Cancer Vaccine Week articles from April 2003

Cancer Vaccine Week archives from April 2003

HPV16-associated, MHC class I+ tumors more susceptible than class I- to therapy.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- Chemoimmunotherapy was more effective in mice carrying HPV16-associated, MHC class I+ tumors than in those carrying and class I- tumors. According to recent research from Czech Republic, "The...

Immature dendritic cell vaccine causes immune response against melanoma.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- The clinical response after intradermal immature dendritic cell vaccination for metastatic melanoma was associated with an immune response to particulate antigen. According to recent research from...

CD4+CD25+ lymphocytes play role in immune response to melanoma antigens.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- CD4+CD25+ suppressor lymphocytes in the circulation of patients immunized against melanoma antigens may play a role in the immune response. "Murine studies have suggested that a population of CD4+ T...

Rapid generation of antigen-presenting cells from leukemic blasts developed.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- A method for the rapid generation of antigen-presenting cells from leukemic blasts in acute myeloid leukemia has been developed. "The ability of acute myeloid leukemia (AML) cells to acquire...

Complement resistance of human CA depends on protein kinases and sialic acid.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- Complement resistance of human CA depends on protein kinases and sialic acid. According to a study from Israel, "Nucleated cells employ several strategies to evade killing by homologous complement....

Pancreatic cancer patient successfully treated with dendritic cell vaccine.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- The successful treatment of a pancreatic cancer patient who received multiple doses of a vaccine consisting of dendritic cells pulsed with allogeneic tumor lysate may provide insights into new...

Patients enrolled in kidney cancer vaccine clinical trial.
April 7, 2003... 2003 APR 7 - (NewsRx.com & NewsRx.net) -- The prestigious Cleveland Clinic is now enrolling patients in a phase I/II clinical trial in kidney cancer conducted by Genzyme Molecular Oncology (GZMO). Ronald Bukowski, MD, of the Cleveland...

Joint presentation of KLH and peptide augments dendritic cell-based vaccine.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- A recent study demonstrated that joint presentation by dendritic cells of Keyhole Limpet hemocyanin and antigenic peptide augments peptide-specific cytotoxic T lymphocyte response. A.L. Millard...

Suppressor lymphocytes may modify T-cell response to anti-tumor immunization.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- CD4+CD25+ suppressor lymphocytes may modify the T-cell response of melanoma patients' T-cell response undergoing tumor antigen immunization, according to a study by U.S. National Institutes of Health...

Phase II colorectal trial results for theratope vaccine to be presented at ASCO.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- Biomira, Inc., (BIOM; BRA) announced that data from the company's phase II Theratope vaccine trial in metastatic colorectal cancer will be presented as a poster presentation at the 2003 Annual Meeting...

Recombinant SFV expressing fusion protein eliminated tumors in vaccinated mice.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- Recombinant Semliki Forest virus expressing a fusion protein of human papillomavirus E6 and E7 eliminated tumors in immunized mice, virologists report. According to researchers in the Netherlands,...

Agreement reached for the production of cancer vaccine.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- GeneMax Corp. (GMXX; GX1) announced a contractual agreement with Molecular Medicine BioServices, Inc., of San Diego, California, for the production of its clinical vector for delivery of the TAP genes...

Immune competence may partly determine DC immunotherapy response.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- Researchers at the University of Queensland suggest assessing melanoma patients' general immune competence before administering dendritic cell-based immunotherapy as this can affect treatment response....

Anti-cancer DNA vaccination is less effective in older mice than younger.
April 14, 2003... 2003 APR 14 - (NewsRx.com & NewsRx.net) -- Study results showed that DNA vaccination to induce immunity against cancerous tumors was less effective in older mice than younger animals. The researchers conducting the work suggest this would...

Dendritic cell vaccination elicits tumoricidal immunity against malignant glioma.
April 28, 2003... 2003 APR 28 - (NewsRx.com & NewsRx.net) -- Intratumoral dendritic cell vaccination elicits potent tumoricidal immunity against malignant glioma in rats. According to a study from the United States, "Dendritic cells (DC) are attractive...

