Cancer Gene Therapy Week articles from January 2009

Cancer Gene Therapy Week archives from January 2009

Scientists at Sichuan University report research in angiogenesis.
January 5, 2009... According to recent research from Chengdu, People's Republic of China, "Bone marrow-derived stromal cells (BMSCs) are important for development, tissue cell replenishment, and wound healing in physiological and pathological conditions. BMSCs...

New cancer gene therapy findings from Jikei University, Medical Department described.
January 5, 2009... According to recent research published in the journal Anticancer Research, "We have explored a gene-therapeutic approach to stimulate antitumor immunity by adenoviral-mediated transfer of CD40 ligand (CD40L) to treat metastatic liver cancer in...

New cancer gene therapy research from Gene Therapy Center outlined.
January 5, 2009... "The p14(ARF) gene encodes a critical negative regulator of cell cycle progression. And upregulation of telomerase activity has been considered a critical step to tumors," scientists in Shanghai, People's Republic of China report (see also...

Research by D.G. Kieback and colleagues in cancer gene therapy provides new insights.
January 5, 2009... "Adenovirus (ADV)-mediated gene therapy with the thymidine kinase (TK) gene under control of the Rous sarcoma virus (RSV) promotor followed by the administration of acyclovir has been established in vitro for the treatment of ovarian cancer...

Research findings from L.J. Duerner et al update understanding of gene therapy.
January 5, 2009... "Virotherapy is currently being developed for many different types of viruses including replication-competent murine leukaemia virus (MLV) as a novel tool in cancer therapy. However, there is the risk of insertional mutagenesis associated with...

Data on gene therapy described by S. Braun et al.
January 5, 2009... Fresh data on gene therapy are presented in the report 'Muscular gene transfer using nonviral vectors.' According to recent research from France, "Skeletal muscle is a target tissue of choice for the gene therapy of both muscle and non-muscle...

Reports outline leukemia gene therapy study findings from RIKEN.
January 5, 2009... Scientists discuss in 'Effects of the ligand sequence modifications on the retargeted transduction by the retroviral vector having a ligand-chimeric Env protein' new findings in leukemia. "There have been various attempts to redirect the cell...

Data on melanoma gene therapy published by M. Zheng and colleagues.
January 5, 2009... Fresh data on melanoma are presented in the report 'Interleukin-24 overcomes temozolomide resistance and enhances cell death by down-regulation of O6-methylguanine-DNA methyltransferase in human melanoma cells.' According to recent research...

Researchers identify new anti-tumor gene and discover a novel mode of interferon-induced, anti-tumor growth suppression.
January 5, 2009... Researchers from Virginia Commonwealth University have identified a new anti-tumor gene called SARI that can interact with and suppress a key protein that is overexpressed in 90 percent of human cancers. The discovery could one day lead to an...

New cancer gene therapy study results from University of Texas described.
January 12, 2009... According to recent research published in the journal Cancer Research, "Phospho-enriched protein in astrocytes (PEA-15) is a 15-kDa phosphoprotein that slows cell proliferation by binding to and sequestering extracellular signal-regulated...

Research from Baylor College of Medicine, College of Medicine broadens understanding of cancer gene therapy.(Report)
January 12, 2009... "Functional somatostatin receptors (SSTR) are lost in human pancreatic cancer. Transfection of SSTR-1 inhibited pancreatic cancer cell proliferation in vitro," investigators in the United States report (see also Cancer Gene Therapy). "We...

Studies from University of Turin reveal new findings on cancer gene therapy.
January 12, 2009... According to recent research from Turin, Italy, "Gene therapy provides a still poorly explored opportunity to treat cancer by ''active'' immunotherapy as it enables the transfer of genes encoding antibodies directed against specific oncogenic...

Study findings from Kyushu University provide new insights into cancer gene therapy.
January 12, 2009... "The recent clinical application of granulocyte macrophage colony-stimulating factor (GM-CSF)-transduced autologous tumor vaccines revealed substantial antitumor activity and valuable clinical results. However, for these vaccines to be...

Data on cancer gene therapy detailed by Y. Zhou and co-authors.(Report)
January 12, 2009... A report, 'Stable suppression of HER-2 gene expression using siRNA increases the lysis of human ovarian carcinoma cells mediated by NK-92 cell line,' is newly published data in Oncology Reports. "The overexpression and amplification of HER-2...

New cancer gene therapy data have been reported by H.J. Wu and co-authors.(Report)
January 19, 2009... According to a study from Wuhan, People's Republic of China, "PTEN (phosphatase and tensin homologue deleted on chromosome 10) is a tumor suppressor gene identified on human chromosome 10q23. Substantial studies have demonstrated that PTEN can...

Emory University, Division of Digestive Diseases publishes research in cancer gene therapy.
January 19, 2009... New investigation results, 'Notch inhibits expression of the Kruppel-like factor 4 tumor suppressor in the intestinal epithelium,' are detailed in a study published in Molecular Cancer Research. According to recent research published in the...

