Cancer Gene Therapy Week articles from March 2004

Cancer Gene Therapy Week archives from March 2004

A dominant-negative mutant of the c-Jun gene stems colorectal cancer growth.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- A dominant-negative mutant of the c-Jun gene stems colorectal cancer growth. "Activator protein-1 (AP-1), a transcription factor, is activated through many oncogenic signals. However, its biological...

5-Fluorocytosine increases the toxicity of oncolytic viruses.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- 5-Fluorocytosine increases the toxicity of oncolytic viruses. "Clinical studies with oncolytic adenoviruses have shown that existing viruses are safe but lack efficacy. To selectively increase the...

The ZD55-gene therapy system is a potent anticancer tool.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- The ZD55-gene therapy system is a potent anticancer tool. According to recent research published in the journal Cell Research, "ONYX-015 is an attractive therapeutic adenovirus for cancer because...

Immune response makes stem cells transduced by lentiviral vectors disappear.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Immune response makes stem cells transduced by lentiviral vectors disappear. "Lentiviral vectors are increasingly being used for transferring genes into hematopoietic stem cells (HSCs) due to their...

FDA approves Genasense NDA.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Genta, Inc., (GNTA) and Aventis (AVE) announced that the U.S. Food and Drug Administration (FDA) has accepted the new drug application (NDA) for Genasense (oblimersen sodium), the first systemic...

Genetic patterns were stable in human malignant glioma xenografted in nude mice.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Studying subcutaneous xenografts in nude mice is promising for analysis of the molecular profile of malignant astrocytoma and oligodendroglioma, researchers report. "In order to develop preclinical...

A new assay detects MGB1 transcript in the blood of breast cancer patients.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Researchers develop a sensitive assay to detect mammaglobin (MGBI)in peripheral blood of breast cancer patients, which may have prognostic significance. According to researchers writing in the...

CHEK2*1100delC germline mutation carriers are at risk for another breast tumor.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Patients who are CHEK2* 1100delC mutation carriers should undergo prolonged surveillance because of increased risk of developing another breast tumor. According to recent research published in the...

Mutations, especially 11q loss, may be involved in early-onset breast tumors.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- The combined use of genomic patterns and molecular targets may provide a useful tool for diagnostic, therapeutic, and prognostic purposes in early-onset breast tumor development in Taiwanese women. ...

Paget carcinoma cells differ from those of the underlying carcinoma.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Study finds that the underlying tumors in the breast are coincidental neoplastic lesions (collision tumors) different from Paget carcinoma (PC) cells. "Paget's carcinoma of the breast is...

Tumor growth is inhibited by targeted alliinase delivery.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Allilcin resulted in tumor growth arrest in a human tumor cell line xenograft in nude mice. "Allicin (diallyl thiosulfinate), a highly active component in extracts of freshly crushed garlic, is the...

Nutrition contributes to aging and cancer development.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- DNA methylation provides an important common link between aging, cancer, and nutrition, researchers say. "Cancer and aging are two coupled developmental processes as reflected by the higher...

HPV, chromosome aberrations correlate with transition to microinvasive carcinoma.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Integration of human papillomavirus (HPV) 16/18 DNA is an important event in the transition of cervical intraepithelial neoplasia (CIN I, II, and III) to microinvasive carcinoma. "Cervical...

Synthetic DNA company announces conversion of series A preferred stock.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Hybridon, Inc., (HBY) announced that essentially all its shares of outstanding series A preferred stock has been converted into 21.2 million shares of common stock. These conversions raise the...

Epstein-Barr virus and Helicobacter pylori may be causes of gastric cancer.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Researchers discuss evidence for a possible role of Helicobacter pylori (H. pylori) and Epstein-Barr virus (EBV) in the development of some gastric cancers. According to recent research from...

Gene clustering analysis may serve as molecular markers for gastric adenoma.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Clustering analysis of expression profiles using a limited number of genes may serve as molecular markers for gastric adenoma with different biological properties, researchers say. "Gastric...

Tumor suppressor gene hypermethylation may predict GI stromal tumor behavior.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Study supports the methylation status of E-cadherin as a prognostic marker for early gastrointestinal stromal tumor (GIST) recurrence and survival. "The growing understanding of the epigenetic...

Massive hyperdiploidy and tetraploidy are rare in AML.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Massive hyperdiploidy and tetraploidy define a prognostically unfavorable cytogenetic group in de novo acute myelocytic leukemia (AML). According to published research from the United States,...

