Cancer Gene Therapy Week articles from June 2003

Cancer Gene Therapy Week archives from June 2003

Uteroglobin transduction has an inhibitory effect on lung cancer cell lines.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- Uteroglobin transduction has an inhibitory effect on lung cancer cell lines. "Uteroglobin is a secretory protein synthesized by most epithelia, including the respiratory tract. It has strong...

Adenovirus-based FasL expression produces bystander killing in local cells.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- Adenovirus-based FasL expression produces bystander killing in local cells. According to published research from the United States, "inducing Fas-mediated apoptosis in prostate cancer (PCa) is a...

Gene expression profiling produces prospective targets for glioblastoma therapy.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- Gene expression profiling produces prospective targets for glioblastoma therapy. According to published research from the United States, "epidermal growth factor receptor (EGFR) overexpression...

Combinatorial IL-12 and IL-18 gene therapy strikes out at distant tumors.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- Combinatorial IL-12 and IL-18 gene therapy strikes out at distant tumors. According to a study from Japan, "the immune response is modulated by genetic adjuvants using plasmid vectors expressing...

ONYX-015 is deemed safe for patients with recurrent cancer.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Researchers at US Oncology of Dallas Texas consider ONYX-015 safe for human patients, based on the results of a pilot study. "ONYX-015 is an adenovirus...

1100delC may be the only CHEK2 allele that contributes to breast cancer.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- 1100delC may be the only CHEK2 allele that contributes to breast cancer. According to a study from England, "We recently reported that a sequence variant in the cell-cycle-checkpoint kinase CHEK2...

Overexpression of KCNK9 in cell lines promotes tumor formation.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- Overexpression of KCNK9 in cell lines promotes tumor formation. "Representational difference analysis (RDA) of human breast cancer was used to discover a novel amplicon located at chromosomal...

DNA methylation markers are promising future tools in the clinic.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- DNA methylation markers are promising future tools in the clinic. According to recent research published in the journal Nature Reviews Cancer, "The past few years have seen an explosion of interest...

p53 Protein is a mechanism of resistance to amifostine-induced apoptosis.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- p53 Protein is a mechanism of resistance to amifostine-induced apoptosis. According to a study from the United States, "To determine the role of p53 protein on the cellular effects of amifostine, we...

CA 72-4 antigen can be considered the marker of choice in patient follow-up.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- CA 72-4 antigen can be considered the marker of choice in patient follow-up. "To date no general agreement has been reached regarding the prognostic significance of CEA, CA 19-9 and CA 72-4 as serum...

Homozygous deletion scanning reveals alternative pathways for carcinogenesis.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- Homozygous deletion scanning reveals alternative pathways for carcinogenesis. "Despite high rates of loss of heterozygosity affecting various chromosomes, the number of tumor suppressor genes (TSGs)...

Strong association seen between penile SCC and the presence of HPV DNA.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- There is a strong association between penile SCC and the presence of HPV DNA. According to published research from France, "Human papillomaviruses (HPV) are thought to be involved in penile squamous...

MOZ gain of function contributes to leukemogenesis.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- MOZ gain of function contributes to leukemogenesis. "The MOZ-TIF2 fusion is associated with acute myeloid leukemia (AML) with inv(8)(p11q13). MOZ is a MYST family histone acetyltransferase (HAT),...

Magnolol induces apoptosis in human leukemia cells.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- Magnolol induces apoptosis in human leukemia cells. "Magnolol, isolated from the stem bark of Magnolia officnalis, was found to inhibit proliferation of human HL-60 cells and Jurkat T leukemia...

PTEN protein may be absent in B-CLL with a normal PTEN genotype.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- PTEN protein may be absent in B-CLL with a normal PTEN genotype. According to a study from Switzerland, "One fifth of B-cell chronic lymphocytic leukemia (B-CLL) patients exhibit loss of...

DNA hypomethylation plays a causal role in tumor formation.
June 2, 2003... 2003 JUN 2 - (NewsRx.com & NewsRx.net) -- DNA hypomethylation plays a causal role in tumor formation. According to published research from the United States, "Genome-wide DNA hypomethylation occurs in many human cancers, but whether this...

