Cancer Gene Therapy Week articles from May 2003

Cancer Gene Therapy Week archives from May 2003

No chromosomal instability was found in radiation exposed normal fibroblasts.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- No chromosomal instability in descendants was found in normal fibroblasts exposed to low or high LET radiation. "Radiation induced genomic instability has been proposed as a very early, if not an...

Molecular targets for cell cycle inhibition are promising for cancer therapy.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Molecular targets for cell cycle inhibition are promising for cancer therapy. "Cell cycle dysregulation is a critical feature of tumor cells. Numerous cell cycle regulators act either as oncogenes...

Tumor suppressors p16INK4a and p14ARF are linked and not inactivated by mutation.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Two tumor suppressor proteins involved in cell cycle control in breast cancer are linked, and their inactivation is due to hypermethylation or deletion. "The INK4a/ARF locus encodes 2 tumor...

Patients have inactivated E-cadherin due to missense mutations in CDH1.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Hereditary diffuse gastric cancer patients have inactivated E-cadherin due to missense mutations in CDH1. "E-cadherin is involved in the formation of cell-junctions and the maintenance of...

A cell can tolerate the absence of p53 function but not excess p53 function.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- A cell can tolerate the absence of p53 function but not excess p53 function. According to a study from the United States, "Manipulation of the mouse genome allows emulation of the genetic defects...

The deleted region is confined to a very small area around 1p36.32.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- The deleted region is confined to a very small area around 1p36.32. in melanoma. "Deletions in 1p36 in malignant melanoma have been found in high percentages in nodular melanomas and melanoma...

Some ATM carriers are predisposed to cancer.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Some ATM carriers are predisposed to developing cancer. According to published research from Israel, "Maintenance of genome stability is essential for avoiding the passage to neoplasia. "The...

t(10;16)(Q22;p13) and MORF-CREBBP fusion is a recurrent event in AML.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- t(10;16)(Q22;p13) and MORF-CREBBP fusion is a recurrent event in acute myeloid leukemia (AML). "Recently, it was shown that t(10;16)(q22;p13) fuses the MORF and CREBBP genes in a case of childhood...

A novel atypical retinoid is endowed with proapoptotic and antitumor activity.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- A novel atypical retinoid is endowed with proapoptotic and antitumor activity. According to recent research published in the Journal of Medicinal Chemistry, "The novel atypical retinoid...

A disaccharide anthracycline, MEN 10755, can binds 2 DNA helices simultaneously.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- A disaccharide anthracycline with broad antitumor activity can form a structure involving two DNA helices. "The crystal structure of the complex formed between the anthracycline antibiotic...

Spike, a novel BH3-only protein, mediates proapoptotic signals.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Spike, a novel BH3-only protein, mediates proapoptotic signals. According to a study from Germany, "We have isolated Spike, a novel and evolutionary conserved BH3-only protein. BH3-only proteins...

TERT requires reverse transcriptase activity and 14-3-3 protein binding ability.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- TERT can suppress apoptosis early and the mechanism needs its reverse transcriptase ability as well as ability to bind 14-3-3 protein. "The catalytic subunit of telomerase (TERT) is a reverse...

Epigallocatechin-3 gallate can activate p53 and induce apoptosis.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Green tea catechin may prevent atherosclerosis, as it can activate p53 and induce apoptosis of proliferating smooth muscle cells. According to a study from the United States, "Green tea polyphenols...

MUC-1 mucin protein expression is common in any state of disease.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- MUC-1 mucin expression is correlated only with lymphoma, and not a particular cell type or disease status, nor was there a correlation with the rearrangement of the gene. "We have recently shown...

Pten in B cells controls homeostasis and IgG class switch recombination.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- The tumor suppressor Pten has roles in B cells ranging from B cell development and homeostasis to control of autoantibody production. "Pten is a tumor suppressor gene mutated in human cancers. We...

The molecular pathogenesis of BCC differs markedly from most other cancers.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- The molecular pathogenesis of basal cell carcinomas (BCC) differs markedly from most other cancers. "Abnormal hedgehog signaling, most commonly caused by loss of PTCH1 inhibitor activity, drives...

