Cancer Gene Therapy Week articles from March 2009

Cancer Gene Therapy Week archives from March 2009

Data on cancer gene therapy discussed by researchers at Dankook University.(Report)
March 2, 2009... "A trans-splicing ribozyme that can specifically reprogram human telomerase reverse transcriptase ( hTERT) RNA was previously suggested as a useful tool for tumor-targeted gene therapy. In this study, we applied transcriptional targeting with...

Findings from Washington University, Medical Department in cancer gene therapy reported.
March 2, 2009... "The ability to achieve tumor selective expression of therapeutic genes is an area that needs improvement for cancer gene therapy to be successful. One approach to address this is through the use of promoters that can be controlled by external...

New cancer gene therapy study findings have been published by scientists at Fourth Military Medical University.
March 2, 2009... According to recent research from Xian, People's Republic of China, " Eukaryotic initiation factor eIF4E, an important regulator of translation, plays a crucial role in the malignant transformation, progression and chemoresistance of many human...

New cancer gene therapy study findings have been reported by researchers at Bayer Healthcare.
March 2, 2009... "Therapeutic monoclonal antibodies continue to achieve clinical success for the treatment of many different diseases, particularly cancer. However, the production and purification of antibodies continues to be a time and labor-intensive process...

New cancer gene therapy study findings recently were reported by L.P. Lefter and co-researchers.(Report)
March 2, 2009... "In this study, we addressed the hypothesis that transcriptional suppression of erythroblastosis virus E26 oncogene homolog 1 (ETS-1) is an efficient therapeutic approach to pancreatic adenocarcinoma by investigating the effect of ETS-1...

Research reports from University of California provide new insights into cancer gene therapy.
March 2, 2009... According to a study from the United States, "Adoptive T-cell therapy is clinically efficacious in the treatment of select cancers. However, it is often difficult to obtain adequate numbers of tumor-specific T cells for therapy." "One...

Studies in the area of cancer gene therapy reported from University of Tsukuba.
March 2, 2009... According to recent research published in the journal Cancer Gene Therapy, "Combination therapy with replicative oncolytic viruses is a recent topic in innovative cancer therapy, but few studies have examined the efficacy of oncolytic...

New enzyme research from University of Pennsylvania, Medical Department outlined.
March 2, 2009... In this recently published article, scientists in the United States conducted a study "To evaluate whether two molecular biomarkers, thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD), could be clinically useful in...

Researchers at Jikei University, Medical Department have published new data on fibrin tissue adhesives.(Report)
March 2, 2009... "The fibrin glue system (FGS) consists of liquid forms of fibrinogen and thrombin and is used widely in surgery for hemostasis. In this study, as a novel and unique approach, the possibility and efficacy of locoregional gene transfer using the...

Recent findings in glioblastoma described by M. Enderlin and colleagues.
March 2, 2009... "Interferon-gamma-inducible protein 10 is a potent chemoattractant for natural killer cells and activated T lymphocytes. It also displays angiostatic properties and some antitumor activity," scientists in Heidelberg, Germany report (see also...

Lund University reports research in life sciences.
March 2, 2009... According to a study from Lund, Sweden, "Bone marrow-derived multipotent mesenchymal stroma cells (MSCs) have emerged as cellular vectors for gene therapy of solid cancers. We implanted enhanced green fluorescent protein-expressing rat MSCs...

Jinan University details research in cancer gene therapy.
March 2, 2009... A report, 'Somatostatin analogues inhibit cancer cell proliferation in an SSTR2-dependent manner via both cytostatic and cytotoxic pathways,' is newly published data in Oncology Reports. "Somatostatin receptors (SSTRs) are inhibitory G-protein...

Research on cancer gene therapy discussed by scientists at Shandong University.
March 2, 2009... Investigators publish new data in the report 'Regulation of the vascular endothelial growth factor and growth by estrogen and antiestrogens through Efp in Ishikawa endometrial carcinoma cells.' According to recent research from Jinan, People's...

