Cancer Gene Therapy Week articles from May 2004

Cancer Gene Therapy Week archives from May 2004

Proteomic approaches in cancer risk and response assessment described.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Researchers describe proteomic approaches in cancer risk and response assessment in a recent issue of Trends in Molecular Medicine. "Proteomics is more than just a list-generating exercise where...

Phase I healthy volunteer trial of HYB2055 completed.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Hybridon, Inc., (HBY) has completed a phase I trial of HYB2055 in healthy volunteer subjects. In this trial, this drug candidate was safe and biologically active. HYB2055 is a second-generation...

DNA vaccines encoding ras epitopes and B7.1 reduced tumor burden in rats.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- DNA vaccines encoding mutated ras epitopes and the costimulatory molecule B7.1 reduced adenocarcinoma tumor burden in rats. "1-Methyl-1-nitrosourea (MNU), a well characterized carcinogen, was used...

BMP-2 modulates proliferation and differentiation of gastric cancer cells.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- BMP-2 modulates the proliferation and differentiation of gastric cancer cells. "Bone morphogenetic protein 2 (BMP-2), a member of the transforming growth factor beta super-family, has been shown to...

MLL gene rearrangement not pathogenic mechanism in de novo MDS.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Mixed lineage leukemia gene rearrangement is not a pathogenic mechanism in de novo myelodysplastic syndromes. "The mixed lineage leukemia (MLL) gene has been identified in 11q23 translocations. The...

EGCG inhibits radiation-induced apoptosis by inactivating capase pathway.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Polyphenol EGCG inhibits radiation-induced apoptosis by inactivating the capase pathway in HaCaT cells. "Green tea is a rich source of polyphenols, and (-)-epigallocatechin-3-gallate (EGCG) is a...

FGFR3 and P53 are often seen in bladder cancer.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Factor growth receptor 3 and P53 mutation may be two separate genetic pathways in the pathogenesis of bladder cancer, researchers say. According to published research from Netherlands, "Fibroblast...

HCCR-2 related to breast cancer development and p53 tumor suppressor regulation.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Oncoprotein HCCR-2 is related to breast cancer development and p53 tumor suppressor regulation. "Transgenic mice containing novel oncogene HCCR-2 were generated to analyze the phenotype and to...

Perillyl alcohol inhibits human breast cancer cell growth in mice.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Researchers report that monoterpene perillyl alcohol (POH) administered to nude mice inhibited breast cancer cell growth. According to a study from Japan, "The effect of POH on cell growth, cell...

Company reports advancements in several pipeline programs at AACR meeting.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- ImClone Systems Inc. (IMCL) presented preclinical data highlighting progress made in the development of several pipeline programs at the 95th annual meeting of the American Association for Cancer...

Microwaves regress colorectal tumor tissue in mice.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Microwaves regress colorectal tumor tissue in mice. "The human LoVo and WI-38 cells were exposed to high power non-invasive microwaves. The apoptotic effect of the microwaves on the cells was...

Radiolanthanides show promise in targeted cancer immunotherapy.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- A series of radiolanthanides have significant antitumor effects in mice. "[superscript]149Pm, [superscript]166Ho, and [superscript]177Lu possess a range of half-lives and...

Research shows evidence of synergy and molecular activity of MG98.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Two poster presentations - one demonstrating synergistic usage of MG98 in combination with interferon in renal cancer cells and another disclosing anticancer activity of MG98 as a single agent in...

gONC increases conformational stability and toxicity for cancer cells.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Glycosylation of onconase increases its conformational stability and toxicity for cancer cells. "Onconase (ONC) is currently in Phase III clinical trials as a cancer chemotherapeutic agent. Despite...

Early FAMM diagnosis and prophylaxis decreases neoplastic transformation risk.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Early FAMM diagnosis and prophylaxis decreases risk of neoplastic transformation of melanocytes. "Familial atypical multiple mole melanoma (FAMMM) syndrome is an autosomal dominant disorder with...

6-Nitro-7-hdroxycoumarin novel therapeutic agent for renal cell carcinoma.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- 6-Nitro-7-hdroxycoumarin may be a novel therapeutic agent for renal cell carcinoma. "Previously, 7-hydroxycoumarin (7-OHC) and 6-nitro-7-hydroxycoumarin (6-NO2-7-OHC) have been shown to be potent...

