Cancer Gene Therapy Week articles from February 2009

Cancer Gene Therapy Week archives from February 2009

New cancer gene therapy research has been reported by scientists at Nanjing Medical University.(Report)
February 2, 2009... "Gemcitabine is the first-line chemotherapeutic agent for advanced adenocarcinoma of the pancreas; however, chemoresistance to gemcitabine remains a major cause of failure for the clinical treatment of this disease. Polo-like kinase 1 (Plk-1)...

Reports from Fudan University describe recent advances in cancer gene therapy.
February 2, 2009... "To study the tumor specificity and antitumor activity of the replication-competent oncolytic adenovirus TOA02, which is controlled by a modified human telomerase reverse transcriptase (hTERT) promoter and expresses granulocyte macrophage...

Reports on cancer gene therapy findings from University of Texas provide new insights.
February 2, 2009... "RB94, which lacks the N-terminal 112 amino-acid residues of the full-length retinoblastoma protein (RB110) is a more potent inhibitor of cancer cell growth than RB110, being cytotoxic to all cancer cell lines studied, independent of their...

Reports summarize cancer gene therapy study results from Xuzhou Medical College, Medical College.(Report)
February 2, 2009... "RNA interference (RNAi) has been proved to be a powerful tool for gene knockdown purpose and holds great promise for the treatment of cancer. Our previous study demonstrated that the reduction of Ki-67 expression by means of chemically...

Researchers from INSERM publish new studies and findings in the area of cancer gene therapy.
February 2, 2009... According to a study from Nice, France, "Unmethylated CpG dinucleotides, present in bacterial DNA, are recognized in vertebrates via the Toll-like receptor 9 (TLR9) and are known to act as an anticancer agent by stimulating immune cells to...

Study data from Kaohsiung Medical University update understanding of gene therapy.
February 2, 2009... According to a study from Kaohsiung, Taiwan, "Non-invasive gene monitoring is important for most gene therapy applications to ensure selective gene transfer to specific cells or tissues. We developed a non-invasive imaging system to assess the...

Studies from University of California update current data on necrosis.
February 2, 2009... "Tumor necrosis factor (TNF)-alpha is a type-II transmembrane protein that is cleaved by TNF-alpha-converting enzyme (TACE/ADAM-17) to release soluble TNF, a cytokine with potent antitumor properties whose use in clinical applications is...

Northeastern University, Department of Pharmaceutical Sciences details research in cancer gene therapy.(Report)
February 2, 2009... A report, 'Epidermal growth factor receptor-targeted gelatin-based engineered nanocarriers for DNA delivery and transfection in human pancreatic cancer cells,' is newly published data in The Aaps Journal [electronic Resource]. "Type B...

Research on cancer gene therapy discussed by scientists at Peking Union Medical College, Biotechnology Department.
February 2, 2009... Researchers detail in 'MR-1 modulates proliferation and migration of human hepatoma HepG2 cells through myosin light chains-2 (MLC2)/focal adhesion kinase (FAK)/Akt signaling pathway,' new data in cancer gene therapy. According to a study from...

Research from Miyagi Cancer Center, Division of Cancer broadens understanding of phosphatase.(Report)
February 2, 2009... Research findings, 'Nuclear inhibitor of protein phosphatase-1 (NIPP1) directs protein phosphatase-1 (PP1) to dephosphorylate the U2 small nuclear ribonucleoprotein particle (snRNP) component, spliceosome-associated protein 155 (Sap155),' are...

Important advance in the treatment of cancer and viral infections.
February 2, 2009... Dr. Andre Veillette, a researcher at the Institut de recherches cliniques de Montreal (IRCM), and his team led by postdoctoral fellow Dr. Mario-Ernesto Cruz-Munoz, will publish in the upcoming issue of the prestigious journal Nature Immunology...

New cancer gene therapy research from University of Pennsylvania described.
February 9, 2009... According to recent research from the United States, "Locally produced transforming growth factor-beta (TGF-beta) promotes tumor-induced immunosuppression and contributes to resistance to immunotherapy. This article explores the potential for...

Reports from Mayo Clinic add new data to research in cancer gene therapy.(Report)
February 9, 2009... According to recent research from the United States, "Our objectives were to, first, determine the oncolytic potential of an engineered measles virus expressing the sodium-iodide symporter gene (MV-NIS) for intratumoral (IT) therapy of...

