Cancer Vaccine Week articles from August 2004

Cancer Vaccine Week archives from August 2004

Autologous lymphoma vaccines induce T cell responses against epitopes.
August 2, 2004... 2004 AUG 2 - (NewsRx.com & NewsRx.net) -- Autologous lymphoma vaccines induce human T cell responses against multiple, unique epitopes. "The clonotypic surface Ig receptor expressed by malignant B cells, idiotype, is a tumor-specific...

DNA fusion gene vaccines against cancer reviewed.
August 2, 2004... 2004 AUG 2 - (NewsRx.com & NewsRx.net) -- Investigators review DNA fusion gene vaccines against cancer in a recent issue of Immunological Reviews. "Vaccination against target antigens expressed by cancer cells has now become a realistic...

NY-ESO-1-related HLA A2-restricted epitopes characterized.
August 2, 2004... 2004 AUG 2 - (NewsRx.com & NewsRx.net) -- Researchers have determined the functional and structural characteristics of NY-ESO-1-related HLA A2-restricted epitopes. According to a study from Australia, "NY-ESO-1, a commonly expressed tumor...

SSX-2 epitope presented by dendritic cells to CD4+ T cells identified.
August 2, 2004... 2004 AUG 2 - (NewsRx.com & NewsRx.net) -- Scientists have identified an SSX-2 epitope presented by dendritic cells to circulating autologous CD4+ T cells. According to recent research from the United States, "Accumulating evidence supports...

Transfection of tumor antigens generates cytotoxic T lymphocytes.
August 2, 2004... 2004 AUG 2 - (NewsRx.com & NewsRx.net) -- Transfection of RNA encoding tumor antigens following maturation of dendritic cells leads to prolonged presentation of antigen and the generation of high-affinity tumor-reactive cytotoxic T lymphocytes....

Vaccine targeting cancer-related antigens appears to prolong survival.
August 2, 2004... 2004 AUG 2 - (NewsRx.com & NewsRx.net) -- Researchers seeking to direct cancer-killing immune cells against the deadliest brain tumors have three new targets that show promise in laboratory studies and in a Phase I patient trial, according to...

Alloantigen presentation linked to CTL antigen response.
August 2, 2004... 2004 AUG 2 - (NewsRx.com & NewsRx.net) -- The duration of alloantigen presentation and avidity of T cell antigen recognition correlate with immunodominance of CTL response to minor histocompatibility antigens. "CD8 T lymphocytes (CTL)...

Antennapedia transduction sequence promotes antitumor immunity.
August 2, 2004... 2004 AUG 2 - (NewsRx.com & NewsRx.net) -- The Antennapedia transduction sequence promotes antitumor immunity to epicutaneously administered CTL epitopes. According to published research from Canada, "The identification of tumor antigens...

Reduced L-selectin expression identifies tumor-specific type 1 T cells.
August 2, 2004... 2004 AUG 2 - (NewsRx.com & NewsRx.net) -- Reduced L-selectin (CD62L[superscript]Low) expression identifies tumor-specific type 1 T cells from lymph nodes draining an autologous tumor cell vaccine. "Reduced expression of CD62L can identify...

TCR DNA vaccine induces humoral response for lymphoma beta chain.
August 2, 2004... 2004 AUG 2 - (NewsRx.com & NewsRx.net) -- A TCR DNA vaccine induced a humoral immunoreaction for the beta chain of T cell lymphoma. According to published research from China, "We exploited the humoral immunoreaction of mice induced by TCR...

DNA microarray format for subtyping human papillomavirus developed.
August 2, 2004... 2004 AUG 2 - (NewsRx.com & NewsRx.net) -- Researchers have developed a DNA microarray format for detection and subtyping of human papillomavirus. "A new human papillomavirus (HPV) assay using high-density DNA microarrays; is described. An...

CXCR3 plays pivotal role in melanoma cell metastasis to lymph nodes.
August 9, 2004... 2004 AUG 9 - (NewsRx.com & NewsRx.net) -- CXCR3 plays a pivotal role in melanoma cell metastasis to the lymph nodes. "Chemokines and their receptors play key roles in leukocyte trafficking and are also implicated in cancer metastasis to...

MAGE-1 peptide recognized by T cells on HLA-B*5701 tumors identified.
August 9, 2004... 2004 AUG 9 - (NewsRx.com & NewsRx.net) -- Scientists have identified a MAGE-1 peptide recognized by cytolytic T lymphocytes on HLA-B*5701 tumors. "'Cancer germline' genes such as those of the MAGE family are expressed in many tumors and in...

