Cancer Gene Therapy Week articles from September 2008

Cancer Gene Therapy Week archives from September 2008

New gene therapy findings from Z.H. Zhang and co-researchers published.
September 1, 2008... "Use of the herpes simplex virus thymidine kinase gene/ ganciclovir (HSV-tk/GCV) system is one of the promising approaches in the rapidly growing area of gene therapy. The ''bystander effect,'' a phenomenon in which HSV-tk(+) cells exposed to...

Recent studies from Brain Tumor Center add new data to gene therapy.(Report)
September 1, 2008... According to recent research published in the Journal of Medical Virology, "Malignant glioma, in particular glioblastoma multiforme (GBM), represents one of the most devastating cancers currently known and existing treatment regimens do little...

Investigators at Okayama University publish new data on cancer gene therapy.
September 1, 2008... Fresh data on cancer gene therapy are presented in the report 'M-RIP, a novel target of JNK signaling and a requirement for human cancer cell invasion.' According to a study from Okayama, Japan, "Cell motility is involved in physiological and...

Researchers from Nagasaki University discuss findings in cancer gene therapy.
September 1, 2008... New investigation results, 'Gene therapy for gastric diseases,' are detailed in a study published in Current Gene Therapy. "Gene therapy for gastric cancer and gastric ulcer is a rationalized strategy since various genes correlate with these...

Researchers from Nagoya University detail findings in cancer gene therapy.
September 1, 2008... A new study, 'Non-engineered, naturally oncolytic herpes simplex virus HSV1 HF-10: applications for cancer gene therapy,' is now available. According to a study from Nagoya, Japan, "Oncolytic HSV-1 has been developed as a novel anticancer...

Researchers' work from University of Kentucky focuses on cancer gene therapy.
September 1, 2008... Researchers detail in 'MAZ drives tumor-specific expression of PPAR gamma 1 in breast cancer cells,' new data in cancer gene therapy. According to recent research from the United States, "The peroxisome proliferator-activated receptor gamma 1...

College of Medicine publishes research in cancer gene therapy vaccines.(Report)
September 1, 2008... Research findings, 'Measles virus as an oncolytic vector platform,' are discussed in a new report. According to a study from the United States, "Viral vector systems are widely being used in the development of new genetic approaches for a...

Johns Hopkins University details research in cancer gene therapy vaccines.
September 1, 2008... A report, 'Current status of experimental therapeutics for prostate cancer,' is newly published data in Cancer Letters. "Hormone refractory prostate cancer (HRPC) is the progression of disease in the presence of castrate serum levels of...

Data on gene therapy reported by researchers at Guangzhou Medical College, Department of Surgery.(Report)
September 1, 2008... Fresh data on gene therapy are presented in the report 'Transfection of the DAAO gene and subsequent induction of cytotoxic oxidative stress by D-alanine in 9L cells.' "D-amino acid oxidase (DAAO) can catalyze the dehydrogenation of D-amino...

Research from St. James's University, Leeds Institute of Molecular Medicine in gene therapy provides new insights.
September 1, 2008... Current study results from the report, 'Post-transcriptional regulation of gene expression by alternative 5'-untranslated regions in carcinogenesis,' have been published. According to a study from Leeds, the United Kingdom,...

Scientists at German Cancer Research Center describe research in gene therapy.(Report)
September 1, 2008... Research findings, 'Generation of efficient human blood progenitor-targeted recombinant adeno-associated viral vectors (AAV) by applying an AAV random peptide library on primary human hematopoietic progenitor cells,' are discussed in a new...

Shin Kong Wu Ho-Su Memorial Hospital describes research in immunotherapy.
September 1, 2008... Fresh data on immunotherapy are presented in the report 'Synergistic anti-tumor effect of combination radio- and immunotherapy by electro-gene therapy plus intra-tumor injection of dendritic cells.' According to recent research from Taipei,...

Reports from University Hospital advance knowledge in myeloma gene therapy.(Report)
September 1, 2008... Research findings, 'Small-molecule inhibition of proteasome and silencing by vascular endothelial cell growth factor-specific siRNA induce additive antitumor activity in multiple myeloma,' are discussed in a new report. "Angiogenesis plays an...

Investigators at University of Padua release new data on cancer gene therapy.(Report)
September 8, 2008... "The side population (SP), recently identified in several normal tissues and in a variety of tumors based on its ability to extrude some fluorescent dyes, may comprise cells endowed with stem cell features. In this study, we investigated the...

Recent findings in cancer gene therapy described by researchers from Indiana University, Medical Department.(Report)
September 8, 2008... According to a study from the United States, "Renal cell carcinoma (RCC) is the third most common urologic neoplasm. This aggressive malignancy has proven refractory to conventional treatment options." "Antiangiogenic agents have shown...

