Cancer Gene Therapy Week articles from October 2003

Cancer Gene Therapy Week archives from October 2003

PTEN gene therapy suppresses tumor growth and sensitizes cells to doxorubicin.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- PTEN gene therapy suppresses tumor growth and sensitizes cells to doxorubicin. "The PTEN gene, located on chromosome 10, is a phosphatase in the phosphatidylinositol 3'-kinase (PI3'K)-mediated...

External controllers would improve the efficacy of cancer gene therapy.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- External controllers would improve the efficacy of cancer gene therapy. According to recent research from Germany, "the use of restricted replication-competent adenoviruses (RRCAs) inducing tumor...

Forced expression of early growth response factor-1 generates apoptosis.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Forced expression of early growth response factor-1 generates apoptosis. "Early growth response factor-1 (EGR-1) is an immediate early gene, which is rapidly activated in quiescent cells by mitogens...

Gadd45 gamma expression is reduced in anaplastic thyroid cancer.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Gadd45 gamma expression is reduced in anaplastic thyroid cancer. "Anaplastic thyroid carcinomas are a highly aggressive and extremely lethal form of human cancer, but the biological characteristics...

Lung cancer vaccines yield promising results in clinical trials.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Lung cancer vaccines are yielding promising results in clinical trials. "A number of cancer vaccine and gene therapy approaches are being evaluated in patients with lung cancer. Cancer vaccine...

Tumor-specific gene therapy diminishes thyroid cancers without adverse effects.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Tumor-specific gene therapy diminishes thyroid cancers without adverse effects. According to a study from Japan, "a tumor-specific targeting system for cancer gene therapy was studied using the...

Functional FAS promoter polymorphisms are associated with increased risk of AML.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Functional FAS promoter polymorphisms are associated with increased risk of AML. "The FAS (TNFRSF6/CD95/APO-1) gene is silenced in many tumor types, resulting in an inability to respond to...

Company announces discovery of positively charged cardiolipin.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- NeoPharm, Inc., (NEOL) announced that it has discovered new analogs of cationic (positively charged) cardiolipin for use in the company's NeoLipid liposomal system. Results were presented via...

Novel mechanisms of apoptosis induced by histone deacetylase inhibitors.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Novel mechanisms of apoptosis can be induced by histone deacetylase inhibitors. "Histone deacetylase inhibitors (HDACIs) are a new class of chemotherapeutic drugs able to induce tumor cell apoptosis...

PS-341 enhances TRAIL-induced apoptosis by increasing the cleavage of caspase 8.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- PS-341 enhances TRAIL-induced apoptosis by increasing the cleavage of caspase 8. "We demonstrate that PS-341, a small molecule inhibitor of the proteasome, markedly sensitizes resistant prostate,...

Pifithrin-alpha promotes p53-mediated apoptosis in JB6 cells.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Pifithrin-alpha promotes p53-mediated apoptosis in JB6 cells. According to recent research from the United States, "Recently, blockage of p53-dependent transcriptional activation and apoptosis by...

BMI and c-erbB-2 expression may be risk factors for contralateral breast cancer.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- BMI and c-erbB-2 expression may be risk factors for contralateral breast cancer. According to published research from the United States, "Women diagnosed with a first breast cancer before the age of...

Brk promotes breast carcinoma cell proliferation.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Brk promotes breast carcinoma cell proliferation. "Brk (PTK6) is a nonreceptor protein tyrosine kinase, which is expressed in over 60% of breast carcinoma tissue samples and breast tumor cell...

Malathion alters cell adhesion of cultured breast carcinoma cells.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Malathion alters cell adhesion of cultured breast carcinoma cells. "We have studied the effects of the organophosphorous pesticide malathion on cell viability, actin cytoskeleton, cell adhesion...

cDNA microarray profiling identifies 5-fluorouracil-inducible target genes.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- cDNA microarray profiling identifies 5-fluorouracil-inducible target genes. According to a study from Northern Ireland, "The fluoropyrimidine 5-Fluorouracil (5-FU) is widely used in the treatment...

Sodium salicylate may be used to protect cells against deleterious stressors.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Sodium salicylate may be used to protect cells against deleterious stressors. According to recent research published in the European Journal of Biochemistry, "As heat shock proteins (Hsps) are...

