Cancer Gene Therapy Week articles from July 2003

Cancer Gene Therapy Week archives from July 2003

Dendrimer-mediated angiostatin and TIMP-2 gene delivery impacts tumor growth.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- Dendrimer-mediated angiostatin and TIMP-2 gene delivery impacts tumor growth. According to published research from France, "gene transfer is an attractive approach to fight cancer by targeting...

Secondary structures mediate small interfering RNAs targeted to IGF1 receptor.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- Secondary structures mediate small interfering RNAs targeted to insulin-like growth factor receptor 1 (IGF1R). "The type 1 IGFR is often overexpressed by tumors and mediates growth and apoptosis...

Monitoring of TCR or immunoglobulin genes improves disease management.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- Following clonality of T cell receptors or immunoglobulin gene rearrangements provides rapid feedback so that pediatric acute lymphoblasic leukemia can be well managed. According to a study from...

Heat activated antisense Ku70 increases tumor cell radiation sensitivity.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Heat-activated expression of antisense molecules known to stifle DNA repair enhances cellular response to ionizing radiation, researchers in the United states...

Level of KIT expression does not appear to matter in imatinib mesylate therapy.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- Level of KIT expression does not appear to matter in imatinib mesylate therapy of gastrointestinal stromal tumors. According to a study from Germany, "More than 90% of gastrointestinal stromal...

Intravesical gene therapy appears safe for those with local bladder cancer.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Adenovirus-mediated p53 gene transfer appears to be safe for treating individuals diagnosed with locally advanced bladder cancer. The p53 tumor suppression...

IgH clonality can be determined by PCR from paraffinized bone marrow.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- PCR can be used to check the clonality of IgH to confirm B cell lymphoma involvement in paraffinized bone marrow biopsy. "We investigated whether the determination of clonality by polymerase chain...

BRCA2 levels are regulated by three mechanisms in a p53-dependent manner.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- BRCA2 levels are regulated by three mechanisms in a p53-dependent manner. According to a study from the United States, "Adriamycin and other DNA-damaging agents have been shown to reduce BRCA2 mRNA...

HIN-1 methylation patterns may be associated with some breast cancer subtypes.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- HIN-1 methylation patterns may be associated with some breast cancer subtypes. According to published research from the United States, "We recently identified a candidate tumor suppressor gene,...

Researchers discover how to activate faulty PTEN gene in several cancers.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- Researchers have discovered the way to activate a key anticancer signal that is inactive in several gynecologic and brain cancers. Since the late 1990s, researchers have known that a gene called...

Data suggest distinct genetic etiologies for Noonan, CFC and Costello syndromes.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- Data suggest distinct genetic etiologies for Noonan, CFC and Costello syndromes. "Costello syndrome (CS) is a rare, multiple congenital anomaly syndrome with characteristic dysmorphic features,...

IL-6 may act in a paracrine rather than an autocrine fashion in these cell lines.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- IL-6 may act in a paracrine rather than an autocrine fashion in these cell lines. "Interleukin 6 (IL-6) is a pleiotropic cytokine with many physiological functions," investigators in Japan report....

There is an etiological association of H pylori in some gastric cancers.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- There is an etiological association of H pylori in some gastric cancers. "Peptic ulcers and gastric malignancies are the two major complication of the course of Helicobacter pylori-associated...

Approximately 5% of colorectal cancer patients have inherited syndromes.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- Approximately 5% of colorectal cancer patients have inherited syndromes. According to recent research published in the journal Hematology-Oncology Clinics of North America, "Colorectal cancer is...

Altered function of ATM plays some pathogenic roles in the development of MLL.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- Altered function of ATM plays some pathogenic roles in the development of MLL. "The possible involvement of germline mutation of the ataxia telangiectasia mutated (ATM) gene in childhood acute...

Porphyrin 3 complexes facilitate oligonucleotide delivery into leukemic cells.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- Porphyrin 3 complexes facilitate oligonucleotide delivery into leukemic cells. "Novel cationic compounds forming complexes with oligodeoxyribonucleotides (ODNs) were prepared, and their ability to...

Rhodexin A inhibits the growth of human leukemia K562 cells.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- Rhodexin A inhibits the growth of human leukemia K562 cells. "We have examined the cytotoxic effect of rhodexin A isolated from the extract of Rhodea japonica on human leukemia K562 cells using a...

