Cancer Gene Therapy Week articles from October 2008

Cancer Gene Therapy Week archives from October 2008

A new therapeutic option for human hepatocyte cancer.
October 6, 2008... p53-impaired tumors may be particularly suitable to parvovirus H-1-induced therapy. Although the p53 deficiency in tumors may induce resistance to chemotherapeutic agents, this will not affect the tumor cell susceptibility to H-1 PV-induced...

Studies in the area of cancer gene therapy reported from P. Yu and co-researchers.
October 6, 2008... "Metastatic diseases cause the majority of morbidity and mortality of cancer patients. Established tumors form both physical and immunological barriers to limit immune detection and destruction," scientists in the United States report (see also...

Study findings from Columbus Children's Hospital broaden understanding of HIV/AIDS.
October 6, 2008... According to a study from the United States, "The host factor a isoform of the tripartite motif 5 (TRIM5 alpha) restricts human immunodeficiency virus type 1 (HIV-1) infection in certain non-human primate species. Restriction of HIV-1 is...

Institute for Digestive Medicine details research in cancer gene therapy.(Report)
October 6, 2008... A report, 'AAV-HGFK1 and Ad-p53 cocktail therapy prolongs survival of mice with colon cancer,' is newly published data in Molecular Cancer Therapeutics. "This study tried to evaluate the application of a novel cancer gene therapy using...

Reports outline cancer gene therapy research from Seoul National University, Department of Biology.
October 6, 2008... Current study results from the report, 'ATR-dependent activation of p38 MAP kinase is responsible for apoptotic cell death in cells depleted of Cdc7,' have been published. According to a study from Seoul, Korea, "Cdc7 is a serine/threonine...

Research reports from Translational Genomics Research Institute provide new insights into cancer gene therapy.
October 6, 2008... Current study results from the report, 'Gene expression profiling-based identification of cell-surface targets for developing multimeric ligands in pancreatic cancer,' have been published. According to recent research published in the journal...

Research results from Queen's University, Center for Cancer Research and Cell Biology update knowledge of cancer gene therapy.(Report)
October 6, 2008... New research, 'Interleukin-8 signaling attenuates TRAIL- and chemotherapy-induced apoptosis through transcriptional regulation of c-FLIP in prostate cancer cells,' is the subject of a report. According to recent research published in the...

Researchers at Chang-Gung University, Institute of Biomedical Science target cancer gene therapy.
October 6, 2008... Fresh data on cancer gene therapy are presented in the report 'Glucose-regulated protein 78 regulates multiple malignant phenotypes in head and neck cancer and may serve as a molecular target of therapeutic intervention.' "Glucose-regulated...

Studies from Kyoto University in the area of cancer gene therapy published.(Report)
October 6, 2008... Research findings, 'Administration of PLK-1 small interfering RNA with atelocollagen prevents the growth of liver metastases of lung cancer,' are discussed in a new report. "Liver metastasis is one of the most important prognostic factors in...

Mount Sinai School of Medicine publishes research in life sciences.(Report)
October 6, 2008... Research findings, 'The administration of IL-12/GM-CSF and Ig-4-1BB ligand markedly decreases murine floor of mouth squamous cell cancer,' are discussed in a new report. According to a study from the United States, "To assess immune-based gene...

Researchers from Dongguk University, Department of Biochemistry discuss findings in life sciences.
October 6, 2008... New investigation results, 'Combination therapy and noninvasive imaging with a dual therapeutic vector expressing MDR1 short hairpin RNA and a sodium iodide symporter,' are detailed in a study published in Journal of Nuclear Medicine. "We...

New Report on 633 Biotechnology Medicines Under Development Released in Michigan.(Clinical report)
October 6, 2008... As the nation combats an alarming rise in chronic diseases, the Pharmaceutical Research and Manufacturers of America (PhRMA) released a new report on the next generation of medicines in research pipelines that offer hope to millions of patients...