Profile of tumor antigens on breast and pancreatic cancer cells created.
August 9, 2004... 2004 AUG 9 - (NewsRx.com & NewsRx.net) -- Researchers have created a profile of internalizing tumor-associated antigens on breast and pancreatic cancer cells by reverse genomics. "Human antibodies directed towards functionally associated...

Two novel human papillomavirus-16 E7 T helper epitopes identified.
August 9, 2004... 2004 AUG 9 - (NewsRx.com & NewsRx.net) -- Researchers have identified two novel human papillomavirus-16 E7 T helper epitopes. According to a study from the United States, "Given the anticipated clinical importance of helper and regulatory...

Vaccine boosts immunity against cancer target.
August 9, 2004... 2004 AUG 9 - (NewsRx.com & NewsRx.net) -- A therapeutic cancer vaccine being co-developed by the Ludwig Institute for Cancer Research (LICR) and the Australian biotechnology company CSL Ltd. successfully induced a comprehensive immune response...

IL-12-engineered allogeneic cell vaccine prevents breast cancer.
August 9, 2004... 2004 AUG 9 - (NewsRx.com & NewsRx.net) -- An interleukin 12-engineered allogeneic cell vaccine prevents HER-2/neu transgenic breast cancer. According to recent research published in the journal Cancer Research, "This study evaluated the...

Method to quantify immune response in cancer patients developed.
August 9, 2004... 2004 AUG 9 - (NewsRx.com & NewsRx.net) -- Scientists have developed a method to directly quantify and monitor in vivo immune responses to a HER2/neu vaccine in breast and prostate cancer patients. According to a study from the United...

Pharmaceutical company reports stockholder approval of proposals, announces plans.
August 9, 2004... 2004 AUG 9 - (NewsRx.com & NewsRx.net) -- Spectrum Pharmaceuticals, Inc. (SPPI) announced that it received approval for all proposed resolutions submitted for stockholder approval at the annual meeting, namely the election of seven directors to...

Vet school professor using gene therapy to battle cancerous tumors.
August 9, 2004... 2004 AUG 9 - (NewsRx.com & NewsRx.net) -- Shulin Li, associate professor in the Louisiana State University (LSU) School of Veterinary Medicine's department of comparative biomedical sciences, is developing a gene therapy treatment for cancer...

Progress on new vaccine strategies to treat and prevent cancer reviewed.
August 9, 2004... 2004 AUG 9 - (NewsRx.com & NewsRx.net) -- Researchers review the progress toward new vaccine strategies for the immunotherapy and prevention of cancer in a recent issue of the Journal of Clinical Investigation. According to recent research...

Patients' cells from tumors, immune system merged for customized cancer therapy.
August 9, 2004... 2004 AUG 9 - (NewsRx.com & NewsRx.net) -- One of the strongest natural allies that cancer patients can tap to help fight tumor growth and metastasis may well be their own immune systems, and scientists affiliated with the Harvard University...

Wyeth, lawyers for fen-phen users propose new settlement.
August 9, 2004... 2004 AUG 9 - (NewsRx.com & NewsRx.net) -- Former fen-phen users seeking compensation for heart problems under a U.S. class-action settlement would get payments sooner but would receive less under a proposed new agreement between drug maker...

Peptide immunogens mimic coiled region of T-cell leukemia virus subunit.
August 9, 2004... 2004 AUG 9 - (NewsRx.com & NewsRx.net) -- Investigators have designed peptide immunogens that mimic the coiled coil region of human T-cell leukemia virus type-1 glycoprotein 21 transmembrane subunit for induction of native protein reactive...

Linda Staley named vice president, IT for cancer biotech.
August 9, 2004... 2004 AUG 9 - (NewsRx.com & NewsRx.net) -- Dendreon Corp. (DNDN) announced that Linda Staley has been appointed vice president, information technology. Staley will be responsible for overseeing strategic planning and technology assessment...

Phase III trial of GVAX prostate cancer vaccine initiated.
August 9, 2004... 2004 AUG 9 - (NewsRx.com & NewsRx.net) -- Cell Genesys, Inc., (CEGE) announced that enrollment has been initiated for a multicenter phase III clinical trial of GVAX prostate cancer vaccine in patients with metastatic hormone-refractory prostate...

