Cancer Gene Therapy Week articles from March 2003

Cancer Gene Therapy Week archives from March 2003

Foreign DNA prevents mammary adenocarcinoma in transgenic mice.
March 3, 2003... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- Researchers in Italy have identified antisense oligodeoxynucleotides that not only treat but also prevent mammary adenocarcinomas in transgenic mice by heightening the innate immune response system. ...

Sporadic and familial forms are genetically and histologically separate.
March 3, 2003... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- "Meningiomas are common tumors of the coverings of the central nervous system (CNS), comprising 20% of intracranial neoplasms. The only genes known to be associated with sporadic meningiomas are NF2 on...

RNA degradation by hPNPase(')(Old-35) is common maintenance factor.
March 3, 2003... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "Terminal differentiation and cellular senescence display common properties including irreversible growth arrest. To define the molecular and ultimately the...

Cell lines characterized by frequent aberrations on chromosomes 2p, 9p.
March 3, 2003... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- According to a study from Germany, "Four Hodgkin's lymphoma cell lines (KM-H2, HDLM-2, L428, L1236) were analyzed for cytogenetic aberrations, applying multiplex fluorescence in situ hybridization,...

Deregulated DNA polymerase beta may enhance UV-induced genetic instability.
March 3, 2003... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- According to recent research from France, "We report here that DNA polymerase beta (pol beta), the base excision repair polymerase, is highly expressed in human melanoma tissues, known to be associated...

Impaired traffic of connexins is major cause of communication deficiency.
March 3, 2003... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- "Gap junctions, composed of connexins, provide a pathway of direct intercellular communication for the diffusion of small molecules between cells. Evidence suggests that connexins act as tumor...

Thiols have role in mediating mitogenic and/or apoptotic signaling events.
March 3, 2003... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "Thiols provide the major intracellular redox milieu and can undergo reversible oxidation and reduction. "To understand the role of thiols in redox...

Mutation in BRCA2 compromises the interaction with replication protein A.
March 3, 2003... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- "Mutations in the BRCA1 and BRCA2 genes predispose women to familial, early onset breast cancer. Both the BRCA1 and BRCA2 proteins appear to function in the homologous recombination pathway of DNA...

Patent issued for cancer therapeutic focuses on DNA core of drug.
March 3, 2003... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- Introgen Therapeutics, Inc. (NASDAQ:INGN) and the Board of Regents of The University of Texas System announced that the U.S. Patent and Trademark Office has issued to the Board of Regents U.S. patent...

Company increases focus on cancer, eliminates broad-based gene therapy research.
March 3, 2003... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- Cell Genesys, Inc. (NASDAQ:CEGE) announced its decision to decrease further resource investment in broad-based gene therapy programs in order to increase the focus on the company's clinical programs...

Induction of apoptosis-modulating p202 occurs, contributing to cell survival.
March 3, 2003... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- According to a report from the United States, "Previous studies have revealed that p202 (52 kDa), an interferon (IFN) and differentiation-inducible protein, negatively regulates cell proliferation and...

Lytic reactivation in infected B cells selectively arrests host functions.
March 3, 2003... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- Researchers in Japan report that "Productive infection and replication of herpesviruses usually occurs in growth arrested cells, but there has been no direct evidence in the case of Epstein-Barr virus...

Acetylation suppresses the proapoptotic activity of GD3 ganglioside.
March 3, 2003... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- According to a study from Italy, "GD3 synthase is rapidly activated in different cell types after specific apoptotic stimuli. De novo synthesized GD3 accumulates and contributes to the apoptotic program...

Two methylase genes, hpyIIIM and hpyIM, are preceded by alternative genes.
March 3, 2003... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- "A recently identified Helicobacter pylori gene, hrgA, was previously reported to be present in 70 (33%) of 208 strains examined," researchers in Japan report. "Sequence analysis of nine such...

Method of mapping integration sites identifies new CISs.
March 3, 2003... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- "Retroviral insertional mutagenesis in mouse hematopoietic tumors provides a powerful cancer gene discovery tool," researchers in the United States report. "Here, we describe a high-throughput,...

Mutational analysis of K-ras defines low and high grade types.
March 3, 2003... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- "We previously proposed a dualistic model for ovarian serous carcinogenesis. One pathway involves the stepwise development of invasive micropapillary serous carcinoma (MPSC) from serous borderline tumor...