Expanded phase II trial of GVAX vaccine launched.
April 28, 2003... 2003 APR 28 - (NewsRx.com & NewsRx.net) -- Cell Genesys, Inc., (CEGE) announced that enrollment has been opened for a multicenter phase II clinical trial of GVAX lung cancer vaccine in patients with advanced-stage, non small-cell lung cancer...

Chaperone-rich tumor cell lysates show promise.
April 28, 2003... 2003 APR 28 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Tumor-derived chaperone-rich cell lysates (CRCL) could be the basis for an effective anti-cancer vaccine, researchers in the United States say. Yi Zeng...

Gene therapy boosts immume system against cancer.
April 28, 2003... 2003 APR 28 - (NewsRx.com & NewsRx.net) -- Transfusions of genetically engineered blood cells could give bowel cancer patients a powerful boost against their disease, scientists from Cancer Research UK report. In a laboratory-based pilot...

Irradiation improves tumor cell transgene expression.
April 28, 2003... 2003 APR 28 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Gamma irradiation does not impair transgene expression by leukemic cells, researchers report. "The majority of immunotherapy-based gene therapy protocols...

Global cancer rates could increase by 50% to 15 million by 2020.
April 28, 2003... 2003 APR 28 - (NewsRx.com & NewsRx.net) -- Cancer rates could further increase by 50% to 15 million new cases by the year 2020, according to the World Cancer Report, the most comprehensive global examination of the disease to date. ...

Transgenic expression of decorin results in cancer cell apoptosis.
April 28, 2003... 2003 APR 28 - (NewsRx.com & NewsRx.net) -- Adenovirus-mediated transfer and expression of human decorin cDNA induced in vivo apoptosis of xenograft tumor cells in nude mice, a new study reports. "Decorin is a well-known, ubiquitous...

Tumor bank will save lives, researchers predict.
April 28, 2003... 2003 APR 28 - (NewsRx.com & NewsRx.net) -- The creation of a national system to collect and analyze cancerous tissue through a virtual U.K. "tumor bank" will provide a vital resource to help researchers find cancer treatments and cures more...

Progress and prospects in naked DNA gene transfer and therapy explored.
April 28, 2003... 2003 APR 28 - (NewsRx.com & NewsRx.net) -- The progress and prospects in naked DNA gene transfer and therapy were explored in a recent review. "Increases in efficiency have made naked DNA gene transfer a viable method for gene therapy....

Clinical research association doubles membership in first year.
April 28, 2003... 2003 APR 28 - (NewsRx.com & NewsRx.net) -- Amid increasing awareness of the need for clinical research organizations to participate in health policy debates regarding drug development issues, the Association of Clinical Research Organizations...

HSA genetic coupling increases activity of circulating angiogenic inhibitors.
April 28, 2003... 2003 APR 28 - (NewsRx.com & NewsRx.net) -- An adenovirus (AdK3-HSA) that carries a chimeric gene encoding a fusion protein between angiostatin K1-3 and human serum albumin (HSA) increases the antitumoral activity of circulating angiogenic...

Alliance to identify novel uses for existing cancer drugs.
April 28, 2003... 2003 APR 28 - (NewsRx.com & NewsRx.net) -- cABC2, CaP CURE, and Ingenuity Systems announced a partnership that will test existing chemotherapeutic agents against recently discovered gene defects associated with prostate and brain cancer...

$50 million grant from Lilly endowment boosts genomics initiative.
April 28, 2003... 2003 APR 28 - (NewsRx.com & NewsRx.net) -- For the second time in three years, the Lilly Endowment, Inc., is demonstrating its strong commitment to Indiana University's flourishing role in life sciences education and research by awarding $50...

Anti-estrogenic compound activates apoptotic pathways in endothelial cells.
April 28, 2003... 2003 APR 28 - (NewsRx.com & NewsRx.net) -- Results of a study of an estrogen antagonist, ICI 182,780 - now Fulvestrant (AstraZeneca) - suggest that the compound not only blocks tumor angiogenesis but inhibits the process by activating apoptotic...

Nasal drug delivery possibilities, problems, and solutions discussed.
April 28, 2003... 2003 APR 28 - (NewsRx.com & NewsRx.net) -- The possibilities, problems, and solutions associated with nasal drug delivery, including vaccine delivery, have been published in a recent review. "This paper discusses the problems associated...