Cancer Gene Therapy Week articles from July 2004

Cancer Gene Therapy Week archives from July 2004

FDA grants fast track designation for MedPulser Electroporation Therapy System.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Genetronics Biomedical Corp. (GEB) has been granted a fast track designation by the U.S. Food and Drug Administration for its MedPulser Electroporation System clinical development program for patients...

Trial results reported in HGS-ETR1 in patients with advanced cancers.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Human Genome Sciences, Inc., (HGSI) announced that the results of ongoing phase I clinical trials demonstrate the safety and tolerability of HGS-ETR1 (agonistic human monoclonal antibody to TRAIL...

Discovery of tumor vascular targets may mean safer cancer treatment.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- A discovery by researchers at the Sidney Kimmel Cancer Center (SKCC) holds the promise of taking treatment of several types of cancer to a much higher level of safety and effectiveness. The...

PELP1 expression modulated by E2-ER pathway and PELP1 is an ER target gene.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- PELP1 expression is modulated by the E2-ER pathway and PELP1 is an ER target gene. "Proline-, glutamic acid- and leucine-rich protein 1 (PELP1)/modulator of nongenomic activity of estrogen receptor...

Infectivity-enhanced adenoviral vectors guide ovarian cancer gene therapy.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Infectivity-enhanced adenoviral vectors guide ovarian cancer gene therapy. "Ovarian carcinoma cells are often infected inefficiently by adenoviruses (Ad) due to low expression of coxsackie...

Bacteria LPS induce IL-6-dependent plasmacytoma proliferation.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Bacterial lipopolysaccharides induce IL-6-dependent plasmacytoma proliferation by MAPK pathway activation. According to published research from Bulgaria, "Mouse plasmacytomas are appropriate models...

Polymers promote heparin uptake and cancer cell apoptosis.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Polymers promote heparin uptake and cancer cell apoptosis. "Heparin/heparan sulfate-like glycosaminoglycans (HSGAGs) are involved in diverse cellular processes in the extracellular matrix (ECM)....

ER- breast cancer cell ERa re-expression recreate hormone-responsive phenotype.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Estrogen receptor negative breast cancer cell ERalpha re-expression recreate a hormone-responsive phenotype. "Estrogen receptor (ER)-negative breast carcinomas are often difficult to treat with...

Encouraging results for Oncotype DX assay in predicting chemotherapy response.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Genomic Health, Inc., and Istituto Nazionale Tumori, a cancer-research institute located in Milan, Italy, announced preliminary results of a clinical trial in which the patterns of expression of a...

Multiple mRNA markers detect metastases in sentinel lymph nodes.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Multiple mRNA markers detect metastases in the sentinel lymph nodes of breast cancer patients. "Disseminated breast tumor cells in sentinel lymph nodes (SNs) were evaluated by quantitative real-time...

New prognostic markers for survival of breast cancer identified.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- New prognostic markers for survival of breast cancer have been identified. According to a study from England, "The normal duct-lobular system of the breast is lined by two epithelial cell types,...

New tumor subtypes with poor clinical outcomes characterized.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- A University of North Carolina (UNC) molecular biologist has identified the pattern of genes that characterize a biologically distinct subtype of estrogen receptor negative breast tumor. Because...

Several parallel and stepwise progression pathways towards breast cancer.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- There are several parallel and stepwise progression pathways towards breast cancer. "Distinct parallel cytogenetic pathways in breast carcinogenesis could be identified in recent years....

Polypropylenimine dendrimers enable delivery of ODN to cancer cells.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Polypropylenimine dendrimers provide a delivery route for therapeutic oligonucleotides to cancer cells. Researchers in the U.S. "used polypropylenimine dendrimers for delivering a 31 nt...

ICOS inks exclusive collaboration for antibody therapeutics.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- ICOS Corp. (ICOS) and Raven biotechnologies, inc., announced that they have entered into an agreement that provides ICOS with an exclusive option to license five of Raven's monoclonal antibody...