New findings from Fourth Military Medical University describe advances in gene therapy.
March 2, 2009... Fresh data on gene therapy are presented in the report 'Knockdown of human bid gene expression enhances survival of CD8+ T cells.' According to recent research from People's Republic of China, "Tumor cells have developed immune evasion...

Data on cancer gene therapy discussed by researchers at Chiba University.
March 9, 2009... "Based on the genetic background of cancer, we have been trying to develop novel diagnostic and therapeutic strategies against human cancers. c-myc gene activation has been detected in many human cancers, indicating a key role of c-myc in tumor...

Findings from University of Pittsburgh in cancer gene therapy reported.(Report)
March 9, 2009... "The aim of this study was to use gene therapy via the Sleeping Beauty (SB) system to increase telomerase promoter activity to target hepatocellular carcinoma (HCC). In previous studies, we identified selective and increased expression of...

New cancer gene therapy research reported from University of Helsinki.
March 9, 2009... "Despite promising preclinical results, the clinical benefits of cancer gene therapy have been modest heretofore. The main obstacle continues to be the level and persistence of gene delivery to sufficiently large areas of the tumor," scientists...

New cancer gene therapy study findings have been reported by scientists at Gene Therapy Center.(Report)
March 9, 2009... According to recent research published in the journal BMC Cancer, "Chemoresistance is one of the main obstacles to successful cancer therapy and is frequently associated with Multidrug resistance (MDR). Many different mechanisms have been...

Research data from A. Mohr and colleagues update understanding of cancer gene therapy.
March 9, 2009... "Lung cancer is a major public health problem in the western world, and gene therapy strategies to tackle this disease systemically are often impaired by inefficient delivery of the vector to the tumour tissue. Some of the main factors...

Scientists at China Pharmaceutical University discuss research in cancer gene therapy.
March 9, 2009... "The survivin gene may be a good target for cancer gene therapy because it is overexpressed in a variety of human tumors, including gastric cancer, bill not in differentiated adult tissues. To explore effects of the siRNA of the survivin gene...

Research from V.K. Agrawal and co-authors yields new data on gene therapy.
March 9, 2009... According to recent research from London, the United Kingdom, "Transfer of healthy autologous tissue as a microvascular free flap facilitates reconstruction during ablative cancer surgery. In addition to filling surgical defects, free flaps...

Studies from B.S. Ko and co-authors have provided new information about gene therapy.
March 9, 2009... "Embryonic stem (ES) cells are considered to have potentials for tissue regeneration and treatment of diverse human diseases. ES cells are capable of indefinite renewal and proliferation, which can be induced to differentiate into tissues of...

Study results from C. Barra and colleagues broaden understanding of gene therapy.
March 9, 2009... According to recent research from Ploufragan, France, "Adenovirus-based vectors are widely developed for potential utilization as vectors in vaccine and gene therapy strategies. We focused on developing a helper-dependent adenoviral (HD-Ad)...

New data from M. Ni et al illuminate research in life sciences.
March 9, 2009... "We prepared single-chain immunoglobulin Fv fragments (scFv) SLH10 specific for the HepG2 cell line after biopanning from a large human-naive phage display library (Griffin. I Library). The three-dimensional (3D) structure of SLH10 was modelled...

Reports outline vascular endothelial growth factor study findings from P. Pechan and colleagues.
March 9, 2009... "Vascular endothelial growth factor (VEGF) is important in pathological neovascularization, which is a key component of diseases such as the wet form of age-related macular degeneration, proliferative diabetic retinopathy and cancer. One of the...

Investigators at University of Alberta release new data on cancer gene therapy.
March 9, 2009... A new study, 'Autotaxin protects MCF-7 breast cancer and MDA-MB-435 melanoma cells against Taxol-induced apoptosis,' is now available. According to recent research from Edmonton, Canada, "Autotaxin (ATX) promotes cancer cell survival, growth,...

