Cancer Gene Therapy Week articles from September 2003

Cancer Gene Therapy Week archives from September 2003

The new nonviral GE7 vector system takes advantage of overexpressed receptors.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- The new nonviral GE7 vector system takes advantage of overexpressed receptors. According to a study from the Peoples Republic of China, "based on the fact that aberrant overexpression of some growth...

Transcriptional and transductional targeting improve gene delivery to ovaries.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Transcriptional and transductional targeting improve gene delivery to the ovaries. "Adenoviruses are efficient gene delivery vehicles but have broad native tropism. To this end, finding ways to...

Diabody-based gene therapy represents a new strategy for cancer therapy.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Diabody-based gene therapy represents a new strategy for cancer therapy. "Infiltrating T cells are found in many malignancies, but they appear to be mostly anergic and do not attack the tumor,...

Adenoviral fiber knob modifications overcome refractory transgene expression.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Adenoviral fiber knob modifications overcome refractory transgene expression. According to published research from the United States, "genetic manipulation of the adenovirus type 5 represents one...

Interleukin-21 gene therapy activates perforin-dependent tumor immunity.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Interleukin-21 gene therapy activates perforin-dependent tumor immunity. According to recent research from the United States, "Interleukin (IL)-21 is a key factor in the transition between innate...

Assay sensitivity sways the results of gene distribution analysis.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Assay sensitivity sways the results of gene distribution analysis. "Despite the widespread use of liposome-mediated gene transfer in cancer therapy protocols, little is known about the tissue...

Targeting TNF pathway along with ATRA may represent route to treat leukemias.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Targeting TNF pathway along with ATRA may represent route to treat leukemias. According to a study from Canada, "The nuclear receptor ligand all-trans retinoic acid (ATRA) causes dramatic terminal...

TSLC1 gene in human lung cancer is probably a cell adhesion molecule.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- The mouse ortholog of TSLC1, a tumor suppressor gene in human lung cancer, is found to be a cell adhesion molecule that may be expressed more to slow metastasis. According to recent research from...

Egr-1 inhibition reverses the transformation of prostate cancer cells.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Egr-1 inhibition reverses the transformation of prostate cancer cells. According to recent research published in the journal Oncogene, "transcription factor early growth response-1 (Egr-1) is a...

New screening for CAR reveals transfection efficiency in cancer cells.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- According to published research from the United States, "virus uptake is the first rate-limiting step for the successful gene delivery of any virus-based gene therapy. For adenovirus-based gene therapy,...

Antibody scFv fragments may be a nuclear delivery system in cancer cells.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Antibody scFv fragments may be a nuclear delivery system in cancer cells. "scFv fragments of a monoclonal antibody that penetrates living cells and localizes in nuclei were designed as fusion...

PEDF gene transfer suppresses angiogenesis and tumor growth.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- PEDF gene transfer suppresses angiogenesis and tumor growth. According to recent research from Spain, "pigment epithelium-derived factor (PEDF) was identified from retinal pigment epithelial cells...

The gef gene blocks the growth of breast cancer cells.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- The gef gene blocks the growth of breast cancer cells. According to recent research from Spain, "the gef gene has cell-killing functions in Escherichia coli. To evaluate the feasibility of using...

Binding sites for Lewis antigens are expressed by human colon cancer cells.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Binding sites for Lewis antigens are expressed by human colon cancer cells. "In colon cancer, endothelial cell selectins can promote tumor cell attachment via interactions with sialylated Lewis...

Different genetic pathways may exist in the development of colorectal adenomas.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Different genetic pathways may exist in the development of colorectal adenomas. According to recent research from Germany, "Cytogenetic changes are widely unknown for nonpolypoid (synonymously...

Human Spy1 promotes survival of mammalian cells following DNA damage.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Human Spy1 promotes survival of mammalian cells following DNA damage. "Speedy (Spy1) is a novel cell cycle regulator that binds and activates cdk2, and was originally identified as a suppressor of...

Primary duodenal carcinoma can show divergent growth patterns.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Primary duodenal carcinoma can show divergent growth patterns. "Primary duodenal adenocarcinoma accounts for less than 0.5% of all gastrointestinal cancers," scientists in the United States report....

