Cancer Gene Therapy Week articles from July 2008

Cancer Gene Therapy Week archives from July 2008

Study data from C. Dufour et al provide new insights into bone marrow.
July 28, 2008... "Fanconi anaemia (FA) is a rare genetic disease characterized by chromosomal instability, somatic abnormalities, marrow failure and cancer proness. The main cause of morbidity and mortality is bone marrow failure, which typically arises in the...

New cancer gene therapy research from University of Alabama described.(Report)
July 28, 2008... According to a study from the United States, "Enhanced production of receptor activator of nuclear factor-kappa B ligand ( RANKL) and its binding to RANK on the osteoclasts have been associated with osteolysis in breast cancer bone metastasis....

New cancer gene therapy research has been reported by C.A. Montielequihua et al.
July 28, 2008... "Expression of the sodium iodide symporter (hNIS) has been detected in breast cancer tissue, but frequently, not at the levels necessary to mediate I-131 accumulation. Transducing the hNIS gene into breast cancer cells with adenovirus could be...

Research data from B. Couderc and colleagues update understanding of cancer gene therapy.
July 28, 2008... According to a study from Toulouse, France, "Ovarian cancers are very aggressive cancers most often diagnosed when metastasis has already occurred in the entire peritoneal cavity. Ovarian adenocarcinoma cells present an undetectable level of...

Studies in the area of cancer gene therapy reported from Okayama University.
July 28, 2008... According to a study from Okayama, Japan, "Cancer gene therapy and oncolytic virotherapy have been studied extensively. However, their clinical application is hampered by their weak anticancer activity." "We previously constructed a...

New angiogenesis research from Osaka University described.
July 28, 2008... Researchers detail in 'Fasudil-induced hypoxia-inducible factor-1{alpha} degradation disrupts a hypoxia-driven vascular endothelial growth factor autocrine mechanism in endothelial cells,' new data in angiogenesis. According to recent research...

Data on cancer gene therapy described by investigators at Institute of Cancer Research.
July 28, 2008... Investigators publish new data in the report 'Attenuated salmonella targets prodrug activating enzyme carboxypeptidase G2 to mouse melanoma and human breast and colon carcinomas for effective suicide gene therapy.' "We engineered the oncolytic...

Findings in cancer gene therapy reported from Cell Genesys, Inc.(Report)
July 28, 2008... Research findings, 'Intratumoral coadministration of hyaluronidase enzyme and oncolytic adenoviruses enhances virus potency in metastatic tumor models,' are discussed in a new report. According to recent research published in the journal...

New cancer gene therapy data have been reported by scientists at University of Pittsburgh, Department of Pathology.
July 28, 2008... Researchers detail in 'Human rhomboid family-1 gene silencing causes apoptosis or autophagy to epithelial cancer cells and inhibits xenograft tumor growth,' new data in cancer gene therapy. According to a study from the United States, "The...

New cancer gene therapy research from Lowe Center for Thoracic Oncology outlined.
July 28, 2008... Investigators publish new data in the report 'EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer.' "The EML4-ALK fusion gene has been detected in approximately 7% of Japanese non-small cell lung cancers (NSCLC). We...

New cancer gene therapy study results from University of Pittsburgh, Pittsburgh Cancer Institute described.
July 28, 2008... Investigators publish new data in the report 'Bortezomib induces apoptosis via Bim and Bik up-regulation and synergizes with cisplatin in the killing of head and neck squamous cell carcinoma cells.' "Head and neck squamous cell carcinomas...

Reports summarize cancer gene therapy study results from Central South University, Cancer Research Institute.
July 28, 2008... New investigation results, 'DNAzymes targeted to EBV-encoded latent membrane protein-1 induce apoptosis and enhance radiosensitivity in nasopharyngeal carcinoma,' are detailed in a study published in Cancer Letters. "Epstein-Barr virus (EBV) is...

Research on cancer gene therapy reported by scientists at Duke University, Comprehensive Cancer Center.
July 28, 2008... Investigators publish new data in the report 'Identification and functional characterization of the human glutathione S-transferase P1 gene as a novel transcriptional target of the p53 tumor suppressor gene.' According to recent research from...

Researchers at University of Texas, M. D. Anderson Cancer Center target cancer gene therapy.
July 28, 2008... Current study results from the report, 'Pinitol targets nuclear factor-kappaB activation pathway leading to inhibition of gene products associated with proliferation, apoptosis, invasion, and angiogenesis,' have been published. According to a...

Researchers from Sichuan University, State Key Laboratory of Biotherapy and Cancer Center detail findings in cancer gene therapy.
July 28, 2008... A new study, 'Human alpha-defensin-1 inhibits growth of human lung adenocarcinoma xenograft in nude mice,' is now available. According to a study from Chengdu, People's Republic of China, "Human alpha-defensin-1 (HNP1), a small antimicrobial...

Researchers from Tongji Hospital, Tongji Medical College describe findings in cancer gene therapy.(Report)
July 28, 2008... Current study results from the report, 'Biodistribution and kinetics of the novel selective oncolytic adenovirus M1 after systemic administration,' have been published. "Oncolytic adenoviruses represent a promising novel therapeutic option for...

Researchers' work from Northwestern University focuses on cancer gene therapy.
July 28, 2008... Data detailed in 'Transforming growth factor-beta1, transforming growth factor-beta2, and transforming growth factor-beta3 enhance ovarian cancer metastatic potential by inducing a Smad3-dependent epithelial-to-mesenchymal transition' have been...

Study findings from University of Yamanashi, Department of Pathology broaden understanding of cancer gene therapy.
July 28, 2008... A report, 'Epigenetic dysregulation in thyroid neoplasia,' is newly published data in Endocrinology and Metabolism Clinics of North America. "Gain-of-function mutations in oncogenes have aided our understanding of the molecular mechanisms of...

University of Crete describes research in cancer gene therapy.
July 28, 2008... Fresh data on cancer gene therapy are presented in the report 'Decorin-induced growth inhibition is overcome through protracted expression and activation of epidermal growth factor receptors in osteosarcoma cells.' According to recent research...

Research on leukemia gene therapy described by scientists at Ohio State University.
July 28, 2008... Researchers detail in 'Phase I study of GTI-2040, an antisense to ribonucleotide reductase, in combination with high-dose cytarabine in patients with acute myeloid leukemia,' new data in leukemia. "Inhibition of ribonucleotide reductase reduces...

Scientists at Children's Hospital, Division of Oncology discuss research in neuroblastoma gene therapy.
July 28, 2008... Researchers detail in 'A functional screen identifies miR-34a as a candidate neuroblastoma tumor suppressor gene,' new data in neuroblastoma. According to recent research from the United States, "MicroRNAs are small noncoding RNAs that have...