Mus81 expression has critical role in genome integrity and tumor suppression.
August 9, 2004... 2004 AUG 9 - (NewsRx.com & NewsRx.net) -- Mus81 expression has a critical role in genome integrity and tumor suppression. "Mus81-Eme1 endonuclease has been implicated in the rescue of stalled replication forks and the resolution of meiotic...

Dendritic cell vaccine safe in patients with advanced breast cancer.
August 16, 2004... 2004 AUG 16 - (NewsRx.com & NewsRx.net) -- Vaccination with p53-peptide-pulsed dendritic cells was safe in patients with advanced breast cancer. "Peptides derived from over-expressed p53 protein are presented by class I MHC molecules and...

Anti-idiotypic scFv used as surrogate tumor antigen characterized.
August 16, 2004... 2004 AUG 16 - (NewsRx.com & NewsRx.net) -- Scientists have characterized a human anti-idiotypic scFv used as a surrogate tumor antigen to elicit an anti-HER-2/neu humoral response in mice. According to recent research published in the...

Antitumor neoglycopeptide vaccine with Tn antigen synthesized.
August 16, 2004... 2004 AUG 16 - (NewsRx.com & NewsRx.net) -- Researchers have synthesized an antitumor neoglycopeptide vaccine bearing a novel homoserine Tn antigen. According to published research from France, "As part of our program on Tn-specific...

Dendritic cell vaccine causes expansion of melanoma-specific T cells.
August 16, 2004... 2004 AUG 16 - (NewsRx.com & NewsRx.net) -- Peptide-pulsed CD34-DC vaccines result in expansion of melanoma-specific cytolytic CD8+ T cell precursors in patients with metastatic melanoma. According to published research from the United...

WT1 peptide vaccine with BCG-CWS is efficient for tumor eradication.
August 16, 2004... 2004 AUG 16 - (NewsRx.com & NewsRx.net) -- WT1 peptide vaccination combined with BCG-CWS is more efficient for tumor eradication than WT1 peptide vaccination alone. "A Wilms' tumor gene WT1 is expressed at high levels not only in most...

CD4 to CD8 conversion occurs in MHC class I-deficient mice.
August 16, 2004... 2004 AUG 16 - (NewsRx.com & NewsRx.net) -- Antigen-specific CD8+ cytotoxic T lymphocytes develop in MHC class I-deficient mice through CD4 to CD8 conversion. According to a study from the United States, "CD8+ CTL are the predominant...

Imatinib mesylate inhibits increases chemosensitivity in sarcoma.
August 16, 2004... 2004 AUG 16 - (NewsRx.com & NewsRx.net) -- Imatinib mesylate inhibits platelet-derived growth factor activity and increases chemosensitivity in feline vaccine-associated sarcoma. According to published research from the United States,...

Monocyte-derived dendritic cells in lymphocytic leukemia characterized.
August 16, 2004... 2004 AUG 16 - (NewsRx.com & NewsRx.net) -- Scientists have characterized monocyte-derived dendritic cells in chronic lymphocytic leukemia patients. According to a study from Italy, "Dendritic cells (DCs) are the most potent...

Dipeptidase 1 is candidate tumor-specific marker in colon cancer.
August 16, 2004... 2004 AUG 16 - (NewsRx.com & NewsRx.net) -- Dipeptidase 1 is a candidate tumor-specific molecular marker in colorectal carcinoma. "The aim of this study was to identify tumor-specific markers for the detection of rare disseminated colorectal...

Dendritic cell vaccine enhances T cell responses in gastric cancer.
August 16, 2004... 2004 AUG 16 - (NewsRx.com & NewsRx.net) -- CEA peptide-pulsed dendritic cells enhance cytotoxic T-lymphocyte responses in patients with gastrointestinal malignancies. "Carcinoembryonic antigen (CEA) is strongly expressed in a vast majority...

Company demands delisting of its common stock from Berlin-Bremen Stock Exchange.
August 16, 2004... 2004 AUG 16 - (NewsRx.com & NewsRx.net) -- Cell Genesys, Inc., (CEGE) announced that it has demanded delisting of the company's common stock from the Berlin-Bremen Stock Exchange since the listing occurred without the approval or consent of...

Shiga toxin subunit inhibits net fluid absorption in human colon.
August 16, 2004... 2004 AUG 16 - (NewsRx.com & NewsRx.net) -- The Shiga toxin 2 B subunit inhibits net fluid absorption in human colon and elicits fluid accumulation in rat colon loops. According to recent research from Argentina, "Shiga toxin...