ATP activates the mitogen-activated protein kinase in neoplasia.
March 3, 2003... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- Recent research from Canada investigated "the role of ATP in ovarian tumorigenesis, examining the expression of the P2U purinoceptor (P2U-R) and effect of ATP on growth stimulation in preneoplastic and...

Prolonged WT1 gene expression in blood can indicate relapse risk.
March 3, 2003... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- Recent research from Hungary aimed "to investigate if monitoring WT1 gene expression in peripheral blood (PBL) is an appropriate approach to monitor the progression of childhood acute lymphoblastic...

p53 Protein needed for arrest in some cells.
March 3, 2003... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "1,25-Dihydroxyvitamin D-3 [1,25-(OH)(2)D-3] is an effective agent for inhibiting the growth of prostate cancer cells including LNCaP and PC-3 cell lines....

UBP deubiquitinating enzymes exhibit a conserved three-domain architecture.
March 3, 2003... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "The ubiquitin-specific processing protease (UBP) family of deubiquitinating enzymes plays an essential role in numerous cellular processes. HAUSP, a...

c-Myc directly activates RNA polymerase III transcription.
March 3, 2003... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- "The proto-oncogene product c-Myc has a direct role in metazoan cell growth and division. RNA polymerase III (polIII) is involved in the generation of transfer RNA and 5S ribosomal RNA, and these...

Elucidating genetic mutations that cause hereditary disease.
March 3, 2003... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "Hereditary renal cancer syndromes can lead to multiple bilateral kidney tumors that occur at a younger age than do nonhereditary renal cancers. ...

Atomic force microscopy reveals kinks in the p53 response element DNA.
March 3, 2003... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "p53 is a 53 kDa nuclear phosphoprotein. Its function as a tumor suppressor critically lies in its ability to recognize its target DNA response elements as a...

Profiles show new marker constellations that may lead to classification changes.
March 3, 2003... 2003 MAR 3 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "Soft tissue tumor pathology is an actively evolving field. Novel clinicopathologic entities are reported each year, and ongoing histological,...

ER(-) cells have increased IL-8 expression that promotes tumor aggressiveness.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to recent research from France, "Estrogen receptor (ER) status is an important parameter in breast cancer management, as ER() breast cancers have a better prognosis than ER(-) tumors. This...

BRCA2 is high-risk susceptibility gene, has potential implication for management.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- "Studies of families with breast cancer have indicated that male carriers of BRCA2 mutations are at increased risk of prostate cancer, particularly at an early age," researchers in England report. ...

Only cancer cells will phosphorylate apoptin, leading to their apoptosis.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to a study from Netherlands, "Apoptin, a chicken anemia virus encoded protein, is thought to be activated by a general tumor specific pathway, because it induces apoptosis in a large number...

Suicide gene therapy expressing bacterial nitroreductase ablates cancer cells.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- Suicide gene therapy expressing bacterial nitroreductase ablates cancer cells. According to recent research from Scotland, "reactivation of telomerase maintains telomere function and is considered...

Trifunctional molecule designed for DNA recognition.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- A trifunctional molecule, dubbed R-132, is a "novel lead compound for the design of gene-targeted anticancer agents," pharmaceutical scientists report. "Control of gene expression is a cherished...

Tumors with gene-expression signature related to metastasis, clinical outcome.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "Metastasis is the principal event leading to death in individuals with cancer, yet its molecular basis is poorly understood. "To explore the...

Femoral extramedullary relapse after allogeneic bone marrow transplantation.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to recent research from Taiwan, "We describe a rare presentation of extramedullary relapse in an adolescent boy with Philadelphia chromosome-positive acute lymphoblastic leukemia who had...

High throughput methyl-single nucleotide polymorphism analysis can be done.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to a study from Germany, "Tumorigenesis is characterized by alterations of methylation profiles including loss and gain of 5-methylcytosine. Recently, we identified a single CpG, which seemed...

Fewer uroplakins are expressed in most cancers than in normal urothelium.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to a study from England, "The uroplakins are widely regarded as urothelium specific markers of terminal urothelial cytodifferentiation. This study investigated the expression of the four...