Chromosomal instability is an early driving force of cancer progression.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Chromosomal instability is an early driving force of cancer progression. According to published research from the United States, "In this paper, we derive analytic solutions of stochastic...

Lysophosphatidic acid signaling has role in cancer progression.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Lysophosphatidic acid signaling has role in cancer progression. According to a study from the United States, "Lysophosphatidic acid (LPA) promotes growth, differentiation, survival and motility in...

New data presented on 1D09C3 in combination with rituxan.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- GPC Biotech, AG, (GPC) announced that promising new data on its anticancer monoclonal antibody, 1D09C3, were presented at the Biotherapy Development Association's Seventh International Meeting and First...

P16 inactivation may be associated with development of uterine cervical cancers.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- P16 inactivation may be associated with development of uterine cervical cancers. According to recent research from India, "In our analysis, alterations in the P16 tumor suppressor gene were seen in...

A low but significant number of colorectal carcinomas are positive for EMR2.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- A low but significant number of colorectal carcinomas are positive for EMR2. "EMR2 and CD97, members of the epidermal growth factor (EGF)-TM7 family, show a very high homology. CD97, whose...

Detection of hepatic disseminated tumor cells is a powerful prognostic factor.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Detection of hepatic disseminated tumor cells is a powerful prognostic factor. According to a study from Germany, "Approximately 30-50% of all colorectal cancer patients with a resectable primary...

Function of APC may be regulation of caspase activity, other apoptotic proteins.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- One of the functions of adenomatous polyposis coli (APC) may be the regulation of caspase activity and other apoptotic proteins. "The adenomatous polyposis coli gene, a member of the WNT pathway,...

PEITC may play an important role in cancer cell killing.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- PEITC may play an important role in the killing of cancerous cells. According to a study from the United States, "Phenethyl isothiocyanate (PEITC) is a potential chemopreventive agent that is...

CRAC1 is unlikely to be implicated in the development of colorectal cancer.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- CRAC1 is unlikely to be implicated in the development of colorectal cancer. "A susceptibility gene to colorectal adenomas and carcinoma (CRAC1) on chromosome region 15q14 similar to q22 has been...

Peptide mass signature genotyping can detect TP53 mutations in tumor DNA.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Peptide mass signature genotyping can detect TP53 mutations in tumor DNA. According to a study from the United States, "This report describes the application of a new approach to tumor genotyping...

Biotechnology and pharmaceutical companies co-developing new anticancer drug.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- OncoGenex Technologies, Inc., and Isis Pharmaceuticals, Inc., (ISIS) have expanded their antisense drug development partnership to include the development of the second-generation antisense anticancer...

Akt may have a pivotal role in regulating endometrial cancer cell survival.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Akt may have a pivotal role in regulating endometrial cancer cell survival. "In a number of different cancers including endometrial cancers, tumor suppressor phosphatase tensin homologue (PTEN, a...

Insensitivity to growth suppression signals might be a mechanism of cell immortality.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Insensitivity to the usual growth suppression signals induced by activin A might be one of the mechanisms of immortality of human endometrial adenocarcinoma cells. "Menstrual cycle-dependent...

PBR-specific ligands cause apoptosis and cell-cycle arrest.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- PBR-specific ligands cause apoptosis and cell-cycle arrest. "Specific ligands of the peripheral benzodiazepine receptor (PBR) are known to induce apoptosis and cell cycle arrest in esophageal...

H. pylori increases proteasome-mediated degradation of p27(Kip1).
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- H. pylori increases proteasome-mediated degradation of p27(Kip1). According to published research from the United States, "Helicobacter pylori infection is associated with increased gastric...

Activation of transcription factors may contribute to stomach cancer development.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Inappropriate activation of intestine-specific transcription factors could contribute to the occurrence of the intestinal-type cancer of the stomach. According to recent research from Japan,...

Telomere dysfunction could contribute to genomic instability in human tumors.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Telomere dysfunction could contribute to genomic instability in human tumors. According to recent research from the United States, "Tumor growth is an evolutionary process that is characterized by...

PEITC potently induces apoptosis and cell-cycle arrest in HepG2 cells.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Beta-phenylethyl isothiocyanate (PEITC) potently induces apoptosis and cell-cycle arrest in HepG2 cells. "Beta-phenylethyl isothiocyanate (PEITC) is a promising chemoprotective compound that is...