Diet and genetics are related to lung cancer susceptibility.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- There is considerable optimism regarding new molecules and antibodies that target specific cellular receptors or mutations in lung cancer, researchers say. "The statistics on lung cancer form a...

API2-MALT1-positive tumors are more aggressive in colorectal lymphoma.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Patients with API2-NALT1-positive tumors should be treated as having more aggressive disease and should be followed longer, researchers say. According to published research from Japan, "The...

Estrogen inhibits paclitaxel-induced apoptosis in ovarian cancer cell lines.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Treatment of patients with ovarian cancer with paclitaxel might be less effective in the setting of postoperative estrogen replacement therapy, researchers say. "The influence of postoperative...

Genetic fingerprinting finds associations between prostate cancer and BPH.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Genetic fingerprinting has found new common changes in the prostates of patients with benign prostatic hypertrophy and prostate cancer. According to a study from the United States, "Two of the most...

Increased cholesterol in prostate tumor cell membranes may be linked to cancer.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Studying lipid rafts in prostate cancer cells may reveal a connection between diet and aggressive malignant disease. According to recent research published in the Journal of Cellular Biochemistry,...

Ras signaling may be responsible for prostate cancer progression.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Growth factors and receptors that utilize Ras family members may drive prostate cancer progression to a state of androgen hypersensitivity, researchers say. According to published research from the...

Researcher receives $9 million grant to launch gene therapy trials.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Henry Ford Hospital researcher has been awarded a $9 million grant by the U.S. National Institutes of Health to study the effectiveness of gene therapy as a treatment for prostate cancer. The...

Understanding apoptosis key to effective prostate cancer therapy.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Inhibition of apoptosis appears to be a critical pathophysiological factor contributing to the development and progression of prostate cancer, researchers say. According to a study from the United...

Germline SDHB mutations can predispose to early-onset renal cell carcinoma.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Researchers find that germline SDHB mutations can predispose to early-onset kidney cancers as well as to paragangliomas. According to a study from the United States, "Hereditary paraganglioma...

Construction of a reporter system can detect fine differences in p53 activation.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Researchers propose constructs for generating reporter cell lines from various cultures in order to identify the genetic or chemical factors that modulate the p53 activity and may be employed in new...

Wilms tumors with unfavorable histology had abnormalities of 17p.
March 1, 2004... 2004 MAR 1 - (NewsRx.com & NewsRx.net) -- Nonrandom losses of 16/16q, 7p, and 14q may point to the importance of genomic imbalance in the pathogenetic consequences and progression of Wilms tumor, researchers say. "Cytogenetic analyses of...

A new gene carrier steers interleukin-12 to solid tumors.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- A new gene carrier steers interleukin-12 to solid tumors. "Delivery of the interleukin-12 (IL-12) gene to solid tumors is a promising anticancer therapy. Vectors are currently being developed to...

Coupled carriers may offer a better way to transfer genes to tumor cells.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Coupled carriers may offer a better way to transfer genes to tumor cells. "In this study, we developed a nonviral, cationic, targeted DNA-carrier system by coupling SAINT/DOPE lipids to monoclonal...

Gutless vectors encoding transgenes enhance the effect of oncolytic viruses.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Gutless vectors encoding transgenes enhance the effect of oncolytic viruses. According to recent research published in the journal Cancer Gene Therapy, "oncolytic adenoviral vectors selectively...

Modified cytotoxic T cells ferry interleukin-12 to local tumor sites.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Modified cytotoxic T cells ferry interleukin-12 to local tumor sites. According to published research from the United States, "adoptive immunotherapy with Epstein-Barr virus (EBV)-specific...

Multiply modified retroviral vectors carry high titers in lab evaluations.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Multiply modified retroviral vectors carry high titers in lab evaluations. "Tumor-specific expression of therapeutic genes is a prerequisite in many approaches to retrovirus-mediated cancer gene...

Deregulated EZH2 gene may be related to poorly differentiated breast carcinoma.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Deregulated expression of EZH2 may be associated with loss of differentiation and development of poorly differentiated breast cancer in humans, researchers say. "Polycomb group (PcG) genes...

Folate-targeted lipid-based gene vectors reduce breast adenocarcinoma volume.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Folate-targeted lipid-based gene vectors reduce breast adenocarcinoma volume. "Gene therapy utilizing lipid-based delivery systems holds tremendous promise for the treatment of cancer. However, due...

