Cancer Gene Therapy Week articles from June 2009

Cancer Gene Therapy Week archives from June 2009

New cancer gene therapy findings from University of Saskatchewan described.
June 1, 2009... According to recent research from Saskatoon, Canada, "Recombinant adenoviral vectors (AdVTNF-alpha) expressing alpha tumor necrosis factor (TNF-alpha) under control of cytomegalovirus (CMV) promoter have been used in cancer gene therapy. To...

Reports outline cancer gene therapy study findings from University of Navarra.
June 1, 2009... "Bioluminescent imaging (BLI) is based on the detection of light emitted by living cells expressing a luciferase gene. Stable transfection of luciferase in cancer cells and their inoculation into permissive animals allows the noninvasive...

Research from Central South University has provided new information about cancer gene therapy.(Report)
June 1, 2009... "Gene therapy provides a promising approach for cancer treatment. Earlier studies suggested that poly-L-lysine-modified iron oxide nanoparticles (IONP-PLL) might be a promising gene delivery system that can transfect DNA efficiently in vitro...

Research reports from University Hospital provide new insights into cancer gene therapy.
June 1, 2009... "Mesenchymal stem cells (MSCs) are appealing as gene therapy cell vehicles given their ease of expansion and transduction. However, MSCs exhibit immunomodulatory and proangiogenic properties that may pose a risk in their use in anticancer...

Data on cancer gene therapy described by researchers at National Cheng-Kung University, Institute of Basic Medical Science.
June 1, 2009... Investigators publish new data in the report 'Multitarget therapy of malignant cancers by the head-to-tail tandem array multiple shRNAs expression system.' "Coexpression of multiple shRNAs can simultaneously inhibit multiple genes or target...

New cancer gene therapy research reported from Zhejiang University, Institute of Immunology.
June 1, 2009... Current study results from the report, 'EBAG9 inducing hyporesponsiveness of T cells promotes tumor growth and metastasis in 4T1 murine mammary carcinoma,' have been published. According to a study from Hangzhou, People's Republic of China,...

New findings from University of Adelaide in the area of cancer gene therapy described.(Report)
June 1, 2009... New investigation results, 'Methylation of CLDN6, FBN2, RBP1, RBP4, TFPI2, and TMEFF2 in esophageal squamous cell carcinoma,' are detailed in a study published in Oncology Reports. "In the development and progression of cancer, tumor suppressor...

Research from Imperial College London, Department of Oncology provide new insights into cancer gene therapy.
June 1, 2009... Scientists discuss in 'Microarray coupled to quantitative RT-PCR analysis of androgen-regulated genes in human LNCaP prostate cancer cells' new findings in cancer gene therapy. According to recent research published in the journal Oncogene,...

Research on cancer gene therapy detailed by scientists at Pusan National University, Department of Molecular Biology.
June 1, 2009... New investigation results, 'p53, secreted by K-Ras-Snail pathway, is endocytosed by K-Ras-mutated cells; implication of target-specific drug delivery and early diagnostic marker,' are detailed in a study published in Oncogene. "p53 is...

Researchers at National Cancer Center Research Institute release new data on cancer gene therapy.
June 1, 2009... Fresh data on cancer gene therapy are presented in the report 'Oncolytic virus therapy for pancreatic cancer using the adenovirus library displaying random peptides on the fiber knob.' "A conditionally replicative adenovirus is a novel...

Researchers from Catholic University describe findings in cancer gene therapy.
June 1, 2009... Current study results from the report, 'Adoptive immunotherapy using human peripheral blood lymphocytes transferred with RNA encoding Her-2/neu-specific chimeric immune receptor in ovarian cancer xenograft model,' have been published. "The...

Researchers from Kuopio University, Department of Medicine report on findings in cancer gene therapy.
June 1, 2009... Researchers detail in 'Eight-year safety follow-up of coronary artery disease patients after local intracoronary VEGF gene transfer,' new data in cancer gene therapy. "Vascular endothelial growth factor (VEGF) has been shown to stimulate...

Researchers from Mie University publish findings in cancer gene therapy.
June 1, 2009... Scientists discuss in 'Rapid alphabeta TCR-mediated responses in gammadelta T cells transduced with cancer-specific TCR genes' new findings in cancer gene therapy. According to recent research from Mie, Japan, "Adoptive T-cell transfer of in...

Researchers from University Hospital, Department of Dermatology discuss findings in cancer gene therapy.
June 1, 2009... New investigation results, 'Transfer of mRNA encoding recombinant immunoreceptors reprograms CD4+ and CD8+ T cells for use in the adoptive immunotherapy of cancer,' are detailed in a study published in Gene Therapy. "Human T lymphocytes can be...

