Cancer Gene Therapy Week articles from February 2004

Cancer Gene Therapy Week archives from February 2004

BAG-1 uses a variety of pathways to generate chemoresistance.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- BAG-1 uses a variety of pathways to generate chemoresistance. "To study the mechanism of action of BAG-1 in drug-induced apoptosis, we constructed an antisense BAG-1 vector and established a stably...

A recombinant fragment of thrombospondin-2 halts VEGF-induced tumor growth.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- A recombinant fragment of thrombospondin-2 halts VEGF-induced tumor growth. "We have previously shown that stable overexpression of the thrombospondin-2 (TSP-2) gene inhibited the tumor growth and...

Nuclear factor kappaB inhibition impairs pancreatic cancer angiogenesis.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Nuclear factor kappaB inhibition impairs pancreatic cancer angiogenesis. According to recent research from the United States, "the effect of blockade of nuclear factor kappaB (NF-kappaB) activity on...

Wound-healing genes influence cancer progression.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Genes that help wounds heal are most often the "good guys," but a new study paints them as the enemy in some types of cancer. Researchers at the Stanford University School of Medicine have found...

Cisplatin does not directly effect mitochondrial oxygen consumption.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Study finds that exposures to alkylating agents and anthracyclines produce immediate and dose-dependent impairment of mitochondrial oxygen consumption. According to recent research published in the...

Beta[subscript]3 integrin expression can lead to increased tumor cell aggressiveness.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Study suggest that increased expression of the alpha[subscript]vbeta[subscript]3 integrin during breast cancer progression can result in increased tumor cell aggressiveness. "Osteopontin (OPN) is a...

Breast cancer resistance protein is a MTX and MTX-polyglutamate transporter.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Study data show that that breast cancer resistance protein (BCRP) is a methotrexate (MTX) and MTX-polyglutamate transporter and reveal a possible mechanism by which it confers resistance. According...

Increased breast cancer risk may be related to the HLA class III subregion.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Study results show a potential role of the HLA class III subregion in susceptibility to breast cancer. According to a study from Netherlands, "BRCA1 and BRCA2 germline mutations account for ...

P1 homozygosity may be a potential risk factor in breast carcinogenesis.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Research suggests that P1 homozygosity could possibly be a risk factor in breast carcinogenesis. According to a study from Greece, "H-ras is a member of the ras superfamily of genes. This gene...

Pooled analysis of LOH in breast cancer finds many nonreproducible results.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Researchers compile a database of loss of heterozygosity (LOH) studies of breast cancer that lays a framework for further investigation. "Somatic loss of heterozygosity (LOH) has been widely...

Steroid hormone-resistant breast cancer can be sensitive to growth factors.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Researchers establish numerous regulatory links between signal transduction pathways elicited by peptide growth factors and progesterone receptors (PR). "Breast cancers often have increased...

Underarm cosmetics with estrogen may contribute to breast cancer.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Further work is needed to determine whether the use of underarm cosmetics (particularly containing estrogenic formulants) contributes to the rising incidence of breast cancer. "A recent review by...

Many BRCA1 and BRCA2 genes mutations are unique to Spain.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Knowledge about the spectrum of BRCA1 and BRCA2 mutations will improve the detection strategy in countries with large Spanish populations, researchers say. According to published research from...

Kahalalide F preferentially induces cell death via oncosis in tumor cells.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Study show that Kahalalide F (KF) induces cell death via oncosis preferentially in human and prostate cancer cell lines. According to a study from Spain, "Kahalalide F is a novel antitumor drug of...

Riddelline is toxic and carcinogenic in rats and mice.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Study demonstrates the toxicity and carcinogenicity of riddelline in rats and mice. "These investigations of riddelliine analyzed potential carcinogenesis and the utility of the...

Evidence identifies the role of potassium homeostasis in apoptosis.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Studies of K+ regulation of apoptosis may lead to novel therapeutic strategies for apoptosis-related diseases, researchers report. According to recent research from the United States, "Programmed...

Silibinin may be useful in colon cancer prevention and intervention.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Silibinin may have efficacy as a cell cycle regulator and apoptosis inducer in human colon carcinoma, researchers report. "Silymarin, a defined mixture of natural flavonoid, has recently been shown...