Human papillomavirus DNA vaccines compared.
August 16, 2004... 2004 AUG 16 - (NewsRx.com & NewsRx.net) -- Scientists compare human papillomavirus DNA vaccines employing intracellular targeting strategies in a recent issue of Gene Therapy. According to published research from the United States,...

Unresectable hepatocellular carcinoma therapies reviewed.
August 16, 2004... 2004 AUG 16 - (NewsRx.com & NewsRx.net) -- Researchers review clinical trials that explore therapies for unresectable hepatocellular carcinoma in a recent issue of Anti-Cancer Drugs. "Hepatocellular carcinoma (HCC) is not only common, but...

Phase II ovarian cancer trial commences.
August 16, 2004... 2004 AUG 16 - (NewsRx.com & NewsRx.net) -- Biomira, Inc., (BIOM, BRA) of Edmonton, Alberta, Canada, announced that Prima BioMed Ltd's (ASX PRR) subsidiary, CancerVac commenced a phase II trial of its immunotherapy technology in patients with...

Antigenic peptide derived from cancer-testis antigen NY-ESO-1.
August 16, 2004... 2004 AUG 16 - (NewsRx.com & NewsRx.net) -- Scientists have identified an antigenic peptide derived from the cancer-testis antigen NY-ESO-1 binding to a broad range of HLA-DR subtypes. According to published research from Germany, "NY-ESO-1...

Strategies to enhance immunostimulatory effects of CpG ODN reviewed.
August 16, 2004... 2004 AUG 16 - (NewsRx.com & NewsRx.net) -- Scientists review strategies for enhancing the immunostimulatory effects of CpG oligodeoxynucleotides (ODN) in a recent issue of the Journal of Controlled Release. According to recent research...

Hybrids of tumor and dendritic cells induce immune responses in melanoma.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- Vaccination with hybrids of tumor and dendritic cells induces tumor-specific T-cell and clinical responses in melanoma stage III and IV patients. "Hybrid cell vaccination was developed as...

Irradiation of tumors promotes vaccine-mediated T-cell killing.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- External beam irradiation of tumors alters phenotype of tumor cells to render them susceptible to vaccine-mediated T-cell killing. According to a study from the United States, "Local radiation is...

Therapeutic idiotype vaccines in B lymphoproliferative diseases reviewed.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- Investigators review therapeutic idiotype vaccines in B lymphoproliferative diseases in a recent issue of Expert Opinion on Biological Therapy. According to a study from the United States, "The...

Apoptotic cell-pulsed dendritic cells elicit T cells against mesothelioma.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- Apoptotic cell-pulsed dendritic cells elicit cytotoxic T cells against mesothelioma. "Malignant pleural mesothelioma is an uncommon tumor largely confined to the thoracic cavity, which is...

Listeria monocytogenes is effective vaccine vector.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- Listeria monocytogenes is an effective vaccine vector. According to recent research published in the Journal of Immunology, "The bacterium Listeria monocytogenes is a proposed vaccine carrier...

Cancer-focused biologics company named among top 15 emerging biotech companies.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- Therion Biologics Corporation has been selected as a member of FierceBiotech's annual "Fierce 15," a list of the top emerging biotech companies of 2004. FierceBiotech editor-in-chief John D....

GVAX maker reports net loss of $26.0 million for the quarter.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- Cell Genesys, Inc., (CEGE) reported a net loss of $26.0 million, or $0.58 per share, for the quarter ended June 30, 2004. This compares with a net loss of $19.1 million, or $0.51 per share, in the...

Complement receptor-related gene tumor vaccine induces antitumor activity.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- Mouse complement receptor-related gene y/p65-neutralized tumor vaccine induces antitumor activity in vivo. According to a study from Japan and the United States, "Two mouse tumor cell lines, Meth...

Dendritic cells targeted with antigen-containing liposomes.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- Targeting dendritic cells with antigen-containing liposomes is a highly effective procedure for induction of antitumor immunity and for tumor immunotherapy. "Dendritic cells (DCs) are potent...

Enzymes expressed by dendritic cells hydrolyze tumor-associated antigen.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- Membrane-associated and soluble enzymes expressed by immature and mature dendritic cells hydrolyzed the tumor-associated antigen epitope gP100[subscript]280-288. "The hydrolysis of the...