Studies from Virginia Commonwealth University in the area of cancer gene therapy published.
September 8, 2008... "The profound toxic effects of conventional cancer therapies such as chemo- and radiotherapy and the nonspecific side effects of small-molecule inhibitors of signaling proteins mandate more effective and preferably nontoxic approaches for...

Emory University, Winship Cancer Institute details research in cancer gene therapy.(Report)
September 8, 2008... New research, 'Perifosine synergistically enhances TRAIL-induced myeloma cell apoptosis via up-regulation of death receptors,' is the subject of a report. "The aim of this study is to investigate the efficacy of a novel Akt inhibitor,...

New cancer gene therapy research has been reported by scientists at University of North Dakota.
September 8, 2008... Investigators publish new data in the report 'Zinc transporter mRNA expression in the RWPE-1 human prostate epithelial cell line.' "The human prostate gland undergoes a prominent alteration in Zn+2 homeostasis during the development of prostate...

Research from M. Ganzinelli and co-authors provides new data about enzyme research.(Report)
September 8, 2008... New research, 'Checkpoint kinase 1 down-regulation by an inducible small interfering RNA expression system sensitized in vivo tumors to treatment with 5-fluorouracil,' is the subject of a report. According to a study from Milan, Italy, "After...

Studies from University Federal of Minas Gerais further understanding of gene therapy.
September 8, 2008... Fresh data on gene therapy are presented in the report 'Molecular alterations in the tumor suppressor gene WWOX in oral leukoplakias.' "Oral leukoplakia is the most prevalent and potentially malignant disorder of the oral mucosa. Previous...

Gene therapy anti-cancer research featured in Scientific American.
September 8, 2008... Scientific American magazine focused on two University of Alabama at Birmingham (UAB) Comprehensive Cancer Center researchers in a news story on experimental next-generation anti-cancer therapies (see also Cancer Gene Therapy). David T....

New cancer gene therapy research from National Taiwan University, Medical Department discussed.(Report)
September 15, 2008... According to recent research from Taipei, Taiwan, "A novel method for generating an antigen-specific cancer vaccine and immunotherapy has emerged using a DNA vaccine. However, antigen-presenting cells (APCs) have a limited life span, which...

Recent findings in cancer gene therapy described by researchers from INSERM.
September 15, 2008... "stromal cells (MSCs) and carcinoma and the possible use of MSCs in cell-based anticancer therapies. MSCs are present in multiple tissues and are defined as cells displaying the ability to differentiate in multiple lineages, including...

Studies from Leiden University in the area of cancer gene therapy described.(Report)
September 15, 2008... According to a study from Netherlands, "Adenovirus vectors have great potential in cancer gene therapy. Targeting of cancer-testis (CT) antigens, which are specifically presented at the surface of tumor cells by human leukocyte antigen (HLA)...

New findings from Harvard University in the area of gene therapy described.
September 15, 2008... According to a study from the United States, "Retroviral-mediated delivery of the P140K mutant 06 -methylguanine-DNA methyltransferase (MGMT(P140K)) into hematopoietic stem cells (HSC) has been proposed as a means to protect against...

New lymphoma gene therapy research has been reported by scientists at University of Pennsylvania.
September 15, 2008... "Cell-based vaccination strategies to induce functional tumor-specific T cells in cancer patients have focused on using autologous dendritic cells. An alternative approach is to use RNA-loaded CD40 activated B cells (CD40-B) that are highly...

Studies from Fraunhofer Institute of Toxicology and Experimental Medicine in the area of cancer gene therapy published.
September 15, 2008... Investigators publish new data in the report 'Cross-talk between aryl hydrocarbon receptor and mitogen-activated protein kinase signaling pathway in liver cancer through c-raf transcriptional regulation.' "c-raf is a serine-threonine kinase and...

Study data from University of Arizona, Arizona Cancer Center update understanding of cancer gene therapy.(Report)
September 15, 2008... New research, 'The multifunctional protein glyceraldehyde-3-phosphate dehydrogenase is both regulated and controls colony-stimulating factor-1 messenger RNA stability in ovarian cancer,' is the subject of a report. According to recent research...

Studies from New York University, Department of Oncological Sciences have provided new data on DNA research.(Report)
September 15, 2008... Investigators publish new data in the report 'Cellular commitment to reentry into the cell cycle after stalled DNA is determined by site-specific phosphorylation of Chk1 and PTEN.' "In this study, we show that depletion of Chk1 by small...

