Cancer Gene Therapy Week articles from November 2003

Cancer Gene Therapy Week archives from November 2003

Antisense to 14-3-3 beta RNA suppresses tumor cell growth in vitro and in vivo.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Antisense to 14-3-3 beta RNA suppresses tumor cell growth in vitro and in vivo. According to recent research published in the journal Carcinogenesis, "the 14-3-3 family of proteins are key...

Hepatitis C virus NS5A expression antagonizes liver cancer cell apoptosis.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Hepatitis C virus NS5A expression antagonizes liver cancer cell apoptosis. "Treatment of hepatocellular carcinoma (HCC) cells with butyrate can induce apoptosis irrespective of hepatitis B virus...

HVJ envelope vector offers efficient gene transfer to the uterus.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- HVJ envelope vector offers efficient gene transfer to the uterus. "The uterus is obviously critical in implantation, development of the fetus, and parturition. Endometrial cancer derived from...

Antibody fragments directed against VEGF have anticancer potential.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Antibody fragments directed against VEGF have anticancer potential. "Single-chain antibodies (scFv) have an enormous potential for clinical application. However, rapid blood clearance and...

YB1 is a potential negative regulator of the p53 tumor suppressor.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- YB1 is a potential negative regulator of the p53 tumor suppressor. "The p53 tumor suppressor plays a major role in preventing tumor development by transactivating genes to remove or repair...

The Simpson-Golabi-Behmel gene is not involved in sporadic Wilms tumorigenesis.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- The Simpson-Golabi-Behmel gene is not involved in sporadic Wilms tumorigenesis. "Many genes have been implicated in Wilms tumor; however, only one gene, WT1, has a proven role in the development of...

Clinical and molecular aspects of adrenocortical tumorigenesis reviewed.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Clinical and molecular aspects of adrenocortical tumorigenesis is reviewed. "Adrenal masses are a common problem affecting 3-7% of the population. The majority turn out to be benign adrenocortical...

Virus delivered nitroreductase/CB1954 acts synergistically with 5-FU on cancer.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- The enzyme-prodrug combination nitroreductase/CB1954 creates cancer cell apoptosis by the caspase pathway, and acts synergistically with 5-fluorouracil. According to published research from England,...

Scanning array-designed antisense oligonucleotides predict effective therapy.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Scanning array-designed antisense oligonucleotides predict effective therapy. According to a study from England, "scanning oligodeoxynucleotide (ODN) arrays appear promising in vitro tools for the...

Abnormal methylation of tumor suppressor genes occurs in sporadic breast cancer.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Abnormal methylation of several tumor suppressor genes occurs in sporadic breast cancer. "Multiplex methylation-sensitive PCR was employed in studying the methylation of CpG islands in the RB1,...

Acetylated Sp3 is a transcriptional activator.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Acetylated Sp3 is a transcriptional activator. According to a study from the United States, "Sp3 transcription factor can either activate or repress target gene expression. "However, the...

Breast cancer classification, prognosis can be based on gene expression profiles.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Breast cancer classification, prognosis can be based on gene expression profiles. "Comprehensive gene expression patterns generated from cDNA microarrays were correlated with detailed...

Circulating tumor DNA may not be accurate reflection of breast cancer status.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Circulating tumor DNA may not be a sufficiently accurate reflection of breast cancer clinical status or tumor activity. "We evaluated the potential utility of occult circulating tumor DNA as a...

Endo180 is a link between uPA-uPAR and setting the internal cellular compass.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Endo180 is a link between uPA-uPAR and setting the internal cellular compass in breast cancer. "Urokinase-type plasminogen activator (uPA) and its receptor (uPAR) play an important role in cell...

Interactions between breast cancer, osteoblastic cells induce osteoclastogenesis.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Direct interactions between breast cancer and stromal or osteoblastic cells induce osteoclastogenesis through modulating RANKL expression. "Bone destruction is primarily mediated by osteoclastic...

In vitro method of culturing cells useful in carcinogenesis studies.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- An in vitro method of culturing cells is useful in carcinogenesis studies. According to a study from the United States, "Mouse mammary epithelial cell cultures previously described bring about...