Genzyme Marks Grand Opening of New Science Center; Among the First Research Laboratories to Earn Gold LEED Rating.
October 6, 2008... Genzyme Corp. (Nasdaq:GENZ) today marked the grand opening of its new Science Center in Framingham, Mass. The facility serves as a central site for early stage research, where scientists are utilizing the most advanced technologies available to...

New approach to gene therapy may shrink brain tumors, prevent their spread.
October 13, 2008... Massachusetts General Hospital (MGH) researchers are investigating a new approach to gene therapy for brain tumors u delivering a cancer-fighting gene to normal brain tissue around the tumor to keep it from spreading. An animal study published...

A promising anti-cancer compound.
October 13, 2008... New approaches in cancer therapy that facilitate selective targeting of cancers have been emerging in recent years. Apoptin represents a new anti-cancer tool in such new approaches with great potentials. Two routes can be taken using Apoptin or...

Studies from M.M.B. Rodriguez et al add new findings in the area of cancer gene therapy.(Report)
October 13, 2008... "Most hepatocellular carcinomas (HCCs) express oncofetal alpha-fetoprotein (AFP). We and others have demonstrated efficient tumor control mediated by cellular immune responses in mice bearing subcutaneous tumors derived from the AFP-expressing...

Data on DNA research discussed by researchers at University of Pittsburgh.
October 13, 2008... According to recent research from the United States, "Overexpression of N-methylpurine DNA glycosylase (MPG) has been suggested as a possible gene therapy approach to sensitize tumor cells to the cell-killing effects of temozolomide, an...

Researchers from Catholic University, Cell Therapy Center provide details of new studies and findings in the area of gene therapy.
October 13, 2008... "Low in vivo transduction efficiency and safety concerns have been hurdles for effective hematopoietic stem cell (HSC) gene therapy. Here, we investigate whether the safety and efficiency of retroviral gene transfer into HSCs can be improved by...

Investigators at University of Ulm publish new data on leukemia gene therapy.
October 13, 2008... "5-Iodo-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) uracil (FIAU) has been used for non-invasive monitoring of gene therapy and as an antiviral agent experimentally and in patients. However, FIAU metabolism in tumor cells is largely unknown,"...

Study results from Indiana University, Medical Department provide new insights into leukemia gene therapy.
October 13, 2008... According to a study from the United States, "Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising cancer therapeutic because of its highly selective apoptosis-inducing action on neoplastic versus normal cells....

Research from Mayo Clinic provides new data on measles.
October 13, 2008... "Gliomas have a dismal prognosis, with the median survival of patients with the most common histology, glioblastoma multiforme, being only 12-15 months. Development of novel therapeutic agents is urgently needed," investigators in the United...

New vaccine efficacy data have been reported by B. Cipriani and co-authors.(Report)
October 13, 2008... "The aim of this study was to evaluate the efficacy of genetic vaccination with rat ErbB2 antigen in a therapeutic setting for the BALB-neuT mouse model of mammary carcinoma and to establish immunological correlates with vaccine efficacy. To...

New findings reported from Medical University of Vienna describe advances in cancer gene therapy.(Report)
October 13, 2008... Research findings, 'Potential involvement of MYC- and p53-related pathways in tumorigenesis in human oral squamous cell carcinoma revealed by proteomic analysis,' are discussed in a new report. "Oral squamous cellular carcinoma is a malignant...

Research from Fourth Military Medical University, State Key Laboratory of Cancer Biology and Institute of Digestive Disease yields new findings on cancer gene therapy.(Report)
October 13, 2008... A new study, 'The inhibitory effect of p75 neurotrophin receptor on growth of human hepatocellular carcinoma cells,' is now available. "p75 neurotrophin receptor (p75NTR), a member of the TNF receptor superfamily, is a focus for study at...

Studies from University of Kuopio, Department of Pharmaceutics reveal new findings on cancer gene therapy.(Report)
October 13, 2008... Investigators publish new data in the report 'Three-step tumor targeting of paclitaxel using biotinylated PLA-PEG nanoparticles and avidin-biotin technology: Formulation development and in vitro anticancer activity.' According to a study from...