Oncogenic transformation by BK virus may lead to human tumors.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Oncogenic transformation by BK virus may lead to human tumors. According to a study from Italy, "BK virus (BKV), a human polyomavirus closely related to JC virus and Simian Virus 40, is ubiquitous...

Anthocyanidins induce apoptosis in human promyelocytic leukemia cells.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Anthocyanidins induce apoptosis in human promyelocytic leukemia cells. According to recent research published in the International Journal of Oncology, "Anthocyanidins are the aglycon nucleuses of...

p15 Methylation has a poor prognostic impact on disease-free survival.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- p15 Methylation has a poor prognostic impact on disease-free survival in leukemia. According to recent research from the People's Republic of China, "Acute promyelocytic leukemia (APL) has distinct...

Loss of PDCD4 expression correlates with tumor progression and prognosis.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Loss of PDCD4 expression correlates with tumor progression and prognosis. According to recent research from Germany, "The programmed cell death 4 gene (PDCD4), a newly identified transformation...

Low levels of chromium(VI) selectively activates Src family kinases, JNK.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Low levels of chromium(VI) selectively activate Src family kinases and JNK. According to published research from the United States, "Inhaled hexavalent chromium (Cr(VI)) promotes pulmonary disease...

Mutation of the BIK gene is a frequent feature of B-cell lymphomas.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Mutation of the BIK gene is a frequent feature of B-cell lymphomas. According to recent research published in the journal Genes Chromosomes & Cancer, "BIK, a BH (Bcl2 homology domain)3-only...

Oncolytic adenovirus may accelerate radiation-induced tumor fibrosis.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Oncolytic adenovirus may accelerate radiation-induced tumor fibrosis. According to a study from France, "In spite of aggressive surgery, irradiation and/or chemotherapy, treatment of malignant...

Imatinib may inhibit the growth-promoting role of wild-type ckit.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Imatinib may inhibit the growth-promoting role of wild-type ckit. "Imatinib has shown to be effective against malignant disease driven by ckit," scientists writing in the journal Lancet report. ...

Both products of the mouse Ink4a/Arf locus suppress melanoma formation in vivo.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Both products of the mouse Ink4a/Arf locus suppress melanoma formation in vivo. "Deletion of the INK4a/ARF locus at 9p21 is detected with high frequency in human melanoma. Within a short genomic...

Knowledge of genetics has generated optimism for prevention program development.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- The ability to validate pathogenetic relevance of mutations in the mouse has generated optimism for development of effective prevention programs, diagnostic measures and targeted therapeutics. ...

Wnt signaling plays a role in the pathogenesis of mesothelioma.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Wnt signaling plays a role in the pathogenesis of mesothelioma. "Malignant pleural mesothelioma is a relatively uncommon and yet incurable tumor. The pathogenesis of mesothelioma remains poorly...

Hypoxia-inducible VEGF gene delivery may treat ischemic heart disease.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Hypoxia-inducible VEGF gene delivery may treat ischemic heart disease. "Therapeutic angiogenesis with gene encoding vascular endothelial growth factor (VEGF) is a new potential treatment in...

TRAF2 controls cell sensitivity to apoptosis.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- TRAF2 controls cell sensitivity to apoptosis. According to recent research published in the journal Molecular and Cellular Biology, "Tumor necrosis factor receptor (TNFR)-associated factor 2...

P/CAF and GCN5 acetylate the AML1/MDS1/EVI1 fusion oncoprotein.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- P/CAF and GCN5 acetylate the AML1/MDS1/EVI1 fusion oncoprotein. "Lysine acetyltransferases modulate the activity of many genes by modifying the lysine residues of both core histones and...

SCCA, EGFR mRNA may be available as markers of circulating cancer cell detection.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Squamous cell carcinoma antigen (SCCA) and epidermal growth factor receptor (EGFR) mRNA may be available as markers of circulating cancer cell detection. "Oral squamous cell carcinoma (OSCC) cells...

FDA gives orphan drug approval to REXIN-G.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Epeius Biotechnologies Corp. announced that the U.S. Food and Drug Administration (FDA) has approved REXIN-G, the first tumor-targeted injectable gene therapy vector, as an orphan drug for pancreatic...

Bombesin may act as a mitogen in prostate cancer.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Bombesin may act as a mitogen in prostate cancer. "Bombesin and its mammalian homologue gastrin-releasing peptide have been shown to be highly expressed and secreted by neuroendocrine cells in...