Research from Bernard O'Brien Institute of Microsurgery in enzyme research provides new insights.
June 1, 2009... A new study, 'Regulation of cell proliferation by NADPH oxidase-mediated signaling: potential roles in tissue repair, regenerative medicine and tissue engineering,' is now available. According to recent research from Fitzroy, Australia, "The...

Data on gene therapy detailed by researchers at Nancy University.(Report)
June 1, 2009... New research, 'P53 and PTEN expression contribute to the inhibition of EGFR downstream signaling pathway by cetuximab,' is the subject of a report. According to recent research from France, "Cetuximab (Erbitux) is an anti-epidermal growth...

Report summarizes life sciences study findings from University of Texas, Health Science Center.
June 1, 2009... Researchers detail in 'DNA methylation inhibits p53-mediated survivin repression,' new data in life sciences. "The molecular progression of endometrial cancer is poorly understood, and both genetic and epigenetic factors play a role. Survivin...

Scientists at University of Birmingham publish new data on cancer gene therapy.
June 8, 2009... According to a study from Birmingham, the United Kingdom, "NTR (nitroreductase NfsB from Escherichia coli) is a flavoprotein with broad substrate specificity, reducing nitroaromatics and quinones using either NADPH or NADH. One of its...

New gene therapy study findings have been published by E. Montini and colleagues.
June 8, 2009... According to recent research from Milan, Italy, "gamma-Retroviral vectors (gamma RVs), which are commonly used in gene therapy, can trigger oncogenesis by insertional mutagenesis. Here, we have dissected the contribution of vector design and...

Kyushu University details research in cancer gene therapy.
June 8, 2009... A report, 'Chemotherapeutic agents potentiate adenoviral gene therapy for pancreatic cancer,' is newly published data in Cancer Science. "Adenovirus-mediated gene therapy combined with chemotherapeutic agents is expected to represent a new...

Researchers at Zhejiang Sci-Tech University, Institute of Medicine release new data on cancer gene therapy.
June 8, 2009... Fresh data on cancer gene therapy are presented in the report 'Potent antitumor activity of double-regulated oncolytic adenovirus-mediated ST13 for colorectal cancer.' "Following targeted gene virotherapy, the suppression of tumorigenicity 13...

Scientists at Kapodistrian University publish new data on cancer gene therapy.
June 8, 2009... Fresh data on cancer gene therapy are presented in the report 'The oncogenic effects of constitutive Stat3 signaling in salivary gland cancer cells are mediated by survivin and modulated by the NSAID sulindac.' "Constitutive activation of the...

Scientists at Saitama Cancer Center, Oncology Department describe research in cancer gene therapy.
June 8, 2009... Data detailed in 'Yolk sac tumor but not seminoma or teratoma is associated with abnormal epigenetic reprogramming pathway and shows frequent hypermethylation of various tumor suppressor genes' have been presented. "Germ cell tumors (GCTs) are...

University of Tokyo, Department of Immunology describes research in cancer gene therapy.
June 8, 2009... Fresh data on cancer gene therapy are presented in the report 'Therapeutic potential of proapoptotic molecule Noxa in the selective elimination of tumor cells.' According to recent research from Tokyo, Japan, "The selective elimination of tumor...

Gene therapy could expand stem cells' promise.
June 15, 2009... Once placed into a patient's body, stem cells intended to treat or cure a disease could end up wreaking havoc simply because they are no longer under the control of the clinician (see also New York- Presbyterian Hospital/Weill Cornell Medical...

Studies from Tongji University further understanding of angiogenesis.
June 15, 2009... According to recent research from Shanghai, People's Republic of China, "As one of the blood-rich malignancies, the growth and metastasis of osteosarcoma both depend on its angiogenesis, a procedure in which vascular endothelial growth factor...

New data from X.W. He et al illuminate research in cancer gene therapy.
June 15, 2009... "A nonviral gene carrier, calcium carbonate (CaCO3)-nanoparticle, was evaluated for the efficient in vitro and in vivo delivery of siRNA-targeting vascular endothelial growth factor-C (VEGF-C). The chemically synthesized CaCO3-nanoparticle has...

New findings from J.K. Yoon and co-authors in the area of cancer gene therapy published.
June 15, 2009... "We investigated whether theophylline has the potential to increase radioiodide uptake in non-thyroidal cancer cells. MCF-7 cells that express endogenous sodium/iodide symporter (NIS) and SNU-C5 cells adenovirally transduced with the human NIS...