A new fusion gene uses vaccine mechanisms to halt kidney cancer.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Researchers at the University of California at Los Angeles have developed a fusion gene that shows promise as a new kidney cancer vaccine. Laboratory...

Genetically engineered virus causes total regression of deadly brain cancer.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Scientists at the Mayo Clinic have evaluated a new genetically engineered measles virus with the ability to fight glioblastoma multiforme, a deadly form of...

CAR expression makes adenovirus-based therapy viable for osteosarcoma patients.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- CAR expression makes adenovirus-based therapy viable for osteosarcoma patients. According to a study from Japan, "recombinant adenovirus is used as a competent vector in a wide spectrum of cancer...

Genomic imbalances are precursors for hepatocellular carcinoma progression.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Genomic imbalances are precursors for hepatocellular carcinoma progression. According to recent research from South Korea, "hepatocellular carcinoma (HCC) is one of the most prevalent...

Novel synthetic deoxyuridines can monitor cancer gene therapy with PET.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Novel synthetic deoxyuridines can monitor cancer gene therapy with PET. "Syntheses of 5-(2-[F-18]fluoroethyl)- 5-(2[Br-80]bromoethyl)- (2), undeprotected (E)-5-(2-[F-18]fluorovinyl)- (3) and...

Bfl-1 gene coexpression enhances response to HSV-thymidine kinase gene therapy.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Bfl-1 gene coexpression enhances response to HSV-thymidine kinase gene therapy systems. "Anticancer suicide gene therapy using herpes simplex virus-thymidine kinase (HSV-tk) and ganciclovir (GCV)...

Chemical genomics strategy can aid in the discovery of new anticancer agents.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Chemical genomics strategy can aid in the discovery of new anticancer agents. "Chemical genomics represents a cooperation of biology and chemistry to identify and intervene the biological targets....

Genetic testing feedback should be given only when there are specific reasons.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Genetic testing feedback should be given only when there are specific reasons. "Women (N=21) who had had breast cancer and had been enrolled in a large genetic breast cancer epidemiological study...

Inactivation of MMR genes is responsible for MSI in breast cancer cell lines.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Inactivation of MMR genes is responsible for MSI in breast cancer cell lines. According to a study from Germany, "At present, there is conflicting evidence whether microsatellite instability (MSI)...

Researchers isolate the first fusion RTK protein from a human astrocytoma.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Researchers isolate the first fusion RTK protein from a human astrocytoma. According to a study from the United States, "The transmembrane proto-oncogene receptor tyrosine kinase (RTK) ROS is an...

HPV status was not associated with the clinical outcome of cervical neoplasia.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- HPV status was not associated with the clinical outcome of cervical neoplasia. "One hundred and eighty-five Japanese women with cervical intraepithelial neoplasia (CIN) were enrolled in this...

Gen-17.1A significantly inhibited colon cancer cell growth in vitro and in vivo.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Gen-17.1A significantly inhibited colon cancer cell growth in vitro and in vivo. According to recent research published in the International Journal of Oncology, "We have shown that genistein, a...

Small interfering RNAs directed against beta-catenin inhibit cancer cell growth.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Small interfering RNAs directed against beta-catenin inhibit cancer cell growth. According to a study from the United States, "The beta-catenin and APC genes are key components of the Wnt signaling...

Colonic epithelial cell apoptosis is induced p47-dependent oxidants.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Colonic epithelial cell apoptosis is induced p47-dependent oxidants. "Exogenous oxidants appear capable of initiating both proliferative and death signals, but the role of endogenous oxidants in...

Arsenite-induced NO generation is cell-cycle- and NBS1-dependent.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Arsenite-induced NO generation is cell-cycle- and NBS1-dependent. According to recent research from Taiwan, "Exposure to arsenic has been reported to cause DNA damage and eventually the occurrence...

The ASPP family of proteins directs cells toward death after p53 upregulation.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- The ASPP family of proteins directs cells toward death after p53 upregulation. "It is well established that p53 is a primary target for mutation in human cancer. p53 carries out the important task...

ORNL researchers expect big things from nanostructures.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Arrays of nanofibers able to deliver genetic material to cells quickly and efficiently have researchers at Oak Ridge National Laboratory excited about potential applications for drug delivery, gene...