Inflammatory pseudotumor due to clonal EBV-infected cells can occur in spleen.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Inflammatory pseudotumor due to clonal EBV-infected cells can occur in the spleen. According to a study from the United States, "We report a case of an inflammatory pseudotumor (IPT) of the spleen...

Tumor and drug-resistant genomes can be shaped by instability and selection.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Tumor and drug-resistant genomes can be shaped by instability and selection. According to a study from the United States, "Tumors with defects in mismatch repair (MMR) show fewer chromosomal changes...

Cyclin E is overexpressed and amplified in many different human tumor types.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Cyclin E is overexpressed and amplified in many different human tumor types. According to published research from Switzerland, "Cyclin E amplification and overexpression have recently been described...

Tumors with a high proliferation index have a poor prognosis.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Tumors with a high proliferation index have a poor prognosis. "Microarrays for gene expression profiling are rapidly becoming important research tools for the identification of novel markers, for...

ALG-2 may be a player in survival pathways in lung cancer.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- ALG-2 may be a player in survival pathways in lung cancer. According to a study from Denmark, "ALG-2 was isolated in a screen for proteins involved in programmed cell death and is the first...

Tumor-associated antigen L6 is involved in cancer invasion and metastasis.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Tumor-associated antigen L6 is involved in cancer invasion and metastasis. "Metastasis is a coordinated process that depends on the interaction of cancer cells with the tumor microenvironment,"...

Interferon-gamma suppresses S100A4 transcription.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Interferon-gamma suppresses S100A4 transcription. "The S100A4 protein has been associated with increased metastatic capacity of cancer cells, and recent studies have suggested a correlation between...

Autoschizis is the principal form of cell death from in vitro vitamins.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Autoschizis is the principal form of cell death from in vitro vitamins. According to a study from the United States, "Human ovarian carcinoma (MDAH 2774) cells were treated with sodium ascorbate...

Novel targets for aberrant methylation in pancreatic carcinoma found.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Novel targets for aberrant methylation in pancreatic carcinoma are found. "To identify potential targets for aberrant methylation in pancreatic cancer, we analyzed global changes in gene expression...

Beta-catenin induces hyperplasias and squamous transdifferentiation.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Beta-catenin induces hyperplasias and squamous transdifferentiation. "The Wnt/beta-catenin signaling pathway is critical for normal mammalian development, the specification of epidermal cells and...

Gene profiling and clinical data can predict prostate cancer recurrence.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Gene profiling and clinical data can predict prostate cancer recurrence. According to a study from Italy, "We show here that gene expression profiling, performed with conventional techniques and...

Rare MSR1 mutations related to increased prostate cancer in African-American men.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Rare MSR1 mutations are associated with increased prostate cancer in African-American men. "Both rare germ-line mutations and common sequence variants of the macrophage scavenger receptor 1 (MSR1)...

Truncated Bcl-2 may be a potential premetastatic marker in prostate cancer.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Truncated Bcl-2 may be a potential premetastatic marker in prostate cancer. "A novel truncated form of Bcl-2, termed Bcl-2psi, was discovered in invasive prostate cancer cells, using laser capture...

Identifying Rb function loss may help researchers understand tumor development.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Identifying Rb loss of function may help researchers understand tumor development. "The study of tumor suppressor gene function has been aided by the creation of discrete gene alterations in the...

Canarypox virus is a safe vector for use in human p53 cancer vaccine.
September 1, 2003... 2003 SEP 1 - (NewsRx.com & NewsRx.net) -- Canarypox virus is a safe vector for use in human p53 cancer vaccine. "Overexpression of p53 occurs in more than 50% of colorectal cancers. Therefore, p53 represents an attractive target antigen for...

Histone H2AX sensitizes glioma cells to genotoxic stimuli.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Histone H2AX sensitizes glioma cells to genotoxic stimuli. According to a study from Japan, "glioblastoma is a life-threatening tumor in the human brain despite the fact that radio-chemotherapy...

B7-1 localizes to specific sites upon particle-mediated gene transfer.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- B7-1 localizes to specific sites upon particle-mediated gene transfer. "The purpose of this study was to evaluate stable DNA transfection of M-21 human melanoma cells with particle-mediated gene...

