Cancer Gene Therapy Week articles from January 2003

Cancer Gene Therapy Week archives from January 2003

Another target gene for microsatellite instability has been located.
January 27, 2003... 2003 JAN 27 - (NewsRx.com & NewsRx.net) -- According to a study from Finland, "defects in the DNA repair system lead to genetic instability because replication errors are not corrected. This type of genetic instability is a key event in the...

Immunogene therapy, dendritic cell therapy may lead to new treatment.
January 27, 2003... 2003 JAN 27 - (NewsRx.com & NewsRx.net) -- Researchers in Japan investigated immunogene therapy for malignant gliomas to improve its therapeutic efficacy. "Dendritic cells were isolated from bone marrow and pulsed with phosphate-buffered...

Metastatic cell clusters identify tumor markers specific to origin.
January 27, 2003... 2003 JAN 27 - (NewsRx.com & NewsRx.net) -- "Patients presenting with metastatic adenocarcinoma of unknown origin are a common clinical problem. Their optimal management and therapy are facilitated by identification of the primary site, yet...

Mesothelial cell transformation requires increased AP-1 binding.
January 27, 2003... 2003 JAN 27 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "Mesothelioma is a unique and insidious tumor associated historically with occupational exposure to asbestos. The transcription factor, activator protein-1...

Genomic hybridization distinguish long-term from typical survivors.
January 27, 2003... 2003 JAN 27 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "Glioblastoma (GBM) remains a highly lethal neoplasm, refractory to current therapies. The molecular genetic aberrations most closely related to clinical...

p53 and p21 protect cells against cyclin E-cdk2 deregulation.
January 27, 2003... 2003 JAN 27 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "Cyclin E, in conjunction with its catalytic partner cdk2, is rate limiting for entry into the S phase of the cell cycle. Cancer cells frequently...

Smoking enhances asbestos-induced genotoxicity.
January 27, 2003... 2003 JAN 27 - (NewsRx.com & NewsRx.net) -- "Several experimental and epidemiological studies have indicated augmentation of asbestos-induced diseases by cigarette smoke by mechanisms which are still unknown. To determine whether smoking...

TGF-beta 1/MAPK/p21 pathway is required for TGF-beta 1-mediated growth inhibition.
January 27, 2003... 2003 JAN 27 - (NewsRx.com & NewsRx.net) -- According to a study from Japan, "Epstein-Barr virus (EBV)-infected, gastric epithelial cell line GT38 is resistant to TGF-beta 1-mediated growth inhibition and apoptosis, although TGF-beta 1 partially...

Genotypes of Helicobacter pylori may explain the African enigma.
January 27, 2003... 2003 JAN 27 - (NewsRx.com & NewsRx.net) -- "The aim of this study was to compare the distribution of virulence-associated genotypes of Helicobacter pylori in two Colombian populations with contrasting gastric cancer risk but with similar H....

Genomic hybridization indicates cyclin L may be candidate oncogene.
January 27, 2003... 2003 JAN 27 - (NewsRx.com & NewsRx.net) -- According to recent research from France, "DNA gains targeting the 3q chromosome are common in head and neck squamous cell carcinomas, as well as in lung, ovarian, and cervical cancer. Several...

As2S2 may be a useful agent in treatment.
January 27, 2003... 2003 JAN 27 - (NewsRx.com & NewsRx.net) -- Researchers in the Peoples Republic of China investigated "the apoptotic effect of As2S2 on K562 cells and its mechanism. "The effect of As2S2 on proliferation of K562 cells was determined by...

Researchers analyze susceptibility to NKG2D-dependent natural killer cells.
January 27, 2003... 2003 JAN 27 - (NewsRx.com & NewsRx.net) -- According to recent research from Italy, "NKG2D, together with NKp46 and NKp30, represents a major triggering receptor involved in the induction of cytotoxicity by both resting and activated human...

P53 mutation is source of aberrant beta-catenin in cancer cells.
January 27, 2003... 2003 JAN 27 - (NewsRx.com & NewsRx.net) -- According to recent research from Turkey, "beta-catenin is involved in both cell to cell interactions and wnt pathway-dependent cell fate determination through its interactions with E-cadherin and...

LDL receptor-related protein 1B can regulate uPAR regeneration.
January 27, 2003... 2003 JAN 27 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "the low density lipoprotein (LDL) receptor-related protein 1B (LRP1B) is a newly identified member of the LDL receptor family and is closely related to...

p53 codon 72 Arg homozygosity is associated with advanced lung cancer.
January 27, 2003... 2003 JAN 27 - (NewsRx.com & NewsRx.net) -- "The association of p53 codon 72 polymorphism with cancer has been investigated by several scientific groups with controversial results. In the present study, we examined the genotypic frequency of...

Genes identified resistant to interferon-alpha in cutaneous T-cell lymphoma.
January 27, 2003... 2003 JAN 27 - (NewsRx.com & NewsRx.net) -- "Interferon alpha therapy has been shown to be active in the treatment of mycosis fungoides; although the individual response to this therapy is unpredictable and dependent on essentially unknown...

Multicolor-FISH analysis of a natural killer cell line (NK-92).
January 27, 2003... 2003 JAN 27 - (NewsRx.com & NewsRx.net) -- "Relatively little is known about the cytogenetics of natural killer (NK) neoplasms, and the emergence of recurrent structural alterations involving specific chromosomal breakpoints is still in its...

Study indicates NGF can act in paracrine and/or autocrine manner.
January 27, 2003... 2003 JAN 27 - (NewsRx.com & NewsRx.net) -- According to recent research from Germany, "Nerve growth factor (NGF) exerts both stimulatory and inhibitory effects on neuronal and certain non-neuronal tumors. In pancreatic cancer NGF is...

Characterization of epithelial senescence may help identify cancer genes.
January 27, 2003... 2003 JAN 27 - (NewsRx.com & NewsRx.net) -- "Evasion of cellular senescence is required for the immortal phenotype of tumor cells. The tumor suppressor genes p16(INK4A), pRb, and p53 have been implicated in the induction of cellular senescence....

TRAP-Mediator complex may play coregulatory role in androgen receptor-mediated gene expression.
January 27, 2003... 2003 JAN 27 - (NewsRx.com & NewsRx.net) -- "The human thyroid hormone receptor associated protein (TRAP)-Mediator complex was originally identified as a large multimeric complex that copurifies with the thyroid hormone receptor (TR) from HeLa...

Thrombin receptor expressed on cell lines associated with bone metastases.
January 27, 2003... 2003 JAN 27 - (NewsRx.com & NewsRx.net) -- In a recent report, researchers in the United States studied ways "to identify genes important in prostate cancer metastatic to bone. Bone-specific metastasis is a common feature of prostate cancer...

Real-time quantitative RT-PCR useful as biomarker for radiation biodosimetry.
January 27, 2003... 2003 JAN 27 - (NewsRx.com & NewsRx.net) -- In a recent report, researchers in the United States assessed "the efficacy of fluorescent-based quantitative reverse transcription-polymerase chain reaction (QRT-PCR) technology to measure gene...