Cancer Vaccine Week articles from August 2003

Cancer Vaccine Week archives from August 2003

Expression of tumor antigens in acute leukemias investigated.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Expression of serologically identified tumor antigens in acute leukemias has been investigated. According to published research from Germany, "Cancer/testis antigens (CTA) are an expanding family...

Naked plasmid DNA injection into solid tumors of mice characterized.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- A team of researchers in Japan has characterized the disposition and gene expression in solid tumors and skeletal muscle after direct injection of naked plasmid DNA in mice. "Previous studies have...

HLA-A2 peptides are targets of HLA-A2-restricted cytotoxic T cells.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Naturally occurring peptides associated with HLA-A2 in ovarian cancer cell lines were identified by mass spectrometry and determined to be targets of HLA-A2-restricted cytotoxic T cells. According...

Lentiviral vaccine targets dendritic cells and induces CD8+ T cell responses.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- In vivo administration of a lentiviral vaccine targets dendritic cells and induces efficient CD8+ T cell responses. "The present study evaluates the potential of third-generation lentivirus vectors...

Tumor escape strategies reviewed.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- The methods by which tumors evade detection and elimination by the immune system have been outlined in a recent issue of the European Journal of Immunogenetics. According to recent research from...

Oral glutamine did not protect against cisplatin-induced nephrotoxicity in rats.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Oral glutamine did not protect against cisplatin-induced nephrotoxicity in rats. "The antioxidant activity of the amino acid glutamine was investigated to obtain protection against peroxidative...

A small fraction of giant cells potentially clonogenic.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- A small fraction of giant cells might be potentially clonogenic. "This study was designed to examine the viability and proliferation of uninucleated and multinucleated giant cells formed after 6 Gy...

Haplotype II is over-represented among chromosomes harboring mutations in BRCA1.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Haplotype II is over-represented among chromosomes harboring mutations in BRCA1. According to a study from Spain, "The BRCA1 gene is included in a 200-400 kb region that is subjected to a...

Bronchioloalveolar carcinoma improved by tyrosine kinase inhibitor ZD1839.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Bronchioloalveolar carcinoma can be improved by tyrosine kinase inhibitor ZD1839. "Bronchioloalveolar carcinoma (BAC), a form of pulmonary adenocarcinoma, presents unique clinical features, such as...

Clinical development of TRAIL Receptor-2 antibody begins.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Human Genome Sciences, Inc., (HGSI) announced it has received a clinical trial exemption (CTX) from the United Kingdom's Medicines and Healthcare products Regulatory Agency, allowing the company to...

Helicase-like transcription factor is inactivated by promoter hypermethylation.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Helicase-like transcription factor is inactivated by promoter hypermethylation. "Helicase-like transcription factor (HLTF), a member of the SWI/SNF (mating type switching/sucrose nonfermenting)...

p16 Promoter hypermethylation in serum may be a marker for tumor DNA.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- p16 Promoter hypermethylation in serum may be a marker for tumor DNA. "For the early detection of tumor-related aberrant DNA in the serum of patients, we examined promoter hypermethylation of the...

Sequence-based cancer genomics presents progress, lessons and opportunities.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Sequence-based cancer genomics presents progress, lessons and opportunities. According to a study from the United States, "Technologies that provide a genome-wide view offer an unprecedented...

Interferon resistance gene needed for modified vaccinia virus Ankara replication.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers in Germany have identified an interferon (IFN) resistance gene whose expression is critical for modified vaccinia virus Ankara (MVA) replication....

Mutations in PTPN11 associated with JMML caused a gain of function.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Mutations in PTPN11 associated with JMML caused a gain of function. "We report here that individuals with Noonan syndrome and juvenile myelomonocytic leukemia (JMML) have germline mutations in...