Akt/mTOR pathway involved in EGF-induced cell transformation.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Akt/mTOR pathway is involved in EGF-induced cell transformation. According to a study from the United States, "Our previous study demonstrated that phosphatidylinositol 3-kinase (PI3K) is necessary...

Chronobiology will result in more active treatment schedules for many diseases.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Chronobiology will result in more active treatment schedules for many diseases. According to recent research published in the journal Pathologie Biologie, "The medical applications of chronobiology...

Nitric oxide-mediated protection of apoptosis is p53-dependent.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Nitric oxide-mediated protection of apoptosis is p53-dependent. "Ser-46 of p53 is phosphorylated in response to DNA-damage in vivo, and it plays a pivotal role for apoptotic signaling by p53 through...

Anti-infective ability of DC should be studied to apply to anticancer efforts.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Dendritic cell based anticancer immunotherapy research should encompass anti-infectious response research. "Dendritic cells (DC) are the most potent antigen-presenting cells (APC) that initiate T...

5-FU chemoresistance is overcome by inhibition of inducible NF-kappaB activation.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- 5-Fluorouracil chemoresistance is overcome by inhibition of inducible NF-kappaB activation. "5-Fluorouracil (5-FU) is used for the treatment of stomach and colon cancer, but many tumors are...

Failure of Mn-SOD mRNA induction may be predictive of gastric cancer.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Failure of Mn-SOD mRNA induction may be predictive of gastric cancer. "Reactive oxygen species (ROS) cause macromolecular damage and may play an important role in tumor development," researchers in...

Researchers study global analysis of G-protein-coupled receptor signaling.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Researchers study global analysis of G-protein-coupled receptor signaling in human tissues. "The G-protein-coupled receptor (GPCR) family mediates a host of cell-cell communications upon activation...

Chemical biology applied on genomic scale may speed translation to therapeutics.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Small-molecule chemical biology applied on a genomic scale promises to speed translation to novel therapeutics. "The recently completed human genome sequence represents an enormous opportunity to...

Cytogenetic characterization of tumors of the vulva and vagina evaluated.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Cytogenetic characterization of tumors of the vulva and vagina is evaluated. According to recent research from Norway, "Neoplasms of the vulva and vagina account for less than 5% of all female...

Introducing mutant p53 into MOLT-4 partially increases cell survival.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Introducing mutant p53 into MOLT-4 partially increases cell survival. According to published research from Japan, "The effects of X-rays on cell survival, apoptosis, and long-term response in the...

Small and large cells differ molecularly in patients with CLL.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Small and large cells differ molecularly in patients with chronic lymphocytic leukemia (CLL). "The genetic events involved in the transformation of chronic lymphocytic leukemia (CLL) to Richter's...

Proteomics analysis of lung cancer valuable for further study.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Comparative proteomics analysis of human lung squamous carcinoma can be valuable for further study. According to recent research from People's Republic of China, "Two-dimensional polyacrylamide gel...

WNT7a induces E-cadherin in lung cancer cells.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- WNT7a induces E-cadherin in lung cancer cells. "E-cadherin loss in cancer is associated with de-differentiation, invasion, and metastasis. Drosophila DE-cadherin is regulated by Wnt/beta-catenin...

Human MUC1 carcinoma antigen regulates intracellular oxidant levels.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Human MUC1 carcinoma antigen regulates intracellular oxidant levels. According to a study from the United States, "The DF3/MUC1 transmembrane oncoprotein is aberrantly overexpressed by most human...

Effects of all-trans retinoic acid (ATRA) on human myeloma cells presented.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Effects of all-trans retinoic acid (ATRA) on human myeloma cells are presented. According to a study from Japan, "All-trans retinoic acid (ATRA) is a natural oxidative metabolite of vitamin A...

BRCA1 mutations are frequent in Polish women with ovarian cancer.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- BRCA1 mutations are frequent in Polish women with ovarian cancer. According to published research from Poland, "There is increasing evidence that hereditary factors play a greater role in ovarian...

E2F3 loss has opposing effects on different pRB-deficient tumors.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- E2F3 loss has opposing effects on different pRB-deficient tumors. According to recent research from the United States, "The E2F transcription factors are key downstream targets of the retinoblastoma...