Cotreatment with SAHA enhances the cytotoxic effects of imatinib.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Cotreatment with SAHA enhances the cytotoxic effects of imatinib. According to recent research from the United States, "Here we demonstrate that treatment with SAHA (suberoylanilide hydroxamic...

INI-1, a partner gene of ALL-1, is highly conserved in human acute leukemia.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- INI-1, a partner gene of ALL-1, is highly conserved in human acute leukemia. According to a study from Japan, "Recently, much interest has been focused on the role of INI-1, a partner gene of...

Researchers found no increased expression in V1-69 alleles, with age.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Researchers found no increased expression in V1-69 alleles, with age. According to recent research from England, "Chronic lymphocytic leukemia (CLL) comprises two subsets, distinguished by...

There is a direct role of Cajal body components in leukemogenesis.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- There is a direct role of Cajal body components in leukemogenesis. According to a study from the United States, "The (11;19)(q23;p13.1) translocation in acute leukemia results in the formation of a...

Arsenic trioxide can inhibit growth of leukemia/lymphoma cells.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Arsenic trioxide (As[superscript]2O[superscript]3) can inhibit growth of leukemia/lymphoma cells. According to a study from Japan, "Although arsenic trioxide (As[superscript]2O[superscript]3) has...

DAS inhibits DES metabolism thus preventing the formation of DNA adducts.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- DAS inhibits DES metabolism thus preventing the formation of DNA adducts. "According to recent research published in the journal Oncology Reports, "Diethylstilbesterol (DES) is known to cause...

Cumulative cigarette smoking plays an important role lung cancer risk.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Cumulative cigarette smoking plays an important role lung cancer risk. According to a study from the United States, "XRCC1 (X-ray cross-complementing group 1) and ERCC2 (excision repair...

GSTP1 exon 6 polymorphism is associated with lung cancer.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- GSTP1 exon 6 polymorphism is associated with lung cancer. "Glutathione transferases (GSTs), a multiple gene family of phase II enzymes, catalyze detoxifying endogenous reactions with glutathione...

Genetic alterations are detected on chromosomes 13 and 14.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Genetic alterations are detected on chromosomes 13 and 14. "Genetic alterations in 28 non-small cell lung carcinoma patients were detected on chromosomes 13q and 14q with microsatellite markers by...

BCL6 deregulation is involved in DLBCL pathogenesis.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- BCL6 deregulation is involved in DLBCL pathogenesis. According to a study from the United States, "The BCL6 proto-oncogene encodes a transcriptional repressor whose expression is deregulated by...

Mouse models provide insight into in vivo genomic and environmental interactions.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Mouse models provide insight into in vivo genomic and environmental interactions. "Many cancers are the pathological consequence of environmentally initiated disruptions to cellular genetic control...

Functional loss of the NF2 protein may be involved in mesothelioma formation.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Functional loss of the NF2 protein may be involved in mesothelioma formation. "Fourteen primary human malignant mesothelioma (HMM) samples obtained from 14 patients were screened for point mutations...

Loss of heterozygosity and p53 polymorphism Pro72Arg led to aggressive therapy.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Loss of heterozygosity and p53 polymorphism Pro72Arg can lead to aggressive therapy. According to a study from Italy, "Differently from conventional primary neuroectodermal tumors (PNETs),...

TNF-alpha magnifies the biological activity of CXC-chemokines in melanocytes.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- TNF-alpha magnifies the biological activity of CXC-chemokines in melanocytes. "The CXC-chemokines Groa and interleukin-8 (IL-8) are ligands for two different G protein-coupled receptors, named...

DNA repair capacity is reduced in young patients suffering from multiple cancers.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- DNA repair capacity is reduced in young patients suffering from multiple cancers. "Young patients less than 45 years old suffering from multiple cancers but lacking typical risk factors were...

Common BRG1 mutations are excluded in prostate cancer.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Common BRG1 mutations are excluded in prostate cancer. According to recent research published in the International Journal of Oncology, "Previous studies in hereditary and sporadic prostate cancer...

There may be a link between the IFN and E2F1 pathways in regulating apoptosis.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- There may be a link between the IFN and E2F1 pathways in regulating apoptosis. According to a study from the United States, "p202, an interferon (IFN) inducible protein, is a phosphonuclear protein...