Chromosomal instability in colorectal cancers may be genetically based.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Researches accumulate additional evidence for a genetic basis for chromosomal instability. "Although most colorectal cancers are chromosomally unstable, the basis for this instability has not been...

k-ras G12C mutation is increased in MYH polyposis colorectal adenomas.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- k-ras mutations in MYH polyposis tumors result in increased dysplasia and tubulovillous morphology. According to published research from Wales, "Colorectal tumors from MYH polyposis patients...

Tumor growth stalls upon electroporation-based antiangiogenic gene transfer.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Tumor growth stalls upon electroporation-based antiangiogenic gene transfer. "Using a nonviral, electroporation-based gene transfection approach, we demonstrate the efficient and consistent...

Enzymatic cleavage of CD95 leaves tumor cells resistant to destruction.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Enzymatic cleavage of CD95 leaves tumor cells resistant to destruction. "The ability of tumor cells to resist apoptosis-inducing signals by cytotoxic T cells may decide the success or failure of...

Final data from INGN 241 phase I study demonstrates clinical, biologic activity.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Introgen Therapeutics, Inc., (INGN) announced that final data from a phase I trial of INGN 241 in patients with solid tumors were presented at the 7th annual meeting of the American Society of Gene...

Folate-targeted immunotherapy may provide strategy to combat malignant disease.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Folate-targeted immunotherapies may provide a strategy for combating malignant disease. "The vitamin, folic acid, has become a useful ligand for targeted cancer therapies because it binds to a...

MLH1 and CDKN2A are important factors in oncogenesis of laryngeal cancer.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Alteration in the RB1 pathway occurs in head and neck squamous cell carcinomas, researchers say. According to recent research published in the British Journal of Cancer, "Our study aimed at...

Oncogenic B-Raf mutations have a crystal structure.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Recent evidence gives insight into how B-RAF mutations transform human tumors. "The Raf/MEK/ERK pathway is a conserved signaling module controlling cell growth, proliferation, apoptosis, and...

Thymidylate synthase can transform murine cells to malignancy.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Elevated thymidylate synthase levels might be linked to tumor progression in some human cancers, researchers say. "A surprising finding in the report by Rahman et al. in this issue of Cancer Cell...

New system can be used to classify pancreatic intraepithelial neoplasia.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Two grades of pancreatic intraepithelial neoplasia (PanIN) are indicative of invasive carcinoma, researchers say. "The phenotypic classification of pancreatic neoplasms is based on their cellular...

Renal cell cancer in families may have a recessive component.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Researchers find that recessive affects may play roles in familial renal cell cancer (RCC). According to a study from Germany, "Cancer in parents and offspring may be due to dominant causes, whereas...

Hypoxia inducible factor ensures telomerase activation in cancer cells.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Hypoxia inducible factor ensures telomerase activation in cancer cells. "Hypoxia-inducible factor 1 (HIF-1) is a key regulator of O[subscript]2 homeostasis, which regulates the expression of several...

Repeated endostatin transfection extends the survival of fibrosarcoma models.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Repeated endostatin transfection extends the survival of fibrosarcoma models. "Intravenous endostatin gene transfection results in tumor suppression in a murine pulmonary metastasis model. We...

Cdk independent actions are needed in cyclin D1-mediated tumorigenesis.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Study discusses the functions of the cyclin D1 oncogene in relation to tumorigenesis. "The proto-oncogene cyclin D1 has been implicated in the genesis of a large proportion of human tumors from...

Leiomyoma and leiomyosarcoma have distinct molecular pathways.
July 5, 2004... 2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Researchers exploring the differences between benign uterine leiomyoma and deadly leiomyosarcoma discovered distinct molecular pathways for each tumor. "Uterine smooth muscle tumors range from the...

Company reports broad utility of lead product ADVEXIN.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Introgen Therapeutics, Inc., (INGN) reported the highlights covered in its symposium "Advances in Clinical Development Program," focusing on the broad utility of its lead cancer product candidate,...

