Cancer Gene Therapy Week articles from December 2008

Cancer Gene Therapy Week archives from December 2008

Studies from University of Illinois describe new findings in angiogenesis.
December 1, 2008... A report, 'uPA/uPAR downregulation inhibits radiation-induced migration, invasion and angiogenesis in IOMM-Lee meningioma cells and decreases tumor growth in vivo,' is newly published data in International Journal of Oncology. "Meningioma is a...

Data on cancer gene therapy detailed by researchers at Sapporo Medical University, Department of Urology.(Report)
December 1, 2008... New research, 'Identification of an immunogenic CTL epitope of HIFPH3 for immunotherapy of renal cell carcinoma,' is the subject of a report. According to recent research from Sapporo, Japan, "CD8(+) CTLs have an essential role in immune...

Data on cancer gene therapy discussed by researchers at Royal Marsden NHS Foundation.
December 1, 2008... A report, 'A phase I study of intravenous oncolytic reovirus type 3 Dearing in patients with advanced cancer,' is newly published data in Clinical Cancer Research. Researchers in the United Kingdom conducted a study "To determine the safety and...

New findings from Hirosaki University in the area of cancer gene therapy described.
December 1, 2008... Investigators publish new data in the report 'Claudin-1 expression is induced by tumor necrosis factor-alpha in human pancreatic cancer cells.' "Claudin-1 is a membrane protein with four transmembrane domains, that is exclusively localized at...

Reports from Fred Hutchinson Cancer Research Center describe recent advances in cancer gene therapy.(Clinical report)
December 1, 2008... Researchers detail in 'Cell proliferation, cell cycle abnormalities, and cancer outcome in patients with Barrett's esophagus: a long-term prospective study,' new data in cancer gene therapy. "Elevated cellular proliferation and cell cycle...

Researchers at Royal Children's Hospital have published new data on cancer gene therapy.(Report)
December 1, 2008... Fresh data on cancer gene therapy are presented in the report 'Health first, genetics second: exploring families' experiences of communicating genetic information.' "Genetic information may have health and reproductive implications for the...

Studies from University of Sydney, Westmead Institute for Cancer Research further understanding of cancer gene therapy.
December 1, 2008... Data detailed in 'Ankyrin repeat domain 1, ANKRD1, a novel determinant of cisplatin sensitivity expressed in ovarian cancer' have been presented. "The standard of care for ovarian cancer includes platinum-based chemotherapy. It is not possible,...

Research results from Memorial Sloan Kettering Cancer Center update understanding of gene therapy.
December 1, 2008... A report, 'Stem cell engineering for the treatment of severe Hemoglobino-pathies,' is newly published data in Current Molecular Medicine. According to recent research published in the journal Current Molecular Medicine, "The beta-thalassemias...

Researchers from Yonsei University, Division of Nuclear Medicine publish findings in gene therapy.(Report)
December 1, 2008... Scientists discuss in 'Imaging of viral thymidine kinase gene expression by replicating oncolytic adenovirus and prediction of therapeutic efficacy' new findings in gene therapy. According to recent research from Seoul, Korea, "We have used a...

Investigators at Martin-Luther University target leukemia gene therapy.(Report)
December 1, 2008... Scientists discuss in 'AML1/ETO-induced survivin expression inhibits transcriptional regulation of myeloid differentiation' new findings in leukemia. "The (8;21)(q22;q22) chromosomal translocation, which involves AML1 gene on chromosome 21 and...

Cryo-Cell Announces Partnership With National Institutes of Health.
December 1, 2008... Cryo-Cell International Inc. and the National Institutes of Health (NIH) Clinical Center announced a research partnership to conduct an exploratory study to determine the homing capabilities of Cryo-Cell's proprietary Endometrial Menstrual Stem...

New cancer gene therapy study findings have been reported by researchers at Technical University of Munich.(Report)
December 8, 2008... According to a study from Munich, Germany, "Pancreatic cancer is one of the most common causes of cancer death in Western civilization and the 5-year survival rate is below 5%. To improve the prognosis of pancreatic cancer, there is the need to...

Reports summarize cancer gene therapy study results from University of Oxford.
December 8, 2008... "Oncolytic viruses are regulated by the tumor phenotype to replicate and lyse cancer cells selectively. To identify optimal strategies for breast cancer we compared five adenoviruses with distinct regulatory mechanisms: Ad-d/922-947 (targets...

Researchers from National Cancer Institute report on findings in cancer gene therapy.
December 8, 2008... According to recent research from the United States, "Nuclear export of certain HIV-1 mRNAs requires an interaction between the viral Rev protein and the Rev response element (RRE), a structured element located in the Env region of its RNA...

Scientists at INSERM publish new data on cancer gene therapy.
December 8, 2008... According to recent research published in the journal Human Gene Therapy, "The hepatocarcinoma-intestine-pancreas (HIP) gene, also called pancreatitis-associated protein-1 (PAP1) or Reg III alpha, is activated in most human hepatocellular...

