Cancer Vaccine Week articles from February 2003

Cancer Vaccine Week archives from February 2003

Mitotic activity index independent prognostic factor for relapse free survival.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- According to recent research from Netherlands, "at the St. Gallen meeting of 2001 it was agreed to select high risk patients for adjuvant systemic therapy by: lymph node status, tumor size, age,...

Inhibition of NF-kappaB unmasks a TRAIL-mediated apoptosis in cells.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces apoptosis in a wide range of malignant cells. However, several...

Combining dendritic cells and CpG oligodeoxynucleotides cures colon cancer in mice.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Large murine colon carcinoma tumors were eliminated in mice co-injected with mature antigen-pulsed dendritic cells (DCs) and CpG oligodeoxynucleotides...

Repeat infection found with assay can select women at risk for cervical lesions.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- "To test the reliability of the Hybrid Capture II (HC-II) assay detecting 13 high-risk human papillomavirus (HR-HPV) types for the screening of cervical lesions, we monitored by cytology, HR-HPV...

Reovirus may be effective agent in therapy.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- According to a study from Canada, "Reoviruses infect cells that manifest an activated Ras-signaling pathway, and have been shown to effectively destroy many different types of neoplastic cells,...

Polycations inhibit HTLV-1 Env-mediated binding and entry.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "Little is known about the requirements for human T-cell leukemia virus type 1 (HTLV-1) entry, including the identity of the cellular receptor(s)....

Former WebMD executive producer joins NewsRx.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- A former WebMD executive producer and medical editor has joined Atlanta-based NewsRx, along with three board-certified editors. Dominique Walton Brooks, MD, with WebMD until 2001, will serve as...

Dendritic cell vaccine shows promise against EBV-positive nasopharyngeal carcinoma.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- According to a team of researchers from Taiwan, the People's Republic of China, and England, "Nasopharyngeal carcinoma (NPC), a common neoplasm in Southeast Asia, is EBV-positive and expresses a limited...

Dual-specific T cells knock out tumors with double punch.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- Immune system cells genetically redesigned to recognize immunogen show promise for treating cancer, United States government researchers indicate. According to a new study, "an effective immune...

Phase I clinical studies begin of two key cancer products: IGN301 and IGN311.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- igeneon, AG, announced that the investigational new drug application (IND) for its cancer vaccine IGN301 is in effect with the U.S. Food and Drug Administration (FDA), and a joint phase Ib study of...

Exclusive rights to develop cancer targets acquired.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- Eos Biotechnology and Aventis Pasteur announced that a 2-year collaboration to identify unique cancer vaccine targets has resulted in Aventis Pasteur exercising its options to develop up to five of...

Bidens pilosa extract prevents hypertension induced by high-fructose diet.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- According to a study from researchers in Cameroon and France, "Chronic fructose treatment in rats has repeatedly been shown to elevate blood pressure in association with insulin resistance and...

Selenium corrects heart damage induced by diabetes.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - The antioxidant sodium selenite reversed the damage caused by oxidative stress in the hearts of diabetic rats, according to a report in the journal,...

Transactivation by E6 could contribute to oncogenesis.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "The expression of human papillomavirus (HPV) E6 oncoprotein is causally linked to high-risk HPV-associated human cancers. We have recently isolated...

FDA clears initiation of lung, colorectal cancer vaccine trials.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- Epimmune, Inc., (EPMN) announced that it has received clearance from the U.S. Food and Drug Administration to start phase I/II clinical trials of its EP-2101 therapeutic, multi-epitope vaccine in lung...

Positive clinical data from melanoma cancer vaccine trial announced.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- Genzyme Molecular Oncology (GZMO) announced positive findings from the completion of one of its cancer vaccine studies in melanoma. The phase I/II trial is the first one of its kind to have used two...

Antigen-specific T cells aggregate at inoculation site of mature dendritic cells.
February 10, 2003... 2003 FEB 10 - (NewsRx.com & NewsRx.net) -- "Cellular immune responses are initiated by direct interaction of naive T cells with professional antigen-presenting cells, i.e, dendritic cells. In general, this interaction takes place in secondary...

Methods leading to stronger EBV-specific T-cell responses may lead to regression.
February 10, 2003... 2003 FEB 10 - (NewsRx.com & NewsRx.net) -- According to recent research from Peoples Republic of China, "Nasopharyngeal carcinoma (NPC), a common neoplasm in Southeast Asia, is EBV-positive and expresses a limited number of antigens, including...

Marketing agreements announced with companies in Italy, Turkey.
February 10, 2003... 2003 FEB 10 - (NewsRx.com & NewsRx.net) -- Aastrom Biosciences, Inc., (ASTM) announced that it has signed two agreements expanding the sales and marketing of its Cell Production Products (CPP) product line in Italy and Turkey. Both...

HLA-DP4 defines a new supertype of peptide-binding specificity.
February 10, 2003... 2003 FEB 10 - (NewsRx.com & NewsRx.net) -- According to recent research from France, "Among HLA-DP specificities, HLA-DP4 specificity involves at least two molecules, HLA-DPA1*0103/DPBI*0401 (DP401) and HLA-DPA1*0103/DPB1*0402 (DP402), which...