Individualized medicine may be possible with pharmacogenomics.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Researchers report that individualized medicines may avoid variation in response by individuals to dugs. "Individuals respond differently to drugs and sometimes the effects are unpredictable,"...

Clinical germline genetic testing for melanoma is now available.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Clinical germline genetic testing for malignant melanoma should probably be performed in a research protocol setting, researchers say. According to a study from the United States, "Clinical genetic...

Companies report "compelling data" from phase I prostate cancer study.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- OncoGenex Technologies, Inc., and Isis Pharmaceuticals, Inc., (ISIS) announced the results of a phase I study showing that once-weekly intravenous administration of OGX-011 is well-tolerated, achieves...

DNA damaged by paclitaxel is repaired over time.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- DNA damaged by incubating cells with paclitaxel was repaired after 24 hours. "This study was designed to assess whether the chemotherapeutic drug paclitaxel can induce DNA damage in peripheral...

Oncogenomics is necessary to develop new cancer therapies.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Researchers recommend a cooperative approach to develop new cancer treatments based on human genome data. According to recent research from the United States, "Scientists have sequenced the human...

Predicting disease may become possible using genomics.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Genomics may enable clinicians to focus more on disease prevention than cure, researchers report. "Information from the human genome sequence will eventually alter many aspects of clinical...

Dopamine[subscript]2 receptor expressed in 80% of corticotroph pituitary tumors.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Dopamine[subscript]2 receptors are expressed in approximately 80% of corticotroph pituitary tumors. According to a study from Italy, "The role of dopamine agonist treatment in corticotroph...

Molecular alterations associated with cyclin D1 overexpression in cancer.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Molecular alterations are associated with cyclin D1 overexpression in endometrial cancer. According to recent research from Spain, "Cyclin DI is frequently overexpressed in human neoplasias by...

Mutant p53 expression linked to drug resistance in a hepatocellular carcinoma.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Study finds that the p53 mutant, R248Q, in a liver cancer cell line may enhance chemotherapy drug resistance. "Chemoresistance is a major problem in the treatment of hepatocellular carcinoma....

Distinct patterns of KSHV gene expression may influence PEL pathogenesis.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Distinct patterns of Kaposi's sarcoma-associated herpesvirus gene expression may influence primary effusion lymphoma pathogenesis. "Primary effusion lymphomas (PEL) are uniformly infected with...

Liver cancer gene therapy relies on tumor vessels for dissemination.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Liver cancer gene therapy relies on tumor vessels for dissemination. "The improvement of initial tumor cell transduction with viral vectors is a major task in tumor gene therapy. We have developed...

HOXA genes might be oncogenic in patients with multiple myeloma.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- HOXA genes can be present in plasma cells (PCs) in the bone marrow and may be oncogenic in multiple myeloma, researchers report. "Multiple myeloma (MM) is an incurable B-cell malignancy...

Gene therapy and chemotherapeutic agents help tumors overcome TRAIL resistance.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Gene therapy and chemotherapeutic agents help tumors overcome TRAIL resistance. According to scientists writing in the journal Molecular Therapy, "we recently found that repeated application of...

MMP-9 modulation may have therapeutic potential in advanced CLL.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- MMP-9 modulation may have therapeutic potential in advanced CLL. According to a study from England, "Matrix metalloproteinases (MMPs) are important for the pathogenesis and progression of different...

Scientists trigger suicide switch in cancer cells.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Genetically engineering viruses to carry a suicide gene into ovarian cancer cells could become a potent way to tackle the disease, a Cancer Research UK scientist revealed at a conference in Glasgow,...

Synthetic retinoids induce apoptosis in ovarian carcinoma cells.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Synthetic retinoids induce apoptosis in ovarian carcinoma cells. "Apoptosis is also known as programmed cell death. Apoptosis plays an essential role in maintaining normal tissue and cell...

Company initiates ILX-651 study in prostate cancer.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- ILEX Oncology, Inc., (ILXO) announced the opening of a multicenter, phase II study of ILX-651 in patients with hormone-refractory prostate cancer whose disease has progressed after first-line treatment...