U.S. patents issued for gene delivery technologies.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Vical Incorporated (VICL) announced the issuance of U.S. Patent No. 6,673,776, covering novel methods of using DNA to deliver biologically active proteins, and U.S. Patent No. 6,670,332, covering a...

New highly scalable GenomeLab system launched.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Beckman Coulter, Inc., (BEC) began shipping its new GenomeLab SNPstream Genotyping System. Capable of performing 4,600 to more than 800,000 genotypes per day, SNPstream offers scalability unmatched...

Essential oils are not effective as anti-Helicobacter agents.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- An animal study finds that essential oils are unlikely to be efficient anti-Helicobacter agents in vivo. "An increased density of Helicobacter pylori in the gastric mucosa can be associated with...

Syndecan-1 may be a prognostic marker in intrahepatic cholangiocarcinoma.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Weak expression of syndecan-1 was predictive or poor prognosis after surgical resection, researchers report. "Syndecan-1, a cell-surface transmembrane heparin sulfate pro-teoglycan, has been...

Genomic changes in premalignant laryngeal lesions could indicate cancer risk.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Study finds that dysplasia correlates with loss of heterozygosity (LOH) at 3p21, 5q21, 9p21 and 17p13 in early laryngeal cancer. According to a study from Spain, "A tissue field of somatic genetic...

Common clonal origin seen in twins with leukemia.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Study results indicate that further postnatal exposures, genetic events, or both are needed to produce clinical disease in twins. "According to a study from England, "Identical infant twins with...

G protein-coupled receptors could participate in regulating metastatic melanoma.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Researchers report the first evidence that G protein-coupled receptors could participate in the regulation of melanoma metastasis. "According to recent research from Japan, "We have recently...

Melanoma progression is related to a mutation in protein phosphatase type 2A.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Study finds that two actions of Deltagamma1 could cause the enhancement of the malignant phenotypes of melanoma cells. "According to recent research published in the journal Histology and...

NSCLC growth in mouse xenografts, in vitro cannot predict patient outcomes.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Researchers report that the ability to propagate tumors in vitro may depend on the histological tumor type and its degree of differentiation. "Leukemic cell growth in SCID mice has been reported as...

Different genetic pathways involved in pediatric vs. adult ogliodendrogliomas.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Researchers say that genomic screening in a larger series is clearly indicated to delineate the unique molecular characteristics of these rare pediatric ogliodendrogliomas (OGs). ...

Zoledronic acid induces apoptosis of human osteogenic sarcoma cells in vitro.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Study shows that zoledronic acid (ZOL) inhibits the proliferation and survival of osteosarcoma cells in vitro, which has implications for future therapy of osteosarcoma in vivo. "The aim of this...

Apoptosis in pancreatic cancer cells is induced by arsenic trioxide.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- New research finds that an old drug, arsenic trioxide, may be valuable for treatment of pancreatic cancer. "We have previously shown that arsenic trioxide blocks proliferation and induces apoptosis...

Quinone oxidoreductase induces growth inhibition of pancreatic cancer.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Research suggests that altering the intracellular redox environment of pancreatic cancer cells may inhibit growth and delineate a potential strategy directed against pancreatic cancer. ...

Vaccine company gets broad patent coverage for its core technology platform.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Juvaris BioTherapeutics, Inc., has received notice of allowance from the U.S. Patent Office covering its core technology platform. The company is focused on the development of a new generation of...

Chronic ovarian hyperstimulation may precede a subset of pituitary adenomas.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Researchers say that estrogen is sufficient for the formation of lactotrope adenomas only in animals with a hyperstimulated ovary. "The majority of pituitary adenomas in humans are...

CYP3A4 and CYP3A5 genotypes, haplotypes, are related to risk of prostate cancer.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Study suggests that the CYP3A4 and CYP3A5 variants, or other alleles on the haplotypes they help distinguish, are associated with prostate cancer risk and aggressiveness. "Previous case-only...

Trioxifene (LY133314) can prolong survival in a PAIII rat prostate cancer model.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Research finds that trioxifene is a selective estrogen receptor modulator (SERM) that can inhibit metastasis in androgen-independent, metastatic prostate adenocarcinoma (PCa). "Trioxifene...

IGF2, a potent growth factor, may play a role in renal clear cell sarcoma.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- The development or progression of clear cell sarcoma of the kidney (CCSK) may be related to IGF2, a potent growth factor. "Clear cell sarcoma of the kidney represents a significant diagnostic and...