New glioblastoma gene therapy research has been reported by scientists at Virginia Commonwealth University.
October 13, 2008... Fresh data on glioblastoma are presented in the report 'Sphingosine-1-phosphate and interleukin-1 independently regulate plasminogen activator inhibitor-1 and urokinase-type plasminogen activator receptor expression in glioblastoma cells:...

New findings from Johns Hopkins University, Medical Department in the area of cancer gene therapy published.
October 20, 2008... "Multimodality treatments that combine conventional cancer therapies with antigen- specific immunotherapy have emerged as promising approaches for the control of cancer. In the current study, we have explored the effect of doxorubicin on the...

Researchers from Hiroshima University report on findings in cancer gene therapy.(Report)
October 20, 2008... According to recent research from Japan, "This study was undertaken to investigate the radiosensitizing effects of fibroblast growth factor receptor 2IIIb (FGFR2IIIb) in androgen-independent human prostate carcinoma PC-3 cells devoid of...

Researchers from University of Texas detail new studies and findings in the area of cancer gene therapy.
October 20, 2008... According to a study from the United States, "We have reported that a gene therapy approach, using a dominant-negative estrogen receptor blocker (DN) gene, can cause cell death in cervical cancer cells in vitro. We investigated the mechanisms...

Research data from F. Benjelloun and colleagues update understanding of gene therapy.(Report)
October 20, 2008... According to a study from Paris, France, "Patients with mutations in the Artemis gene display a complete absence of T-and B lymphocytes, together with increased cellular radiosensitivity; this leads to a radiosensitive severe combined...

Research from Okayama University provides new data on gene therapy.
October 20, 2008... According to a study from Okayama, Japan, "Gene therapy and virotherapy are one of the approaches used to treat malignant pleural mesothelioma. To improve the efficiency of targeting malignant mesothelioma cells-, we designed a novel system...

Keio University describes research in cancer gene therapy.
October 20, 2008... Scientists discuss in 'Expression of heparanase in renal cell carcinomas: implications for tumor invasion and prognosis' new findings in cancer gene therapy. According to recent research published in the journal Clinical Cancer Research,...

Recent studies from Queen Mary's School of Medicine and Dentistry add new data to cancer gene therapy.
October 20, 2008... Data detailed in 'Therapeutic potential of replication-selective oncolytic adenoviruses on cells from familial and sporadic desmoid tumors' have been presented. According to recent research from London, the United Kingdom, "Constitutive...

Research from Stanford University in cancer gene therapy provides new insights.(Report)
October 20, 2008... Scientists discuss in 'Multimodality imaging of IL-18--binding protein-Fc therapy of experimental lung metastasis' new findings in cancer gene therapy. According to recent research published in the journal Clinical Cancer Research, "Interleukin...

Scientists at University of Oviedo publish research in cancer gene therapy.
October 20, 2008... Data detailed in 'The TP53 Arg72Pro polymorphism and lung cancer risk in a population of Northern Spain' have been presented. "Polymorphisms in tumor suppressor genes might contribute to the individual susceptibility to develop different types...

Tokyo Medical University, Department of Urology details research in cancer gene therapy.(Report)
October 20, 2008... New investigation results, 'Effects of a KiSS-1 peptide, a metastasis suppressor gene, on the invasive ability of renal cell carcinoma cells through a modulation of a matrix metalloproteinase 2 expression,' are detailed in a study published in...

Investigators at University of Michigan release new data on cancer gene therapy.(Report)
October 27, 2008... "Antiangiogenic therapies have shown varying results partly because each tumor type secretes a distinct panel of angiogenic factors to sustain its own microvascular network. In addition, recent evidence demonstrated that tumors develop...

Reports summarize cancer gene therapy study results from Soochow University.
October 27, 2008... According to a study from Suzhou, People's Republic of China, "Interleukin-24 (IL-24) has been shown to be a tumor-suppressor gene and the protein product found to be constitutively expressed by melanocytes, nerve cells, and some primary...