SCLC cells are highly resistant to apoptosis mediated by death receptors.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- SCLC cells are highly resistant to apoptosis mediated by death receptors. According to a study from Switzerland, "Small cell lung cancer cell lines were resistant to FasL and TRAIL-induced...

Epidermal PAF-R augments chemotherapy-induced apoptosis in human cancer cells.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- Epidermal PAF-R augments chemotherapy-induced apoptosis in human cancer cells. According to published research from the United States, "most chemotherapeutic agents exert their cytotoxic effects in...

Intermediate dose thalidomide has comparable efficacy and less toxicity.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- Intermediate dose thalidomide has comparable efficacy and less toxicity. According to recent research from England, "Thalidomide at doses > 200 mg has 100% grade 1-2 and 25% grade 3-4 toxicities...

Methylation of TSHR may provide a novel diagnostic marker of thyroid malignancy.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- Methylation of TSHR may provide a novel diagnostic marker of thyroid malignancy. "Thyroid-stimulating hormone receptor (TSHR) expression is frequently silenced in epithelial thyroid cancers...

Pendred syndrome gene SLC26A4 hypermethylation is early event in tumorigenesis.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- Hypermethylation of Pendred syndrome gene SLC26A4 is an early event in tumorigenesis of thyroid cancer. "Expression of the recently cloned Pendred syndrome gene SLC26A4 or PDS has been found to be...

Circulating EBV DNA molecules are naked DNA fragments not contained in virions.
July 7, 2003... 2003 JUL 7 - (NewsRx.com & NewsRx.net) -- Circulating EBV DNA molecules are naked DNA fragments not contained in virions. "Despite the increasing clinical applications of circulating EBV DNA analysis as a tumor marker, the molecular nature...

The bystander effect of TRAIL gene therapy relies on cell-to-cell contact.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- The bystander effect of TRAIL gene therapy relies on cell-to-cell contact. "We have previously reported that direct transfer of the TNF-related apoptosis-inducing ligand (TRAIL) gene resulted in an...

Intramuscular gene transfer gives a boost to antitumor DNA vaccine.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Researchers in Canada believe proteins made by cells following intramuscular gene transfer could be key to increasing the effectiveness of tumor immune...

Homozygous deletions demonstrated in cervical carcinoma in 3p21.3T and 3p21.3C.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- Homozygous deletions demonstrated in cervical carcinoma in 3p21.3T and 3p21.3C. According to a study from Sweden, "We report chromosome 3p deletion mapping of 32 cervical carcinoma (CC) biopsies...

TRAIL gene therapy for hepatocellular carcinoma calls for a stringent protocol.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- TRAIL gene therapy for hepatocellular carcinoma calls for a stringent protocol. According to recent research published in the journal Cancer Research, "ligands of the tumor necrosis factor family...

Interferon-beta gene transfer protects against metastasis from uveal melanoma.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - The murine form of interferon (IFN)-beta protects mice with intraocular melanomas from the formation of metastatic liver lesions when it is delivered as gene...

Chimeric immunogene therapy diminishes established tumors in murine models.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- Chimeric immunogene therapy diminishes established tumors in murine models. According to a study from Israel, "targeted adoptive immunotherapy is an attractive option for prostate cancer given its...

Defective endosomal acidification may contribute to cisplatin resistance.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- Defective endosomal acidification may contribute to cisplatin resistance. According to a study from the United States, "We isolated human KB adenocarcinoma cisplatin-resistant (CP-r) cell lines...

NQ01 genetic polymorphism and risk of bladder cancer are associated.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- NQ01 genetic polymorphism and risk of bladder cancer are associated According to a study from the United States, "NAD(P)H:quinone oxidoreductase (NQO1) is a detoxification enzyme that plays a...

DeltaEGFR may contribute to glioblastoma development.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- DeltaEGFR may contribute to glioblastoma development. According to a study from Australia, "In de novo glioblastoma multiforme, loss of the tumor suppressor protein PTEN can coincide with the...

Recognition of molecular subtypes may help elucidate causes of glioblastoma.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- Recognition of molecular subtypes may help elucidate causes of glioblastoma. "Glioblastoma (GBM) is the most important primary brain tumor, both in terms of its incidence and its devastating impact...