Epigallocatechin-3-gallate selectively induces apoptosis in prostate cancer cells.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Epigallocatechin-3-gallate selectively induces apoptosis in prostate cancer cells. "Chemical inhibitors of fatty acid synthase (FAS) inhibit growth and induce apoptosis in several cancer cell lines...

Researchers review recent advances in pediatric renal neoplasia.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Researchers review recent advances in pediatric renal neoplasia. According to a study from the United States, "Over the past 6 years, molecular genetic studies have significantly advanced our...

Retinoblastoma inactivation is achieved by different kinase cascades.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Retinoblastoma inactivation is achieved by different kinase cascades. "Inactivation of the retinoblastoma (Rb) tumor suppressor protein is essential for the G[subscript]1/S transition during...

Gene rearranged by 2p21 aberrations in thyroid adenomas is identified.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Gene rearranged by 2p21 aberrations in thyroid adenomas is identified. "Thyroid adenomas belong to the cytogenetically best investigated human epithelial tumors. Cytogenetic studies of about 450...

Bcl-2 inhibits TNF-alpha-mediated increase of glycolytic enzyme activities.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Bcl-2 inhibits TNF-alpha-mediated increase of glycolytic enzyme activities. According to recent research published in the journal Molecules and Cells, "To understand the effects of bcl-2 on glucose...

Hsp27 plays a negative role in down-regulating IKK signaling.
November 3, 2003... 2003 NOV 3 - (NewsRx.com & NewsRx.net) -- Hsp27 plays a negative role in down-regulating IKK signaling. According to recent research published in the Journal of Biological Chemistry, "Heat shock protein 27 (Hsp27) is a ubiquitously...

Select peptides guide gene therapies to their intended targets.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Select peptides guide gene therapies to their intended targets. "To provide cell-binding ligands for ex vivo gene therapy and chronic lymphocytic leukemia (CLL)-targeting ligands for in vivo drug...

BAD overexpression improves the way anchorage-loss encourages apoptosis.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- BAD overexpression improves the way anchorage-loss encourages apoptosis. "BAD is a BH3-only protein, and its proapoptotic activity is negatively regulated by serine phosphorylation. Here, we show...

Gene therapy incorporating retroviral constructs should be used with prudence.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Gene therapy incorporating retroviral constructs should be used with prudence. According to recent research published in the journal Biochemical and Biophysical Research Communications, "to improve...

Hypoxia compels macrophages to produce genes linked to pathogenic processes.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Hypoxia compels macrophages to produce genes linked to pathogenic processes. "Macrophages accumulate in ischemic areas of such pathological tissues as solid tumors, atherosclerotic plaques and...

Reductase enzymes potentiate how indolequinones attack cancer cells.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Reductase enzymes potentiate how indolequinones attack cancer cells. "Indolequinones such as mitomycin C (MMC) require enzymatic bioreduction to yield cytotoxic moieties. An attractive approach to...

PTEN is involved in the regulation of several basic cellular functions.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- PTEN is involved in the regulation of several basic cellular functions. According to recent research published in the journal Trends in Cell Biology, "The PTEN tumor suppressor gene is mutated...

History of anticancer drug development at the U.S. NCI reviewed.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- History of anticancer drug development at the U.S. National Cancer Institute has been summarized. "Anticancer drug discovery and development is a rapidly evolving field. Recent advances in...

Thymidylate synthase inhibitors may have promise as anticancer agents.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Thymidylate synthase inhibitors may have promise as anticancer agents. According to a study from the United States, "Thymidylate synthase (TS) is a folate-dependent enzyme that catalyzes the...

A panel of human cancer cell lines provides valuable database for drug discovery.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- A panel of human cancer cell lines provides valuable database for drug discovery. According to recent research from Japan, "Studies conducted at the U.S. National Cancer Institute (NCI) and in our...

Promise, pitfalls of genotype versus gene products are discussed.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Promise, pitfalls of genotype versus gene products are discussed. "We present a critical assessment of the promise and pitfalls of genotype versus gene function measures in cancer epidemiology...

Synergy between systemic toxicity and genotoxicity is relevant to cancer risk.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Synergy between systemic toxicity and genotoxicity is relevant to cancer risk "The health risk manager and policy analyst must frequently make recommendations based upon incomplete toxicity data....