Research from D.S. Yyu and co-authors provides new data about cancer gene therapy.(Report)
February 9, 2009... According to a study from Guangzhou, People's Republic of China, "Previous studies revealed that drug-loaded poly(ethylene-glycol)-poly(gamma-benzyl-L-glutamate) (PEG-PBLG) nanoparticles exhibit favorable pharmacokinetic characteristics in the...

Research results from University of Modena update knowledge of gene therapy.
February 9, 2009... "Deficiency of the basement membrane component laminin-5 (LAM5) causes junctional epidermolysis bullosa (JEB), a severe and often fatal skin adhesion defect. Autologous transplantation of epidermal stem cells genetically corrected with a...

Study results from Washington University, Medical Department broaden understanding of gene therapy.
February 9, 2009... "Neonatal intravenous injection of gammaretroviral vectors (gamma-RVs) with an intact long terminal repeat (LTR) and an internal liver promoter can result in long-term expression in liver cells and correction of mucopolysaccharidosis. Some...

Studies from Breakthrough Breast Cancer Research Center yield new information about cancer gene therapy.(Report)
February 9, 2009... New research, 'ERBB2 influences the subcellular localization of the estrogen receptor in tamoxifen-resistant MCF-7 cells leading to the activation of AKT and RPS6KA2,' is the subject of a report. According to a study from London, the United...

Study data from All India Institute of Medical Sciences, Department of Biochemistry provide new insights into gene therapy.(Report)
February 9, 2009... Research findings, 'Frequent loss of heterozygosity and altered expression of the candidate tumor suppressor gene 'FAT' in human astrocytic tumors,' are discussed in a new report. According to a study from New Delhi, India, "We had earlier...

New leukemia gene therapy study findings recently were published by researchers at Cornell University.
February 9, 2009... A report, 'Akt regulates vitamin D3-induced leukemia cell functional differentiation via Raf/MEK/ERK MAPK signaling,' is newly published data in European Journal of Cell Biology. "1,25-dihydroxyvitamin D3 (vitamin D3) induces differentiation of...

Findings in bioengineering reported from A. Ambade and co-researchers.
February 16, 2009... "The potential of cytokine gene therapy using naked plasmid DNA encoding human IL-2 cDNA in a xenograft nude mouse model was investigated. To overcome the T cell deficiency in nude mice, Adoptive T Cell Transfer [ATCT] into tumour bearing nude...

Findings in cancer gene therapy reported from M. Takanashi and co-researchers.(Report)
February 16, 2009... According to a study from Shinjuku, Japan, "Heterochromatin protein 1 (HP1) is a chromosomal protein that participates in both chromatin packaging and gene silencing. Three HP1 isoforms (alpha, beta, and gamma) occur in mammals, but their...

New cancer gene therapy research from Fourth Military Medical University described.
February 16, 2009... "To investigate the inhibiting mechanism of multi-drug resistance (MDR) using expression vectors of short hairpin RNA (shRNA) in a MDR human ovarian cancer cell line (A2780/cp70). Two shRNA expression vectors were constructed and introduced...

New cancer gene therapy research from W.F. Shi and colleagues discussed.
February 16, 2009... According to a study from Shanghai, People's Republic of China, "The aim of our study was to develop an effective gene delivery system for ovarian cancer gene therapy. The expression of heparin sulfate proteoglycan (HSPG) and integrins...

New cancer gene therapy study findings have been reported by researchers at University of Hong Kong.
February 16, 2009... According to recent research from Hong Kong, People's Republic of China, "Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide, yet effective therapeutic options for advanced HCC are limited. Kringle 1 domain of HGF...

Scientists at National Taiwan University, Medical Department target gene therapy.
February 16, 2009... "Many tumors evade host immunity by lowering expression of major histocompatibility complex (MHC) molecules. Theoretically, low MHC expression should activate natural killer (NK) cells and in some cases suppress tumor growth; nevertheless, some...

Investigators at Tianjin Medical University zero in on cancer gene therapy.
February 16, 2009... New investigation results, 'Changes of the alternative splicing variants of human telomerase reverse transcriptase during gastric carcinogenesis,' are detailed in a study published in Pathobiology. "We attempted to reveal the changes of the...

Reports from National Institutes of Health highlight recent research in cancer gene therapy.
February 16, 2009... Researchers detail in 'Nitric oxide prodrug JS-K inhibits ubiquitin E1 and kills tumor cells retaining wild-type p53,' new data in cancer gene therapy. According to a study from the United States, "Nitric oxide (NO) is a major effector molecule...