Real-time reverse transcriptase-PCR measures SIL-TAL1 fusion gene transcripts.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Real-time reverse transcriptase-PCR measures SIL-TAL1 fusion gene transcripts. "TAL1 disruption at 1p32 [del(1p)] is a common rearrangement in the development of T-cell acute lymphocytic leukemia...

EBV + T-cell Asian lymphoma may have prognostic correlations.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- EBV + T-cell Asian lymphoma may have prognostic correlations. According to recent research from the United States, "Evidence of Epstein-Barr virus (EBV) infection in patients continues to be...

Lymphoma development in Bax transgenic mice is inhibited by Bcl-2.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Lymphoma development in Bax transgenic mice is inhibited by Bcl-2. According to published research from the United States, "Bax is a Bcl-2 family member that promotes apoptosis but has paradoxical...

Murine models are useful for studying human lymphoid neoplasias.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Murine models are useful for studying human lymphoid neoplasias. According to recent research published in the journal Leukemia Research, "Using an animal model for the study of murine thymic...

New Media Japan, Inc., tapped as Asian representatives.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Large Scale Biology Corp. (LSBC) has appointed New Media Japan, Inc., of Tokyo as its representative to promote biopharmaceutical product partnering in Asia. New Media Japan, Inc., is known for it...

A new transmembrane collagen is identified in rat metastatic tumor cells.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- A new transmembrane collagen is identified in rat metastatic tumor cells. "We have identified a transmembrane collagen, collagen XXIII, in rat prostate carcinoma cells. Differential display of mRNA...

Alpha1-ARs play a role in promoting hPCE cell proliferation via TRP channels.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Alpha1-ARs play a role in promoting hPCE cell proliferation via TRP channels. "The prostate gland is a rich source of alpha1-adrenergic receptors (alpha1-ARs). Alpha1-AR antagonists are commonly...

Novel IL-10 signaling mechanism regulates TIMP-1 expression in tumor cells.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Novel IL-10 signaling mechanism regulates TIMP-1 expression in tumor cells. According to a study from the United States, "We have previously reported that interleukin 10 (IL-10) signaling stimulated...

Plant-derived 3,3'-diindolylmethane is a strong androgen antagonist.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Plant-derived 3,3'-diindolylmethane is a strong androgen antagonist. According to a study from the United States, "3,3'-Diindolylmethane (DIM) is a major digestive product of indole-3-carbinol, a...

Translation inhibitors sensitize prostate cancer cells to apoptosis.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Translation inhibitors sensitize prostate cancer cells to apoptosis. According to a study from the United States, "Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis...

Chk2 tumor suppressor is not required for p53 responses in human cancer cells.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Chk2 tumor suppressor is not required for p53 responses in human cancer cells. "Ionizing radiation damages chromosomal DNA and activates p53-dependent transcription in mammalian cells. The Chk2...

TRAIL signaling pathway circumvents caspase-8 activation.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- TRAIL signaling pathway circumvents caspase-8 activation in rhabdomyosarcoma. According to recent research from the United States, "Tumor necrosis factor-related apoptosis inducing ligand (TRAIL)...

Novel therapies for patients with granulocytic sarcoma are required.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Novel therapies for patients with granulocytic sarcoma are required. According to recent research from the United States, "Granulocytic sarcoma (GS) is an extramedullary tumor composed of immature...

Molecular analysis of esopharyngeal brush samples could detect head, neck cancer.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Molecular analysis of esopharyngeal brush samples could detect head, neck cancer. "Esopharyngeal brush (OPB) sampling with cytological analysis can yield exfoliated cells from asymptomatic tumors of...

Tumor cells evolve in vivo after generation of double-strand DNA breaks.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Tumor cells evolve in vivo after generation of double-strand DNA breaks. "In vitro, the ratio of single- to double-strand DNA breaks (DSB) and their absolute values determine the cell death pathway....

Chk1 and Chk2 are unlikely to be regulators of p53 in some human tumor cells.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Chk1 and Chk2 are unlikely to be regulators of p53 in some human tumor cells. According to a study from the United States, "Cdc25C and p53 have been reported to be physiological targets of...

