Cancer Gene Therapy Week articles from February 2003

Cancer Gene Therapy Week archives from February 2003

Multifocal lesions are clonal in origin as determined by microsatellite analysis.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- "The reported incidence of satellite tumor lesions in renal cell carcinoma (7-25%) suggests that there is a risk of local recurrence after nephron sparing surgery. It remains largely unknown whether...

Tumor suppressor gene product p27(KIP1) has prognostic significance.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- A study from Japan sought to discover "whether a prognostic role for expression of the tumor suppressor gene (TSG) products exists in resected non-small cell lung cancers (NSCLCs)," as this remains...

Reasons found for differing quality of recovery following various treatments.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- Researchers in England investigated "the molecular stress responses related to the quality of recovery of normal tissue after various treatments for bladder cancer: hyperthermia, ionizing radiation,...

Karyotypic aberrations related to disease-free survival.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- According to a study from Scotland, "breast cancer has a high incidence and associated mortality rate, yet little is known of the sequence of genetic events that underlie the clinical course." This...

Maspin expression is possible inverse marker for all stages of disease.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "maspin, a novel serine protease inhibitor, has been shown to inhibit prostate tumor cell motility and invasion in vitro and to inhibit prostate...

Chromosome 5p13-12 data can predict adverse prognosis regardless of stage/ grade.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- According to recent research from Germany, "the individual prognosis in patients with bladder cancer is only partially predicted by tumor stage and grade. Various molecular markers have been shown to...

Cytogenetic, molecular studies helpful for identifying subgroup with Ph/BCR-ABL.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- According to recent research from Taiwan, "From 1986 to 1998, 26 (23%) of 114 adult acute lymphoblastic leukemia (ALL) patients and 11 (4%) of 328 pediatric patients were found to have Philadelphia (Ph)...

Former WebMD executive producer joins NewsRx.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- A former WebMD executive producer and medical editor has joined Atlanta-based NewsRx, along with three board-certified editors. Dominique Walton Brooks, MD, with WebMD until 2001, will serve as...

Tumor supressor gene DBCCR1 linked to upregulation of ASML3a.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "the function of the tumor suppressor gene DBCCR1 (deleted in bladder cancer chromosome region 1) is unknown despite data supporting an important role for...

Complex regulation of acetylcholinesterase products found in lesions.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- "To study the regulation of acetylcholinesterase (AChE) gene expression in human brain tumors, 3' splice variants of AChE mRNA and potentially relevant transcription factor mRNAs were labeled in primary...

Higher Cyclin E2 may contribute to pathogenesis.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "The increased expression of G, cyclins has been associated with many types of human tumors. In primary solid tumors, however, the expression and...

Oral contraceptives may increase risk in BRCA1 but not BRCA2 mutation carriers.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- According to a study from Canada, "oral contraceptive use has been associated with an increase in the risk of breast cancer in young women. We examined whether this association is seen in women at high...

WNT gene clusters might be amplified, translocated similar to FGF gene cluster.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- "Mouse mammary tumor virus (MMTV) is a retrovirus, activating Wnt genes (Wnt1/int-1, Wnt3/int-4, Wnt10b), Fgf genes (Fgf3/int-2, Fgf4, Fgf8) and other genes (Notch4/int-3, Eif3s6/int-6) due to proviral...

Cerivastatin enhances 5-FU cytotoxicity on chemosensitive, resistant cell lines.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- According to a study from Scotland, "Cerivastatin is one of the synthetic 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors used for the treatment and prevention of hypercholesterolaemia. The...

Curcumin induces growth arrest and apoptosis in colon cancer cells.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "The development of nontoxic natural agents with chemopreventive activity against colon cancer is the focus of investigation in many laboratories. Curcumin...

Extracellular thiol/disulfide redox state affects proliferation rate.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "Redox mechanisms function in regulation of cell growth, and variation in redox state of plasma thiol/ disulfide couples occurs in various physiologic...

Matrix metalloproteinase (MMP)-1, MMP-3 genes may be related to risk in Japanese.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- According to a study from Japan, "Matrix metalloproteinase (MMP)-1 and MMP-3 genes are associated with tumor cell invasion and metastasis with their promoter polymorphisms influencing the level of...