Generex enters collaboration on Ii-suppression technology.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Generex Biotechnology Corp.'s (GNBT) Antigen Express subsidiary announced a research collaboration with Transgene, S.A., Strasbourg, France, (TRGNY) to assess the Ii-suppression technology in...

New report addresses drug delivery in cancer.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Jain PharmaBiotech announced the release of the new report titled "Drug Delivery in Cancer: Technologies, Markets, and Companies." The report describes various drug delivery methods, including...

CA-RP VIII plays a role in the process of invasion in colorectal cancer.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- CA-RP VIII plays a role in the process of invasion in colorectal cancer. "Carbonic anhydrase-related protein (CA-RP) VIII, which is a member of the CA gene family, has been shown to have no...

Cancer susceptibility testing among PCPs may be influenced by patient inquiry.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Cancer susceptibility testing among PCPs may be influenced by patient inquiry. According to published research from the United States, "Primary care physicians (PCPs) are assuming greater roles in...

Genes that induce proliferation are strategic targets for human therapy.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Genes that induce proliferation are strategic targets for human therapy. "One of the major challenges in the post-genome era is the correlation between genes and function or phenotype. We have...

CD38 is a signaling molecule in B-cell chronic lymphocytic leukemia cells.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- CD38 is a signaling molecule in B-cell chronic lymphocytic leukemia cells. "The prognosis for patients with B-cell chronic lymphocytic leukemia (B-CLL) is generally less favorable for those...

CCND1 G/A polymorphism is associated with the early onset of lung cancer in men.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- CCND1 G/A polymorphism is associated with the early onset of lung cancer in men. "The objective was to study the relationship between cyclin D1 gene (CCND1) polymorphism and lung cancer in the...

Gene expression profiles in human non-small, small cell lung cancers analyzed.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Gene expression profiles in human non-small and small-cell lung cancers are analyzed in this study. According to recent research published in the European Journal of Cancer, "Suppression...

Researchers identify small molecules that can reactivate mutant p53.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Researchers identify small molecules that can reactivate mutant p53. According to a study from Sweden, "Around half of all human tumors carry mutant p53. "This allows escape from p53-induced...

Nitroreductase mutants improve cell sensitivity to chemotherapy.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Nitroreductase mutants improve cell sensitivity to chemotherapy. According to recent research from England, "Escherichia coli nitroreductase (NTR) activates the prodrug CB1954 to a cytotoxic...

Ghrelin promotes pancreatic adenocarcinoma cell proliferation and invasiveness.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Ghrelin promotes pancreatic adenocarcinoma cell proliferation and invasiveness. "Ghrelin, a newly described potent orexigenic peptide, may have therapeutic potential in patients with cachexia. We...

8p22 deletion was the strongest parameter to predict prostate cancer progression.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- 8p22 deletion was the strongest parameter to predict prostate cancer progression. According to recent research published in the journal Aktuelle Urologie, "The natural course of human prostate...

LIM kinase 1 is essential for the invasive growth of prostate epithelial cells.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- LIM kinase 1 is essential for the invasive growth of prostate epithelial cells. "Mammalian LIM kinase 1 (LIMK1) is involved in reorganization of actin cytoskeleton through inactivating...

Researchers present comprehensive evaluation of pathogenesis of thyroid cancer.
November 10, 2003... 2003 NOV 10 - (NewsRx.com & NewsRx.net) -- Researchers present comprehensive evaluation of pathogenesis of thyroid cancer. "A number of molecular abnormalities have been described in association with the progression from normal thyroid...

Interleukins 21 and 23 genes produce an antitumor effect in pancreatic cancer.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- Interleukins 21 and 23 genes produce an antitumor effect in pancreatic cancer "We examined whether novel cytokines, interleukin (IL)-21 and IL-23, that were expressed in tumors could produce...

Interleukin-2 gene therapy shows early signs of diminishing prostate cancer.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- Interleukin-2 gene therapy shows early signs of diminishing prostate cancer. According to research from Canada, "preclinical studies demonstrate that intratumoral delivery of adenovirus expressing...

P-ethoxy antisense oligonucleotides target lymphoma Bcl-2.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- P-ethoxy antisense oligonucleotides target lymphoma Bcl-2. According to published research from the United States, "a P-ethoxy oligonucleotide (oligo), 20 bases long and specific for the...