Deficiency of Mbd2 suppresses intestinal tumorigenesis in the mouse.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Deficiency of Mbd2 suppresses intestinal tumorigenesis in the mouse. "Gene silencing through de novo methylation of CpG island promoters contributes to cancer," wrote O.J. Sansom and colleagues,...

Mutation CDP may allow tumor growth.
August 4, 2003... 2003 AUG 4 - (NewsRx.com & NewsRx.net) -- Mutation CDP may allow tumor growth. According to published research from Australia, "Leiomyomas are the most common gynecologic tumors in women, but very little is known about their molecular...

Dendritic cell vaccines offer new hope for treatment of endocrine tumors.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- Dendritic cell vaccines offer new hope for the treatment of metastasized endocrine malignancies. "Dendritic cells (DCs) are antigen-presenting cells that are involved in the induction of primary...

RNA transfection of dendritic cells induces immunity against breast cancer.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- Transfection of dendritic cells with RNA induced CD4- and CD8-mediated T cell immunity against breast cancer and revealed the immunodominance of presented T cell epitopes. "Transfection of...

Anti-idiotype antibody elicits antibody response in breast cancer patients.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- A strong, specific antibody response occurred in breast cancer patients immunized with an anti-idiotype antibody mimicking NeuGc-containing gangliosides. According to recent research published in...

Spontaneous and full recovery from advanced cancers is found in mouse model.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- Spontaneous and full recovery from advanced cancers is possible; there is a mouse strain with this immune capacity. According to a study from the United States, "We have established and studied a...

Comutation of HPV16 E6 and E7 genes in Thai cervical tumors found.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- A comutation of the HPV16 E6 and E7 genes were found in the squamous cervical carcinomas of women in Thailand. "Infection with high-risk HPV16 is well associated with invasive cervical carcinomas....

Role of dendritic cells in chronic lymphocytic leukemia reviewed.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- The role of monocyte-derived dendritic cells in chronic lymphocytic leukemia has been reviewed in the journal Leukemia and Lymphoma. According to published research from France, "Chronic...

Apoptosis triggered redistribution of caspase-9 from cytoplasm to mitochondria.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- Apoptosis triggered redistribution of caspase-9 from cytoplasm to mitochondria. According to recent research from Slovenia, "Caspase-9 is an apoptosis initiator protease activated as a response to...

Putative tumor suppressor gene KLF6 is mutated in astrocytic gliomas.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- KLF6, a putative tumor suppressor gene, is mutated in astrocytic gliomas. "Gliomas are the most common tumors of the central nervous system and have a grave prognosis. Deletion of chromosome 10p15...

JNK/SAPK pathway activation may be a therapeutic intervention in breast cancer.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- JNK/SAPK pathway activation may be a therapeutic intervention in breast cancer. "Pharmacologic induction of cancer cell differentiation has potential in the treatment of breast cancer," scientists...

Mutant p53 and aberrant cytosine methylation silence gene expression.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- Mutant p53 and aberrant cytosine methylation silence gene expression. According to published research from the United States, "p53 is an important transcriptional regulator that is frequently...

No association in polymorphisms in ERbeta gene and risk of breast cancer.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- No association in polymorphisms in ERbeta gene and risk of breast cancer. "Polymorphisms in the estrogen receptor beta (ERbeta) gene may influence the cellular growth regulating effects of...

Inhibition of signaling pathways may represent promising therapeutic strategies.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- Inhibition of signaling pathways may represent promising therapeutic strategies. According to recent research published in the journal Anticancer Research, "The role of growth factors in tumor...

A syngeneic endothelial cell vaccine jumpstarts antitumor immunity in mice.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- A syngeneic endothelial cell vaccine jumpstarts antitumor immunity in mice. "Tumor endothelium could represent a novel target for active and passive immunotherapies of cancer. Here, we show that...