Response to 5-FU is modified by dietary folic acid deficiency in Apc(Min/+) mice.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "5-Fluorouracil (5-FU) has been the foundation of advanced colorectal cancer treatment for over 40 years. The Apc(Min/+) mouse, which is genetically...

Stomach cancer, malignant lymphoma risk may be lower than previously reported.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- "The extremely high risk reported for some types of cancer among patients with common variable immunodeficiency (CVID) is based on a limited number of investigations. Therefore, we examined the risks...

cDNA microarrays are improved strategy for gene discovery in human cancer.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "The goals of this study were to evaluate the potential of detecting cryptic amplification and deletion of cancer-related genes using array-based...

E-cadherin expression correlated most with endometrioid carcinoma form.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- In a recent report, researchers in the United States compared "the frequency and pattern of E-cadherin expression in endometrioid, papillary serous, and clear cell carcinomas of the endometrium. ...

PB-FISH reliably monitors response to treatment in chronic myeloid leukemia.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "Conventional cytogenetic analysis (CCA) is the standard method for monitoring of the Philadelphia (Ph) chromosome in chronic myeloid leukemia (CML)....

Interference with clathrin-mediated trafficking pathways may be mechanism.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "Rearrangements involving the MLL gene at chromosome band 11q23 are common in infant acute myeloid leukemias (AMLs). We recently encountered an...

Rocaglamide derivatives inhibit NF-kappa B activation in T-cells.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- According to recent research from Germany, "Crude extracts from different Aglaia species are used as anti-inflammatory remedies in the traditional medicine of several countries from Southeast Asia....

The MPO-463 A allele is associated with reduced risk for small cell lung cancer.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- According to recent research from Germany, "Myeloperoxidase (MPO) participates in the metabolic activation of tobacco carcinogens such as PAHs. A frequent MPO-463 G-->A polymorphism in the promoter...

Four new cell lines will aid in study of progression.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- Researchers in the United States "have developed four new mammary adenocarcinoma cell lines from the C3(1)/SV40 Large T-antigen (Tag) transgenic mouse model: M28(N2) and M27(H4) (weakly tumorigenic), M6...

Differential expression of human 5S snoRNA genes may relate to carcinogenesis.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- According to a study from Taiwan, "4 novel small nucleolar RNAs (snoRNAs); h5sn1, h5sn2, h5sn3, and h5sn4, were successfully amplified from human total RNAs using RT-PCR, They exhibited the structural...

Alterations in the BZLF1 promoter can subclassify Epstein-Barr Virus diseases.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- According to recent research from Saudi Arabia, "although the Epstein-Barr virus (EBV) is associated with malignant and nonmalignant diseases, its lytic replication is predominately associated with...

p21(Cip1) and p27(Kip1) suppress tumor formation in mice.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "Events that contribute to tumor formation include mutations in the ras gene and loss or inactivation of cell cycle inhibitors such as p21(Cip1) and...

A case of composite angioimmunoblastic T-cell, diffuse large B-cell lymphoma.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- Researchers in the United States "report a rare case of composite angioimmunoblastic T-cell lymphoma (AILT) and diffuse large B-cell lymphoma occurring in a 48-year-old woman with generalized...

Synergism between rViscumin and cisplatin is not dependent on ERCC-1 expression.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- According to a study from Germany, "Interactions between recombinant mistletoe lectin (rViscumin) and anticancer drugs were investigated in vitro. rViscumin enhanced the cytotoxic effects of...

A modest centromere numerical abnormality may be a characteristic.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- According to a study from Japan, "Papillary adenocarcinoma of the stomach is a relatively uncommon histological type, and it is often detected in the early stage. We recently characterized the...

Coding variants in human double-strand break DNA repair genes identified.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- According to a study from Canada, "DNA repair is essential for the maintenance of genomic integrity. Consequently, altered repair capacity may impact individual health in such areas as aging and...