Androgen receptor activation promotes apoptosis in cancer cells.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- Androgen receptor activation promotes apoptosis in cancer cells. "Androgen independence is the major cause of endocrine therapy failure in advanced prostate cancer (PC). To examine the effects of...

Suicide gene expression halts runaway vector infection.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- Suicide gene expression halts runaway vector infection. According to published research from Germany, "replication-competent adenoviral vectors hold the promise to be more efficient gene delivery...

Bisdioxopiperazines target ATP-bound topoisomerase II.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- Bisdioxopiperazines target ATP-bound topoisomerase II. According to recent research from the United States, "Type IIA topoisomerases both manage the topological state of chromosomal DNA and are...

Barrett esophagus is excellent model to study early neoplastic progression.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- Barrett esophagus is an excellent model in which to study the early events of neoplastic progression. According to recent research published in the World Journal of Surgery, "Human cancer...

A neural survival factor is a candidate oncogene in breast cancer.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- A neural survival factor is a candidate oncogene in breast cancer. According to recent research published in the journal Proceedings of the National Academy of Sciences USA, "Using serial analysis...

An RNA molecule functions as a tumor suppressor in human breast cancer.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- An RNA molecule functions as a tumor suppressor in human breast cancer. According to published research from the United States, "Prohibitin is a candidate tumor suppressor gene located on human...

BRC repeat, RAD51 sequence conservation shows import of BRCA2-RAD51 interactions.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- Conservation of BRC repeat, RAD51 sequence substantiates functional significance of BRCA2-RAD51 interactions. According to a study from England, "In humans, the interactions between the breast...

BRCA1 might function as a molecular scaffold for p53 response.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- BRCA1 might function as a molecular scaffold for p53 response. According to published research from Netherlands, "The tumor suppressor gene p53, mutated in approximately 50% of all human cancers,...

Genetic polymorphisms in ER-alpha gene may play role in breast cancer etiology.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- Genetic polymorphisms in ER-alpha gene may play role in breast cancer etiology. "Estrogen receptor (ER) is a ligand-activated transcription factor that mediates estrogen actions in target tissues....

Human breast tumors aberrantly express lipoxygenases and cyclooxygenase-2.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- human breast tumors aberrantly express lipoxygenases and cyclooxygenase-2. "Lipoxygenases and cyclooxygenase are key mediators of arachidonic acid metabolism. The eicosanoids metabolites from these...

Short trinucleotide repeat genotypes of AR gene protect against breast cancer.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- Short trinucleotide repeat genotypes of the AR gene protect against breast cancer. "Up to one-third of women with breast cancer have a family history of breast cancer, and approximately 5% of cases...

Tamoxifen can induce, support changes that lead to altered ERalpha expression.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- Tamoxifen can induce and/or support certain cellular changes that lead to altered ERalpha expression. According to published research from the United States, "MCF-7 breast tumor cells form...

Nutrition's role in cancer prevention still needs more study.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- Nutrition's role in cancer prevention still needs more study. "Cancer is the major cause of death in the UK, and the Government has set a target to reduce death rate from cancer in individuals ...

Cancer cell telomerase inhibition doesn't compromise chemotherapy.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- Cancer cell telomerase inhibition doesn't compromise chemotherapy. According to recent research from the United States, "telomerase is expressed in most types of tumor cells but not in most...

Company publishes results of studies on the mechanism of action of Virulizin.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- Scientists at Lorus Therapeutics, Inc., have published the results of experimental studies with Virulizin, the company's lead anticancer drug in the clinic. The results appear in an article...

GMCSF gene modified tumor vaccine shows promise in advanced lung cancer.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- A GMCSF gene modified tumor vaccine has shown promise for the treatment of advanced stage non-small cell lung cancer. According to a study from the United States, "Treatment for advanced stage...

Ionizing radiation induces heritable disruption of epithelial cell interactions.
November 17, 2003... 2003 NOV 17 - (NewsRx.com & NewsRx.net) -- Ionizing radiation induces heritable disruption of epithelial cell interactions. According to published research from the United States, "Ionizing radiation (IR) is a known human breast carcinogen....