Stat5 inhibition produces death in human prostate cancer cells.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Stat5 inhibition produces death in human prostate cancer cells. "Identifying regulators of prostate cancer cell survival may lead to new therapeutic strategies for prostate cancer. We now report...

Hypermethylation can selectively silence multiple promoters of steroid receptors.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Hypermethylation can selectively silence multiple promoters of steroid receptors. "Multiple promoters and differential splicing of 5' upstream exons are often found in various nuclear receptor genes...

The TARP promoter might control prostate cancer gene expression systems.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- The TARP promoter might control prostate cancer gene expression systems. According to recent research from Sweden, "TARP (T cell receptor gamma-chain alternate reading frame protein) is uniquely...

RUNX3 methylation is mostly cancer-specific, and may be a malignancy predictor.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- RUNX3 methylation is mostly cancer-specific, and may be a malignancy predictor. "According to recent research published in the journal Cancer Science, "Silencing of tumor suppressor and...

Drugs that target complex processes offer attractive target opportunities.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Drugs that target complex processes offer attractive target opportunities. According to published research from the United States, "The efficacy of conventional anticancer drugs is puzzling in view...

Carbonic anhydrases may inhibit tumor growth and invasion.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Carbonic anhydrases may inhibit tumor growth and invasion. "The carbonic anhydrases (CAs) comprise a family of evolutionarily ancient enzymes found ubiquitously in nature," investigators in England...

Study finds genetic origin of the familial aggregation of brain tumors.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Genetic origin of the familial aggregation of brain tumors found. "Our study investigated whether the familial aggregation of glioma is due to environmental or genetic effects and it investigated...

ADAM-9 mRNA and protein is expressed in human breast cancer.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- ADAM-9 mRNA and protein is expressed in human breast cancer. "The ADAMs (a disintegrin and metalloprotease) are membrane proteins containing both protease and adhesion domains and thus may be...

Bisphosphonates may protect against breast cancer-induced osteolysis.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Bisphosphonates may protect against breast cancer-induced osteolysis. "Bone tissue constitutes a fertile 'soil' for metastatic tumors, notably breast cancer. High concentrations of growth factors...

PI-3K/Akt might be a critical target molecule for anticancer intervention.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- PI-3K/Akt might be a critical target molecule for anticancer intervention. "Activated Ras utilizes several downstream pathways, including the mitogen-activated protein kinase (MAPK) kinase...

Resveratrol increases BRCA1 and BRCA2 mRNA expression in breast tumor cell lines.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Resveratrol increases BRCA1 and BRCA2 mRNA expression in breast tumor cell lines. "The phytochemical resveratrol, found in grapes, berries and peanuts, has been found to possess cancer...

The epithelial-mesenchymal transition regulates breast cancer metastasis.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- The epithelial-mesenchymal transition regulates breast cancer metastasis. "When carcinoma cells metastasize, they change their phenotype to enhance motility. Cells making this switch selectively...

Researchers suggest a link between aging and cancer.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Researchers suggest a link between aging and cancer. According to recent research published in the journal Mechanisms of Ageing and Development, "Development is a very robust but far from perfect...

Immigrant and ethnic populations lack information about genetic testing.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Immigrant and ethnic populations lack information about genetic testing for cancer risk. According to a study from the United States, "This study identified factors associated with awareness of...

Gene and prodrug therapy won't override ABCG2-mediated drug resistance.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Gene and prodrug therapy won't override ABCG2-mediated drug resistance. According to recent research published in the journal Molecular Pharmacology, "the recently introduced camptothecin-derived...

Diagnostic x rays, DNA repair genes, and childhood ALL need more study.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Diagnostic x rays, DNA repair genes, and childhood ALL need more study. According to a study from Canada, "A model for childhood leukemia proposes that characteristic chromosomal translocations can...

Heat sensitizes tumor cells, but not normal mucosa, to doxorubicin activity.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Heat sensitizes tumor cells, but not normal mucosa, to doxorubicin activity. According to recent research from Italy, "There is little information on the pharmacokinetics and pharmacodynamics of...

Folate and alcohol may be associated with changes in promoter hypermethylation.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Folate and alcohol may be associated with changes in promoter hypermethylation in colorectal cancer. According to recent research published in the journal Cancer Research, "Sporadic colorectal...