8q24 amplification occurs in transitional cell carcinoma of bladder.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- 8q24 amplification occurs in transitional cell carcinoma of bladder. According to recent research published in the journal Applied Immunohistochemistry & Molecular Morphology, "Genomic...

Bidirectional signaling between EGFR and ER contributes to pathophysiology.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Bidirectional signaling between EGFR and ER contributes to pathophysiology. "Interactions between the estrogen receptor (ER) and the epidermal growth factor receptor (EGFR) contribute to the...

Data support an important role for TP53 in mammary carcinogenesis.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Data support an important role for TP53 in mammary carcinogenesis. "The TP53 gene (p53) is found altered in breast carcinomas in approximately 20% - 40% of all cases depending on tumor size and...

In breast cancers, 24 genes showed significant overexpression.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Twenty-four genes showed significant overexpression in breast cancers. "Chromosome region 17q12-23 commonly shows an increase in DNA copy number in breast cancers, suggesting that several oncogenes...

TP53 mutations may occur in familial breast cancer.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- TP53 mutations may occur in familial breast cancer. According to recent research from England, "Mutation in p53 (TP53) remains one of the most commonly described genetic events in human neoplasia....

There is tight correlation between the expression of HGF, matriptase, and MET.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- There is tight correlation between the expression of hepatocyte growth factor (HGF), matriptase, and MET in breast cancer outcome. According to published research from the United States, "Numerous...

4-Hydroxymethyl-3-aminoacridine derivatives are new anticancer agents.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- 4-Hydroxymethyl-3-aminoacridine derivatives are new anticancer agents. According to published research from France, "3-Amino- and 3-alkylamino-4-hydroxymethylacridines bearing various substituents...

Understanding cancer requires new statistical and computational approaches.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Understanding cancer requires new statistical and computational approaches for analysis of the genetic and signaling networks that orchestrate cancer susceptibility. "The past decade has seen great...

Hue-Saturation-Intensity (HSI) works better than the gold standard.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Histochemical staining of lung cancer tissue by hue saturation density for levels of proliferating cells with Ki-67 worked better than the gold standard. "We tested a recently developed flexible...

Mammalian Exo1 functions in mutation avoidance.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Mammalian Exo1 functions in mutation avoidance and is essential for male and female meiosis. "Exonuclease 1 (Exol) is a 5'-3' exonuclease that interacts with MutS and MutL homologs and has been...

New findings published on diagnostic applications of HAAH Oncology Program.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Panacea Pharmaceuticals, Inc., announced that new important findings on the diagnostic applications of its HAAH Oncology Program were published in the Proceedings of the 2003 Annual Meeting of the...

DOCK4, a GTPase activator, is disrupted during tumorigenesis.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- DOCK4, a GTPase activator, is disrupted during tumorigenesis. "We used representational difference analysis to identify homozygous genomic deletions selected during tumor progression in the mouse...

P27(Kip1)/cyclin-dependent kinase/retinoblastoma pathway is regulatory.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Vascular occlusive disorders may be based on Kip1 cyclin dependent kinase inhibitor malfunction, as the protein appears to be involved in the control of cell proliferation and locomotion. According...

Mutation of p53 appears to be unrelated to the presence or absence of HPV.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Mutation of p53 appears to be unrelated to the presence or absence of human papillomavirus (HPV). "Functional loss of the tumor suppressor p53 by alterations in its TP53 gene is a frequent event in...

Therapy-related myelodysplastic syndrome can occur by rearrangement of MOZ gene.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Therapy-related myelodysplastic syndrome can occur by rearrangement of the MOZ gene. "In this study, we examined a pediatric case of therapy related myelodysplastic syndrome (tMDS). The symptoms...

Inhibitors of P-glycoprotein may be chemopreventive agents.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Inhibitors of P-glycoprotein may be chemopreventive agents against colorectal carcinogenesis. According to published research from Japan, "Aberrant transactivation of a certain set of target genes...

Nuclear export of the APC tumor suppressor controls beta-catenin function.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Nuclear export of the adenomatous polyposis coli (APC) tumor suppressor controls beta-catenin function. "The adenomatous polyposis coli (APC) protein is inactivated in most colorectal tumors. APC...