Gamma-tocotrienol can induce apoptosis in human breast cancer cells.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Cytochrome c may not be the critical protein released from mitochondria that triggers gamma-tocotrienol-induced apoptosis in MDA-MB-231 cells, researchers say. "Tocotrienols, which are Vitamin E...

Amidox inhibits ribonucleotide reductase in human leukemia cells.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Amidox is cytotoxic against human HL-60 promyelocytic leukemia cells. According to published research from Austria, "Amidox, a new polyhydroxy-substituted benzoic acid derivative, is a potent...

Clinical study to investigate the combination of GTI-2040 and gemcitabine.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Lorus Therapeutics, Inc., announced the initiation of a clinical trial aimed at examining the clinical application of its antisense drug, GTI-2040, in combination with gemcitabine in patients with solid...

p53 Gene transfer won't harm normal cells.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- p53 Gene transfer won't harm normal cells. According to recent research from Italy, "the p53 oncosuppressor is strictly maintained in an inactive form under normal conditions, while it is...

Atypical glandular cells in HPV+ patients may indicate serious disease.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Human papilloma virus (HPV)-positive atypical glandular cells (AGS) may be helpful in evaluating patients with atypical endocervical cells. According to recent research from the United States,...

Cervical cancer prevention should include human papillomavirus testing.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Researchers recommend ways to incorporate human papilloma virus (HPV) testing into clinical practice. "A clear causal relationship has been established between human papilloma virus (HPV) infection...

Gender and location may be related to the pathogenesis of colon cancer.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Researchers report that low 17HSD type 2 mRNA expression is an independent marker of favorable prognosis in females with distal colorectal cancer. "The mRNA expression of 17beta-hydroxysteroid...

Osteopontin correlates with colon cancer tumor progression.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Assay of 12,000 genes reveals osteopontin to be a marker for colon cancer, researchers say. "Identifying molecular markers for colon cancer is a top priority. Using a pooled sample approach with...

Study shows RAY1/ST7 is not a colorectal cancer tumor suppressor gene.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Researchers screen colorectal cancers and find that RAY1/ST7 does not have a role as a colorectal cancer tumor suppressor gene. According to recent research published in the journal Cancer Letters,...

Albuferon maker reports increased net loss in 2003.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Human Genome Sciences, Inc., (HGSI) announced financial results for the quarter and full year periods ended December 31, 2003, and provided guidance for financial results anticipated for the full year...

A cell-mediated approach to sFlt-1 gene therapy targets thyroid cancer.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- A cell-mediated approach to sFlt-1 gene therapy targets thyroid cancer. According to recent research from the United States, "tumor progression largely depends on blood supply and neovessel...

Estrogen affects ultrastructure of testis germinal epithelium in Wistar rats.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Injections of estrogens over the long term may result in sterilization in young patients. "Estrogens are used extensively in cancer therapy of male genital organs. They may cause feminization in...

VIR201 data presented at conference.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Virax Holdings, Ltd., announced that its research partner, the Australian National Centre for HIV Epidemiology and Clinical Research (NCHECR), presented data and released results of the recent clinical...

Some types of familial isolated hyperparathyroidism have unknown cause.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Mutations in the HRPT2 gene are not responsible for the development of familial isolated hyperparathyroidism (FIHP). "Familial isolated hyperparathyroidism (FIHP) can result occasionally from the...

CIBEX contains experimental data on gene expression research.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- The Center for Information Biology gene EXpression database (http://cibex.nig.ac.jp) (CIBEX) is a public database with information from laboratories throughout the world on experimental gene expression...

Researchers develop a retroviral tagged cancer gene database.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Researchers can identify integrations of interest and compare their results with those for multiple tumor models and tumor types using an information system called the Retroviral Tagged Cancer Gene...

SNP500Cancer database helps researchers map diseases.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- The SNP500Cancer is a valuable resource for investigators to select single nucleotide polymorphisms (SNPs) for analysis, design genotyping assays using validated sequence data, choose selected assays...

GATA1 mutations are common children with Down syndrome.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- The method by which mutagenesis of GATA 1 contributes to leukemia in Down syndrome (DS) remains unknown, researchers say. According to recent research published in the journal Blood, "GATA-1 is the...

Mutations in the K-ras gene are involved in B6C3F1 lung carcinogenesis mice.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "Based on long-term toxicity and carcinogencity studies in B6C3F1 mice conducted by the National Toxicology Program, 2,2-Bis(bromomethyl)-1,3-propanediol...

Peroxisome proliferator-activated receptor-gamma activation inhibits NSCLC.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligands may serve as potential therapeutic agents for non-small cell lung cancer (NSCLC). According to recent research from the United...