Retinoid-related molecule potently induces apoptosis in prostate cancer cells.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Retinoid-related molecule potently induces apoptosis in prostate cancer cells. "Synthetic retinoid-related molecules, such as N-(4-hydroxyphenyl)retinamide (fenretinide) and...

Secreted transforming growth factor beta 2 is needed by some tumor cells.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- The TGFbeta2-NF-kappaB pathway is important for the viability of prostate cancer Pc3 cells, researchers report. According to published research from the United States, "The basis of constitutive...

MTI-MMP plays critical role in esophageal squamous cell carcinoma progression.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- MTI-MMP plays critical role in esophageal squamous cell carcinoma progression. According to a study from Japan, "Matrix metalloproteinase (MMP) is critical for carcinoma progression. In our study,...

New cytokine-dependent AML cell line with novel features established.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- A new cytokine-dependent acute myeloid leukemia cell line with novel features has been established. According to recent research from Germany, "Continuous human leukemia-lymphoma (LL) cell lines...

NST effective additional therapeutic option for patients with AML in remission.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- Non-myeloablative stem cell trasplantation is an effective additional therapeutic option for patients with AML in remission. According to recent research published in the journal Leukemia &...

DNA vaccines suppress angiogenesis to inhibit tumor growth.
July 12, 2004... 2004 JUL 12 - (NewsRx.com & NewsRx.net) -- DNA vaccines suppress angiogenesis to inhibit tumor growth. "Four novel oral DNA vaccines provide long-lived protection against melanoma, colon, breast, and non-small cell lung carcinoma in mouse...

Tissue-specific promoters ensure oncolytic viruses target cancer tissues.
July 19, 2004... 2004 JUL 19 - (NewsRx.com & NewsRx.net) -- Tissue-specific promoters ensure oncolytic viruses target cancer tissues. According to recent research from Finland, "adenoviral cancer gene therapy approaches have resulted in promising recent...

Receptor deficiency stalls the efforts of lung cancer gene therapy.
July 19, 2004... 2004 JUL 19 - (NewsRx.com & NewsRx.net) -- Receptor deficiency stalls the efforts of lung cancer gene therapy. "Adenovirus-mediated wild-type p53 gene transfer induces apoptosis in a variety of human cancer cells. Although clinical trials...

The Cre/lox system helps Wnt-targeted gene therapy destroy colorectal cancer.
July 19, 2004... 2004 JUL 19 - (NewsRx.com & NewsRx.net) -- The Cre/lox system helps Wnt-targeted gene therapy destroy colorectal cancer. "Wnt-targeted gene therapy has been proposed as a treatment for human colorectal cancer (CRC). The Cre-lox system...

Mutant insulin-like growth factor receptor reduces tumor growth and invasion.
July 19, 2004... 2004 JUL 19 - (NewsRx.com & NewsRx.net) -- Mutant insulin-like growth factor receptor reduces tumor growth and invasion. According to published research from Canada, "the receptor for the type 1 insulin-like growth factor (IGF-IR) was...

FRET inhibition effective for measuring AS-ODN activity in vivo.
July 19, 2004... 2004 JUL 19 - (NewsRx.com & NewsRx.net) -- The inhibition of fluorescence resonance energy transfer (FRET) can be used to effectively and directly to measure antisense oligodeoxynucleotides (AS-ODNs), which may be an effective approach to human...

Immusol initiates collaboration to advance oncology drug-discovery efforts.
July 19, 2004... 2004 JUL 19 - (NewsRx.com & NewsRx.net) -- Immusol has initiated a strategic collaboration with Affymetrix, Inc., (AFFX) that will facilitate the discovery and characterization of new as well as existing targets for cancer therapies. ...

DNA lesion type defines death characteristics of colon carcinoma cells.
July 19, 2004... 2004 JUL 19 - (NewsRx.com & NewsRx.net) -- DNA lesion type defines death characteristics of colon carcinoma cells. "The pleiotrophic cellular response to DNA damage includes activation of cell cycle checkpoints, induction of DNA repair...