Mapping on the long arm of chromosome 7 may play role in pathogenesis.
February 3, 2003... 2003 FEB 3 - (NewsRx.com & NewsRx.net) -- According to a study from England, "Splenic lymphoma with villous lymphocytes (SLVL) is a low-grade lymphoproliferative disorder characterized by splenomegaly and circulating villous lymphocytes in the...

Vaccine-based therapy demonstrates antitumor activity against intestinal tumors.
February 10, 2003... 2003 FEB 10 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "By virtue of its tissue-specific expression, carcinoembryonic antigen (CEA) is an important self, tumor-associated antigen, which is expressed by...

Antiapoptotic factors such as p450 can enhance prodrug activation gene therapy.
February 10, 2003... 2003 FEB 10 - (NewsRx.com & NewsRx.net) -- "Cytochrome P450 gene-directed enzyme prodrug therapy substantially augments intratumoral activation of anticancer prodrugs, such as cyclophosphamide (CPA), leading to a strong increase in antitumor...

New human chromosome 22 genomic microarray identifies candidate tumor suppressor.
February 10, 2003... 2003 FEB 10 - (NewsRx.com & NewsRx.net) -- According to a study from Sweden, they "have constructed the first comprehensive microarray representing a human chromosome for analysis of DNA copy number variation. This chromosome 22 array covers...

Loss of pRb2/p130 expression can be associated with lower overall survival.
February 10, 2003... 2003 FEB 10 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "altered expression of cell cycle regulators represents a frequent event in both small cell and non-small cell lung cancer (NSCLC). Despite several studies...

Dual-specific T cells combine proliferation and antitumor activity.
February 10, 2003... 2003 FEB 10 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "An effective immune response against cancer requires the activation and expansion of specific T cells. Tumor antigens, however, are generally poor...

CRE-decoy ODN may serve as target-based tool to treat cancer, other diseases.
February 10, 2003... 2003 FEB 10 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "Enhancer DNA decoy oligodeoxynucleotides (ODNs) inhibit transcription by competing for transcription factors. A decoy ODN composed of the cAMP...

The expression of RhoGDI2 inversely correlates with tumor progression.
February 10, 2003... 2003 FEB 10 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, researchers have "recently characterized T24T, an invasive and metastatic variant of the T24 human bladder cell line, resulting in a model for bladder...

Craniopharyngiomas of adamantinomatous type harbor beta-catenin gene mutations.
February 10, 2003... 2003 FEB 10 - (NewsRx.com & NewsRx.net) -- According to recent research from Japan, "Craniopharyngioma is a rare tumor occurring in the sellar region comprising 3% of all intracranial tumors. To elucidate the contribution of beta-catenin gene...

Mouse DAM1 regulates pro-apoptotic activity of BLK in mammary epithelial cells.
February 10, 2003... 2003 FEB 10 - (NewsRx.com & NewsRx.net) -- According to recent research from South Korea, "Mouse mammary gland cDNA library was screened to search for BLK-interacting protein using yeast two-hybrid system, and a mouse DNA amplified in mammary...

Culture method useful for expansion of progenitors, lentiviral gene transduction.
February 10, 2003... 2003 FEB 10 - (NewsRx.com & NewsRx.net) -- According to a study from Japan, "Since dendritic cells (DC) play pivotal roles in both innate and adaptive immunity, DC can be a good target for immunogene therapy. "However, the optimal...

Genome-wide analysis in intestinal-type gastric cancers may predict metastases.
February 10, 2003... 2003 FEB 10 - (NewsRx.com & NewsRx.net) -- Researchers in Japan studied "mechanisms that underlie development and/or progression of intestinal-type gastric cancer. "We compared expression profiles of cancer cells obtained by laser-capture...

Ku70 and Ku80 expression may be related to cell proliferation/ carcinogenesis.
February 10, 2003... 2003 FEB 10 - (NewsRx.com & NewsRx.net) -- According to a study from South Korea, "Cyclooxygenase-2 (COX-2) expression is mediated by constitutive NF-kappaB and regulates human gastric cancer cell growth and proliferation. Inactivating Ku70 or...