The Libechov minipig model is suitable for studying human melanoma.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- The minipig model is an interesting model for human melanoma study, since most melanomas regressed spontaneously within the first year of the piglets' lives. According to published research from...

Genetic abnormalities are related to neuroendocrine tumor progression.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Various neuroendocrine tumors (NETS) are associated with genetic abnormalities and varied molecular pathways, researchers say. "Neuroendocrine tumors originate in tissues that contain cells derived...

Raf is necessary for Ras transformation of ovarian epithelial cells.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Researchers find that, in contrast to other epithelial cell types, Raf is a major effector for Ras transformation of ovarian epithelial cells." "According to a study from the United States,...

Beta-catenin nuclear signaling molecule may be an oncogene in prostate cancer.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Further understanding of the molecular mechanisms responsible for prostate cancer (CaP) development and progression is paramount for overcoming the current diagnostic and therapeutic hurdles presented...

Gonadal teratoma behavior depends upon tumor site and patient age.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- The typical ovarian teratoma derives from a benign germ cell in a parthenogenetic-like fashion, whereas the typical postpubertal testicular example derives from a malignant germ cell, researchers say....

Amine oxidases and tumors are correlated.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Both oxidant and antioxidant enzymes are involved in carcinogenesis, researchers say. "The physiological function in living organisms of amine oxidases (AO) is not completely established but is...

Tumor-pulsed dendritic cells activate antitumor protection.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Tumor-pulsed dendritic cells activate antitumor protection. According to a study from Taiwan, "to improve the efficacy of tumor cell-based and dendritic cell (DC)-based cancer vaccines, this study...

Single photon emission computed tomography tracks genes in minute lung tumors.
March 8, 2004... 2004 MAR 8 - (NewsRx.com & NewsRx.net) -- Single photon emission computed tomography tracks genes in minute lung tumors. "The Na+/I- symporter (NIS) is a membrane glycoprotein that facilitates the uptake of iodine into thyroid follicular...

A novel tissue-specific promoter system provides controlled gene expression.
March 15, 2004... 2004 MAR 15 - (NewsRx.com & NewsRx.net) -- A novel tissue-specific promoter system provides controlled gene expression. According to recent research from Japan, "present cancer gene therapy using proapoptotic genes has had limited success...

Tumors that resist wild-type p53 respond to p53AIP1 gene therapy.
March 15, 2004... 2004 MAR 15 - (NewsRx.com & NewsRx.net) -- Tumors that resist wild-type p53 respond to p53AIP1 gene therapy. According to published research from Japan, "the p53AIP1 gene, which we recently identified as a novel p53-target, mediates...

Anti-cathepsin L single chain variable fragment prohibits melanoma metastasis.
March 15, 2004... 2004 MAR 15 - (NewsRx.com & NewsRx.net) -- Anti-cathepsin L single chain variable fragment prohibits melanoma metastasis. According to scientists writing in the journal Cancer Research, "we demonstrated previously that the switch from...

Mutant adenovirus can destroy multidrug-resistant cancer cells.
March 15, 2004... 2004 MAR 15 - (NewsRx.com & NewsRx.net) -- Mutant adenovirus can destroy multidrug-resistant cancer cells. According to a study from Germany, "resistance to chemotherapy is responsible for a failure of current treatment regimens in cancer...

HPC/plasmid constructs promote gene transfer to murine kidney cancer.
March 15, 2004... 2004 MAR 15 - (NewsRx.com & NewsRx.net) -- HPC/plasmid constructs promote gene transfer to murine kidney cancer. "We report here that the anticancer drug hexadecylphosphocholine (HPC) can control plasmid DNA-mediated gene transfer to renal...

Caspase 9 releases Smac, leading to the rapid induction of apoptosis.
March 15, 2004... 2004 MAR 15 - (NewsRx.com & NewsRx.net) -- Study finds that two retinoid analogs with unique characteristics activate two distinct apical caspases (2 or 9) to initiate apoptosis, researchers say. According to a study from the United States,...

Cell-cell contacts trigger a programmed necrotic process.
March 15, 2004... 2004 MAR 15 - (NewsRx.com & NewsRx.net) -- Human dermal fibroblast cell-to-cell contacts activate a programmed and irreversible necrotic process that functionally involves COX-2, researchers report. "Necrosis was induced by cell-cell...

p53 must be absent in order for 5-aza-2'-deoxycytidine to induce apoptosis.
March 15, 2004... 2004 MAR 15 - (NewsRx.com & NewsRx.net) -- Genetically defined tumors in mice responded to 5-aza-2'-deoxycytidine (5-aza-dC or decitabine). "The absence of functional p53 has complex consequences on the cellular responses to cytotoxic...