There is little evidence for MLH3 involvement in colorectal cancer predisposition.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- There is little evidence for involvement of MLH3 in colorectal cancer predisposition. According to recent research from Finland, "Mutations in the DNA MMR genes MSH2, MLH1, MSH6 and PMS2 underlie a...

p73 Protein has unique determinants for transactivation and growth suppression.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- p73 protein has unique determinants for transactivation and growth suppression. According to recent research published in the journal Oncogene, "p73, a p53 family member, is highly similar to p53 in...

Homozygous deletions scanning in tumor cell lines detect unsuspected loci.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Homozygous deletions scanning in tumor cell lines detect unsuspected loci. "High rates of loss of heterozygosity commonly affect multiple chromosomes in individual tumor types, yet the number of...

Werner syndrome protein limits MYC-induced cellular senescence.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Werner syndrome protein limits MYC-induced cellular senescence. "The MYC oncoprotein is a transcription factor that coordinates cell growth and division," scientists in the United States report....

DDTC-induced cytotoxicity is via oxidative shift in intracellular redox state.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Diethyldithiocarbamate-induced cytotoxicity is via an oxidative shift in the intracellular redox state. According to recent research from Japan, "Diethyldithiocarbamate (DDTC) has been shown to...

Reactive oxygen species are essential mediators in BTS-induced apoptosis.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Reactive oxygen species are essential mediators in BTS-induced apoptosis. "In this work, we describe the process of cell death induced by a series of new benzo(b)thiophenesulphonamide 1,1-dioxide...

Connexin 37 gene is not mutated in lung carcinomas 3LL and CMT.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Connexin 37 gene is not mutated in lung carcinomas 3LL and CMT. "Our previous studies have shown that intercellular communication mediated by gap junctions is impaired in most tumors as well as in...

Genetic alterations of lung cancer in relation to smoking, ethnicity discussed.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Genetic alterations of lung adenocarcinoma in relation to smoking and ethnicity are discussed. "Adenocarcinoma of the lung is now the most common histologic subtype of non-small-cell lung cancer...

Pro-gastrin-releasing peptide (ProGRP) can discriminate NSCLC versus SCLC.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Pro-gastrin-releasing peptide (ProGRP) can discriminate NSCLC versus SCLC. "The study presents data comparing the new tumor marker, ProGRP, with the established markers, NSE, CYFBA 21 -1 and CEA in...

TMSI methylation may play a role in the pathogenesis of lung and breast cancer.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- TMSI methylation may play a role in the pathogenesis of lung and breast cancer. "TMSI (target of methylation-induced silencing) is a CpG island-associated gene that functions in the regulation of...

Deregulated expression of BCL6 may allow lymphoma cells to resist chemotherapy.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Deregulated expression of BCL6 may allow lymphoma cells to resist chemotherapy. "Chromosomal translocations and somatic mutations occurring in the 5' noncoding region of the BCL6 gene, encoding a...

Reovirus prolongs survival and reduces spinal and leptomeningeal metastases.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Reovirus prolongs survival and reduces spinal and leptomeningeal metastases. "Medulloblastoma (MB), the most common pediatric brain tumor, is a highly malignant disease with a 5-year survival rate...

Betulinic acid can induce programmed cell death in human melanoma cells.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Betulinic acid can induce programmed cell death in human melanoma cells. "Betulinic acid, a naturally occurring triterpene found in the bark of the white birch tree, has been demonstrated to induce...

Ellipticine can rescue mutant p53 transcription function.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Ellipticine can rescue mutant p53 transcription function. "The p53 tumor suppressor is frequently inactivated in tumors by point mutations in the DNA-binding domain, resulting in loss of...

Epigenetic change in body fluids could be screen for nasopharyngeal carcinoma.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Epigenetic change in body fluids could be screen for nasopharyngeal carcinoma. "The purpose of our study was to evaluate the frequency of hypermethylated tumor suppressor genes (TSGs) in peripheral...

Ovarian carcinoma develops through multiple modes of chromosomal evolution.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Ovarian carcinoma develops through multiple modes of chromosomal evolution. "Ovarian carcinoma has the highest mortality of all of the gynecologic cancers. The chromosomal changes in this tumor type...