Research from Boston University, Cancer Research Center broadens understanding of cancer gene therapy.
February 16, 2009... Data detailed in 'Requirement for chromatin-remodeling complex in novel tumor suppressor HIC1-mediated transcriptional repression and growth control' have been presented. "HIC1 is a newly discovered tumor suppressor and transcriptional...

Research on cancer gene therapy detailed by scientists at Case Western Reserve University, CASE Comprehensive Cancer Center.
February 16, 2009... Data detailed in 'Disruption of the EGFR E884-R958 ion pair conserved in the human kinome differentially alters signaling and inhibitor sensitivity' have been presented. "Targeted therapy against epidermal growth factor receptor (EGFR)...

Study results from University of North Carolina provide new insights into cancer gene therapy.
February 16, 2009... Current study results from the report, 'In vitro and in vivo analysis of B-Myb in basal-like breast cancer,' have been published. "A defining feature of basal-like breast cancer, a breast cancer subtype with poor clinical prognosis, is the high...

University of Virginia reports research in cancer gene therapy.
February 16, 2009... A report, 'Decreased BRCA1 confers tamoxifen resistance in breast cancer cells by altering estrogen receptor-coregulator interactions,' is newly published data in Oncogene. "The breast cancer susceptibility gene 1 (BRCA1) is mutated in...

Researchers at University Kebangsaan Malaysia, Pathology Department target lymphoma gene therapy.(Report)
February 16, 2009... Investigators publish new data in the report 'BCL2 protein expression in follicular lymphomas with t(14;18) chromosomal translocations.' According to a study from Kuala Lumpur, Malaysia, "The t(14;18)(q32;q21) chromosomal translocation induces...

Research data from M. Gimenezalejandre and colleagues update understanding of gene therapy.
February 23, 2009... According to a study from Barcelona, Spain, "A critical obstacle for efficient gene therapy and virotherapy of cancer with adenoviral vectors and oncolytic adenoviruses is to target tumor cells in vivo. Recent reports indicate that, contrary to...

Data on immunotherapy detailed by researchers at University of Pennsylvania.
February 23, 2009... According to recent research published in the journal Immunologic Research, "To be effective for the treatment of cancer and infectious diseases, T cell adoptive immunotherapy requires large numbers of cells with abundant proliferative reserves...

Data on cancer gene therapy described by researchers at Johns Hopkins University.
February 23, 2009... Investigators publish new data in the report 'Imaging of cationic multifunctional liposome-mediated delivery of COX-2 siRNA.' "Liposomes are a useful means of delivering molecular targeting agents such as small interfering RNA (siRNA) to...

Data on cancer gene therapy detailed by researchers at University of Texas, M.D. Anderson Cancer Center.(Report)
February 23, 2009... New research, 'Oncolytic adenovirus retargeted to Delta-EGFR induces selective antiglioma activity,' is the subject of a report. According to recent research from the United States, "The fact that glioblastomas, which are one of the most...

Data on cancer gene therapy discussed by researchers at Osaka University.
February 23, 2009... A report, 'The effects of trichostatin A on the oncolytic ability of herpes simplex virus for oral squamous cell carcinoma cells,' is newly published data in Cancer Gene Therapy. According to a study from Suita, Japan, "Combining the use of a...

Investigators at Sun Yat-Sen University, Cancer Center publish new data on cancer gene therapy.
February 23, 2009... Scientists discuss in 'The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells' new findings in cancer gene therapy. According to a study from Guangzhou, People's...

Recent studies by A.W. Tong and co-authors add new data to cancer gene therapy findings.(Report)
February 23, 2009... Research findings, 'MicroRNA profile analysis of human prostate cancers,' are discussed in a new report. "We examined the microRNA (miRNA) expression profile of 40 prostatectomy specimens from stage T2a/b, early relapse and non-relapse cancer...

Reports summarize cancer gene therapy research from Cancer Research Center.
February 23, 2009... Researchers detail in 'Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect,' new data in cancer gene therapy. According to a study from Madrid, Spain, "Sirtuin 1 (Sirt1) and Sirtuin 2 (Sirt2) belong to the family of...

Research on cancer gene therapy described by G.J. Dougherty and colleagues.(Report)
February 23, 2009... Current study results from the report, 'Exploiting the tumor microenvironment in the development of targeted cancer gene therapy,' have been published. "The future success of cancer gene therapy is critically dependent upon the development of...