The human transcription factor AP-2 gamma may rely on an initiator element.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "Human activation protein-2 gamma (hAP-2gamma) is a key developmental transcription factor. It has been implicated in mammary carcinogenesis...

P-glycoprotein-mediated multidrug resistance can be blocked by ginsenoside Rg3.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- P-glycoprotein-mediated multidrug resistance can be blocked by ginsenoside Rg3. According to a study from South Korea, "Multidrug resistance has been a major problem in cancer chemotherapy. In...

Most tumor cells have potential to metastasize, have molecular signature.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- "Theories of cancer biology have long held that the metastatic process originates with rare cells within the primary tumor," researchers in the United States report. "A new study using expression...

Various DNA repair processes are altered, leading to mutagenesis.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to recent research from Germany, "Even though compounds of nickel, arsenic, cobalt, and cadmium are carcinogenic, their mutagenic potentials are rather weak. In contrast, they exert...

A large nuclear protein complex is responsible for recognizing nonnatural DNA.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- Researchers from the United States report that "Thiopurine treatment of human leukemia cells deficient in components of the mismatch repair system (Nalm6) initiated apoptosis after incorporation into...

EXO1 variants occur commonly in normal population, may not have role in disease.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to a study from Netherlands, "Mutations in the currently known mismatch repair genes cannot explain all cases of hereditary nonpolyposis colorectal cancer (HNPCC), and novel predisposing...

Screening reveals multiple aberrations including 8p deletion and 16q gain.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- "The majority of genetic studies of colorectal carcinogenesis have focused on changes found in primary tumors. Despite the fact that liver metastases are a leading cause of colorectal cancer deaths,...

Irinotecan metabolism and effects vary greatly from one patient to another.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- "Irinotecan, a camptothecin analogue, is a prodrug which requires bioactivation to form the active metabolite SN-38. SN-38 acts as a DNA topoisomerase I poison. Irinotecan has been widely used in the...

Oxidative damage background by 8-oxo-7,8-dihydroguanine is still problematic.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to recent research from Scotland, "The European Standards Committee on Oxidative DNA Damage (ESCODD) was set up to resolve the problems associated with the measurement of background levels of...

Nuclear antigen leader protein (EBNA-LP) may also regulate apoptosis.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to a study from Japan, "Epstein-Barr virus (EBV) nuclear antigen leader protein (EBNA-LP) plays a critical role in EBV induced transformation. An earlier report by Kawaguchi showed that...

DICE1 mutations don't appear responsible for allelic loss on chromosome 13q14.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "Previous studies have shown frequent allelic loss on chromosome 13 in esophageal squamous cell carcinoma (ESCC). We assessed the frequency of allelic loss...

Comet-FISH assay demonstrates very rapid gene repair following irradiation.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to recent research from North Ireland, "The alkaline single cell gel electrophoresis (comet) assay can be combined with fluorescence in situ hybridization (FISH) methodology to investigate...

Bispecific antisense treatment downregulates genes in cancer cells.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- Bispecific antisense treatment downregulates genes in cancer cells. "The functions of the antiapoptotic proteins Bcl-2 and Bcl-xL were examined in glioblastoma cells. Expression of both Bcl-2 and...

Molecular biology of tumorigenesis.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "Gliomas are the most common intracranial malignant tumors in humans, and high-grade gliomas in particular pose a unique challenge due to their...

Suicide gene therapy, ganciclovir, and irradiation produce cancer regression.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- Suicide gene therapy, ganciclovir, and irradiation produce cancer regression. According to recent research from Japan, "the application of adeno-associated virus (AAV) vectors to cancers is limited...

Misspecification of genetic random effects can occur due to family selection.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- "Family studies to identify disease related genes frequently collect only families with multiple cases. It is often desirable to determine if risk factors that are known to influence disease risk in...

RARA FISH accuracy for t(15;17) overcomes the drawbacks of PML gene FISH.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to a study from South Korea, "Determination of the remission of acute promyelocytic leukemia (APL) after chemotherapy can be difficult because many cases of APL show RT-PCR positivity after...

Profiling technology used in high-throughput multiplexed gene expression study.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- Althea Technologies, Inc., announced that the results of a pioneering study using multiplexed gene expression in compound library screening were published in the journal Molecular Cancer Therapeutics....