Thyroglobulin polymorphic variation increases non-medullary thyroid cancer risk.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Polymorphic variation in thyroglobulin increases risk for non-medullary thyroid cancer. "Benign thyroid disorders are strong risk factors for non-medullary thyroid cancer (NMTC). Germline variation...

Genetic cancer alterations seen between ethnic populations.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Genetic cancer alterations exist between ethnic populations. "The cancer spectrum and genetic pathways underlying tumorigenesis vary among different ethnic populations due to genetic background...

Cyclin-dependent kinase inhibitor p21 induces Flt3-ITD leukemogenesis.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Cyclin-dependent kinase inhibitor p21 induces Flt3-ITD leukemogenesis. "Flt3 is a type III RTK and approximately 30% of AML patients harbor an internal tandem duplication (ITD) of the juxta-membrane...

Notch1 gene involved in ATRA-modulated differentiation process in APL.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- The notch1 gene may be involved in the ATRA-modulated differentiation process in acute promyelocytic leukemia. "The effect of all-trans retinoid acid (ATRA) on the expression of Notch1 gene by...

P73 A4T14 genotype associated with cervical cancer risk.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- P73 A4T14 genotype is associated with risk of cervical cancer. A "possible association between cervical cancer and p73 G4C14-to-A4T14 in exon 2 and p53 Arg72Pro polymorphisms" was examined in an...

Ptc acts as a tumor suppressor gene in bladder cancer.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Ptc acts as a tumor suppressor gene in bladder cancer. "The PATCHED (PTC) gene is recognized as a tumor suppressor in basal cell carcinoma. Mapping of a minimal region of deletion at 9q22.3 and...

Eurya emarginata extracts inhibit leukemia cell growth via apoptosis induction.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Eurya emarginata extracts inhibit leukemia cell growth via induction of apoptosis. The "inhibitory effect of Eurya emarginata extracts on the growth of cancer cells" was examined. "The ethylacetate...

DNA vaccine expressing L1 protein protects against papillomavirus challenge.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- A single vaccination with a vesicular stomatitis virus vector expressing high levels of L1 protein provided complete protection from papillomavirus challenge. "We generated an attenuated,...

Genetic trick adapted from viruses makes gene-therapy vectors more versatile.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- A genetic trick used by viruses to replicate themselves has been adapted for laboratory use to build complex protein structures required by immune system cells, according to investigators at St. Jude...

ATRA and TSA therapy useful in acute leukemia displaying MLL-AF9 fusion gene.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- ATRA and TSA are therapeutically useful in patients with acute leukemia displaying the MLL-AF9 fusion gene. In acute "leukemia patients with MLL (mixed linage leukemia), rearrangements tend to...

Familial melanoma syndrome increases risk of malignant neoplasms.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Patients with familial atypical multiple mole melanoma (FAMMM) syndrome are at increased risk of developing melanoma and other cancers, as well, researchers report. "FAMMM syndrome is an autosomal...

Genetic factors regulate 3'-azido-3'-deoxythymidine-induced cytogenetic damage.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Genetic factors regulate 3'-azido-3'-deoxythymidine-induced cytogenetic damage. "The activation of telomerase in phytohemagglutinin-stimulated peripheral lymphocytes is thought to play a role in...

Oncogenesis from single base mutation in IRES of Epstein-Barr nuclear antigen 1.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Oncogenesis develops from a single base mutation in the internal ribosome entry site of Epstein-Barr nuclear antigen 1. Recently published data show that "the U leader exon located within the 5'...

PML tumor suppressor gene mutations indicate poor APL prognosis.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Promyelocytic leukemia tumor suppressor gene mutations indicate a poor acute promyelocytic leukemia prognosis. "The promyelocytic leukemia (PML) tumor suppressor of acute promyelocytic leukemia...

Metastasis-associated protein analysis indicates different metastasis roles.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Metastasis-associated protein analysis indicates different roles they may play in metastasis. "Metastasis is the most insidious and life threatening aspect of cancers. However little is known about...

Nedd 4 or ubiquitin ligase Nedd4 regulates human T-cell leukemia virus type 1.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Nedd 4 or ubiquitin ligase Nedd4 regulates human T-cell leukemia virus type 1. "The Gag protein of human T-cell leukemia virus type 1 (HTLV-1) contains the conserved sequences PPxY and PTAP, which...

PKC delta tumor-suppressing effects mediated by p53 transcription activation.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- PKC delta tumor-suppressing effects are mediated through p53 transcription activation. "In response to DNA damage, signal transduction pathways are activated that result in the increase of p53...