Scientists at Osaka University discuss research in cancer gene therapy.
December 8, 2008... "Metastasis is a key aspect of tumor malignancy, and several malignant tumors show expression of various rnature N-type glycans. In particular, beta 1-6 branching N-acetylglucosamine (GIcNAc) is abundantly expressed as a part of high-mannose...

Studies from University of California, Department of Neurosurgery in the area of gene therapy published.
December 8, 2008... Current study results from the report, 'Murine retroviruses re-engineered for lineage tracing and expression of toxic genes in the developing chick embryo,' have been published. "We describe two replication incompetent retroviral vectors that...

New findings in human papillomavirus gene therapy described from Chung-Shan Medical University.(Report)
December 8, 2008... Research findings, 'Human telomerase reverse transcriptase activated by E6 oncoprotein is required for human papillomavirus-16/18-infected lung tumorigenesis,' are discussed in a new report. "Our recent report indicates that human...

Reports outline liver fibrosis gene therapy research from Tokai University.(Report)
December 8, 2008... New research, 'Glycyrrhizin and its metabolite inhibit Smad3-mediated type I collagen gene transcription and suppress experimental murine liver fibrosis,' is the subject of a report. According to a study from Isehara, Japan, "Glycyrrhizin has...

Studies conducted at Harvard University, Medical Department on brain cancer recently published.
December 15, 2008... According to a study from the United States, "Glioblastoma multiforme (GBM) is a devastating form of brain cancer for which there is no effective treatment. Here, we report a novel approach to brain tumor therapy through genetic modification of...

Reports from Xi'an Jiao Tong University describe recent advances in cancer gene therapy.
December 15, 2008... " CXC chemokine receptor-4 (CXCR4) is closely involved in bone metastasis of prostate cancer, and CXCR4 levels are frequently increased in prostate cancer cells and tissues. In the present study, its biological effects on prostate cancer in...

Research findings from Okayama University update understanding of cancer gene therapy.(Report)
December 15, 2008... According to recent research from Shikata, Japan, "REIC/Dickkopf-3 (Dkk-3), a tumor suppressor gene, has been investigated in gene therapy studies. Our previous study suggested that REIC/Dkk-3-induced apoptosis mainly resulted from...

Research on cancer gene therapy reported by scientists at National Taiwan University.(Report)
December 15, 2008... According to a study from Taipei, Taiwan, "Human hepatocellular carcinoma (HCC) often arises from a background of liver cirrhosis. Therefore, in order to develop therapeutic strategies for HCC, an animal model bearing multifocal liver tumors...

Studies from K.N. Barton and co-researchers yield new data on cancer gene therapy.
December 15, 2008... "To monitor noninvasively potentially therapeutic adenoviruses for cancer, we have developed a methodology based on the sodium iodide symporter (NIS). Men with clinically localized prostate cancer were administered an intraprostatic injection...

Gene Therapy Corrects Sickle Cell Disease in Laboratory Study.
December 15, 2008... Using a harmless virus to insert a corrective gene into mouse blood cells, scientists at St. Jude Children's Research Hospital have alleviated sickle cell disease pathology. In their studies, the researchers found that the treated mice showed...

Findings from University of Washington broaden understanding of adenovirus.(Report)
December 22, 2008... "Gene transfer vectors containing adenovirus (Ad) serotype 35 (Ad35) fibers have shown promise for cancer and stem cell gene therapy. In this study, we attempted to improve the in vitro and in vivo infection properties of these vectors by...

Data on cancer gene therapy detailed by researchers at University of Ghent.
December 22, 2008... According to recent research published in the journal Oncogene, "The epidermal growth factor receptor (EGFR) is frequently overexpressed in various tumours of epidermal origin and is held responsible for tumourigenicity and tumour persistence....

Fox Chase Cancer Center describes research in cancer gene therapy.(Report)
December 22, 2008... Fresh data on cancer gene therapy are presented in the report 'Antisense MDM2 enhances E2F1-induced apoptosis and the combination sensitizes androgen-dependent and androgen-independent prostate cancer cells to radiation.' According to recent...

Research from Indiana University, Cancer Center provide new insights into cancer gene therapy.
December 22, 2008... A report, 'c-FLIP knockdown induces ligand-independent DR5-, FADD-, caspase-8-, and caspase-9-dependent apoptosis in breast cancer cells,' is newly published data in Biochemical Pharmacology. According to recent research from the United States,...

Researchers from Medical University of South Carolina publish findings in cancer gene therapy.
December 22, 2008... Data detailed in 'The role of Sp1 in IL-1beta and H. pylori-mediated regulation of H,K-ATPase gene transcription' have been presented. According to recent research published in the American Journal of Physiology - Gastrointestinal and Liver...