Unusual leukemia caused by rare combination of genes.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Two children who developed leukemia after receiving gene therapy for an inherited disease may have been victims of a rare combination of genes that is unlikely to happen in gene therapy for other...

Progressive alterations in global and GC-rich DNA methylation help tumorigenesis.
February 2, 2004... 2004 FEB 2 - (NewsRx.com & NewsRx.net) -- Progressive alterations in global and GC-rich methylation appear to be mechanistically important during tumor promotion. "DNA methylation plays a key role in the regulation of gene expression, and...

Bcl-xL-transduced stem cells provide better bone marrow transplantation.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Bcl-XL-transduced stem cells provide better bone marrow transplantation. According to a study from the United States, "the prolonged survival of donor hematopoietic stem cells is crucial to the...

Radiolabeled FIAU monitors the progress of cancer gene therapy.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Radiolabeled FIAU monitors the progress of cancer gene therapy. According to recent research from Taiwan, "an experimental cancer gene therapy model was employed to develop a non-invasive imaging...

The cytocidal gene construct rexin-G arrests pancreatic tumor growth.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- The cytocidal gene construct rexin-G arrests pancreatic tumor growth. According to a study from the United States, "metastatic or non-resectable (stage IV) pancreatic cancer has a rapidly fatal...

Clinical trials use gene therapy for GI cancer.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Researchers at Mount Sinai School of Medicine have begun clinical trials on a unique and promising approach to gene therapy for colorectal cancer. The study uses genes to make the cancer cells look...

Thymidylate synthase antisense blocks the oncogenic properties of colon cancer.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Thymidylate synthase antisense blocks the oncogenic properties of colon cancer. "5-Fluorouracil (5-FU), a fluoropyrimidine analogue, is one of the most commonly used anticancer drugs for the...

Antisense suppression of DDEFL1 blocks hepatocellular carcinoma cell growth.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Antisense suppression of DDEFL1 blocks hepatocellular carcinoma cell growth. According to a study from Japan, "to disclose mechanisms of hepatocellular carcinogenesis and to identify novel...

Increased Bim mRNA and protein can cause apoptosis in breast cancer cells.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Study shows that siRNA specific for Bim reduced the levels of Bim protein and inhibited apoptosis in paclitaxel-treated MCF-7 breast cancer cells. According to a study from England, "Paclitaxel is...

Salivary-type neoplasms of the breast and lung need further molecular study.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- The molecular pathology of salivary gland tumors has been reasonably well investigated in that location; however; there are few molecular studies devoted to salivary-type tumors of the breast and lung,...

Using established epidemiological methods can best answer molecular questions.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Research should employ the established epidemiological data and methods in order to contribute to the best use of the new molecular technology. According to recent research from the United States,...

Company reports on mechanism for immunotherapy cure of prostate cancer.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Generex Biotechnology Corp. (GNBT) announced the recent presentation of a poster at the Keystone Symposium, "Rational Design of Vaccines and Immunotherapies," on a novel cancer vaccination method...

Cancer vaccine delivers antigen to dendritic cells.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Researchers have developed an adenoviral vector cancer vaccine that delivers a tumor-associated antigen/CD40-ligand fusion protein to dendritic cells. "To develop a method to overcome the anergy...

Arsenic is associated with increased cancer incidence.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Study discusses the molecular mechanisms of arsenic carcinogenesis. "Arsenic is a metalloid compound that is widely distributed in the environment. Human exposure of this compound has been...

A unique coculture system improves in vitro investigations of gene therapy.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- A unique coculture system improves in vitro investigations of gene therapy. According to recent research published in the journal Mutagenesis, "due to the very limited transduction capacity of...

Cervical neoplasia is an HPV-associated malignancy.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Understanding human papilloma virus (HPV) has improved understanding of cervical carcinogenesis, researchers say. "Human papillomaviruses are present in virtually all cervical cancers and cancer...

DNA testing for HPV complicates management of atypical cervical cytology.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- The recent approval of concurrent use of high-risk human papillomavirus DNA testing with cytology in the screening of women for cervical neoplasia adds a new dilemma to patient management, researchers...

Role of injectable progesterones in cervical cancer remains unconfirmed.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- A research study failed to confirm the role of injectable progesterones in cervical carcinogenesis. "According to recent research from South Africa, "Various risk factors have been implicated in...