BRCA1 expression modulates chemosensitivity of HCC1937 breast cancer cells.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- BRCA1 expression modulates chemosensitivity of HCC1937 breast cancer cells. "Germline mutations of the tumor suppressor gene BRCA1 are involved in the predisposition and development of breast...

Monocytes and breast cancer cells promote factors involved in cancer aggression.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- Monocytes and breast cancer cells promote factors involved in cancer aggression. According to a study from France, "In breast cancers, clinical symptoms of inflammation localized around the tumor...

Mutations in BRCA1 may be associated with a lower risk of breast cancer.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- Mutations in BRCA1 may be associated with a lower risk of breast cancer. According to a study from Australia, "If the risk of disease is not the same for all germline mutations in a given gene, or...

Vitamin D-3 compounds trigger apoptosis independent of estrogen signaling.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- Vitamin D-3 compounds trigger apoptosis independent of estrogen signaling. "In estrogen receptor (ER)-positive breast cancer cells such as MCF-7 cells, the antitumor effects of...

Ras homolog member I (ARHI) inhibits growth of ovarian and breast cancers.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- Ras homolog member I (ARHI) inhibits growth of ovarian and breast cancers. "Our group recently identified Ras homolog member I (ARHI), a novel maternally imprinted tumor suppressor gene that...

EGF can protect ME180S cells from TNF-alpha-induced apoptosis.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- EGF can protect ME180S cells from TNF-alpha-induced apoptosis. "The tumor suppressor protein p53 is the most frequently mutated gene in human cancer," scientists in Australia report. "The...

Free radical generators appear to be useful for hyperthermic cancer therapy.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- Free radical generators appear to be useful for hyperthermic cancer therapy in cervical and uterine cancer. According to a study from Japan, "Hyperthermia-induced apoptosis and its enhancement in...

Malignant colon cells had 42 gastrin-releasing peptide receptor gene mutations.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- Malignant cells had 42 gastrin-releasing peptide receptor gene mutations. According to recent research published in the journal Molecular Carcinogenesis, "Epithelial cells lining the mature human...

TNF-alpha antagonists may be useful in cancer prevention and treatment.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- TNF-alpha antagonists may be useful in cancer prevention and treatment. According to recent research from England, "The proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) was...

Myelodysplastic syndrome develops in two children with Wolf-Hirschhorn syndrome.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- Myelodysplastic syndrome develops in two children with Wolf-Hirschhorn syndrome. According to recent research published in the American Journal of Medical Genetics Part a, "Wolf-Hirschhorn syndrome...

Tetrandrine induced cell cycle arrest and apoptosis in Hep G2 cells.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- Tetrandrine induced cell cycle arrest and apoptosis in Hep G2 cells. According to a study from Taiwan, "The effects of tetrandrine in the human hepatoblastoma G2 (Hep G2) cell line were...

Manipulating telomeres, telomerase will be significant in cancer treatment.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- Manipulating telomeres and telomerase will be clinically significant in treatment of human cancers. "Specialized nucleoprotein structures, termed telomeres, cap the ends of human chromosomes,"...

FISH analysis should be performed when cytogenetic, molecular tests disagree.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- FISH analysis should be performed when cytogenetic and molecular tests disagree. "Of 51 infants with acute leukemia, 13 (25%) had contradictory findings on 11q23/MLL rearrangements that were...

Mice lacking a transcriptional corepressor Tob are predisposed to cancer.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- Mice lacking a transcriptional corepressor Tob are predisposed to cancer. "Tob is a member of antiproliferative family genes. Mice lacking tob are prone to spontaneous formation of tumors,"...

A mutation in the TAP-1 gene leads to mRNA degradation and MHC-I downregulation.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- A mutation in the antigen presentation gene TAP-1 leads to mRNA degradation and HLA Class I downregulation, in a melanoma cell line. According to published research from the United States, "Both...

Polymorphism of stress protein HSP70-2 gene found to be associated with NPC.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- Genetic polymorphisms in stress protein HSP70-2, but not TNF-alpha, were associated with nasopharyngeal carcinoma. "Several studies have shown statistical evidence of association between...