Atelocollagen leads small interfering RNA to vascular growth factor.
July 19, 2004... 2004 JUL 19 - (NewsRx.com & NewsRx.net) -- Atelocollagen leads small interfering RNA to vascular growth factor. According to a study from Japan, "vascular endothelial growth factor (VEGF) plays a critical role during normal embryonic...

Novel lipid-based cochleates drive gene uptake into mammalian cells.
July 19, 2004... 2004 JUL 19 - (NewsRx.com & NewsRx.net) -- Novel lipid-based cochleates drive gene uptake into mammalian cells. According to recent research published in the journal Anticancer Research, "although gene therapy holds great promise for the...

Ets gene PEA3 assists beta-catenin-Lef-1/c-Jun in OPN transcription regulation.
July 19, 2004... 2004 JUL 19 - (NewsRx.com & NewsRx.net) -- Ets gene PEA3 assists beta-catenin-Lef-1/c-Jun in osteopontin transcription regulation. According to recent research from North Ireland, "Osteopontin (OPN) is a multifunctional protein implicated...

Flt-1 gene transfer suppresses gastric cancer peritoneal metastasis.
July 19, 2004... 2004 JUL 19 - (NewsRx.com & NewsRx.net) -- Flt-1 gene transfer suppresses gastric cancer peritoneal metastasis. According to a study from Japan, "the prognosis of gastric cancer with peritoneal metastasis has not improved. Despite many...

EGFR mutations in lung cancer may predict sensitivity to gefitinib therapy.
July 19, 2004... 2004 JUL 19 - (NewsRx.com & NewsRx.net) -- Study finds that EGFR mutations in a lung cancer tumor cell line result in response to gefitinib treatment. "Receptor tyrosine kinase genes were sequenced in non-small cell lung cancer (NSCLC) and...

Two patents awarded for applications of electroporation therapy.
July 19, 2004... 2004 JUL 19 - (NewsRx.com & NewsRx.net) -- Genetronics Biomedical Corp. (GEB), a company focused on the electroporation-enhanced delivery of drugs, DNA vaccines, and gene therapies intended to treat cancer, infectious diseases, and other...

Renal epithelial neoplasms can be associated with familial tumor syndromes.
July 19, 2004... 2004 JUL 19 - (NewsRx.com & NewsRx.net) -- Researchers discuss the classification of renal neoplasms, which is based on molecular and biological characteristics. "Renal neoplasms are not necessarily high in frequency, but they are...

Flavopiridol sensitizes cells to apoptotic stimuli.
July 19, 2004... 2004 JUL 19 - (NewsRx.com & NewsRx.net) -- Flavopiridol sensitizes cells to apoptotic stimuli. According to a study from the United States, "flavopiridol (FP) inhibits gene expression and causes apoptosis, and these effects cannot be...

DNA methylation shows promise for treating advanced prostate cancer.
July 26, 2004... 2004 JUL 26 - (NewsRx.com & NewsRx.net) -- DNA methylation shows promise for treating advanced prostate cancer. "Estrogen receptor (ER)-beta is thought to exert anti-proliferative effects in the normal prostate but supports prostate cancer...

The novel Escherichia coli YeiK gene product is a gene therapy candidate.
July 26, 2004... 2004 JUL 26 - (NewsRx.com & NewsRx.net) -- The novel Escherichia coli YeiK gene product is a gene therapy candidate. According to recent research from Italy, "enzymes with nucleoside hydrolase (NH) activity are crucial for salvaging nucleic...

New data suggest FUS1 therapy may play role in preventing onset of lung cancer.
July 26, 2004... 2004 JUL 26 - (NewsRx.com & NewsRx.net) -- Introgen Therapeutics, Inc., (INGN) announced the publication of data in Cancer Research that describes results from preclinical studies testing one of Introgen's product candidates called INGN 401....