Marrow fibrosis indicates therapy failure in chronic myeloid leukemia.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Study finds that marrow fibrosis (MF) is an independent poor prognostic complication of chronic myeloid leukemia (CML), indicating therapy failure. "Marrow fibrosis has rarely been considered in...

Aggrus expression is frequently upregulated in colorectal tumors.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- TAggrus/T1alpha is a newly identified, platelet aggregation-inducing factor expressed in colorectal tumors, researchers report. "Platelets play an important role in hemostasis, thrombosis, and...

BRAF mutations associated with sporadic colorectal cancers.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Study shows that BRAF activation may participate in the carcinogenesis of sporadic colorectal cancers (CRCs) with hMLH1 hypermethylation in the proximal colon. According to a study from Japan,...

Beta-catenin has a role in invasion and metastasis of colorectal carcinomas.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Research suggests that nuclear beta-catenin activates the coordinated expression of the interacting proinvasive proteins laminin gamma2 chain and MTI-MMP, thereby leading to a promigratory activity at...

Tumor-related Rac1b not regulated by Rho-GDP dissociation inhibitors.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Tumor-related alternatively spliced Rac1b is not regulated by Rho-GDP dissociation inhibitors and exhibits selective downstream signaling. According to a study from Portugal, "Rac1 is a member of...

p53 Arg/Arg genotype linked to higher risk of cutaneous melanoma over age 50.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Researchers have found some evidence that in subjects over 50, p53 Arg/Arg genotype is associated with increased risk of cutaneous melanoma (CM) as compared to genotypes Arg/Pro or Pro/Pro. "The...

A PI3K inhibitor holds promise as an antitumor agent for gastric carcinoma.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Study finds that the PI3K-Akt pathway plays an important role in preventing Fas-mediated apoptosis in gastric cancer. "It is well known that Fas ligand and anti-Fas antibodies can induce apoptosis,...

Genetic, environmental factors evaluated in germ-cell cancer of three brothers.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Researchers investigating germ-cell tumors in three brothers suspect that a recessive hereditary factor predisposed the men to the cancer. "A thorough cytogenetic investigation and an analysis of...

CYP1A1 polymorphism unrelated to gynecological malignancies in the Japanese.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Although the frequency of CYP1A1 polymorphism in the Japanese population is higher than that in the Caucasian population, CYP1A1 polymorphism is not related to gynecological malignancies in Japanese...

Adaphostin can damage both myeloid and lymphoid leukemia cells.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Adaphostin might have a broader spectrum of activity than originally envisioned, researchers say. "Adaphostin (NSC 680410), an analog of the tyrphostin AG957, was previously shown to induce Bcr/abl...

High spontaneous colony growth in CMML predicts short survival.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Researchers find that high (>100) spontaneous granulocyte/macrophage colony (CFU-GM) formation in chronic myelomonocytic leukemia (CMML) at presentation correlates with increased disease activity and...

Somatic mitochondrial DNA mutations are associated with adult-onset leukemia.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Using PCR-RFLP analysis and real-time PCR, researchers demonstrate that somatic mitochondrial DNA (mtDNA) mutations are associated specifically adult-onset leukemia. "Mitochondrial genome...

TP53 is frequently altered in acute lymphoblastic leukemia.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- A new study finds that TP53 is altered in 40% of the acute lymphoblastic leukemia (ALL) samples studied in this series. According to a study from Spain, "Different mechanisms, such as chromosomal...

P-glycoprotein may have a role in liver cancer development.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Study results indicate a possible intrinsic role for P-glycoprotein (Pgp) in liver cancer development and introduce another promising unexplored therapeutic approach in liver cancer treatment. ...

Osteopontin enhances metastatic behavior in hepatocellular cancer cells.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Osteopontin (OPN) binds to the alpha[subscript]vbeta[subscript]3-integrin to increase plasma membrane CD44v6 expression and augment in vitro adhesion to hyaluronate (HA), which may help OPN enhance...

Hypermethylation of p16 in sputum and plasma may indicate lung cancer.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Hypermethylation of p16 in sputum and plasma samples may provide a more sensitive approach to molecular diagnosis of lung cancer than relying on conventional cytological analysis. "According to a...

TSLC1 gene is one of the target tumor suppressor genes of nasopharyngeal cancer.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Researchers studying the role of TSLC1 gene in NPC tumorigenesis have found the gene's expression plays a role in promoter hypermethylation. According to recent research from the People's Republic...