A bicistronic construct driven by an adenovirus vector diminishes glioblastoma.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- A bicistronic construct driven by an adenovirus vector eradicates glioblastoma in murine models. According to a study from the United States, "the binding of urokinase plasminogen activator (uPA)...

Cationic emulsions improve cancer cell uptake of oligonucleotides.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- Cationic emulsions improve cancer cell uptake of oligonucleotides. "The aim of this study was to investigate the in vivo ability of O/W cationic emulsions to deliver oligonucleotides (ON) in...

Telomerase is a potential target for human cancer gene therapy.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- Telomerase is a potential target for human cancer gene therapy. "A number of different approaches have been developed to target human cancer on the basis of its specific expression of telomerase...

A hamster model is valuable for studying p16-related pancreatic oncogenesis.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- A hamster model is valuable for studying p16-related pancreatic oncogenesis. According to recent research published in the journal Biochemical and Biophysical Research Communications, "The...

CDKN1A and CDKN1B variants are associated with advanced prostate cancer.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- CDKN1A and CDKN1B variants are associated with advanced prostate cancer. According to a study from the United States, "A multigenic model of prostate cancer susceptibility has been proposed, in...

As a consequence of p53 activation, cells can undergo marked phenotypic changes.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- As a consequence of p53 activation, cells can undergo marked phenotypic changes. According to published research from Israel, "The p53 tumor-suppressor plays a critical role in the prevention of...

Smad4 and ERalpha form a complex that regulates estrogen target gene promoter.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- The estrogen target gene promoter is regulated by a complex formed of ERalpha and Smad4; also, the complex is inducible by antiestrogen compounds. "Antiestrogen compounds exhibit a variety of...

Combination gene therapy staunches bladder cancer growth mechanisms.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- Combination gene therapy staunches bladder cancer growth mechanisms. According to recent research published in the British Journal of Cancer, "mutations or loss of heterozygosity of p53 are...

The PATCHED gene is putative suppressor at 9q22 locus in urothelial cancer.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- The PATCHED gene is a putative suppressor at the 9q22 locus in urothelial cancer. "Chromosome 9 alterations are the most frequently encountered cytologic anomalies in urothelial carcinoma (UC),"...

The coxsackievirus and adenovirus receptor is a tumor suppressor in glioma.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- The coxsackievirus and adenovirus receptor is a tumor suppressor in glioma. According to recent research from the United States, "the coxsackievirus and adenovirus receptor (CAR) is a membrane...

p73 may have a role to play as a tumor suppressor.
July 14, 2003... 2003 JUL 14 - (NewsRx.com & NewsRx.net) -- p73 may have a role to play as a tumor suppressor. According to recent research from India, "p73 is a p53 homolog, as they are similar structurally and functionally. Unlike p53, p73 is not...

Thymidine kinase gene therapy targets angiogenesis in murine lung tumors.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Scientists in France have concluded that targeting endothelial cells with suicide gene therapy may be a feasible way to strike at angiogenesis in solid tumors....

Adenovirus-mediated TRAIL transfer overcomes the problems of soluble cytokine.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Researchers believe they have found the key to generating more stable TRAIL expression in cancer cells, thus offering a better way to generate tumor cell...

Osteoblast-related transcription factors are expressed in breast cancer cells.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Osteoblast-related transcription factors are expressed in breast cancer cells. "Human breast cancers are known to preferentially metastasize to skeletal sites, however, the mechanisms that mediate...

Cyclin D1 overexpression inhibits tumor necrosis factor-induced growth arrest.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Cyclin D1 overexpression inhibits tumor necrosis factor-induced growth arrest. According to a study from Spain, "Although activated macrophages destroy cancer cells more effectively than normal...

Interleukin-transduced melanoma-reactive T lymphocytes rely on restimulation.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Interleukin-transduced melanoma-reactive T lymphocytes rely on restimulation. According to recent research published in the Journal of Immunotherapy, "A major obstacle limiting the efficacy of...

BRCA1 transcription is regulated by specific single-stranded DNA binding factors.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- BRCA1 transcription is regulated by specific single-stranded DNA binding factors. According to a study from the United States, "Since the majority of high-grade breast cancers express reduced...

E-cadherin, involved in lobular carcinomas, isn't responsible for ductal cancer.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- E-cadherin, involved in lobular carcinomas, isn't responsible for low grade ductal carcinoma. "Grade I invasive ductal breast carcinomas have a specific pattern of genetic aberrations, namely gain...