Folate receptor-targeted lipid vesicles ferry oligodeoxynucleotides to tumors.
May 3, 2004... 2004 MAY 3 - (NewsRx.com & NewsRx.net) -- Folate receptor-targeted lipid vesicles ferry oligodeoxynucleotides to tumors. "A major problem in exploring the full potential of antisense ODN is the lack of a safe and efficient delivery system....

Ring finger protein RNF11 important target for novel cancer therapies.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Ring finger protein RNF11 may be an important target for novel cancer therapies. "The identification of novel tumor-associated genes represents an important area of cancer research. To that end," a...

C20orf9-003 (ACI-1) encodes for protein with nucleotide binding site.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- C20orf9-003 (ACI-1) is a gene localized on chromosome 20q13.12 encoding for a 49-kD cytoplasmic protein with a putative nucleotide binding site. "Murine NGD5 is a gene identified from NG108-15...

The hypoxia-inducible factor-1 inhibitor PX-478 abates large tumor growth.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- The hypoxia-inducible factor-1 inhibitor PX-478 abates large tumor growth. According to a study from the United States, "the hypoxia-inducible factor-1 (HIF-1) transcription factor is an important...

Alginate puts a damper on viral leakage after gene delivery.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Alginate puts a damper on viral leakage after gene delivery. According to recent research from the United States, "intense research has focused on methods for overcoming the various barriers to...

High-dose chromium induces apoptosis; low-dose activates antioxidant system.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- High-doses of chromium induce apoptosis while low-dose activates the antioxidant defense system in vitro. "In order to investigate the low-dose long-term Cr(VI) action on antioxidant enzymes in...

In vivo expression technology identifies virulence genes in H. pylori.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- In vivo expression technology identifies virulence genes in H. pylori. "Some pathogenic factors of Helicobacter pylori, a bacterium involved in peptic ulcer and gastric cancer, have already been...

Cathepsin B inhibition suppresses angiogenesis in human glioblastoma cells.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Cathepsin B inhibition suppresses angiogenesis in human glioblastoma cells. According to recent research from the United States, "the cysteine proteinase cathepsin B has been implicated in tumor...

Estrogen receptor-alpha mutation K303R not found in Japanese breast carcinomas.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Estrogen receptor-alpha mutation K303R was not found in Japanese breast carcinomas. A "common somatic mutation, A-to-G transition at nucleotide 908, in the estrogen receptor-alpha (ERalpha) gene...

Perillyl alcohol suppresses breast cancer cell growth in vitro and in vivo.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Perillyl alcohol suppresses breast cancer cell growth in vitro and in vivo. "The effect of monoterpene perillyl alcohol (POH) on cell growth, cell cycle progression, and expression of cell...

Fiber-mutant adenovirus vectors have antitumor activity.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- A series of novel adenovirus vectors may be useful for gene therapy of ovarian and other tumors. In a study from Japan, "fiber-mutant adenovirus vectors encoding chemokines, Ad-RGD-mCCL17,...

NCI grant to help company discover second-generation Hsp90 inhibitors.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Kosan Biosciences, Inc., (KOSN) announced that it has been awarded a 2-year, $750,000, phase II, small business innovative research (SBIR) grant from the National Cancer Institute (NCI). The grant...

Prodrugs becoming an integral part of the drug discovery paradigm.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Prodrugs are becoming an integral part of the drug discovery paradigm. "Prodrugs are bioreversible derivatives of drug molecules used to overcome some barriers to the utility of the parent drug...

Intracellular MDA-7/IL-24 mediates activity in lung cancer cells.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Intracellular MDA-7/IL-24 mediates activity in lung cancer cells. "Melanoma differentiation associated gene (mda-7)/interleukin-24 (IL-24) (HGMW-approved symbol IL24) is a tumor suppressor gene...

Biallelic MYH mutations confer susceptibility to colorectal cancer.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Biallelic MYH mutations confer susceptibility to colorectal cancer. "Mutations in the base excision repair gene MYH have recently been shown to confer recessive susceptibility to colorectal...

Thymidylate synthase expression not linked to colon cancer phenotype.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- No significant association exists between polymorphisms in the thymidylate synthase gene or the expression of thymidylate synthase mRNA and the microsatellite instability phenotype of colorectal...

Challenges of virtual screening for kinase targets demystified.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Challenges of virtual screening for kinase targets are demystified. "Kinases have become a major area of drug discovery and structure-based design. Hundreds of 3D structures for more than thirty...