E2F plays a pivotal role in cell cycle control.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- E2F plays a pivotal role in cell cycle control. "The E2F family of transcription factors plays a central role in regulating cellular proliferation by controlling the expression of both the genes...

CTGF acts as a negative regulator of cell growth in oral squamous cell carcinoma.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- CTGF acts as a negative regulator of cell growth in oral squamous cell carcinoma. According to a study from Japan, "Connective tissue growth factor (CTGF) is known to be a multifunctional growth...

Activating BRAF mutations may be important in papillary thyroid carcinoma.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Activating BRAF mutations may be important in papillary thyroid carcinoma. "The BRAF gene has been found to be activated by mutation in human cancers, predominantly in malignant melanoma,"...

MTIG and CRABPI are likely involved in the pathogenesis of sporadic PTC.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- MTIG and CRABPI are likely involved in the pathogenesis of sporadic papillary thyroid carcinoma (PTC). According to published research from the United States, "We previously obtained gene...

Nitric oxide evoked p53-accumulation and apoptosis.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Nitric oxide evoked p53-accumulation and apoptosis. According to published research from Germany, "The tumor suppressor p53 accumulates under conditions of cellular stress and affects cell cycle...

Tight regulation of p53 activation is imperative for preventing tumorigenesis.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Tight regulation of p53 activation is imperative for preventing tumorigenesis. According to recent research from the United States, "The p53 tumor suppressor exerts anti-proliferative effects,...

Diverse treatment goals alter the way viral vectors can be used for therapy.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- Diverse therapeutic goals alter the way viral vectors can be used for therapy. "The idea of using viruses as gene vehicles to combat disease is tantalizing for the simplicity of its principle, and...

The mastery of oncolytic adenoviruses would improve their use in cancer therapy.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- The mastery of oncolytic adenoviruses would improve their use in cancer therapy. "Malignant gliomas are devastating diseases that localize within the central nervous system and are notoriously...

TauT may represent a downstream target gene of WT1 during renal development.
June 9, 2003... 2003 JUN 9 - (NewsRx.com & NewsRx.net) -- TauT may represent a downstream target gene of WT1 during renal development. According to recent research published in the journal FEBS Letters, "In the present study we have demonstrated that WT1...

Cytokine gene therapy combinations could become viable anticancer agents.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Combinations of interferon-alpha and interleukin-12 gene therapy could be refined so that their feasibility for treating human cancers would be enhanced. ...

Sodium iodide symporter gene is associated with low retention and absorption.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Sodium iodide symporter gene is associated with low retention and absorption. "Transfer of the sodium iodide symporter (hNIS) has been proposed as a new principle of cancer gene therapy. Using...

Gene overexpression increased from low- to high-grade lesions to cancer.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Gene overexpression increased from low- to high-grade lesions to cervical cancer. "The Pap test has effectively reduced the incidence and mortality of cervical cancer," investigators in the United...

Vector-based RNA interference knocks down genes associated with angiogenesis.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Vector-based RNA interference holds back genes associated with angiogenesis. "Vascular endothelial growth factor (VEGF) carries out multifaceted functions in tumor development, and it exists as at...

SCH66336 has good in vitro antitumor activity in both human and mouse melanoma.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- SCH66336 has good in vitro antitumor activity in both human and mouse melanoma. According to a study from the United States, "The constitutive activity of a number of growth and cell survival...

Study highlights potential danger of gene therapy.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Gene therapy uses viruses that have been genetically engineered to carry a "normal" human gene to replace the missing function of an "abnormal," disease-causing gene in a patient's cells. A paper...

Papillary serous adenocarcinoma was less likely to express vimentin.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Papillary serous adenocarcinoma was less likely to express vimentin. "Adenocarcinomas of the uterine cervix show a wide range of morphological features, and can be confused with endometrial...

Regulatory RNA: B16 RNA provides antimelanoma activity, upregulating NF-kappa B.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- B16 RNA treatment appears to provide anti-melanoma effect, as that RNA appears to be a regulatory RNA. "Regulatory RNAs are noncoding RNAs that can regulate gene expression. Our previous results...

PI3K-Akt has been shown to be the target of various antitumor drugs.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- PI3K-Akt has been shown to be the target of various antitumor drugs. According to published research from Japan, "Recent progress in the development of molecular cancer therapeutics has revealed...