Ad/TRAIL-F/RGD may be potent therapeutic agent for pancreatic cancer.
July 26, 2004... 2004 JUL 26 - (NewsRx.com & NewsRx.net) -- Ad/TRAIL-F/RGD may be a potent therapeutic agent for pancreatic cancer. "An adenoviral vector with RGD-modified fibers and expressing the human tumor necrosis factor-related apoptosis-inducing...

Phase II trial of GVAX lung cancer vaccine begins.
July 26, 2004... 2004 JUL 26 - (NewsRx.com & NewsRx.net) -- Cell Genesys, Inc., (CEGE) announced enrollment has been initiated for a multicenter, phase II, clinical trial of GVAX lung cancer vaccine in patients with advanced-stage bronchoalveolar carcinoma...

Rapid rise in PSA level sign of aggressive prostate cancer.
July 26, 2004... 2004 JUL 26 - (NewsRx.com & NewsRx.net) -- Prostate cancer is much more likely to kill if a man's PSA level rises rapidly before the cancer is even diagnosed, according to a study that suggests a new and far more meaningful way of looking at...

Genetic profiling has advanced our knowledge of non-small cell lung cancer.
July 26, 2004... 2004 JUL 26 - (NewsRx.com & NewsRx.net) -- Genetic profiling has advanced our knowledge of non-small cell lung cancer. According to a study from Scotland, "non-small cell lung cancer (NSCLC) is the most common cause of premature death from...

Bcl-2 antisense agent G3139 invokes a response to refractory multiple myeloma.
July 26, 2004... 2004 JUL 26 - (NewsRx.com & NewsRx.net) -- According to recent research published in the journal Leukemia, "expression of Bcl-2 in multiple myeloma is associated with resistance to chemotherapeutic drugs. Conversely, suppression of Bcl-2...

CD40 ligand gene therapy halts Th2-mediated tumor escape.
July 26, 2004... 2004 JUL 26 - (NewsRx.com & NewsRx.net) -- CD40 ligand gene therapy halts Th2-mediated tumor escape. "Tumors exhibit immune escape properties that promote their survival. These properties include modulation of Ag presentation, secretion of...

Amplifications in chromosome arm 1p identified.
July 26, 2004... 2004 JUL 26 - (NewsRx.com & NewsRx.net) -- Amplifications in chromosome 1p have been identified in a pair of neuroblastoma tumors. "Deletion of chromosome arm 1p is one of the most frequent genetic alterations in neuroblastoma," oncologists...

Proteo-genomics system identifies malignant antibody targets.
July 26, 2004... 2004 JUL 26 - (NewsRx.com & NewsRx.net) -- A proteo-genomics system can help identify antibody targets in cancer. According to researchers in Massachusetts, "[i]dentification of antibody targets associated with malignant disease is...

Gerhard Baumgartner joins Chemophase maker's scientific advisory board.
July 26, 2004... 2004 JUL 26 - (NewsRx.com & NewsRx.net) -- Halozyme Therapeutics, Inc., (HZYM), a development-stage biopharmaceutical company developing and commercializing recombinant human enzymes, announced the appointment of Gerhard Baumgartner, MD, to...

Novel candidate oncogene identified.
July 26, 2004... 2004 JUL 26 - (NewsRx.com & NewsRx.net) -- A novel potential oncogene has been linked to prostate cancer pathogenesis. "Gains in the long arm of chromosome 8 (8q) are believed to be associated with poor outcome and the development of...

Drug-discovery company to focus resources on expanding clinical pipeline.
July 26, 2004... 2004 JUL 26 - (NewsRx.com & NewsRx.net) -- Exelixis, Inc., (EXEL) has implemented a restructuring and consolidation of its research and discovery organizations designed to optimize its ability to generate multiple new, high-quality...

Deletion of chromosome band 13q14 prognostic factor in multiple myeloma with SCT.
July 26, 2004... 2004 JUL 26 - (NewsRx.com & NewsRx.net) -- The deletion of chromosome band 13q14 is a prognostic factor in multiple myeloma patients receiveing allogeneic dose-reduced stem cell transplantation. According to recent research published in the...