New gene therapy findings from Center for Biomedical Genetics described.
September 15, 2008... New investigation results, 'The RapGEF PDZ-GEF2 is required for maturation of cell-cell junctions,' are detailed in a study published in Cellular Signalling. "The small G-protein Rap1 is a critical regulator of cell-cell contacts and is...

Study findings from Nantong University, Department of Pathology provide new insights into gene therapy.(Report)
September 15, 2008... New research, 'Mutant p27(Kip1) and its potential effect as hepatocellular gene therapy,' is the subject of a report. "The cyclin-dependent kinase (cdk) inhibitor p27(Kip1) is an important regulator of cell cycle progression as it negatively...

St. Vincent's Hospital, Department of Orthopaedics publishes research in osteosarcoma gene therapy.(Report)
September 15, 2008... Research findings, 'c-Jun Is critical for the progression of osteosarcoma: proof in an orthotopic spontaneously metastasizing model,' are discussed in a new report. According to a study from Melbourne, Australia, "The oncogene c-Jun has been...

Researchers from Duke University, Department of Biomedical Engineering publish findings in solid cancer gene therapy.
September 15, 2008... Scientists discuss in 'Relaxin treatment of solid tumors: effects on electric field-mediated gene delivery' new findings in solid cancer. According to recent research from the United States, "Pulsed electric fields have been shown to enhance...

Encouraging Gene Therapy Results in Genetic Form of Blindness.(Clinical report)
September 22, 2008... All three patients who received intraocular adeno-associated virus-based gene therapy to treat Leber congenital amaurosis (LCA), an incurable genetic disorder that results in blindness, had improved vision, according to a paper published online...

Data on cancer gene therapy published by S.K. Pavelic and colleagues.
September 22, 2008... "We investigated the effects of p21(waf1/cip1) gene overexpression in human laryngeal squamous carcinoma cells HEp-2 lacking p53 protein expression on apoptosis induction upon the treatment with two commonly used chemotherapeutic agents,...

Findings from University of Texas in cancer gene therapy reported.(Report)
September 22, 2008... "Vaccinia virus has recently been used as an expression vector for gene delivery and an oncolytic agent for cancer therapy. Although it has been established that interferon-induced double-stranded RNA (dsRNA)-activated protein kinase (PKR) and...

Research in the area of cancer gene therapy reported from National University.
September 22, 2008... According to a study from Copenhagen, Denmark, "Transcriptionally targeted gene therapy is a promising experimental modality for treatment of systemic malignancies such as small cell lung cancer (SCLC). We have identified the human...

Studies from L. Wu et al further understanding of cancer gene therapy.
September 22, 2008... According to a study from the United States, "Oncolytic vesicular stomatitis virus (VSV) is being developed as a novel therapeutic agent for cancer treatment, although it is toxic in animals when administered systemically at high doses. Its...

New leukemia gene therapy study findings have been published by scientists at University of California.
September 22, 2008... "Serious adverse events in some human gene therapy clinical trials have raised safety concerns when retroviral or lentiviral vectors are used for gene transfer. We evaluated the potential for generating replication-competent retrovirus (RCR)...

Investigators at College of Medicine zero in on cancer gene therapy.(Report)
September 22, 2008... Current study results from the report, 'Expanding the roles for pregnane X receptor in cancer: proliferation and drug resistance in ovarian cancer,' have been published. "We examined the presence of the pregnane X receptor (PXR) and its effects...

Research on cancer gene therapy detailed by J. Briese and co-authors.
September 22, 2008... Data detailed in 'Correlations between reduced expression of the metastasis suppressor gene KAI-1 and accumulation of p53 in uterine carcinomas and sarcomas' have been presented. According to a study from Hamburg, Germany, "Kangai (KAI)-1...

Researchers at University of Illinois have published new data on cancer gene therapy.(Report)
September 22, 2008... New research, 'Nuclear and extranuclear pathway inputs in the regulation of global gene expression by estrogen receptors,' is the subject of a report. "Whereas estrogens exert their effects by binding to nuclear estrogen receptors (ERs) and...

Researchers from Institute of Immunology discuss findings in cancer gene therapy.
September 22, 2008... New investigation results, 'Comparative evaluation of viral, nonviral and physical methods of gene delivery to normal and transformed lung epithelial cells,' are detailed in a study published in Anti-Cancer Drugs. "Few studies have directly...

Scientists at College of Medicine describe research in cancer gene therapy.(Report)
September 22, 2008... Scientists discuss in 'In vitro susceptibility to anticancer agents of the human KB carcinoma cell line transfected with COX-2 cDNA' new findings in cancer gene therapy. "In order to investigate the malignant phenotype of cyclooxygenase (COX)-2...