SLIT2 is an excellent candidate tumor suppressor gene for colorectal cancer.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- SLIT2 is an excellent candidate tumor suppressor gene for colorectal cancer. "We have shown recently that SLIT2 has tumor suppressor activity and that it is epigenetically silenced in >40% of lung...

TP53 mutation status may make a difference in chemotherapeutic outcome.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- P53 status of colorectal cancer patients needs to be incorporated into chemotherapeutic outcome studies, as there may be differences in effectiveness of therapy depending on that status. According...

Human cancer cell lines have tissue type specific patterns.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- DNA methylation in human cancer cell lines does differ slightly from primary tumors, but the common patterns can be used to determine tissue origin. According to published research from Spain,...

Regulation of gene expression is a dynamic response to environmental signals.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- The genome responds to environmental signals that can alter gene expression; this epigenetic regulation is accomplished through DNA methylation. According to a study from the United States, "Cells...

AP-2 alpha's DNA binding is enhanced by the oncogene DEK.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- DEK appears to be a transcriptional coactivator for AP-2 alpha, enhancing its binding capacity for DNA. According to recent research from Spain, "Cell differentiation and development are highly...

Transdermal gene delivery eradicates tumors expressing hepatitis C proteins.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer-A series of research experiments has demonstrated that hepatitis C virus (HCV) DNA vaccine can suppress tumor growth. The vaccine, developed by researchers at...

Inhibition of the PI3K-Akt/PKB survival pathway may contribute to apoptosis.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Inhibition of the PI3K-Akt/PKB survival pathway may contribute to apoptosis. "Synthetic alkyl-lysophospholipids (ALPs) represent a new class of anti-tumor agents that target cell membranes and...

p53, BLM functionally interact during resolution of stalled DNA replication.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- p53 and BLM functionally interact during resolution of stalled DNA replication. According to a study from the United States, "Diverse functions, including DNA replication, recombination and repair,...

Genetic inactivation of ACVR2 gene may indicate it is a tumor suppressor.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Genetic inactivation of the activin A type II receptor (ACVR2) gene in gastrointestinal and pancreatic cancer points to the gene as being a tumor suppressor. "The activin signaling pathway parallels...

Caution required when analyzing the significance of p53 mutations.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Great caution is required when analyzing the significance of p53 mutations because 5% have only been described once, indicating that the mutational event could be rare. "A detailed analysis of p53...

E2F1 blocks and c-Myc accelerates hepatic ploidy in transgenic mouse models.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- E2F1 blocks and c-Myc accelerates hepatic ploidy in transgenic mouse models. "Previously, we have shown that over-expression of either E2F1 or c-Myc promotes hepatocarcinogenesis and that E2F1 mice...

Tumor-derived suppressor molecules impede host antitumor immune activity.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Tumor-derived suppressor molecules impede host antitumor immune activity. According to recent research published in the journal Experimental Biology and Medicine, "Tumors can evade immune responses...

The UMD-p53 database is useful for research on p53 related mutations.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- The UMD-p53 database has a new series of modules and data useful for research on p53 related mutations. According to recent research published in the journal Human Mutation, "The tumor suppressor...

Homozygous mutations in the same genes result in severe neurological impairment.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Homozygous mutations in the same genes result in severe neurological impairment. According to recent research from the United States, "Mitochondrial defects have been associated with neurological...

A BMPR1A germline mutation occurs in juvenile polyposis without SMAD4 mutation.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- A BMPR1A germline mutation occurs in juvenile polyposis without SMAD4 mutation. According to recent research from South Korea, "Juvenile polyposis (JP) is characterized by the development of...

CD38 is co-expressed with its ligand CD31 on B-CLL cells.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- CD38 is co-expressed with its ligand CD31 on B-CLL cells. "A ligand for CD38 was identified as CD31, a molecule prevalently expressed by endothelial cells and selected lymphocyte populations,"...

F11782 topoisomerase inhibitor induces apoptosis through Bax and caspase action.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- F11782 is a dual topoisomerase inhibitor that can induce Bax and caspase activation resulting in apoptosis of leukemia cells. "F11782 (2'',3''...

RACE-PCR showed that HOXC13 was the partner gene of NUP98.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- RACE-PCR showed that HOXC13 was the partner gene of NUP98 in leukemia. According to published research from Italy, "The chimeric gene NUP98/HOXC13 was detected in a patient with a de novo acute...