Cdc37 is necessary for normal human prostate epithelial cell survival.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Cdc37 is necessary for normal human prostate epithelial cell survival. According to published research from the United States, "Cdc37 is a co-chaperone protein that recruits several immature client...

Grape seed extract may be an effective therapeutic agent for prostate cancer.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Grape seed extract may be an effective therapeutic agent in prostate cancer. According to a study from the United States, "The alarmingly high rate of prostate cancer (PCA) mortality as well as the...

Polymorphism in codon 10 of ERalpha may be a risk factor for prostate cancer.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Polymorphism in codon 10 of ERalpha may be a risk factor for prostate cancer. "Estrogen receptor (ER) polymorphisms have been shown to be involved in the oncogenesis of several organs. We...

U19 suppresses prostate tumor growth.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- U19 suppresses prostate tumor growth. According to recent research published in the journal Cancer Research, "Androgens control prostate homeostasis and regulate androgen response genes. ...

SUMO-1/Ubc9 promotes nuclear accumulation and metabolic stability Smad4.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- SUMO-1/Ubc9 promotes nuclear accumulation and metabolic stability Smad4. According to a study from the United States, "Tumor suppressor Smad4/DPC4 is a central intracellular signal transducer for...

Analysis of differentiation therapy might provide targeted molecules for therapy.
October 6, 2003... 2003 OCT 6 - (NewsRx.com & NewsRx.net) -- Analysis of molecular mechanisms of tumor differentiation therapy by vesnarinone might provide selective and targeted molecules for novel tumor dormancy therapy. According to a study from Japan,...

An autocrine loop controls angiogenic growth factors in pancreatic cancer.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- An autocrine loop controls angiogenic growth factors in pancreatic cancer. "Activation of the insulin-like growth factor-I receptor (IGF-IR) was recently shown to modulate angiogenesis by...

Gene expression mechanisms enhance magnetic resonance images of prostate cancer.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Gene expression mechanisms enhance magnetic resonance images of prostate cancer. According to published research from Germany, "the term 'molecular imaging' can be broadly defined as the in vivo...

CARP-1 is a novel regulator of retinoids that diminish cancer.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- CARP-1 is a novel regulator of retinoids that diminish cancer. "CD437, a novel retinoid, causes cell cycle arrest and apoptosis in a number of cancer cells including human breast carcinoma (HBC)...

Liposomal conjugation improves adenoviral transduction of squamous cell cancer.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Liposomal conjugation improves adenoviral transduction of squamous cell cancer. According to a study from Japan, "adenovirus (Ad) vectors are commonly used in gene therapy trials because of their...

Oligonucleotide-based microarrays characterize the gene profile of brain tumors.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Oligonucleotide-based microarrays characterize the gene profile of brain tumors. "Diffuse astrocytoma of World Health Organization (WHO) grade H has an inherent tendency to spontaneously progress...

Nonradioactive iodide stimulates apoptosis in genetically modified cancer cells.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Nonradioactive iodide stimulates apoptosis in genetically modified cancer cells. "We assessed a nonradioactive approach to induce apoptosis in non-small cell lung cancer by a novel iodide uptake...

TRF-1 expression level may have prognostic value in adrenal tumors.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- The level of TRF-1 expression may have prognostic value in adrenal tumors. According to a study from the United States, "It is often difficult to distinguish histologically between an adrenal...

Inactivation of KLF4 is one of the frequent steps toward bladder carcinogenesis.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Inactivation of KLF4 is one of the frequent steps toward bladder carcinogenesis. "Kruppel-like factors (KLFs) are key transcriptional regulators of cell differentiation and proliferation. Among the...

Patients with preserved nuclear myopodin expression survived longer.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Bladder cancer patients with preserved nuclear myopodin expression survived longer. According to recent research from the United States, "Myopodin is a dual compartment protein that displays...

Polymerase chain reaction has use in urinary diagnosis of bladder cancer.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Polymerase chain reaction has use in the urinary diagnosis of bladder cancer. According to a study from Germany, "The polymerase chain reaction (PCR) is a highly sensitive and specific method for...

p73 in neuroblastoma may have oncosupressor, oncogenic properties.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- p73 in neuroblastoma may have oncosupressor, oncogenic properties. "The p73 gene is a p53 homologue localized at 1p36.3, a chromosomal region frequently deleted in neuroblastoma. p73 was...