Cases emphasize relevance of early screening for endocrine disorders.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to recent research from Japan, "Two juvenile patients with multiple endocrine neoplasia type 1 (MEN1) who developed pituitary adenomas are reported. "The first case, a 14-year-old girl,...

EBV's LMP-1 has high prevalence of 30-bp deletion and Xho1 polymorphisms.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to recent research from Malaysia, "Nasopharyngeal carcinoma (NPC), a malignancy associated closely with Epstein-Barr virus (EBV), is prevalent among Chinese of Southern China origin....

The CD40 receptor can be useful target for cancer gene therapies.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Medical researchers believe CD40 would be an excellent candidate receptor for adenovirus-mediated gene therapies targeting cancer in the ovaries and other...

Manganese-containing superoxide dismutase is a highly conserved enzyme.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- "Manganese-containing superoxide dismutase (MnSOD) is a major detoxifying enzyme that functions in cellular oxygen metabolism by converting O[subscript]2- to H[subscript]2O[subscript]2. A cDNA...

Pediatric intestinal intussusception led to tumor and syndrome diagnosis.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to recent research from Japan, "A 12 year old boy visited our hospital with complaints of severe upper abdominal pain and vomiting. Marked tenderness was present in the upper abdomen, and a...

Chromosomal regions of 13q, 5q, and 16 are linked to metastasis and pathology.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to a study from England, "49 primary retinoblastoma (Rb) tumors were analyzed by the use of comparative genomic hybridization (CGH), and clinical/histological correlations were performed....

A less than or equal to600 kb region on human chromosome 1q42.3 induces cellular senescence.
March 10, 2003... 2003 MAR 10 - (NewsRx.com & NewsRx.net) -- According to recent research from Japan, "The introduction of a human chromosome 1 via microcell mediated chromosome transfer (MMCT) induces the cellular senescence in mouse melanoma B16-F10 cells....

Extracellular matrix affects BRCA1 expression and phosphorylation.
March 17, 2003... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Extracellular matrix affects BRCA1 expression and phosphorylation. "Germ line mutations in the breast cancer susceptibility gene BRCA1 account for the increased risk of early onset of familial...

Intravenous endostatin gene therapy alleviates murine lung metastasis.
March 17, 2003... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Intravenous endostatin gene therapy alleviates murine lung metastasis. According to a study from Japan, "tumors require ongoing angiogenesis to support their growth. Inhibition of angiogenesis by...

The relationship with telomeres and telomerase needs further investigation.
March 17, 2003... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- The relationship with telomeres and telomerase needs further investigation. According to recent research from the United States, "Telomeres are located at the ends of eukaryotic chromosomes. The...

Nuclear transport may be a target for cell growth.
March 17, 2003... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Nuclear transport may be a target for cell growth. According to recent research from the United States, "The function of many key proteins and transcription factors involved in cell growth can be...

Studies of the VHL gene may lead to treatments for many disorders.
March 17, 2003... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Studies of the VHL gene may lead to treatments for many disorders. According to a study from the United States, "The von Hippel-Lindau hereditary cancer syndrome was first described about 100...

Flat urothelial hyperplasias may relate to bladder cancer after all.
March 17, 2003... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Flat urothelial hyperplasias may relate to bladder cancer after all. According to a study from Germany, "Flat urothelial hyperplasia, defined as markedly thickened urothelium without cytological...

Studies defining new mechanism for potential cancer therapies reported.
March 17, 2003... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Cyclis Pharmaceuticals, Inc., announced publication of laboratory studies demonstrating that an experimental anticancer agent, beta-lapachone, can selectively kill tumor cells while sparing healthy...

Emodin activates caspase 3 cascade but not reactive oxygen.
March 17, 2003... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Emodin activates caspase 3 cascade but not reactive oxygen. According to recent research from Taiwan, "Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is an active constituent of Rheum palmatum,...

Dexamethasone inhibits the antitumor effect of interleukin 4 in rodent glioma.
March 17, 2003... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Dexamethasone inhibits the antitumor effect of interleukin 4 in rodent glioma. According to a study from Italy, "retroviral-mediated gene transfer of the IL-4 gene into experimental gliomas can...