Hh inhibitors could be a valid therapeutic approach for treating BCC.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Hh inhibitors could be a valid therapeutic approach for treating BCC. "The link between basal cell carcinoma (BCC) and aberrant activation of the Hedgehog (Hh) signaling pathway has been well...

Increased cancer risk and BLMAsh mutation are not related.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Increased cancer risk and BLMAsh mutation are not related in Bloom syndrome. According to a study from Canada, "Bloom syndrome is an autosomal recessive disorder whose characteristics include an...

SCH58500 provides measurable efficacy in preclinical brain tumor models.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- SCH58500 provides measurable efficacy in preclinical brain tumor models. "Malignant gliomas remain incurable entities that provide fertile ground for experimental therapy," researchers in the...

Akt may be a target for enhancing radiotherapy response.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Akt may be a potential target for enhancing the response to radiotherapy. "The phosphatidylinositol 3-kinase (PI-3K)/Akt pathway, regulated by its upstream growth factor receptor tyrosine kinases,...

The collagen alpha2(I) gene is methylated in multiple cancer cell lines.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- The collagen alpha2(I) gene is methylated in multiple cancer cell lines. "Collagen production plays a significant role in tumor development, especially in breast cancer, hepatocarcinomas, and...

Researchers have no evidence that D213N increases the risk of cancer.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Researchers have no evidence that D213N increases the risk of cancer. According to a study from England, "Inherited mutations of the BRCA1 and BRCA2 genes, whose protein products are necessary for...

Inflammation should be treated appropriately for chemoprevention of cancers.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Inflammation should be treated appropriately for chemoprevention of cancers. According to recent research published in the journal Toxicology Letters, "Chronic infection and inflammation are...

CEP-6800 could be used as a chemopotentiating agent.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- CEP-6800 could be used as a chemopotentiating agent. According to a study from the United States, "Poly(ADP-ribose) polymerase 1 (PARP-1) is a nuclear zinc finger DNA-binding protein that is...

Inhibition of HDAC is an early event in cells treated with CI-994.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Inhibition of HDAC is an early event in cells treated with CI-994. "CI-994 or N-acetyldinaline [4-(acetylamino)-N-(2-amino-phenyl) benzamide] is an antitumor cytostatic agent currently undergoing...

FLIP and BCL-XL expression may reduce sensitivity of cancer cells to therapies.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- FLIP and BCL-XL expression may reduce sensitivity of cancer cells to therapies. "The extrinsic cell death pathway is initiated upon ligand-receptor interactions at the cell surface including FAS...

Tumor-suppressor genes show a gene-type specific methylation profile.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Tumor-suppressor genes show a gene-type specific methylation profile. "The stomach is one of the organs whose epithelia] cells frequently undergo aberrant methylation of CpG islands. To date,...

(MAsO)-O-III should be considered in treating other hematologic malignancies.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- (MAsO)-O-III should be considered in treating other hematologic malignancies. According to recent research from the United States, "Treatment with arsenic trioxide (As[superscript]2O[superscript]3)...

Apoptosis inhibitors cIAP1 and cIAP2 are overexpressed and may be oncogenes.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- Many lung cancers overexpress cIAP1 and 2, with or without high genetic copy numbers, thus these apoptosis inhibitors may be oncogenes. "Amplification of oncogenes is an important mechanism that...

EGFRvIII is a potential therapeutic target in non-small cell lung cancer.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- EGFRvIII is a potential therapeutic target in non-small cell lung cancer. According to recent research from the United States, "The epidermal growth factor receptor (EGFR) variant type III...

High expression of Skp2 and Cks1 may be involved in the pathogenesis of NSCLCs.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- High expression of Skp2 and Cks1 may be involved in the pathogenesis of NSCLCs. According to a study from Japan, "Enhanced degradation of cyclin-dependent kinase (CDK) inhibitor p27(Kip1) is known...

A change in phenotype can occur in long-term tumor cultures.
June 16, 2003... 2003 JUN 16 - (NewsRx.com & NewsRx.net) -- A change in phenotype can occur in long-term tumor cultures of melanoma. "We employed G-banding cytogenetic analysis to follow the clonal constitution of short-term cultures of metastatic malignant...