Antisense p21 ODN triggers breast cancer cell apoptosis.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- An antisense p21 ODN triggers apoptosis in breast cancer cells. "Whereas 40% of human breast carcinomas harbor mutations in the tumor suppressor protein p53, the use of tests demonstrating the...

FTI and tamoxifen may increase the antitumor effect of either drug alone.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- FTI and tamoxifen may increase the antitumor effect of either drug alone. According to recent research published in the International Journal of Cancer, "The efficacy of tamoxifen in the hormonal...

Low levels of PPARgamma and PGC-I are associated with poor clinical outcomes.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Low levels of PPARgamma and PGC-I are associated with poor clinical outcomes. "Peroxisome-proliferator activated receptor-gamma (PPARgamma) belongs to a family of nuclear receptors and acts as...

Novel taxane analogs could effectively kill MDR1-positive breast cancer cells.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Novel taxane analogs could effectively kill MDR1-positive breast cancer cells. According to published research from the United States, "This study aimed to investigate the apoptotic effects of...

Women with mutated BRCA 1 or 2 should avoid repeated x-ray use.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Women with mutated BRCA 1 or 2 should avoid repeated x-ray use. According to recent research from Germany, "It is generally assumed that the radiation risk from mass screening for breast cancer...

The roles of BRCA1 alternative splicing are emerging.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- The roles of BRCA1 alternative splicing are emerging. "Germline mutations of the BRCA1 gene predispose individuals mainly to the development of breast and/or ovarian cancer," scientists in Hungary...

COX-2 inhibitors may be used as radiosensitizing agents for cancer therapy.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- COX-2 inhibitors may be used as radiosensitizing agents for cancer therapy. "Prostaglandins have long been known to impact the radiosensitivity of cells and tissues, and many studies have centered...

Canadian company gets patents protecting cancer and infectious disease programs.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- MethylGene, Inc., has received two patents from the United States Patent and Trademark office. "Acyl Phosphonate Inhibitors of beta-Lactamases" and "beta-Lactamase and DD-Peptidase Inhibitors"...

Clusterin may be a biomarker in murine and human intestinal neoplasia.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Clusterin may be a biomarker in murine and human intestinal neoplasia. According to published research from the United States, "Early detection of colorectal cancer is critical for the management...

Dysregulated RNA-binding of TIA-1 promotes COX-2 expression in neoplasia.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Dysregulated RNA-binding of TIA-1 promotes COX-2 expression in neoplasia. "The cyclooxygenase-2 (COX-2) enzyme catalyzes the rate-limiting step of prostaglandin formation in inflammatory states,...

Nemo-like kinase induces apoptosis in DLD-1 human colon cancer cells.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Nemo-like kinase induces apoptosis in DLD-1 human colon cancer cells. According to a study from Japan, "Deregulation of Wnt/beta-catenin signaling is thought to play a critical role in human...

Stomach cancer cells in vivo may need Omi/HtrA2 expression for apoptosis.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Stomach cancer cells in vivo may need Omi/HtrA2 expression for apoptosis. "The serine protease Omi/HtrA2 is released from mitochondria into the cytosol after apoptosis stimuli, inducing apoptosis...

There is a high degree of overexpression of COX-2 in upper GI cancers.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- There is a high degree of overexpression of COX-2 in upper GI cancers. According to a study from the United States, "Cancers of the esophagus, stomach, and pancreas have been successfully treated...

Interleukin-10 therapy stifles angiogenesis and ovarian cancer tumor growth.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Interleukin-10 therapy stifles angiogenesis and ovarian cancer tumor growth. According to a study from Japan, "interleukin-10 (IL-10) is an immunosuppressive cytokine produced by T lymphocytes and...

Aberrant somatic hypermutation linked to AIDS-associated NHL development.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- Aberrant somatic hypermutation may play a key role in the development of AIDS-associated NHL. "The pathogenesis of AIDS-related non-Hodgkin lymphomas (AIDS-NHLs) is associated with chromosomal...

P19ARF inhibits the functions of the HPV16 E7 oncoprotein.
October 13, 2003... 2003 OCT 13 - (NewsRx.com & NewsRx.net) -- P19ARF inhibits the functions of the HPV16 E7 oncoprotein. "The E7 oncoprotein encoded by high-risk types of human papillomavirus (HPV) plays a significant role in the development of HPV-related...