Reports on cancer gene therapy findings from Umea University provide new insights.
June 15, 2009... According to recent research published in the journal Human Gene Therapy, "Selective replication-competent adenovirus serotype 5 vectors have been used for prostate cancer therapy. Unfortunately, gene transfer is inefficient because...

Recent findings in therapy described by researchers from National Heart, Lung, & Blood Institute.
June 15, 2009... According to recent research published in the journal Nanomedicine, "Nanotechnology provides a broad range of opportunities to develop new solutions for clinical problems. For the pulmonary field, nanotechnology promises better delivery of...

HungKuang University, College of Medicine details research in cancer gene therapy.
June 15, 2009... A report, 'Immunotherapy: rAAV2 expressing interleukin-15 inhibits HeLa cell tumor growth in mice,' is newly published data in Journal of Biomedical Science. "Human interleukin-15 (hIL15) has anti-tumor activities, but it is not convenient for...

Research from Y. El Hiani and co-researchers in the area of cell proliferation described.
June 15, 2009... Current study results from the report, 'Extracellular signal-regulated kinases 1 and 2 and TRPC1 channels are required for calcium-sensing receptor-stimulated MCF-7 breast cancer cell proliferation,' have been published. "The calcium-sensing...

Harbin Medical University describes research in gene therapy.(Report)
June 15, 2009... Fresh data on gene therapy are presented in the report 'Ultrasound-mediated microbubble destruction facilitates gene transfection in rat C6 glioma cells.' According to recent research from Harbin, People's Republic of China, "The goal of this...

Findings in cancer gene therapy reported from University of Pennsylvania, Medical Department.(Report)
June 22, 2009... According to a study from the United States, "Human head and neck squamous cell carcinoma (HNSCC) in addition to lung, skin, ovarian, and other cancers overexpress fibroblast growth factor (FGF) receptors on both individual tumor cells and...

New cancer gene therapy research from A. Azatian and colleagues discussed.(Report)
June 22, 2009... According to recent research published in the Journal of Gastrointestinal Surgery, "The thymidine kinase gene of the herpes simplex virus (HSV-tk) is a suicide gene when administrated with the prodrug ganciclovir (GCV). This study investigated...

Report summarizes cancer gene therapy study findings from Hokkaido University, Medical Department.
June 22, 2009... According to a study from Sapporo, Japan, "Over-expression of eIF4E indicates a poor prognosis in different tumors. In the present study, we investigated the frequency of eIF4E, 4E-BP1 and phosphorylated 4E-BP1 expression in PDAC cell lines,...

Research on cancer gene therapy reported by E. Kuwada et al.
June 22, 2009... According to a study from Tokyo, Japan, "A drawback of cancer gene therapy is the failure of toxic gene introduction into a proportion of the tumor cells, resulting in re-progression of the disease. Cancer cell-specificity of the gene...

Data from Nanhua University, Cancer Research Institute advance knowledge in cancer gene therapy.
June 22, 2009... Researchers detail in 'Possible roles of a tumor suppressor gene PIG11 in hepatocarcinogenesis and As2O3-induced apoptosis in liver cancer cells,' new data in cancer gene therapy. "Our previous studies demonstrated that p53-induced gene 11...

Studies conducted at University of Tokyo on leukemia gene therapy recently published.
June 22, 2009... Fresh data on leukemia are presented in the report 'Pathogenetic significance of ecotropic viral integration site-1 in hematological malignancies.' "The ecotropic viral integration site-1 (Evi-1) gene was first identified as a common locus of...

Vaporized viral vector shows promise in anti-cancer gene therapy.
June 22, 2009... A new lung cancer therapy employing a vaporized viral vector to deliver a cancer-inhibiting molecule directly to lung tissue shows early promise in mouse trials, according to researchers at the Ministry of Education, Science and Technology in...

ASGT 12th Annual Meeting: Modified herpes virus may treat melanoma.
June 22, 2009... A herpes virus better known for causing cold sores has shown promise as a treatment for late-stage skin cancer, according to research presented at the American Society of Gene Therapy's 12th Annual Meeting, May 27 (see also Cancer Gene...

ASGT 12th Annual Meeting: Incorporate gene therapy to make stem cell treatment safer, more effective.
June 22, 2009... Gene therapy should be used in tandem with stem cell therapy to enhance the reliability of stem cells, provide an opportunity to limit adverse effects and increase treatment success, according to research presented at the American Society of...

Why some prostate cancer returns.
June 22, 2009... The majority of men who receive one of the standard treatments for localized prostate cancer - surgery or radiation therapy - have an excellent outcome (see also Henry Ford Health System). But for the small group whose prostate cancer...