Peptide vaccination augments antitumor response, but efficacy is limited.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- CD4-directed peptide vaccination augments an antitumor response, but the efficacy is limited by the number of CD8+ T cell precursors. "Peptide vaccination is an immunotherapeutic strategy being...

Pre-designated peptides used in individualized peptide vaccination regimen.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- Researchers have evaluated the effectiveness of vaccination with pre-designated peptides frequently selected as vaccine candidates in an individualized peptide vaccination regimen. According to a...

Trojan antigen peptide vaccines induce antitumor immune responses.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- Multi-epitope Trojan antigen peptide vaccines induce antitumor cytotoxic T lymphocyte and Th immune responses. According to published research from the United States, "We describe in this study a...

U.S. approves deal to license cancer drugs from Cuban institute.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- In an unusual commercial transaction between Cuba and the U.S., CancerVax Corporation, a Californian biotechnology company, received a rare U.S. government approval to license three experimental cancer...

HPV vaccine targets women age 24-45.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- A vaccine that appears to protect against four common strains of human papillomavirus virus (HPV) - two that cause cervical cancer and two that cause genital warts - is under study at the Medical...

DNA vaccine targets human papillomavirus type 16 E6 or E7 oncoprotein.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- DNA vaccine targets human papillomavirus type 16 E6 or E7 oncoprotein According to recent research from the United States, "DNA vaccines expressing the E6 or E7 oncoproteins of human papilloma...

Interleukin-18 mutant gene transfer activates antitumor immunity.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- Interleukin-18 mutant gene transfer activates antitumor immunity. According to researchers in South Korea, "we report here that gene transfer using recombinant adenoviruses encoding interleukin...

Abstract presented on the use of peptide vaccine for melanoma.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- Generex Biotechnology Corp. (GNBT) announced the presentation of a research abstract by Cathy Blackwell of its Antigen Express immunomedicines subsidiary at the 12th International Congress of...

CD4+ responses identified in patient vaccinated with NY-ESO-1.
August 30, 2004... 2004 AUG 30 - (NewsRx.com & NewsRx.net) -- Scientists have identified immunodominant CD4+ responses in a patient vaccinated with full-length NY-ESO-1 formulated with ISCOMATRIX adjuvant. According to recent research from Australia, "There...

Epithelial cancer-related antigens applicable for peptide-based immunotherapy.
August 30, 2004... 2004 AUG 30 - (NewsRx.com & NewsRx.net) -- Investigators review the expression of epithelial cancer-related antigens in hematologic malignancies applicable for peptide-based immunotherapy in a recent issue of the Journal of Immunotherapy. ...

Exosomes from plasmacytoma cells show promise as tumor vaccine.
August 30, 2004... 2004 AUG 30 - (NewsRx.com & NewsRx.net) -- Exosomes from plasmacytoma cells show promise as a tumor vaccine. "Exosomes are membrane-bound vesicles derived from multivesicular bodies that are externalized by cells through fusion with the...

Viral chemokine fusions trigger antitumor immunity independent of chemotaxis.
August 30, 2004... 2004 AUG 30 - (NewsRx.com & NewsRx.net) -- Genetic fusions with viral chemokines target delivery of nonimmunogenic antigen to trigger antitumor immunity independent of chemotaxis. "The ideal vaccine carrier should be able to target antigen...

Efficacy of melanoma vaccines enhanced in the absence of B lymphocytes.
August 30, 2004... 2004 AUG 30 - (NewsRx.com & NewsRx.net) -- Researchers have enhanced the efficacy of melanoma vaccine in the absence of B lymphocytes. According to recent research from the United States, "Provoking a specific cellular immune response...

Farnesyl transferase inhibitors show promise as therapies for breast cancer.
August 30, 2004... 2004 AUG 30 - (NewsRx.com & NewsRx.net) -- Farnesyl transferase inhibitors show promise as targeted therapies for breast cancer. According to recent research published in the journal Endocrine-Related Cancer, "The ras family of...

Peptides inducing immune responses in breast cancer patients identified.
August 30, 2004... 2004 AUG 30 - (NewsRx.com & NewsRx.net) -- Scientists have identified HER2/neu-derived peptides capable of inducing both cellular and humoral immune responses in HLA-A24 positive breast cancer patients. "HRE2/neu-specific cellular and...