Research from Fourth Military Medical University in the area of cancer gene therapy described.(Report)
October 27, 2008... " Resistance to chemotherapy is a major cause of treatment failure and poor prognosis in pancreatic carcinoma. Myeloid cell leukemia-1 (Mcl-1) is highly up-regulated in pancreatic carcinoma and is associated with the anti-apoptosis and the...

Research from Johns Hopkins University, Medical Department provide new insights into cancer gene therapy.
October 27, 2008... According to recent research from the United States, "We have developed a hypoxia-inducible gene therapy approach for the expression of the mature form of human endonuclease G to facilitate cell death in hypoxic regions of the tumor. The...

Research reports on cancer gene therapy from University of Sao Paulo provide new insights.(Report)
October 27, 2008... According to a study from Sao Paulo, Brazil, "Considering that mycobacterial heat-shock protein 65 (hsp65) gene transfer can elicit a profound antitumoral effect, this study aimed to establish the safety, maximum-tolerated dose (MTD) and...

Researchers from Kanazawa University, Cancer Research Institute describe findings in apoptosis gene therapy.
October 27, 2008... Current study results from the report, 'Tumor cell apoptosis induces tumor-specific immunity in a CC chemokine receptor 1- and 5-dependent manner in mice,' have been published. "The first step in the generation of tumor immunity is the...

Data on cancer gene therapy discussed by researchers at Dongguk University, Department of Physiology.
October 27, 2008... Current study results from the report, 'Hepatocellular carcinoma-related gene targeting using the large circular antisense library,' have been published. According to recent research from Korea, "The large circular (LC)-antisense library to the...

Data on cancer gene therapy reported by researchers at Ehime University.(Report)
October 27, 2008... Scientists discuss in 'Stat3 as a molecular target in RNA interference-based treatment of oral squamous cell carcinoma' new findings in cancer gene therapy. "Constitutive activation of signal transducer and activator of transcription 3 (Stat3)...

New cancer gene therapy research from Wuhan University, Center for Medical Research described.(Report)
October 27, 2008... Current study results from the report, 'Positive regulation of migration and invasion by vasodilator-stimulated phosphoprotein via Rac1 pathway in human breast cancer cells,' have been published. According to a study from Hubei, People's...

Study results from S. Toffanin et al provide new insights into cancer gene therapy.
October 27, 2008... Fresh data on cancer gene therapy are presented in the report 'Clusterin: a potential target for improving response to antiestrogens.' "Antiestrogens represent the first line of therapy in the treatment of estrogen receptor-positive (ER+)...

Reports outline life sciences research from Asthma and Allergy Center.
October 27, 2008... Fresh data on life sciences are presented in the report 'Histamine-releasing factor/translationally controlled tumor protein (HRF/TCTP)-induced histamine release is enhanced with SHIP-1 knockdown in cultured human mast cell and basophil...

Study results from M. Debba-Pavard and colleagues in the area of telomerase published.
October 27, 2008... A report, 'Vaccination against Marek's disease reduces telomerase activity and viral gene transcription in peripheral blood leukocytes from challenged chickens,' is newly published data in Vaccine. "We investigated whether telomerase activity...

Regenerative Meds Future & Floridas Connection.
October 27, 2008... As body parts (albeit fake plastic ones) adorn the outside of homes, decorate parties and give kids some laughs and scares in preparation for Halloween, Florida experts from both the corporate world and new and specialized industry institutes...

Cyto Pulse, the Karolinska Institute and Uppsala University Hospital Receive Approval from the Swedish Medical Products Agency to Start a Clinical Trial Using a Xenogenic PSA DNA Vaccine.
October 27, 2008... Cyto Pulse Sciences, a leading producer of electric field based, intradermal DNA Vaccine delivery systems, announced approval by Swedish regulatory authorities to begin a Phase I/II study of DNA vaccination in patients with recurring prostate...