviral vectors offer cancer prevention. "We report that 100% mice survival after tumor challenge is achieved with cytokine-engineered cells employing nonviral...

Lung adenocarcinoma may be associated with atypical adenomatous hyperplasia.
January 19, 2004... 2004 JAN 19 - (NewsRx.com & NewsRx.net) -- Constitutional or genetic factors may increase the risk of developing atypical adenomatous hyperplasia (AAH) and extrapulmonary primary carcinomas. "According to a study from Japan, "Atypical...

Full T-cell expansion, function require days of exposure to antigen complex.
January 19, 2004... 2004 JAN 19 - (NewsRx.com & NewsRx.net) -- CD8 T cell clonal expansion, effector function need at least 40 h exposure to antigen, costimulatory molecule, and signal 3 cytokine. "Full activation of naive CD8 T cells requires antigen (Ag),...

Vitamin E succinate may be a prototype for selective antitumor activity.
January 19, 2004... 2004 JAN 19 - (NewsRx.com & NewsRx.net) -- Alpha-tocopheryl succinate (alpha-TOS) has great promise as an anticancer drug of the future. "Great hope has been given to micronutrients as anticancer agents, since they present natural...

RNA aptamers can bind and inhibit CTLA-4, increasing antitumor activity.
January 19, 2004... 2004 JAN 19 - (NewsRx.com & NewsRx.net) -- Multivalent RNA aptamers bind and inhibit CTLA-4, increasing antitumor activity. "The potency of cancer immunotherapy can be enhanced by administration of high-avidity ligands specific to receptors...