Findings from National Defense Medical College, Department of Biochemistry provide new insights into cancer gene therapy.
January 19, 2009... New investigation results, 'The knockdown of endogenous replication factor C4 decreases the growth and enhances the chemosensitivity of hepatocellular carcinoma cells,' are detailed in a study published in Liver International. In this recent...

New cancer gene therapy data have been reported by scientists at Kyoto Prefectural University, Department of Molecular.(Report)
January 19, 2009... New research, 'Anti-gout agent allopurinol exerts cytotoxicity to human hormone-refractory prostate cancer cells in combination with tumor necrosis factor-related apoptosis-inducing ligand,' is the subject of a report. According to a study from...

University of California details research in gene therapy.(Report)
January 19, 2009... Research findings, 'Menin promotes the Wnt signaling pathway in pancreatic endocrine cells,' are discussed in a new report. "Menin is a tumor suppressor protein mutated in patients with multiple endocrine neoplasia type 1. We show that menin is...

Gene therapy eliminates brain tumors through selective recruitment of immune cells.(Report)
January 26, 2009... Scientists seeking to harness the power of the immune system to eradicate brain tumors face two major hurdles: recruiting key immune cells called dendritic cells into areas of the brain where they are not naturally found and helping them...

Gene Marker May Improve Odds of Stem Cell Therapies for Disease.
January 26, 2009... A single tumor-suppressor gene may provide a unique marker for senescence in Mesenchymal stem cells (MSCs) in vitro, while also playing a role in moving MSCs into senescence, researchers at the Human Health Foundation and the Sbarro Institute...

New findings from Y. Zhang and co-authors describe advances in cancer gene therapy.(Report)
January 26, 2009... According to recent research from Guangzhou, People's Republic of China, " The failure of hormone treatment for advanced prostate cancer might be related to aberrant activation of the androgen receptor. We have shown that I-125 labeled...

Reports outline cancer gene therapy research from K.H. Jung and colleagues.(Report)
January 26, 2009... "Although the success of sodium/iodide symporter (NIS) gene-based cancer therapy is critically dependent on the level of radioiodide accumulation attained, recent evidence indicates that successful therapy relies not solely on NIS amount but...

Research on cancer gene therapy published by S.P. Ren et al.(Report)
January 26, 2009... According to a study from Beijing, People's Republic of China, "Incidence of nasopharyngeal carcinoma (NPC) remains high in endemic regions. Prevention of tumor recurrences and metastases is a crucial approach to improve therapeutic outcome in...

Researchers' work from Technical University of Munich focuses on metalloproteinase.(Report)
January 26, 2009... According to recent research from Munich, Germany, "Formation of multiple and scattered metastases in target organs, leading to disruption of organ functional integrity, is the death-determining step for most lethal cancers. In the clinic,...

Research from P. Rio and colleagues has provided new data on stem cell research.(Clinical report)
January 26, 2009... According to a study from Madrid, Spain, "Fanconi anemia (FA) is an inherited recessive DNA repair disorder mainly characterized by bone marrow failure and cancer predisposition. Studies in mosaic FA patients have shown that reversion of one...

Data on cancer gene therapy described by researchers at University of Tokyo, Institute of Medical Science.(Report)
January 26, 2009... Investigators publish new data in the report 'Involvement of epithelial cell transforming sequence-2 oncoantigen in lung and esophageal cancer progression.' "This study aims to isolate potential molecular targets for diagnosis, treatment,...

Researchers from Central South University, Department of Gastroenterology publish findings in cancer gene therapy.(Report)
January 26, 2009... Scientists discuss in 'Tissue specific cytotoxicity of colon cancer cells mediated by nanoparticle-delivered suicide gene in vitro and in vivo' new findings in cancer gene therapy. According to recent research from People's Republic of China,...

Researchers from National Institutes of Health report on findings in cancer gene therapy.
January 26, 2009... Researchers detail in 'Characterization of genetically modified T-cell receptors that recognize the CEA:691-699 peptide in the context of HLA-A2.1 on human colorectal cancer cells,' new data in cancer gene therapy. "Carcinoembryonic antigen...

Researchers from University of Melbourne, Department of Orthopaedics discuss findings in cancer gene therapy.
January 26, 2009... New investigation results, 'Cancer, chitosan nanoparticles and catalytic nucleic acids,' are detailed in a study published in The Journal of Pharmacy and Pharmacology. "The aim of this review was to examine gene therapy involving DNAzyme and...

Burzynski Research Institute Gets SPA Clearance from the FDA to Initiate Pivotal Phase III Trial of Combination Antineoplaston Therapy and Radiation Therapy.
January 26, 2009... The Burzynski Research Institute, Inc. (BRI) announced that it has reached an agreement with the U.S. Food and Drug Administration (FDA) that enables the company to move forward immediately with a pivotal Phase III clinical trial of combination...