HLA-DP3-restricted peptides from EBNA1 recognized by CD4+ T cells.
February 17, 2003... 2003 FEB 17 - (NewsRx.com & NewsRx.net) -- "The EBV-encoded nuclear antigen 1 (EBNA1) is required for the maintenance and replication of the viral episome in EBV-transformed human B-lymphoblastoid cell lines. It is expressed in all...

Review details vaccine history and current strategy for cervical cancer.
February 17, 2003... 2003 FEB 17 - (NewsRx.com & NewsRx.net) -- "Primary prevention of uterine cervix cancer spans the gamut of human papillomavirus; vaccine development, dietary adjustment, chemoprevention, and risk reduction," researchers in the United States...

Anti-idiotype antibody vaccine therapy for cancer reviewed.
February 17, 2003... 2003 FEB 17 - (NewsRx.com & NewsRx.net) -- "The use of anti-idiotype (Id) antibodies as vaccines to stimulate antitumor immunity is one of several promising immunologic approaches to the therapy of cancer. Extensive studies in animal tumor...

Dendritic cell-based vaccines for cancer therapy reviewed.
February 17, 2003... 2003 FEB 17 - (NewsRx.com & NewsRx.net) -- A review from investigators in the United States explores the avenues of research into dendritic cell vaccines for the treatment of cancer. "Dendritic cells (DCs) are the most potent professional...

Overexpression of MT1 melatonin receptor may inhibit tumor formation.
February 17, 2003... 2003 FEB 17 - (NewsRx.com & NewsRx.net) -- "Overexpression of the MT1 melatonin receptor in MCF-7 human breast cancer cells significantly enhances the response of these cells to the growth-inhibitory actions of melatonin," researchers in the...

Synthesis and cytotoxic activity of a new potent daunomycinone derivative.
February 17, 2003... 2003 FEB 17 - (NewsRx.com & NewsRx.net) -- According to recent research from Greece, "The preparation and cytotoxic activity of 4'-azido-3'-bromo-3'-deamino-4'-deoxydaunorubicin is described. "The new compound was found to be less active...

Amifostine differentially modulates DNA damage evoked by idarubicin.
February 17, 2003... 2003 FEB 17 - (NewsRx.com & NewsRx.net) -- According to recent research from Poland, "Human lymphocytes, p53 protein-deficient acute promyelocytic leukemia cell line HL-60, murine pro-B lymphoid cell line BaF3 and its TEL/ABL-transformed clone...

A guanylate cyclase inhibitor induces apoptosis; may be useful chemotherapeutic.
February 17, 2003... 2003 FEB 17 - (NewsRx.com & NewsRx.net) -- "Using microarray analysis, we have detected downregulation of several components of the cGMP signaling pathway during replicative senescence of primary human diploid fibroblasts (HDFs). Therefore, the...

Outer membrane protein A interacts with antigen presenting cells.
February 24, 2003... 2003 FEB 24 - (NewsRx.com & NewsRx.net) -- According to recent research from France, "Outer membrane protein A (OmpA) is a class of proteins highly conserved among the Enterobacteriaceae family and throughout evolution. We have observed that...

T cell turnover rate may affect cancer treatment.
February 24, 2003... 2003 FEB 24 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "Rapid turnover of lymphocytes observed in patients with cancer appears to be driven by increased apoptosis of T lymphocytes or insufficient thymic...

Viral oncoprotein, LMP1, has role as a key effector molecule in pathogenesis.
February 24, 2003... 2003 FEB 24 - (NewsRx.com & NewsRx.net) -- "The Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) is a key effector of EBV-mediated B cell transformation," researchers in the Peoples Republic of China report. "LMP1 displays...

Cyclooxygenase 2 selective inhibitors in cancer treatment and prevention.
February 24, 2003... 2003 FEB 24 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "Prostaglandin synthesis by a number of enzymes is important at all stages during the genesis of cancer. "The availability of prostaglandin H-2 as a...

Clinical trials expanded with novel vaccine for metastatic colon cancer.
February 24, 2003... 2003 FEB 24 - (NewsRx.com & NewsRx.net) -- Several additional cancer centers in the United States and Canada are enrolling patients in an innovative clinical trial evaluating the use of a therapeutic cancer vaccine in patients with first-line...

Tumor-derived exosomes are a new source of tumor rejection antigens.
February 24, 2003... 2003 FEB 24 - (NewsRx.com & NewsRx.net) -- Researchers in France are investigating a novel type of antigen that causes tumor rejection in animal models. "Exosomes are small vesicles released by a broad array of hematopoietic cells,"...

Cancer vaccine maker reports quarter and year end net losses.
February 24, 2003... 2003 FEB 24 - (NewsRx.com & NewsRx.net) -- Cell Genesys, Inc., (CEGE) reported a net loss for the quarter ended December 31, 2002, of $12.3 million, or $0.34 per share, and a net loss for the year then ended of $27.3 million, or $0.76 per...