Study findings from Scripps Research Institute provide new insights into cancer gene therapy.
March 9, 2009... Scientists discuss in 'Deficiency of a potential 3p21.3 tumor suppressor gene UBE1L (UBA7) does not accelerate lung cancer development in K-rasLA2 mice' new findings in cancer gene therapy. "Genetic lesions in chromosomal region 3p21.3 marks...

Investigators at Shandong University, Department of Hematology have published new data on chemotherapy.(Report)
March 9, 2009... A new study, 'Down-regulation of Notch-1 increases co-cultured Jurkat cell sensitivity to chemotherapy,' is now available. "The bone marrow (BM) microenvironment plays a critical role in malignant cell growth, patient survival and response to...

Data on life sciences detailed by researchers at Georgetown University.(Report)
March 9, 2009... New research, 'The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling,' is the subject of a report. According to recent research from the United States, "Hepatocellular carcinoma (HCC) is the...

Researchers at National Institutes of Health have published new data on cancer gene therapy.(Report)
March 16, 2009... According to a study from the United States, "Recently, considerable efforts have been directed toward antivascular therapy as a new modality to treat human cancers. However, targeting a therapeutic gene of interest to the tumor vasculature...

New leukemia gene therapy data have been reported by S. Kaneko and co-authors.
March 16, 2009... "Long-term clinical remissions of leukemia, after allogeneic hematopoietic stem cell transplantation, depend on alloreactive memory T cells able to self-renew and differentiate into antileukemia effectors. This is counterbalanced by detrimental...

Data on cancer gene therapy detailed by researchers at Case Western Reserve University, Department of Biochemistry.
March 16, 2009... A report, '9-Aminoacridine-based anticancer drugs target the PI3K/AKT/mTOR, NF-kappaB and p53 pathways,' is newly published data in Oncogene. According to a study from the United States, "Acquisition of a transformed phenotype involves...

Report summarizes cancer gene therapy study findings from Kanazawa University, Cancer Research Institute.
March 16, 2009... Scientists discuss in 'Essential contribution of Ets-1 to constitutive Pim-3 expression in human pancreatic cancer cells' new findings in cancer gene therapy. "We previously demonstrated that the proto-oncogene Pim-3 with serine/threonine...

Reports by J.L. Hsieh and co-researchers describe recent advances in cancer gene therapy.
March 16, 2009... A report, 'Transthyretin-driven oncolytic adenovirus suppresses tumor growth in orthotopic and ascites models of hepatocellular carcinoma,' is newly published data in Cancer Science. According to recent research published in the journal Cancer...

RNA interference toward MMP-2 may be an effective therapeutic strategy for cancer.
March 23, 2009... The invasion or metastasis of pancreatic cancer has been known to be a complex process involving many molecular mechanisms, of which proteolytic degradation of extracellular matrix (ECM) exerted by matrix metalloproteinases (MMPs) was...

Data on cancer gene therapy described by K.J. Kelly et al.
March 23, 2009... According to a study from the United States, "There is a clinical need for improved intraoperative detection of lymph node metastases from malignant melanoma (MM). We aimed to investigate the use of recombinant vaccinia virus 1h68, expressing...

Researchers at Vrije University Amsterdam target glioma.
March 23, 2009... According to a study from Netherlands, "The inevitable clinical recurrence of high grade gliomas after standard treatment is due to the highly diffuse infiltrating parts of these tumors, which remain after surgery and respond poorly to...

Research from University of London, Imperial College has provided new information about proteomics.(Report)
March 23, 2009... "Targeting specific receptors is attracting growing interest in the fields of drug delivery and gene therapy for cancer treatment. The urokinase plasminogen activator receptor (uPAR) is overexpressed on many tumors, particularly that of...

Researchers from Third Military Medical University discuss findings in suicide.(Report)
March 23, 2009... According to a study from Chongqing, People's Republic of China, "Suicide gene therapy, particularly that utilizing the cytosine deaminase/5-fluorocytosine (CD/5-FC) system, represents a novel and attractive methodology of cancer research....