Peking Union Medical College details research in cancer gene therapy cell biology.
September 22, 2008... A report, 'Effect of Ad-TIMP3 on biologic behavior of choriocarcinoma cells in vitro,' is newly published data in The Journal of Reproductive Medicine. "To investigate the effect of adenovirus delivered tissue inhibitor of metalloproteinases-3...

New findings from University of Suwon in the area of gene therapy described.
September 22, 2008... Investigators publish new data in the report 'Effect of anti-histone acetyltransferase activity from Rosa rugosa Thunb. (Rosaceae) extracts on androgen receptor-mediated transcriptional regulation.' "ETHNOPHARMACOLOGICAL RELEVANCE: Rosa rugosa...

Reports from University of Utah, Huntsman Cancer Institute add new data to research in RNA research.
September 22, 2008... Data detailed in 'Therapeutic siRNAs for dominant genetic skin disorders including pachyonychia congenita' have been presented. According to recent research from the United States, "The field of science and medicine has experienced a flood of...

Exosome Diagnostics Appoints Johan Skog, Ph.D., as Director of Genetics Research.
September 22, 2008... Exosome Diagnostics, Inc. announced the appointment of Johan Skog, Ph.D., as director of genetics research. In this role, Dr. Skog will oversee the research program that underlies the company's development of its blood-based diagnostics that...

Exosome Diagnostics Announces Formation of its Scientific Advisory Board.
September 22, 2008... Exosome Diagnostics, Inc. announced the formation of its scientific advisory board with the appointments of Dennis Brown, Ph.D.; Xandra Breakefield, Ph.D.; and Richard L. Edelson, M.D (see also Neurology). Dr. Brown serves as director of...

Epeius Biotechnologies' Lead Product, Rexin-G for Metastatic Cancer, Aptly Highlighted by National Cancer Institute Journal.
September 29, 2008... Epeius Biotechnologies Corporation announced that Rexin-G, its lead product in development for metastatic cancer, has been highlighted in a recent NEWS article published by the Journal of the National Cancer Institute (JNCI, Sept. 9, 2008). The...

Research from Kitasato University, Medical Department has provided new information about cancer gene therapy.(Report)
September 29, 2008... "Tissue-specific expression is of key importance in gene therapy and can be achieved by using tissue-specific promoters to drive therapeutic gene expression. The uroplakin (UP) promoter is a powerful tool for bladder cancer gene therapy, but...

Research on cancer gene therapy detailed by scientists at Mayo Clinic.(Report)
September 29, 2008... According to a study from the United States, "Oncolytic measles virus strains have activity against multiple tumor types and are currently in phase I clinical testing. Induction of the heat shock protein 70 (HSP70) constitutes one of the...

Study data from J.A. Westwood and co-authors update knowledge of leukemia gene therapy.
September 29, 2008... According to recent research published in the journal Gene Therapy, "There is considerable concern regarding the transforming potential of retroviral vectors currently used for gene therapy, with evidence that retroviral integration can lead to...

Data on DNA research discussed by investigators at University of New Mexico, Cancer Research and Treatment Center.(Report)
September 29, 2008... New research, 'Expression levels of the human DNA repair protein metnase influence lentiviral genomic integration,' is the subject of a report. According to recent research published in the journal Biochimie, "We recently identified a...

New gene therapy study results from Aarhus University, Department of Dermatology described.
September 29, 2008... Researchers detail in 'IL-8 and p53 are inversely regulated through JNK, p38 and NF-kappaB p65 in HepG2 cells during an inflammatory response,' new data in gene therapy. "It is reported that Nuclear factor-kappaB (NF-kappaB) activation is...

University College, University College of London details research in gene therapy.
September 29, 2008... A report, 'Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients,' is newly published data in The Journal of Clinical Investigation. "X-linked SCID (SCID-X1) is...

Data on leukemia gene therapy described by S. Hacein-Bey-Abina et al.
September 29, 2008... Fresh data on leukemia are presented in the report 'Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1.' According to recent research from Paris, France, "Previously, several individuals with X-linked SCID...

Research conducted at Chiba Cancer Center Research Institute, Division of Biochemistry has provided new information about neuroblastoma gene therapy.(Report)
September 29, 2008... New research, 'KIF1Bbeta functions as a haploinsufficient tumor suppressor gene mapped to chromosome 1p36.2 by inducing apoptotic cell death,' is the subject of a report. According to recent research from Chiba, Japan, "Deletion of the distal...

Gene therapy for chronic pain gets first test in people.
September 29, 2008... This week, University of Michigan scientists will begin a phase 1 clinical trial for the treatment of cancer-related pain, using a novel gene transfer vector injected into the skin to deliver a pain-relieving gene to the nervous system (see...