Dendritic cells prevent metastasis of HPV 16-associated tumors.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- Bone marrow-derived dendritic cells exhibited anti-metastatic effects in mice carrying human papillomavirus 16-associated tumors. "Oncogenic, moderately immunogenic MK16/1/ IIIABC (MK16) cells...

Oncolytic adenoviral vector expressing GM-CSF exhibits anti-tumor activity.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- An oncolytic adenoviral vector expressing granulocyte-macrophage colony-stimulating factor (GM-CSF) exhibited strong anti-tumor activity. "Oncolytic adenoviruses are being tested as biological...

Imaging agent developer reports net profit of $0.10 per share.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- Advanced Magnetics, Inc., (AVM) announced its operating results and revenues for the third fiscal quarter and 9 months ended June 30, 2003. Revenues for the quarter were $1,429,046 as compared to...

COX-2 inhibition may offer a new approach for HCC chemoprevention.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- COX-2 inhibition may offer a new approach for HCC chemoprevention. According to a study from the Peoples Republic of China, "Cyclooxygenase (COX-2) has been recently suggested to play a role in...

Colon cancer cells that express interleukin-23 generate systemic immunity.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- "Interleukin-23 (IL-23), a novel cytokine composed of a newly identified p19 molecule and the p40 subunit of IL-12, can stimulate the proliferation in vitro of memory T cells. We examined whether Colon...

Gene modified cytotoxic T lymphocytes present anticancer possibilities.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- Gene modified cytotoxic T lymphocytes present anticancer possibilities. According to a study from Japan, "genes encoding 2C T cell receptor (TCR) alpha, beta chains from H-2(b)-restricted...

Some T-cell and immunological defects might stem from VEGF overexpression.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- Some T-cell and immunological defects might stem from VEGF overexpression. According to recent research from the United States, "T-cell defects and premature thymic atrophy occur in cancer patients...

Insertion of MLL sequences is a rare abnormality associated with infant leukemia.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- Insertion of MLL sequences is a rare abnormality associated with infant leukemia. According to recent research published in the journal Genes Chromosomes & Cancer, "MLL gene rearrangements leading...

Positive preclinical results reported with humanized antibodies.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- CancerVax Corporation announced the results of preclinical studies demonstrating that humanized monoclonal antibodies under development by its wholly owned subsidiary Cell-Matrix, Inc., suppress blood...

Researchers pinpoint genes involved in cancer growth.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- In a study made possible by the sequencing of the human genome, scientists at the University of Illinois at Chicago have identified 57 genes involved in the growth of human tumor cells. Some of...

Balance of pathways may determine the effect of IL-6 on AR transactivation.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- Balance of pathways may determine the effect of IL-6 on AR transactivation. According to recent research from the United States, "The effects of IL-6 on prostate cancer cells are well documented...

Human epithelial cell immortalization is a step in carcinogenesis.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- Human epithelial cell immortalization is a step in carcinogenesis. "Human epithelial cells encounter two senescence barriers that enforce a limited proliferative potential. A first barrier is...

Analysis of the ATP7B gene and/or protein will help in choosing chemotherapy.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- Analysis of the ATP7B gene and/or protein will help in choosing chemotherapy. According to a study from Japan, "A major obstacle in the treatment of human solid carcinomas is the intrinsic/acquired...

Tumor cells can be epigenetically reprogrammed into normal cell types.
August 11, 2003... 2003 AUG 11 - (NewsRx.com & NewsRx.net) -- Tumor cells can be epigenetically reprogrammed into normal cell types. According to published research from the United States, "Cancer cells escape from growth control by accumulating genetic and...

Dendritic cell vaccine induces antigen-specific protective antitumor immunity.
August 18, 2003... 2003 AUG 18 - (NewsRx.com & NewsRx.net) -- Murine dendritic cells pulsed with an anti-idiotype antibody induce antigen-specific protective antitumor immunity. "In this study, using the carcinoembryonic antigen (CEA)-expressing C15 murine...