New cancer gene therapy research from University of Pittsburgh outlined.
December 29, 2008... "Recombinant adenoviral vectors (AdV) are potent vehicles for antigen engineering of dendritic cells (DC). DC engineered with AdV to express full length tumor antigens are capable stimulators of antigen-specific polyclonal CD8+ and CD4+ T...

New cancer gene therapy research has been reported by M. Loeffler et al.
December 29, 2008... According to a study from the United States, "Previous studies have shown that intravenously applied bacteria can accumulate in tumors and lead to sporadic tumor regression. Recently, systemic administration of attenuated Salmonella typhimurium...

Reports from University of Strasbourg advance knowledge in cancer gene therapy.
December 29, 2008... "Human group C adenoviruses can infect many cell types, and this is due to the widespread expression of their receptor, the coxsackievirus and adenovirus receptor (CAR). Adenovirus vectors for cancer gene therapy could be significantly improved...

Research conducted at Y. Gan and co-researchers has updated our knowledge about cancer gene therapy.(Report)
December 29, 2008... According to recent research from Shanghai, People's Republic of China, "We had characterized earlier the novel tumor suppressor gene hepatocellular carcinoma suppressor 1 (HCCS1), and demonstrated that expression of exogenous HCCS1 gene in...

Research data from Osaka Medical College, Medical College update understanding of cancer gene therapy.
December 29, 2008... "Cancer metastasis contributes significantly to cancer mortality and is facilitated by lymphangiogenesis and angiogenesis. Vascular endothelial growth factor-C (VEGF-C) and VEGF-A are involved in lymphangiogenesis and angiogenesis," scientists...

National Institutes of Health reports research in gene therapy.
December 29, 2008... According to recent research from the United States, "In human gene therapy applications, lentiviral vectors may have advantages over gamma-retroviral vectors in several areas, including the ability to transduce nondividing cells, resistance to...

Laval University reports research in glioblastoma.(Report)
December 29, 2008... "Herpes simplex virus thymidine kinase (TK) gene transfer followed by ganciclovir (GCV) administration is an approach investigated for glioblastoma treatment. The bystander effect (BE) enhances the cytotoxic effect of this strategy by allowing...

New apoptosis gene therapy data have been reported by I. Carmona-Cuenca and co-authors.
December 29, 2008... A report, 'Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity,' is newly published data in Journal of Hepatology. "The transforming growth factor-beta (TGF-beta) induces apoptosis in...

Reports from University of Texas, M.D. Anderson Cancer Center describe recent advances in cancer gene therapy.
December 29, 2008... New investigation results, 'The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells,' are detailed in a study published in The Journal of Clinical Investigation. "The role of autophagy in oncogenesis...

Research from M. Vias and co-authors reveals new findings on cancer gene therapy.
December 29, 2008... Current study results from the report, 'Terminal and progenitor lineage-survival oncogenes as cancer markers,' have been published. "Tumour classification has traditionally focused on differentiation and cellular morphology, and latterly on the...

Studies in the area of cancer gene therapy reported from S.K. Jain and co-researchers.
December 29, 2008... Data detailed in 'Development and characterization of 5-fU bearing ferritin appended solid lipid nanoparticles for tumour targeting' have been presented. "Ferritin coupled solid lipid nanoparticles were investigated for tumor targeting. Solid...

Hoshi University, Institute of Medicinal Chemistry describes research in gene therapy.(Report)
December 29, 2008... Fresh data on gene therapy are presented in the report 'Folate-linked lipid-based nanoparticles for synthetic siRNA delivery in KB tumor xenografts.' According to recent research from Tokyo, Japan, "RNA interference (RNAi) is a...

Hoshi University, Institute of Medicinal Chemistry details research in gene therapy.
December 29, 2008... A report, 'NaCl induced high cationic hydroxyethylated cholesterol-based nanoparticle-mediated synthetic small interfering RNA transfer into prostate carcinoma PC-3 cells,' is newly published data in Biological and Pharmaceutical Bulletin. "The...

Researchers from St. Vincent's Hospital, Department of Orthopaedics discuss findings in gene therapy.
December 29, 2008... New investigation results, 'Biocompatible chitosan-dnazyme nanoparticle exhibits enhanced biological activity,' are detailed in a study published in Journal of Microencapsulation. "DNAzymes are oligonucleotides capable of specific catalysis of...

Investigators at University of Bonn, Department of Internal Medicine I release new data on life sciences.
December 29, 2008... Data detailed in 'siRNA targeting VEGF inhibits hepatocellular carcinoma growth and tumor angiogenesis in vivo' have been presented. According to a study from Bonn, Germany, "We have investigated whether siRNA targeted against VEGF inhibits...

Researchers identify new anti-tumor gene.
December 29, 2008... Researchers from Virginia Commonwealth University have identified a new anti-tumor gene called SARI that can interact with and suppress a key protein that is overexpressed in 90 percent of human cancers. The discovery could one day lead to an...