Novel carrier peptides assist delivery of therapeutics into cancer cells.
March 17, 2003... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Novel carrier peptides assist delivery of therapeutics into cancer cells. According to recent research from Norway, "cancer therapy is currently limited by the difficulty of achieving efficient...

hTERT mRNA is extremely high in carcinoma, could be diagnostic tool.
March 17, 2003... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- hTERT mRNA is extremely high in carcinoma; it could be a diagnostic tool. According to a study from England, "Telomerase is a ribonucleoprotein enzyme that synthesises telomeres after cell division...

High-isothiocyanate diet lowers risk in GST polymorphism-null patients.
March 17, 2003... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- High-isothiocyanate diet lowers risk in GST polymorphism-null patients. According to a study from Singapore, "Dietary intake of cruciferous vegetables (Brassica spp.) has been inversely related to...

p53 may facilitate high-fidelity DNA double-strand break repair.
March 17, 2003... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- p53 may facilitate high-fidelity DNA double-strand break repair. "We investigated the effect of pifithrin-alpha (PFTalpha), a chemical inhibitor of p53, on DNA double-strand break (DSB) repair in...

Chromosomal abnormalities have been detected in Ewing Sarcoma.
March 17, 2003... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Chromosomal abnormalities have been detected in cases of Ewing sarcoma. "Several structural and numerical chromosomal abnormalities have been identified as primary and secondary chromosomal...

Plasmin and plasminogen receptors may play crucial roles in cell migration.
March 17, 2003... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Plasmin and plasminogen receptors may play crucial roles in cell migration. According to a study from the United States, "Many eukaryotic and prokaryotic cells bind plasminogen in a specific and...

Antisense-mediated downregulation of Bcl-2 protein chemosensitizes myeloma.
March 17, 2003... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Antisense-mediated downregulation of Bcl-2 protein chemosensitizes myeloma. According to recent research from Netherlands, "an antisense oligodeoxynucleotide (ODN) complementary to the first six...

Defined human cellular systems used to study of brain tumor development.
March 17, 2003... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Defined human cellular systems are being used to study brain tumor development. According to recent research from the United States, "The creation and characterization of permanent cell lines...

Differential analysis identifies all disease-related protein expression changes.
March 17, 2003... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Differential analysis identifies all disease-related protein expression changes. According to a study from South Korea, "Hepatocellular carcinoma (HCC) is a common malignancy worldwide and is a...

Targeting ras signalling pathways might inhibit tumor growth.
March 17, 2003... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Targeting ras signalling pathways might inhibit tumor growth. "The RAS proteins control signaling pathways that are key regulators of several aspects of normal cell growth and malignant...

Genetic alterations in benign meningiomas can lead to malignancy and metastases.
March 17, 2003... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Genetic alterations in benign meningiomas can lead to malignancy and metastases. According to a study from Spain, "The authors report on a 75-year-old man with histologically benign fibroblastic...

Novel therapeutic approaches for myeloma are needed.
March 17, 2003... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Novel therapeutic approaches for myeloma are needed. "Multiple myeloma remains largely incurable despite conventional and high-dose therapies, and so novel biologically based treatment approaches...

Ataxin-2 promotes apoptosis of human neuroblastoma cells.
March 17, 2003... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Ataxin-2 promotes apoptosis of human neuroblastoma cells. "Neuroblastoma is a highly heterogeneous tumor of young children. Although many advances have been made toward understanding the molecular...

Molecular and genetic advances will provide insight into neurological tumors.
March 17, 2003... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Molecular and genetic advances will provide insight into neurological tumors. "There are no effective therapies for many tumors of the nervous system. This is, in part, a consequence of their...

Antisense p53 transduction lessens apoptosis in multiple myeloma.
March 17, 2003... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Antisense p53 transduction lessens apoptosis in multiple myeloma. According to recent research from the United States, "multiple myeloma is a malignant proliferation of plasma cells which fail to...

Telomeres are sometimes maintained in the absence of telomerase.
March 17, 2003... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Telomeres are sometimes maintained in the absence of telomerase. "According to a study from Australia, "Activation of a telomere maintenance mechanism seems to be indispensable for the...

Important aspects of pancreatic ductal adenocarcinoma still poorly understood.
March 17, 2003... 2003 MAR 17 - (NewsRx.com & NewsRx.net) -- Important aspects of pancreatic ductal adenocarcinoma are still poorly understood. "Pancreatic ductal adenocarcinoma is characterized by invasiveness, rapid progression, and profound resistance to...