Resveratrol may have genotoxic/hormonal activity in humans.
February 10, 2003... 2003 FEB 10 - (NewsRx.com & NewsRx.net) -- According to a study from Germany, "Resveratrol (RES) is a natural polyphenol present in red wines and various human food items. The estrogenic activity of RES was demonstrated in two in vitro assay...

Deregulation of translation is associated with a wide range of cancers.
February 10, 2003... 2003 FEB 10 - (NewsRx.com & NewsRx.net) -- According to recent research from Germany, "In the past decade, translational control has been shown to be crucial in the regulation of gene expression. Research in this field has progressed rapidly,...

The Caudal homeodomain protein activates Drosophila E2F gene expression.
February 10, 2003... 2003 FEB 10 - (NewsRx.com & NewsRx.net) -- According to a study from South Korea, "The Drosophila caudal homeobox gene is required for definition of the anteroposterior axis and for gut development, and CDX1 and CDX2, human homologs, play...

Isolated liver perfusion offers advantages for chemotherapy/biotherapy.
February 10, 2003... 2003 FEB 10 - (NewsRx.com & NewsRx.net) -- "Many treatments have been proposed for nonresectable primary or secondary hepatic cancer but the results have generally been disappointing," researchers in Switzerland report. "Isolated Hepatic...

Gene mutations may lead to leukocyte survival, prolonged inflammatory response.
February 10, 2003... 2003 FEB 10 - (NewsRx.com & NewsRx.net) -- "Significant breakthroughs in our understanding of the molecular basis of the inflammatory response have been achieved in the past five years, with the successive identification of the genetic basis of...

DNA damage checkpoint pathway may be linked to high frequency of p53 mutations.
February 10, 2003... 2003 FEB 10 - (NewsRx.com & NewsRx.net) -- According to a study from Denmark, "53BP1 is a conserved nuclear protein that is implicated in the DNA damage response. After irradiation, 53BP1 localizes rapidly to nuclear foci, which represent...

Schwannomin requires HRS interaction to inhibit STAT activation.
February 10, 2003... 2003 FEB 10 - (NewsRx.com & NewsRx.net) -- "Mutations in the neurofibromatosis 2 (NF2) gene with the resultant loss of expression of the NF2 tumor suppressor schwannomin are one of the most common causes of benign human brain tumors, including...

Cdc25 inhibitor could contribute to cell cycle progression.
February 10, 2003... 2003 FEB 10 - (NewsRx.com & NewsRx.net) -- "The Cdc25 dual specificity phosphatases coordinate cell cycle progression, but potent and selective inhibitors have generally been unavailable. "In the present study, we have examined one...

HEPSIN inhibits cell growth/invasion in prostate cancer cells.
February 10, 2003... 2003 FEB 10 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "Expression of HEPSIN, a type II transmembrane serine protease in prostate cancer (CaP), has been highlighted by several studies analyzing...

Plasmid vector sensitizes cells to DNA-damaging treatments.
February 10, 2003... 2003 FEB 10 - (NewsRx.com & NewsRx.net) -- "Poly (ADP-ribose) polymerase (PARP) has strong affinity for DNA strand breaks and cycles on and off the DNA ends to allow DNA repair. A DNA-binding domain of PARP (PARP-DBD) acts as a...

XIAP may be candidate as cancer therapy for overcoming drug resistance.
February 10, 2003... 2003 FEB 10 - (NewsRx.com & NewsRx.net) -- According to recent research from Japan, "XIAP directly inhibits executor caspases, making it the most downstream antiapoptotic molecule. Here, we examined the expression and function of XIAP in...

Changes in cancer can be reversed more easily by therapeutic interventions.
February 17, 2003... 2003 FEB 17 - (NewsRx.com & NewsRx.net) -- "Knowledge of the molecular events that occur during the early stages of cancer has advanced rapidly. The initiation and development of cancer involves several molecular changes, which include...

Oral cancer gene markers include a LOH at 2q35 correlating 100% with metastasis.
February 17, 2003... 2003 FEB 17 - (NewsRx.com & NewsRx.net) -- "To evaluate the role of chromosome 2 deletions in human oral squamous cell carcinoma (SCC) progression and to define the precise location of putative tumor suppressor genes, we examined 40 primary...