The c-Myc oncoprotein interacts with Bcr.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- The c-Myc oncoprotein interacts with multifunctional protein Bcr in leukemia. "Bcr is a multifunctional protein that is the fusion partner for Abl (p210 Bcr-Abl) in Philadelphia chromosome positive...

Thymidylate synthase genotype is not associated with relapse.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Thymidylate synthase genotype is not associated with relapse. According to recent research published in the journal Haematologica, "We investigated a tandem-repeat polymorphism within the promoter...

Some types of SCLC might recapitulate a critical, Hh-regulated event.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Some types of small-cell lung cancer (SCLC) might recapitulate a critical, Hh-regulated event and may respond to pharmacological blockade of the Hh signaling pathway. According to published...

G1 arrest was p21(WAF1/CIP1) and p53 dependent.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Cell cycle arrest at G1 was p21(WAF1/CIP1) and p53 dependent in mesothelioma. "Knowledge of the function of the cell cycle checkpoints in tumor cells may be important to develop treatment strategies...

Proteome technology maps Helicobacter pylori clinical isolates.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Proteome technology maps Helicobacter pylori clinical isolates demonstrating the potential of the technology. According to a study from Russia, "The Gram-negative bacterium Helicobacter pylori is...

TACE is required for the activation of the EGFR by TGF-alpha in tumors.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- TACE is required for the activation of the EGFR by TGF-alpha in tumors. According to a study from Spain, "The factors and mechanisms that transduce the intracellular signals sent upon activation of...

Some MLH1 mutations may be a source of human infertility.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Some, but not all, MLH1 mutations may be a source of human infertility. "To test whether missense mutations in the cancer susceptibility gene MLH1 adversely affect meiosis, we examined 14 yeast...

The cAMP signaling pathway has opposing effects on Rac and Rho in B16F10 cells.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- The cAMP signaling pathway has opposing effects on Rac and Rho in B16F10 cells. According to recent research published in the journal Pigment Cell Research, "A hallmark of melanocytic cells is their...

Undefined tumor necrosis factor gene therapy can lead to adverse effects.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer-Tumor necrosis factor gene therapy can lead to tumor regression, but it may also cause significant adverse effects, researchers in Japan advise. That finding...

Differential regulation of cell motility and invasion occurs in FAK gene.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- FAK is involved in cell motility and invasion by different pathways. According to published research from the United States, "Cell migration and invasion are fundamental components of tumor cell...

PS-341 inhibits genotoxic stress response pathways.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- PS-341 inhibits genotoxic stress response pathways in multiple myeloma. According to published research from the United States, "The proteasome inhibitor PS-341 inhibits nuclear factor-kappaB...

Alpha 2,9-PolyNeu5Ac glycoprotein in C-1300 is discovered.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Alpha 2,9-PolyNeu5Ac glycoprotein in C-1300 is discovered. "Alpha2,8-PolyNeu5Ac is expressed on neural cell adhesion molecules during embryogenesis and also re-expressed on certain tumors,"...

RecQ helicases protect against cancer by maintaining genomic stability.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- RecQ helicases protect against cancer by maintaining genomic stability. According to recent research from England, "RecQ helicases are highly conserved from bacteria to man. Germline mutations in...

Human IgG2 can form covalent dimers.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Human IgG2 can form covalent dimers in myeloma cells. According to recent research published in the Journal of Immunology, "Unlike IgA and IgM, IgG has not yet been shown to form covalent polymers....

RANK ligand and osteoprotegerin prevented skeletal complications.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- RANK ligand and osteoprotegerin prevented skeletal complications in myeloma disease. According to a study from Germany, "Myeloma bone disease is due to interactions of myeloma cells with the bone...

Restoration of TR2 expression enhances IFN-gamma-induced TRAIL sensitivity.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Restoration of TR2 expression by transfection enhances IFN-gamma-induced TRAIL sensitivity. "The resistance of neuroblastoma (NB) cells to tumor necrosis factor-related apoptosis-inducing ligand...

Heat-directed suicide gene therapy reduces breast cancer cell survival.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer-Scientists in Ontario, Canada have discovered that heat-directed suicide gene therapy can reduce breast cancer cell survival. Researchers at the University...