Dendritic cell-based glioma immunotherapy reviewed.
August 18, 2003... 2003 AUG 18 - (NewsRx.com & NewsRx.net) -- A review of dendritic cell-based glioma immunotherapy has been published in a recent issue of the International Journal of Oncology. According to a study from Japan, "Despite advances in radiation...

Novel vaccine to be manufactured from live bacterium.
August 18, 2003... 2003 AUG 18 - (NewsRx.com & NewsRx.net) -- Cobra Biomanufacturing has announced an agreement with Advaxis, Inc., to supply clinical trials and, potentially, commercial supplies of the active ingredient for its Listeria monocytogenes-based...

CD80 and CD86 expression produces tumor vaccine better than either alone.
August 18, 2003... 2003 AUG 18 - (NewsRx.com & NewsRx.net) -- Dual expression of CD80 and CD86 produced a tumor vaccine superior to single expression of either molecule. According to recent research from the United States, "A murine model for neuroblastoma,...

Recent progress in tumor vaccine development reported.
August 18, 2003... 2003 AUG 18 - (NewsRx.com & NewsRx.net) -- A report on recent progress in tumor vaccine development has been published in the journal Expert Opinion on Investigational Drugs. "Immunotherapy offers an exciting opportunity to treat human...

Importance of CD4+ helper T-cells in antitumor immunity detailed.
August 18, 2003... 2003 AUG 18 - (NewsRx.com & NewsRx.net) -- The importance of CD4+ helper T-cells in antitumor immunity has been detailed. "CD8+ cytotoxic T-lymphocytes are major effector cells involved in immunologically specific tumor destruction in vivo,...

Docetaxel may be the preferred taxane for HER-2/neu overexpressing breast tumors.
August 18, 2003... 2003 AUG 18 - (NewsRx.com & NewsRx.net) -- Docetaxel may be the preferred taxane for HER-2/neu overexpressing breast tumors. According to recent research from the United States, "Taxanes are effective in the treatment of metastatic breast...

ATM mutations may contribute to familial breast and ovarian cancer.
August 18, 2003... 2003 AUG 18 - (NewsRx.com & NewsRx.net) -- ATM mutations may contribute to familial breast and ovarian cancer. "This study addresses the prevalence of ATM mutations and the association with breast cancer in Austrian families selected for a...

BRCA1 transcriptionally regulates some DNA-repair genes.
August 18, 2003... 2003 AUG 18 - (NewsRx.com & NewsRx.net) -- BRCA1 transcriptionally regulates some DNA-repair genes. "Interest in BRCA1 stems from its role as a tumor suppressor in breast and ovarian cancer," researchers in the United States report. ...

Epidermal growth factor receptor is frequently dysregulated in cancer cells.
August 18, 2003... 2003 AUG 18 - (NewsRx.com & NewsRx.net) -- Epidermal growth factor receptor is frequently dysregulated in cancer cells. "Progress in identifying and understanding the molecular and cellular causes of cancer has led to the discovery of...

Aurora-2 may be an attractive target for anticancer drug development.
August 18, 2003... 2003 AUG 18 - (NewsRx.com & NewsRx.net) -- Aurora-2 may be an attractive target for anticancer drug development. "Aurora-2 kinase has been shown to contribute to oncogenic transformation and is frequently overexpressed and amplified in many...

Alliance targets oncolytic virus therapy products.
August 18, 2003... 2003 AUG 18 - (NewsRx.com & NewsRx.net) -- Cell Genesys, Inc., (CEGE) announced a global alliance between Cell Genesys and Novartis AG (NVS) for the development and commercialization of oncolytic virus therapies. Under the agreement, Cell...

Endometrial cancer patients had longer alleles than normal healthy controls.
August 18, 2003... 2003 AUG 18 - (NewsRx.com & NewsRx.net) -- Endometrial cancer patients had longer alleles than normal healthy controls. "Human androgen receptor (AR) gene contains polymorphic CAG repeats in the N-terminal domain that influence...