Researchers at Vall d'Hebron University, Medical Oncology Department release new data on cancer gene therapy.
February 23, 2009... Fresh data on cancer gene therapy are presented in the report 'Lapatinib, a HER2 tyrosine kinase inhibitor, induces stabilization and accumulation of HER2 and potentiates trastuzumab-dependent cell cytotoxicity.' "Lapatinib is a human epidermal...

Researchers from Justus-Liebig University, Department of Internal Medicine II publish findings in cancer gene therapy.
February 23, 2009... Scientists discuss in 'Intravenous injection of siRNA directed against hypoxia-inducible factors prolongs survival in a Lewis lung carcinoma cancer model' new findings in cancer gene therapy. According to recent research from Giessen, Germany,...

Researchers from National Cancer Institute report on findings in cancer gene therapy.
February 23, 2009... Researchers detail in 'DLC1 tumor suppressor gene inhibits migration and invasion of multiple myeloma cells through RhoA GTPase pathway,' new data in cancer gene therapy. "DLC1 (deleted in liver cancer 1), a tumor suppressor gene that encodes a...

Scientists at INSERM target cancer gene therapy.
February 23, 2009... A report, 'Specific association between the methyl-CpG-binding domain protein 2 and the hypermethylated region of the human telomerase reverse transcriptase promoter in cancer cells,' is newly published data in Carcinogenesis. According to...

Studies from F. Hoffmann-LaRoche Ltd. add new findings in the area of cancer gene therapy.(Report)
February 23, 2009... New research, 'Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab,' is the subject of a report. According to a study from Penzberg, Germany, "Three-dimensional (3D)...

Studies from Seoul National University, Dental Research Institute yield new data on cancer gene therapy.
February 23, 2009... Fresh data on cancer gene therapy are presented in the report 'CXCR-4 knockdown by small interfering RNA inhibits cell proliferation and invasion of oral squamous cell carcinoma cells.' "Oral squamous cell carcinomas (OSCCs) are characterized...

Reports summarize enzyme research from Kyungpook National University, College of Natural Sciences.
February 23, 2009... A report, 'Silencing of cytosolic NADP(+)-dependent isocitrate dehydrogenase by small interfering RNA enhances the sensitivity of HeLa cells toward staurosporine,' is newly published data in Free Radical Research. According to recent research...

Data from University of Florida, Shands Cancer Center provide new insights into gene therapy.
February 23, 2009... Researchers detail in 'C/EBPbeta-mediated transcriptional regulation of bcl-xl gene expression in human breast epithelial cells in response to cigarette smoke condensate,' new data in gene. "In earlier studies, we have shown that cigarette...

Scientists at Got-A-Gene AB detail research in gene therapy.
February 23, 2009... Researchers detail in 'Re-targeted adenovirus vectors with dual specificity; binding specificities conferred by two different Affibody molecules in the fiber,' new data in gene therapy. According to recent research from Sweden, "Vectors based...

Scientists at New York University, University Cancer Institute report research in gene therapy.
February 23, 2009... A new study, 'Controlled propagation of replication-competent Sindbis viral vector using suicide gene strategy,' is now available. "A major concern of using viral gene therapy is the potential for uncontrolled vector propagation and infection...

Reports outline hepatomas therapy research from P. Garcia-Maceira and colleagues.(Report)
February 23, 2009... Investigators publish new data in the report 'Silibinin inhibits hypoxia-inducible factor-1alpha and mTOR/p70S6K/4E-BP1 signalling pathway in human cervical and hepatoma cancer cells: implications for anticancer therapy.' "The hypoxia-inducible...

Scientists at University of Pennsylvania, Department of Medicine describe research in leukemia gene therapy.(Report)
February 23, 2009... New research, 'BCR/ABL induces chromosomal instability after genotoxic stress and alters the cell death threshold,' is the subject of a report. "Earlier reports have suggested that the BCR/ABL oncogene, associated with chronic myeloid leukemia,...

Fundamentals of Drug Delivery in Cancer Revealed in This Recently Updated Report as Approx. 12.5 Million New Cases of Cancer Diagnosed Each Year.(Report)
February 23, 2009... Research and Markets (http://www.researchandmarkets.com/research/91d63e/drug_delivery_in_c) has announced the addition of Jain PharmaBiotech's new report "Drug Delivery in Cancer - Technologies, Markets and Companies" to their offering (see...

Personalized Medicine - the Scientific and Commercial Aspects.(Report)
February 23, 2009... Research and Markets (http://www.researchandmarkets.com/research/49001f/personalized_medic) has announced the addition of Jain PharmaBiotech's new report "Personalized Medicine - Scientific and Commercial Aspects" to their offering (see also...