Data on cancer gene therapy reported by researchers at University of Louis Pasteur.
March 23, 2009... Fresh data on cancer gene therapy are presented in the report 'von Hippel-Lindau tumor suppressor gene-dependent mRNA stabilization of the survival factor parathyroid hormone-related protein in human renal cell carcinoma by the RNA-binding...

New cancer gene therapy data have been reported by scientists at University of Turku.
March 23, 2009... A new study, 'Suppression of breast cancer cell growth by a monoclonal antibody targeting cleavable ErbB4 isoforms,' is now available. According to recent research from Turku, Finland, "ErbB4 isoforms mediate different cellular activities...

Scientists at Gunma University, Institute for Molecular and Cellular Regulation describe research in cancer gene therapy.(Report)
March 23, 2009... Research findings, 'LPA1 receptors mediate stimulation, whereas LPA2 receptors mediate inhibition, of migration of pancreatic cancer cells in response to lysophosphatidic acid and malignant ascites,' are discussed in a new report. "Malignant...

Scientists at Hiroshima University, Department of Molecular Pathology publish research in cancer gene therapy.
March 23, 2009... Scientists discuss in 'Transcriptome dissection of gastric cancer: identification of novel diagnostic and therapeutic targets from pathology specimens' new findings in cancer gene therapy. "Gastric cancer is the fourth most common malignancy in...

Study data from A. Lopergolo and co-authors update knowledge of cancer gene therapy.
March 23, 2009... Data detailed in 'Apollon gene silencing induces apoptosis in breast cancer cells through p53 stabilisation and caspase-3 activation' have been presented. According to recent research from Milano, Italy, "We analysed the effects of small...

Study findings from Medical School broaden understanding of cancer gene therapy.
March 23, 2009... Data detailed in 'The retinoblastoma gene Rb and its family member p130 suppress lung adenocarcinoma induced by oncogenic K-Ras' have been presented. "Mutations of the retinoblastoma tumor suppressor gene RB are frequently observed in human...

Researchers from University of Sheffield discuss findings in gene therapy.
March 23, 2009... New investigation results, 'Bacterial delivery of a novel cytolysin to hypoxic areas of solid tumors,' are detailed in a study published in Gene Therapy. "The efficacy of current anti-cancer gene therapies is limited by the inability of gene...

New life sciences research from University of Tubingen described.(Report)
March 23, 2009... Current study results from the report, 'Post-transcriptional regulation of adapter molecules by IL-10 inhibits TLR-mediated activation of antigen-presenting cells,' have been published. According to a study from Tubingen, Germany, "Toll-like...

Researchers from Chinese Academy of Medical Sciences, Department of Medical Oncology describe findings in solid cancer immunology.
March 23, 2009... Current study results from the report, 'A phase I trial of intratumoral administration of recombinant oncolytic adenovirus overexpressing HSP70 in advanced solid tumor patients,' have been published. "Our pre-clinical studies demonstrated that...

Reports outline vaccines study results from Cancer Research UK London Research Institute.(Report)
March 23, 2009... New investigation results, 'Role of TLR3 in the immunogenicity of replicon plasmid-based vaccines,' are detailed in a study published in Gene Therapy. "Replicon plasmids encoding an alphavirus RNA replicase constitute an alternative to...

Investigators at Sichuan University zero in on cancer gene therapy.
March 30, 2009... "Angiogenesis plays an important role in the growth of solid tumors. To date, no information has been acquired on the effectiveness of gene therapy in the orthotopic lung cancer model of syngeneic immunocompetent mice treated with an...

Reports on cancer gene therapy findings from Yale University, Medical Department provide new insights.
March 30, 2009... "mRNA transfection is a useful approach for temporal cell reprogramming with minimal risk of transgene-mediated mutagenesis. We applied this to redirect lymphocyte cytotoxicity toward malignant cells," scientists in the United States report...