Tamoxifen and soluble tumor-associated antigens suppress breast cancer.
August 30, 2004... 2004 AUG 30 - (NewsRx.com & NewsRx.net) -- Treatment with tamoxifen and soluble tumor-associated antigens stimulate T- and B-lymphocyte responses to breast cancer tumors. According to recent research published in the journal Oncology...

Pharma company reports second quarter 2004 results.
August 30, 2004... 2004 AUG 30 - (NewsRx.com & NewsRx.net) -- Point Therapeutics, Inc., (NASDAQ: POTP) reported results for the fiscal quarter and 6 months ended June 30, 2004. During the second quarter of 2004, Point achieved the following key milestones:...

Lentiviral transfection of dendritic cells upregulates alloreactive T cells.
August 30, 2004... 2004 AUG 30 - (NewsRx.com & NewsRx.net) -- Lentiviral transfection of dendritic cells upregulates alloreactive T cells. According to recent research from Japan, "gene-modified dendritic cells (DCs) are promising targets for cancer...

Antibody-targeted radiation cancer therapy reviewed.
August 30, 2004... 2004 AUG 30 - (NewsRx.com & NewsRx.net) -- Scientists review antibody-targeted radiation cancer therapy in a recent issue of Nature Reviews Drug Discovery. According to a study from the United States, "Several monoclonal antibodies are now...

Antigen-loading strategies of dendritic cells for cancer vaccines compared.
August 30, 2004... 2004 AUG 30 - (NewsRx.com & NewsRx.net) -- Investigators compare antigen-loading strategies of dendritic cells for tumor immunotherapy in a recent issue of the Journal of Immunotherapy. "Dendritic cells (DCs) loaded with antigens can...

Mesothelin is new target for immunotherapy of mesotheliomas.
August 30, 2004... 2004 AUG 30 - (NewsRx.com & NewsRx.net) -- Mesothelin is a new target for immunotherapy of mesotheliomas. According to a study from the United States, "Mesothelin is a differentiation antigen present on normal mesothelial cells and...

Monoclonal antibodies recognize idiotypic immunoglobulins of lymphoma cells.
August 30, 2004... 2004 AUG 30 - (NewsRx.com & NewsRx.net) -- Human monoclonal antibodies produced in transgenic BABK kappa,lambda mice recognize idiotypic immunoglobulins of human lymphoma cells. According to a study from Spain, "Clonal idiotypic...

Thymus-leukemia antigen acts as tumor-specific antigen.
August 30, 2004... 2004 AUG 30 - (NewsRx.com & NewsRx.net) -- Researchers are investigating thymus-leukemia antigen (TL) as a major histocompatibility complex (MHC) class lb molecule and tumor-specific antigen. According to recent research from Japan, "Mouse...

Positive results reported: Electroporation-enabled DNA delivery sans anesthesia.
August 30, 2004... 2004 AUG 30 - (NewsRx.com & NewsRx.net) -- Genetronics Biomedical Corp.Bernie Hertel, +1-858-410-3101 Genetronics Biomedical Corp. (GEB), a late-stage developer of cancer and other therapies using electroporation-enabled delivery of drugs,...

B7-1 gene transduction enhances immune response to metastatic tumor cells.
August 30, 2004... 2004 AUG 30 - (NewsRx.com & NewsRx.net) -- B7-1 gene transduction enhances immune response to metastatic tumor cells. According to recent research from Japan, "B7-1, a co-stimulatory factor, has been reported to induce cytotoxic T...

Stress activation boosts the immunogenicity of tumor cells.
August 30, 2004... 2004 AUG 30 - (NewsRx.com & NewsRx.net) -- Stress activation boosts the immunogenicity of tumor cells. "Heat shock protein expression and release is closely associated with immunogenic forms of cell death. We show that activation of the...

European patent for Vaxfectin adjuvant granted to biopharmaceutical company.
August 30, 2004... 2004 AUG 30 - (NewsRx.com & NewsRx.net) -- Vical Incorporated (VICL) announced the grant of European Patent No. EP1165140, covering vaccination with a novel adjuvant, Vaxfectin. Specific claims include compositions and methods for...

Vaccine against LH-releasing fusion protein does not increase prostate cancer.
August 30, 2004... 2004 AUG 30 - (NewsRx.com & NewsRx.net) -- Immunization against luteinizing hormone (LH)-releasing fusion proteins does not increase prostate cancer in the transgenic adenocarcinoma mouse prostate model. "This study was undertaken to test...