Research discovers how to target cell fusion; could lead to therapies, vaccines.
March 15, 2004... 2004 MAR 15 - (NewsRx.com & NewsRx.net) -- Mayo Clinic cancer researchers have developed a way to biologically fuse living cells through the use of a genetically engineered cell membrane. This process, which Mayo researchers call...

p53 Deficiency instigates urothelial proliferation but not tumorigenesis.
March 15, 2004... 2004 MAR 15 - (NewsRx.com & NewsRx.net) -- Complete loss of p53 - not merely a reduction - is necessary to induce Ha-ras to promote tumorigenesis, researchers say. "Mutation and deletion of the p53 tumor suppressor gene are arguably the...

In vitro, two herbal teas are effective only in high concentrations.
March 15, 2004... 2004 MAR 15 - (NewsRx.com & NewsRx.net) -- In vitro studies shows that two herbal teas (Essiac (ES) and Flor-Essence (FE)) showed some antiproliferative activity at high concentrations. According to a study from Canada, "Essiac and...

Resveratrol induces apoptosis in human breast carcinoma MCF-7 cells.
March 15, 2004... 2004 MAR 15 - (NewsRx.com & NewsRx.net) -- Researchers report a mechanism by which resveratrol induces cell death in breast cancer. According to published research from South Korea, "Resveratrol, which is found in grapes and wine, has been...

Calponin proteins can inhibit melanoma and adenocarcinoma cell motility in vitro.
March 15, 2004... 2004 MAR 15 - (NewsRx.com & NewsRx.net) -- Calponin has a role in the mechanical stabilization in the process of metastasis. "Metastasis of diseased cells is the basic event leading to death in individuals with cancer. Establishment of...

Anticancer effects of silibinin combined with conventional agents shows promise.
March 15, 2004... 2004 MAR 15 - (NewsRx.com & NewsRx.net) -- Combinations of silibinin with conventional cytotoxic agents shows efficacy toward cell growth inhibition and in induction of apoptosis in breast cancer cell lines, researchers say. "Significant...

Caspases 2 and 8 mediate HOXA5-induced apoptosis in breast cancer cells.
March 15, 2004... 2004 MAR 15 - (NewsRx.com & NewsRx.net) -- Expression of HOXA5 can induce apoptosis in breast cancer cells through an apoptotic mechanism mediated by caspases 2 and 8, researchers say. According to a study from the United States, "HOXA5 is...

Inhibition of the PI3K/AKT signaling pathway restores apoptosis in AML.
March 15, 2004... 2004 MAR 15 - (NewsRx.com & NewsRx.net) -- The inhibition of the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway restores apoptosis in acute myeloid leukemia (AML) and may be explored as a novel target for molecular therapeutics in...

Myostatin could be used to inhibit rhabdomyosarcoma cell proliferation.
March 15, 2004... 2004 MAR 15 - (NewsRx.com & NewsRx.net) -- Rhabdomyosarcoma (RMS) tumor cell proliferation could be inhibited by myostatin, researchers say. According to recent research from New Zealand, "Rhabdomyosarcoma tumors are the most common...

PI 3-kinase inhibitor stifles squamous cell carcinoma antigen in certain cells.
March 15, 2004... 2004 MAR 15 - (NewsRx.com & NewsRx.net) -- Treatment with a phosphatidylinositol -3 (PI 3)-kinase inhibitor suppressed squamous cell carcinoma antigen (SCCA) production in SKG-IIIa cells, researchers say. According to recent research from...

Pegylated recombinant interferon alpha-2b is effective in treating CML.
March 15, 2004... 2004 MAR 15 - (NewsRx.com & NewsRx.net) -- Pegylated recombinant interferon (rIFN)-alpha2b is an active agent for the treatment of newly diagnosed chronic myelogenous leukemia (CML), researchers say. "Recombinant rIFN-alpha2b is an...

Preclinical data supports utility of INGN 241 combination regimens.
March 15, 2004... 2004 MAR 15 - (NewsRx.com & NewsRx.net) -- Three abstracts evaluating the role of mda-7/IL-24, the active ingredient in Introgen Therapeutics' (INGN) INGN 241, in models of lung and breast cancer were presented at the Society of University...