Farnesyltransferase inhibitors are well tolerated.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Farnesyltransferase inhibitors are well tolerated in advanced pancreatic cancer. According to published research from Germany, "Ras oncogenes (K-, H- and N-ras) are known to be involved in signal...

Researchers discuss the role of Smad4 (DPC4) inactivation in human cancer.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Researchers discuss the role of Smad4 (DPC4) inactivation in human cancer. "The tumor suppressor gene Smad4 (DPC4) at chromosome 18q21.1 belongs to the Smad family, which mediates the TGFbeta...

Prostate cancer is a dynamic illness with shifting targets.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Prostate cancer is a dynamic illness with shifting targets. "Despite high response rates and palliative clinical benefits, androgen ablation does not cure advanced prostate cancer because of the...

Polymorphisms of the ERalpha gene may be associated with renal cell cancer.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Polymorphisms of the ERalpha gene may be associated with renal cell cancer. "Renal cell carcinoma is the most common form of kidney cancer. However, the genetic basis of renal cancer is not fully...

bHLH-LZ subfamily may be critical in regulating (aberrant) renal cellular growth.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- bHLH-LZ subfamily may be critical in regulating (aberrant) renal cellular growth. According to recent research published in the journal Human Molecular Genetics, "The MITF/TFE subfamily of basic...

Parents of children with solid tumors have slightly increased incident cancer.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Parents of children with solid tumors have slightly increased incident cancer. "The purpose is to determine cancer incidence and mortality from all causes among parents of children with solid tumors...

Researchers identify some novel biomarkers for cutaneous disease.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Researchers identify some novel biomarkers for cutaneous squamous cell carcinoma. "Squamous cell carcinoma (SCC) is the second most common form of skin cancer in Caucasians. Here we report on the...

Recombinant expression of 1-8U in human cell lines can block cell proliferation.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- Recombinant expression of 1-8U in human cell lines can block cell proliferation. "Interferon (IFN)-inducible proteins of the 1-8 gene family mediate homotypic adhesion and transduction of...

The marmoset can be incorporated into preclinical gene therapy trials.
September 8, 2003... 2003 SEP 8 - (NewsRx.com & NewsRx.net) -- The marmoset can be incorporated into preclinical gene therapy trials. According to recent research from the United States, "the owl monkey (Aotus trivirgatus) has served as the standard non-human...

Systemic gene delivery lessens pathology in an orthotopic bladder cancer model.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- Systemic gene delivery lessens pathology in an orthotopic bladder cancer model. According to recent research from the United States, "successful systemic gene therapy has been hindered by...

Gene therapy containing p21 inhibits androgen-dependent and independent cancers.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- Gene therapy containing p21 inhibits androgen-dependent and independent cancers. According to recent research from Japan, "to assess the potential of p21 as a gene therapy treatment for prostate...

Downstream-regulated gene 2 inhibits glioblastoma cell growth.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- Downstream-regulated gene 2 inhibits glioblastoma cell growth. "The most severe form of brain glioma, glioblastoma (GBM), is highly malignant and usually resistant to chemotherapy. Therefore,...

Estradiol enhances tumor regression in breast cancer models given gene therapy.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- Estradiol enhances tumor regression in breast cancer models given gene therapy. "The majority of breast cancers are estrogen dependent and although current treatment strategies have improved,...

Gene silencing points to zinc finger protein 185 in prostate cancer pathology.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- Gene silencing points to zinc finger protein 185 in prostate cancer pathology. "We profiled the expression of genes in benign and untreated human prostate cancer tissues using oligonucleotide...

Melanoma cells normally tolerant to endogenous p53 respond to p53 transduction.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- Melanoma cells normally tolerant to endogenous p53 respond to p53 transduction. "Malignant melanomas are frequently characterized by elevated levels of wild-type p53, suggesting that p53 function...

Aggressive breast tumors have a reduced level of delta-6-desaturase.
September 15, 2003... 2003 SEP 15 - (NewsRx.com & NewsRx.net) -- Aggressive breast tumors have a reduced level of delta-6-desaturase. According to recent research published in the International Journal of Molecular Medicine, "Highly unsaturated fatty acids...