Study shows in vivo phosphorylation of the somatostatin 2A receptor in vivo.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- A new study has found that analysis of sst2A phosphorylation promises to provide a sensitive indicator of the effectiveness of somatostatin (SS) analogs in diagnostic and therapeutic situations in tumor...

Beta3Gal-T5 counteracts malignancy-related glycosylation in cancer cells.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Beta3Gal-T5 counteracts malignancy-related glycosylation in cancer cells. According to researchers in Italy, "we investigated the role of beta3Gal-T5, a member of the beta1,3galactosyltransferase...

Viral gene therapy shows promise for treating sarcoma.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Viral gene therapy shows promise for treating sarcoma. According to a study from Germany, "soft tissue sarcomas are a challenge for medical oncology and gene therapy. Protective and sensitizing...

Antibiotics related to geldanamycin could promote development of carcinoma.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Antitumor drugs that target Hsp90, such as antibiotics related to geldanamycin, could disrupt LKB1 function and promote the development of polyps and carcinomatous lesions. According to recent...

TRPS1 may play a role in androgen regulation of PSA gene expression.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Prostate-specific antigen (PSA) is considered as an important marker for prostate cancer. "Regulation of PSA gene expression is mediated by androgens bound to androgen receptors via androgen...

Interim clinical results of GTI-2040 in combination chemotherapy announced.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Lorus Therapeutics, Inc., announced interim results from a recently conducted exploratory phase II clinical trial of GTI-2040 in patients with advanced, end-stage renal cell cancer in the United States....

Recombinant constructs revive p53 tumor-suppressor activity in tumor cells.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Recombinant constructs revive p53 tumor-suppressor activity in tumor cells. "Human adenovirus (Ad) vectors are extensively used as gene transfer vehicles. However, a serious obstacle for the use of...

Several genetic loci are known to regulate adenovirus-based gene therapy.
February 9, 2004... 2004 FEB 9 - (NewsRx.com & NewsRx.net) -- Several genetic loci are known to regulate adenovirus-based gene therapy. According to published research from the United States, "a key aspect of the immune response to adenovirus (Ad) gene therapy...

Monocyte chemoattractant protein-1 sensitizes cervical cancer to cisplatin.
February 16, 2004... 2004 FEB 16 - (NewsRx.com & NewsRx.net) -- Monocyte chemoattractant protein-1 sensitizes cervical cancer to cisplatin. "Cervical cancers at advanced stages or with recurrent status are mainly treated by platinum-based chemotherapy, such as...

Tumor irradiation improves cytokine gene therapy targeting murine kidney cancer.
February 16, 2004... 2004 FEB 16 - (NewsRx.com & NewsRx.net) -- Tumor irradiation improves cytokine gene therapy targeting murine kidney cancer. "To circumvent the toxicity caused by systemic injection of cytokines, cytokine cDNA genes encoding the human...

Suppressed protein kinase B signals augment breast cancer heat treatment.
February 16, 2004... 2004 FEB 16 - (NewsRx.com & NewsRx.net) -- Suppressed protein kinase B signals augment breast cancer heat treatment. According to researchers in Canada, "we have previously demonstrated that protein kinase B (PKB) is a mediator of...

Liposomal suicide gene therapy attacks peritoneal cancer.
February 16, 2004... 2004 FEB 16 - (NewsRx.com & NewsRx.net) -- Liposomal suicide gene therapy attacks peritoneal cancer. "Peritoneal dissemination is a common end-stage complication of pancreatic cancer for which novel therapeutic modalities are actively...

The additive effects of TRAIL and p53 gene therapy diminish cancer cell growth.
February 16, 2004... 2004 FEB 16 - (NewsRx.com & NewsRx.net) -- The additive effects of TRAIL and p53 gene therapy diminish cancer cell growth. "Tumor necrosis factor-alpha-related apoptosis-inducing ligand (TRAIL) is a cytokine that can induce tumor-specific...

Extranodal versus nodal disease at presentation may be clinically important.
February 16, 2004... 2004 FEB 16 - (NewsRx.com & NewsRx.net) -- Genetic data from a study of B-cell lymphoma patients indicates that nodal versus extranodal disease in diffuse large B-cell lymphomas (DLBCL) is important in survival. According to recent...