Telomerase inhibitor PinX1 not involved in gastrointestinal tract carcinoma.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Telomerase inhibitor PinX1 is not involved in gastrointestinal tract carcinoma. "PinX1 was isolated as a Pin2/TRF1 binding protein that also binds to the telomerase catalytic subunit hTERT. The...

The introduction of VEGFR2 fragments into tumors slows their growth.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- The introduction of VEGFR2 fragments into tumors slows their growth. According to a study from the Peoples Republic of China, "the interaction of vascular endothelial cell growth factor (VEGF) and...

Collaboration with p53 and p63, p73 responds to cell genotoxic damage.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- A collaboration exists between p53 and p63 and p73 in response to cell genotoxic damage. "Homologies in sequence and gene organization of p53 and their relatives, p73 and p63, suggest similar...

LCR promotes beta-globin transcription repression in committed cells.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- LCR promotes beta-globin transcription repression in committed cells. "During erythroid differentiation, beta-globin gene expression is regulated by the locus control region (LCR). The...

Interleukin-10-related cytokines and their receptors are therapeutic targets.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Interleukin-10-related cytokines and their receptors are therapeutic targets. According to a study from the United States, "Interleukin (IL)-10 is an important mediator of immunoregulation, which...

Vesicular stomatitis virus infusions staunch hepatocellular carcinoma in rats.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Vesicular stomatitis virus infusions staunch hepatocellular carcinoma in rats. According to a study from the United States, "hepatocellular carcinoma (HCC) is a lethal malignancy with poor...

Molecular footprints may gives clues about human lung cancer progression.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- The identification of environmental as well as genetic factors inducing or suppressing the occurrence of such alterations would be a clue to find novel ways of preventing lung cancer, researchers say....

Patients with multiple primary melanoma have INK4A mutations.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Researchers say the risk of melanoma can be shown by INK4A mutations. According to a study from the United States, "Estimation of the relative risk of cancer due to rare germline mutations using...

Promoter activity of AVL-A LTR region related to induction of glial neoplasm.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- The promoter activity of the avian leukosis virus subgroup A LTR region may be related to the induction of glial neoplasm. "So-called fowl glioma is a retroviral infectious disease caused by avian...

FGFR3 and P53 mutations affect pathogenesis of urothelial cell carcinoma.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- FGFR3 and P53 mutations affect the pathogenesis of urothelial cell carcinoma. "Fibroblast growth factor receptor 3 (FGFR3) and P53 mutations are frequently observed in bladder cancer. The...

CHEK2*1100delC mutation has no major contribution in esophageal carcinogenesis.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- The CHEK2*1100delC mutation has no major contribution in esophageal carcinogenesis. "In response to DNA damage, the cell cycle checkpoint kinase 2 (CHEK2) may phosphorylate p53, Cdc25A and Cdc25C,...

Novel cooperation up-regulate vitamin D receptor protein.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Genistein and 1,25-dihydroxyvitamin D[subscript]3 up-regulate the vitamin D receptor protein. The "mechanisms by which genistein and 1,25-dihydroxyvitamin D[subscript]3...

The androgen receptor may be a target for prostate caner therapy.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Researchers review the functions of the androgen receptor and its role in the development of prostate cancer. According to recent research published in the journal Steroids, "The androgen receptor...

CXCR4 restricts adenovirus-mediated transgene expression to tumor cells.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- CXCR4 restricts adenovirus-mediated transgene expression to tumor cells. "Adenoviral vectors are considered to be good gene delivery vectors for cancer gene therapy due to their wide host tissue...

Autocrine stimulation by osteopontin sustains carcinoma proliferation in vitro.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Autocrine stimulation by osteopontin sustains carcinoma proliferation in vitro. "Papillary thyroid carcinomas are characterized by rearrangements of the RET receptor tyrosine kinase generating...

Acetylation of Ku70 by CBP and PCAF controls Bax-mediated apoptosis.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Acetylation of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. "Apoptosis is a key tumor suppression mechanism that can be initiated by activation of the proapoptotic factor Bax. The Ku70 DNA...

Fbw7 essential in controlling cyclin E and Notch signaling pathways.
May 10, 2004... 2004 MAY 10 - (NewsRx.com & NewsRx.net) -- Fbw7 is essential in controlling cyclin E and Notch signaling pathways in the mouse. "The mammalian F-box protein Fbw7 and its Caenorhabditis elegans counterpart Sel-10 have been implicated in the...