Studies from F. Mori et al in the area of cancer gene therapy described.
March 30, 2009... "A genetic vaccine platform based on DNA electroporation (DNA-EP) and adenovirus ( Ad) was used to generate immune response against human carcinoembryonic antigen (CEA) and antitumor effects in murine models with spontaneous tumors arising in...

Studies from F.J. Zhao and co-researchers update current data on cancer gene therapy.(Report)
March 30, 2009... According to a study from Shenyang, People's Republic of China, "C-erbB-2 is a chief proto-oncogene of endometrial cancer, which plays an important role in the biological behavior of endometrial cancer. Its overespression is an important factor...

Studies from Y.L. Ran and colleagues yield new information about cancer gene therapy.
March 30, 2009... "Esophageal cancer is characterized by rapid clinical progression and poor prognosis, due to early-stage invasion of adjacent tissues and metastasis. Tissue factor pathway inhibitor-2 (TFPI-2) has been implicated as a metastasis-associated gene...

Research on cancer gene therapy reported by scientists at Juntendo University, Department of Respiratory Medicine.(Report)
March 30, 2009... Current study results from the report, 'Osteopontin is involved in the formation of malignant pleural effusion in lung cancer,' have been published. According to recent research published in the journal Lung Cancer, "Malignant pleural effusion...

Research reports on cancer gene therapy from Institute of Cancer Research provide new insights.
March 30, 2009... Researchers detail in 'Targeting Tankyrase 1 as a therapeutic strategy for BRCA-associated cancer,' new data in cancer gene therapy. According to a study from London, the United Kingdom, "The BRCA1 and BRCA2 proteins are involved in the...

Researchers from Harvard University, Cancer Center publish findings in cancer gene therapy.(Report)
March 30, 2009... Scientists discuss in 'Comparison of intravenous versus intraperitoneal administration of oncolytic herpes simplex virus 1 for peritoneal carcinomatosis in mice' new findings in cancer gene therapy. According to recent research from the United...

Researchers from INSERM discuss findings in cancer gene therapy.
March 30, 2009... New investigation results, 'Preclinical study of an ex vivo gene therapy protocol for hepatocarcinoma,' are detailed in a study published in Cancer Gene Therapy. "Preclinical studies in several animal models as well as clinical trials have...

Researchers from Jinan University describe findings in cancer gene therapy.
March 30, 2009... Current study results from the report, 'Overexpression of SSTR2 inhibited the growth of SSTR2-positive tumors via multiple signaling pathways,' have been published. "Somatostatin receptors (SSTR1-5) are inhibitory G-protein coupled receptors...

Researchers from University of Kentucky report on findings in cancer gene therapy.
March 30, 2009... Researchers detail in 'PDGF-A promoter and enhancer elements provide efficient and selective antineoplastic gene therapy in multiple cancer types,' new data in cancer gene therapy. "Development of antineoplastic gene therapies is impaired by a...

University of Chicago publishes research in cancer gene therapy.(Report)
March 30, 2009... Research findings, 'Translational strategies exploiting TNF-alpha that sensitize tumors to radiation therapy,' are discussed in a new report. According to a study from the United States, "TNFerade is a radioinducible adenoviral vector...

Data on cancer gene therapy vaccines described by C. Tosch et al.
March 30, 2009... Fresh data on cancer gene therapy are presented in the report 'Adenovirus-mediated gene transfer of pathogen-associated molecular patterns for cancer immunotherapy.' According to recent research from Strasbourg, France, "The delivery of...

Tianjin Medical University, Department of Neurosurgery details research in gene therapy.
March 30, 2009... A report, 'Downregulation of Wnt2 and beta-catenin by siRNA suppresses malignant glioma cell growth,' is newly published data in Cancer Gene Therapy. "Increasing evidence suggests that aberrant activation of Wnt signaling is involved in tumor...