Reduced expression of Syk gene correlates with poor prognosis.
February 17, 2003... 2003 FEB 17 - (NewsRx.com & NewsRx.net) -- According to recent research from Japan, "Syk is a nonreceptor type of protein-tyrosine kinase that is widely expressed in hematopoietic cells. Syk expression has been reported in breast tissue....

JC virus may be biomarker for tumors.
February 17, 2003... 2003 FEB 17 - (NewsRx.com & NewsRx.net) -- "Chromosomal instability (CIN) is present in most colorectal cancers, though the mechanism for these genetic aberrations is unclear," researchers in the United States report. "An explanation may...

Microporation offers painless means of delivering adenovirus-based therapy.
February 17, 2003... 2003 FEB 17 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Microporation appears to be a reliable way to deliver therapies comprising adenovirus-based vaccines, according to researchers in Canada. Many...

Human erb-B-3 transgenic mouse model elucidates tumorigenesis mechanism.
February 17, 2003... 2003 FEB 17 - (NewsRx.com & NewsRx.net) -- "Erb-B-3 overexpression is associated with poor prognosis in non-small cell lung cancer and is often overexpressed in breast cancers. MMTVhuman-erb-B-3 transgenic mice were generated to evaluate the...

Aberrant CEBPA methylation infrequent, may occur preferentially in M2 phenotype.
February 17, 2003... 2003 FEB 17 - (NewsRx.com & NewsRx.net) -- "The gene CEBPA, encoding the transcription factor C/EBPalpha, is crucial for granulocyte differentiation," researchers in the Peoples Republic of China report. "We investigated the frequency of...

Bacteria delivers endostatin directly to targeted tumors.
February 17, 2003... 2003 FEB 17 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Medical researchers in China have proposed an innovative new way to deliver endostatin gene therapy to solid tumors with a select strain of bacteria. ...

Silatrane methyl groups are important for growth inhibition.
February 17, 2003... 2003 FEB 17 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "A stereoselective synthesis of 3'-O-((R,R,R)-trimethylsilatranyl)thymidine (R,R,R-1) and synthesis of 3'-O-silatranylthymidine (5) via an improved...

BRCA1 and BRCA2 bind Stat5a and suppress its transcriptional activity.
February 17, 2003... 2003 FEB 17 - (NewsRx.com & NewsRx.net) -- According to a study from Iceland, "Germline mutations in the breast cancer susceptibility genes, BRCA1 and BRCA2, are thought to account for a large portion of familial breast cancer. "The...

Antisense molecules deplete Hsp70 and obliterate cancer cells.
February 17, 2003... 2003 FEB 17 - (NewsRx.com & NewsRx.net) -- According to a study from Denmark, "heat shock protein 70 (Hsp70) is an antiapoptotic chaperone protein highly expressed in human tumors. Here we demonstrate that locoregional application of...

The role of chromosomal instability in tumor initiation.
February 17, 2003... 2003 FEB 17 - (NewsRx.com & NewsRx.net) -- "Chromosomal instability (CIN) is a defining characteristic of most human cancers. Mutation of CIN genes increases the probability that whole chromosomes or large fractions of chromosomes are gained or...

Tool creates molecular portraits of cancer.
February 17, 2003... 2003 FEB 17 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "The twenty-first century heralds a new era for the biological sciences and medicine. "The tools of our time are allowing us to analyze complex...

Post-replicating mismatch gene polymorphism found only in some lymphomas.
February 17, 2003... 2003 FEB 17 - (NewsRx.com & NewsRx.net) -- According to a study from Ecuador, "given the importance of mismatch repairing genes in keeping the genetic stability in cells, any alterations in their structure or function could generate instability...

A means for systematic detection of DNA copy number changes on a genomic scale.
February 17, 2003... 2003 FEB 17 - (NewsRx.com & NewsRx.net) -- "Alterations in the genetic content of a cell are the underlying cause of many human diseases, including cancers. We have developed a method, called digital karyotyping, that provides quantitative...