Overexpressed L36a gene associates with hepatocellular carcinoma proliferation.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- Overexpressed L36a gene associates with hepatocellular carcinoma proliferation. According to a study from South Korea, "using messenger RNA (mRNA) differential display, we identified a single...

Treatment targeting oncogenes could sensitize tumors to antiangiogenic agents.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- Treatment targeting oncogenes could sensitize tumors to antiangiogenic agents. According to a study from Canada, "among novel promising approaches that have recently entered the scene of anticancer...

Magnaese superoxide dismutase mutant has potent antitumor effects.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- Magnaese superoxide dismutase mutant has potent antitumor effects. "Mn-SOD serves as the primary cellular defense against oxidative damage by converting superoxide radicals (O[subscript]2(radical...

Gastrin aids progression of Barrett metaplasia via antiapoptotic pathways.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- Gastrin aids progression of Barrett metaplasia via antiapoptotic pathways. "Mechanisms by which premalignant Barrett's metaplasia (BM) progresses to esophageal adenocarcinoma are currently being...

Epigenetic downregulation of CTMP transcription common in glioblastomas.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- Epigenetic downregulation of CTMP transcription is common in glioblastomas. "The carboxyl-terminal modulator protein (CTMP) has been identified as a negative regulator of protein kinase B/Akt....

540 protein inhibitors promising treatments for postmenopausal breast cancer.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- 540 protein inhibitors are promising treatments for postmenopausal breast cancer. "The P450 family of proteins has more than 1000 representatives, which despite sometimes relatively low sequence...

Bcl-2 overexpression prevents Tc-99m-MIBI uptake in breast cancer cells.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- Bcl-2 overexpression prevents Tc-99m-MIBI uptake in breast cancer cells in vitro. A "correlation between the absence of technetium-99m methoxyisobutylisonitrile (Tc-99m-MIBI) uptake and...

Brk protein tyrosine kinase therapeutic cancer target.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- Brk protein tyrosine kinase is a therapeutic cancer target. "Brk is an intracellular protein tyrosine kinase that is significantly overexpressed in a majority of breast tumors, while being...

L-myc gene polymorphism not associated with lung ADCA risk and prognosis.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- L-myc gene polymorphism is not associated with lung adenocarcinoma risk and prognosis. "The non-coding variation in the second intron of the L-myc gene, generating an EcoRI polymorphism, is...

Dacogen and Taxotere show synergistic activity against human carcinoma cells.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- Dacogen and Taxotere show synergistic activity against human carcinoma cells in vitro. "The antineoplastic activity of 5-aza-2-deoxycytidine (5-AZA-CdR) and docetaxel (Taxotere, Taxo) alone or in...

Novel 2-nitroimidazole-tethered tricyclic quinoline compounds cytotoxic.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- Novel 2-nitroimidazole-tethered tricyclic quinoline compounds are cytotoxic. "Two novel nitroimidazole-based bioreductive compounds,...

Novel drug wrenchnolol impairs transcription of Her2 oncogene.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- A novel drug, wrenchnolol, impairs transcription of the Her2 oncogene. "Development of synthetic molecules that provide external control over the transcription of a given gene represents a...

The recombinant disintegrin domain of metargidin diminishes tumor vessels.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- The recombinant disintegrin domain of metargidin diminishes tumor vessels. According to a study from France, "metargidin, a transmembrane protein of the adamalysin family, and integrins, (e.g....

Human papillomavirus detection is not yet predictive of cervical cancer.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- Further research will be necessary before the presence of human papilloma virus can be clinically valuable in predicting cervical cancer, researchers say. "Cervical cancer is a major cause of...

Microtubule depolymerization collapses vascular networks rapidly.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- Microtubule depolymerization collapses vascular networks rapidly. "Maintenance of endothelial cell tube integrity is dependent on an intact cytoskeleton. We present data indicating that rapid...

Ameloblastic carcinoma gene expression profile characterized via DNA microarray.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- The gene expression profile of ameloblastic carcinoma (AC) has been characterized through DNA microarray analysis. AC "is a malignant epithelial odontogenic tumor that histologically retains the...

Human chromosome 13 DNA sequenced and analyzed.
May 17, 2004... 2004 MAY 17 - (NewsRx.com & NewsRx.net) -- Human chromosome 13 DNA has been sequenced and analyzed. "Chromosome 13 is the largest acrocentric human chromosome. It carries genes involved in cancer including the breast cancer type 2 (BRCA2)...