Loss of $16.6M reported by cancer therapeutics firm; trial updates provided.
August 18, 2003... 2003 AUG 18 - (NewsRx.com & NewsRx.net) -- Antigenics, Inc., (AGEN) reported results for the quarter ended June 30, 2003, and provided an update on its clinical trials. The company incurred a net loss of $16.6 million, or $0.42 per share,...

RNA may be significant in genotoxic stress.
August 18, 2003... 2003 AUG 18 - (NewsRx.com & NewsRx.net) -- RNA may be significant in genotoxic stress. According to published research from the United States, "RNA in a cell is subject to many of the same insults as DNA. "RNA damage can induce...

Tumor M2-PK is not a useful indicator of hematological malignancies.
August 18, 2003... 2003 AUG 18 - (NewsRx.com & NewsRx.net) -- Tumor M2-PK is not a useful indicator of hematological malignancies. "Circulating Tumor M2-PK serum levels were measured in 118 patients with various hematological malignancies," investigators in...

Suppression of Bcl-xL deamidation may play a role in regulating cell death.
August 18, 2003... 2003 AUG 18 - (NewsRx.com & NewsRx.net) -- Suppression of Bcl-xL deamidation may play a role in regulating cell death. According to recent research from Japan, "Bcl-xL is an antiapoptotic member of the Bcl-2 family, which inhibits apoptosis...

Positive results reported from first clinical trial of recombinant human gelatin.
August 18, 2003... 2003 AUG 18 - (NewsRx.com & NewsRx.net) -- FibroGen, Inc., announced positive results from the first clinical safety study of recombinant human gelatin, finding the study material safe and well tolerated at all doses tested. The data...

HCCS1 gene might be involved in acceleration of Korean hepatocellular carcinoma.
August 18, 2003... 2003 AUG 18 - (NewsRx.com & NewsRx.net) -- HCCS1 gene might be involved in acceleration of Korean hepatocellular carcinoma. According to published research from South Korea, "We analyzed the gene mutations and loss of heterozygosity (LOH)...

Genistein and etoposide induce p21(WAF1/Cip1) expression in p53-dependent manner.
August 18, 2003... 2003 AUG 18 - (NewsRx.com & NewsRx.net) -- Genistein and etoposide induce p21(WAF1/Cip1) expression in p53-dependent manner. "The p21(WAFI/Cip1) gene plays a central role in cell cycle regulation. Here we show that topoisomerase II...

K-ras mutations may provide useful diagnostic markers for lung cancer.
August 18, 2003... 2003 AUG 18 - (NewsRx.com & NewsRx.net) -- K-ras mutations may provide useful diagnostic markers for lung cancer. "Mutations in the K-ras gene are frequently found in lung tumors and are implicated in the development of lung cancer,"...

DNA microarray analysis aids understanding of malignant lymphomas.
August 18, 2003... 2003 AUG 18 - (NewsRx.com & NewsRx.net) -- DNA microarray analysis aids understanding of malignant lymphomas. According to recent research from Germany, "Recently, DNA microarray technology has opened new avenues for the understanding of...

The two subtypes of Burkitt lymphoma have unexplained different prognoses.
August 18, 2003... 2003 AUG 18 - (NewsRx.com & NewsRx.net) -- The two subtypes of Burkitt lymphoma have unexplained different prognoses. "To clarify the clinical and genetic features of Burkitt lymphoma with or without leukemic presentation, we have conducted...

Legumain involved in tumor metastasis may be halted by doxorubicin bound target.
August 18, 2003... 2003 AUG 18 - (NewsRx.com & NewsRx.net) -- Legumain involved in metastatic ability serves as a perfect target for a doxorubicin-linked cleavable peptide drug. According to recent research from the United States, "Expression of legumain, a...