Menin interacts with many proteins in multiple endocrine neoplasia type 1.
February 17, 2003... 2003 FEB 17 - (NewsRx.com & NewsRx.net) -- "Multiple endocrine neoplasia type 1 (MEN1) is a familial cancer syndrome characterized mostly by tumors of the parathyroids, pancreas, and anterior pituitary. The gene responsible (MEN1) encodes...

Phospholipase A2 group IIA expression may yield better survival, less metastasis.
February 17, 2003... 2003 FEB 17 - (NewsRx.com & NewsRx.net) -- "We analyzed gene expression patterns in human gastric cancers by using cDNA microarrays representing approximately 30,300 genes," wrote S.Y. Leung and coauthors, Stanford University, School of...

P16 hypermethylation, p53 mutation could play role in pathogenesis.
February 17, 2003... 2003 FEB 17 - (NewsRx.com & NewsRx.net) -- "The objective of this study was to investigate the contribution of p16 inactivation in gastric cancer and to compare it with p53. A cohort of 34 primary GCs were analyzed for p16 mutations and...

Synthesized nucleotide may increase survival of hepatocellular carcinoma.
February 17, 2003... 2003 FEB 17 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Man-made nucleotides could some day extend survival in patients with hepatocellular carcinoma, researchers in the United States have proposed. According...

New splicing variants of human proto-oncogene show different tissue tropism.
February 17, 2003... 2003 FEB 17 - (NewsRx.com & NewsRx.net) -- According to a study from Japan, "The DBL (MCF-2) proto-oncogene is a prototype guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. In this communication we describe the...

Cockayne syndrome group B has a mutation in mitochondrial DNA repair gene.
February 17, 2003... 2003 FEB 17 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "reactive oxygen species, which are prevalent in mitochondria, cause oxidative DNA damage including the mutagenic DNA lesion 7,8-dihydroxyguanine...

Genetic alterations common to other gliomas are rare/absent in neoplasm.
February 17, 2003... 2003 FEB 17 - (NewsRx.com & NewsRx.net) -- According to a study from Germany, "pleomorphic xanthoastrocytoma (PXA) is a rare, usually well circumscribed, superficially located neoplasm that preferentially arises in the cerebral cortex of...

NF-kappa B activator Act1 involved in IL-1/Toll-mediated signaling through TRAF6.
February 17, 2003... 2003 FEB 17 - (NewsRx.com & NewsRx.net) -- "NF-kappaB activator 1 (Act1), also called CIKS, is a recently identified protein with NF-kappaB and AP-1 activation activities through its association with the IkappaB kinase complex," researchers in...

Genomic abnormalities observed as ongoing acquisition, then loss of 3q.
February 17, 2003... 2003 FEB 17 - (NewsRx.com & NewsRx.net) -- According to recent research from Spain, "among 20 cases of typical splenic marginal zone lymphoma (SMZL), 2 cases had blastic transformation. The genetic mechanisms underlying the morphologic...

Tissue origin and geographic differences found in genetic methylation profiles.
February 17, 2003... 2003 FEB 17 - (NewsRx.com & NewsRx.net) -- "Aberrant methylation of several known or putative tumor suppressor genes occurs frequently during the pathogenesis of lung cancers. There are major smoke exposure, histology, geography, and gender...

Pediatric disease has heterogenous 7q36/12p13 insertions or translocations.
February 24, 2003... 2003 FEB 24 - (NewsRx.com & NewsRx.net) -- According to a study from the United States, "The t(7;12)(q36;p13) is a recurrent abnormality in acute myeloid leukemia (AML) of childhood. The involved gene on chromosome 12 is TEL; the 7q36 partner...

Two RET protooncogene variants occur in an ACTH-producing pheochromocytoma.
February 24, 2003... 2003 FEB 24 - (NewsRx.com & NewsRx.net) -- According to a study from Brazil, "Multiple endocrine neoplasia type 2 (MEN 2) comprises a heterogeneous group of neoplastic disorders that most commonly have a single missense substitution of the RET...