Cell lines with SMAD4 inactivation show distinct expression responses to TGFB1.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Cell lines with SMAD4 inactivation show distinct expression responses to TGFB1. "Transforming growth factor beta-1 (TGFB1)-induced gene expression was studied in five pancreatic carcinoma cell lines...

RXL peptide-treated tumors undergo apoptosis.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- RXL peptide-treated tumors undergo apoptosis and may provide selective antiproliferative agents. According to published research from the United States, "A central function of the tumor suppressor...

Endometriosis doesn't appear premalignancy-based when tested for clonality.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Endometriotic foci do not appear to be premalignant when tested for clonality. According to recent research published in the FASEB Journal, "Since 1925, epidemiological and histological evidence for...

Androgen receptor may modulate gene expression.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Androgen receptor may modulate gene expression and may play an important role in prostate cancer progression. According to a study from the United States, "AR may communicate with the general...

Prostate tumor aggressiveness locus may play a role in prostate cancer.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Prostate tumor aggressiveness locus may play a role in prostate cancer. "Whole-genome scan studies recently identified a locus on chromosome segments 19q 12-q 13.11 linked to prostate tumor...

PUB/PUG domain may be involved in the ubiquitin/proteasome-related pathway.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- PUB/PUG domain may be involved in the ubiquitin/proteasome-related pathway. According to a study from the United States, "A cytoplasmic peptide:N-glycanase has been implicated in the proteasomal...

Relative expression levels of some genes may indicate radiation exposures.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Relative expression levels of some genes may indicate radiation exposures. According to recent research from South Korea, "Biomarkers to indicate past exposure to radiation have not been entirely...

Oral mucositis was avoided by plasmid/liposome delivery of SOD2 gene.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Post radiational oral cavity mucositis could be avoided by overexpression of the manganese superoxide dismutase gene. "Oral cavity mucositis is a major toxicity of radiation therapy for head and...

UVA radiation produces apoptosis of immortalized human keratinocytes.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- UVA radiation treated immortalized keratinocytes creates GSH efflux, increasing intracellular oxidative stress and apoptosis. "We have investigated the role played by GSH efflux in apoptosis of...

Approximately half of all skin cancers have TP53 mutations.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Approximately half of all skin cancers have TP53 mutations. "The p53 gene (TP53) is mutated in numerous human cancers. We have used it as a molecular target to characterize the induction of...

Telomeres shorten in rat organs, except the brain, in an age-dependent manner.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Telomeres shorten in rat organs, except the brain, in an age-dependent manner. According to recent research from England, "Telomeres, the non-coding sequences at the ends of chromosomes, in the...

Increased CD26/dipeptidyl pepticlase IV on cell membrane increases sensitivity.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Increased CD26/dipeptidyl pepticlase IV on cancer cells increases sensitivity to topoisomerase II inhibitors. "CD26/dipeptidyl peptidase IV (DPPIV) is a surface antigen with multiple functions,...

There is an important role for HGK in cell transformation and invasiveness.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- There is an important role for HGK in cell transformation and invasiveness of tumor cell lines. "HGK (hepatocyte progenitor kinase-like/germinal center kinase-like kinase) is a member of the human...

Petrosaspongiolide M is a potent inhibitor of the NF-kappaB pathway.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Petrosaspongiolide M is a potent inhibitor of the NF-kappaB pathway. "Petrosaspongiolide M (PT) is a potent secretory phospholipase A inhibitor and anti-inflammatory agent. This marine metabolite...

p53 promoters are readily accessible to constitutive DNase I.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- p53 promoters are readily accessible to constitutive DNase I. According to recent research from the United States, "The ability of p53 to alter, at the transcriptional level, the gene expression of...

Mth1 gene disruption suppressed tumorigenesis caused by an Ogg1 deficiency.
May 5, 2003... 2003 MAY 5 - (NewsRx.com & NewsRx.net) -- Mth1 gene disruption suppressed tumorigenesis caused by an Ogg1 deficiency. "Using Mth1 and Ogg1 knockout mice, we evaluated the roles of these enzymes to prevent tumorigenesis and the accumulation...