ERbeta expression could be a useful breast cancer biomarker in its own right.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- ERbeta expression could be a useful breast cancer biomarker in its own right. According to recent research from the United States, "The recent discovery of a second estrogen receptor (ER),...

Elevated protein kinase C alpha may predict tamoxifen treatment failure.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Elevated protein kinase C alpha may predict tamoxifen treatment failure. "We previously reported that stable transfection of protein kinase C alpha (PKCalpha) into T47D human breast cancer cells...

UbcH5c binds only to the BRCA1 RING domain and not the BARD1 RING.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- UbcH5c binds only to the BRCA1 RING domain and not the BARD1 RING. According to recent research from the United States, "BRCA1 is a breast and ovarian cancer tumor suppressor protein that...

Tart cherry anthocyanins and cyanidin may reduce the risk of colon cancer.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Tart cherry anthocyanins and cyanidin may reduce the risk of colon cancer. According to a study from the United States, "Anthocyanins, which are bioactive phytochemicals, are widely distributed in...

Tumor DNA is found in the serum of many recurrent colorectal cancer patients.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Tumor DNA is found in the serum of many recurrent colorectal cancer patients. According to a study from Japan, "We previously proved that p16 promoter methylation present in the tumors of...

Expression patterns are discerned that defined premalignant and tumor subtypes.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Expression patterns are discerned that defined premalignant and tumor subtypes. According to a study from Australia, "Current epidemiological evidence supports a pathogenetic model of gastric...

p53 mutations were frequently detected in recurrent hepatocellular carcinoma.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- p53 mutations were frequently detected in recurrent hepatocellular carcinoma. "p53 has recently been identified as a downstream target of ZBP-89, a zinc finger transcription factor. ZBP-89 promotes...

p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. According to a study from the United States, "We identified and characterized two new ING family genes, p29ING4 and p28ING5,...

Improving cancer therapy may be improved by non-genotoxic activation of p53.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Improving cancer therapy may be improved by non-genotoxic activation of p53. According to recent research published in the European Journal of Cancer, "Inactivation of p53 function is a common...

Cancer in the ileocecal valve can be derived from the colonic part of the valve.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Cancer in the ileocecal valve can be derived from the colonic part of the valve. "The ileocecal valve consists of an upper and lower segment formed by a duplication of the wall of the small and...

Fas gene expression is diverse at a mRNA level in T-cell leukemia.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Fas gene expression is diverse at a mRNA level in T-cell leukemia. According to recent research published in the journal Cancer Letters, "In adult T-cell leukemia (ATL), tumor cells commonly...

NUP98-HOXD13 can be implicated in leukemic transformation.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- NUP98-HOXD13 can be implicated in leukemic transformation. "HOX genes, notably members of the HOXA cluster, and HOX cofactors have increasingly been linked to human leukemia," investigators in...

GSTP1 polymorphism was associated with squamous cell lung carcinoma in Taiwan.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- GSTP1 polymorphism was associated with squamous cell lung carcinoma in Taiwan. According to recent research published in the journal Lung Cancer, "We assessed the association of three genetic...

MALT1 may be a dominant oncogene that plays a role in the pathogenesis of B-NHL.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- MALT1 may be a dominant oncogene that plays a role in the pathogenesis of B-NHL. "The MALT1 gene was identified through its involvement in t(11;18)(q21;q21), seen in 30% of cases of...

Aneuploidy is sufficient to cause structural instability of chromosomes.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Aneuploidy is sufficient to cause structural instability of chromosomes. According to published research from the United States, "Structurally altered or marker chromosomes are the cytolgenetic ha...

Some mammalian tumor-suppressor mechanisms can contribute to aging.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Some mammalian tumor-suppressor mechanisms can contribute to aging. "Organisms with renewable tissues use a network of genetic pathways and cellular responses to prevent cancer," scientists...

Loss of hMLH1 and improved survival in advanced ovarian cancer may be related.
July 21, 2003... 2003 JUL 21 - (NewsRx.com & NewsRx.net) -- Loss of hMLH1 and improved survival in advanced ovarian cancer may be related. According to recent research from Italy, "Preclinical data suggest a relationship between DNA MisMatch Repair (MMR)...