Cancer Gene Therapy Week articles from August 2008

Cancer Gene Therapy Week archives from August 2008

New findings from T. Parvez and co-authors describe advances in glioblastoma.
August 4, 2008... "The standard treatment for glioblastoma multiforme is surgery, radiation, and chemotherapy. Yet this aggressive therapy has only a modest effect on survival with most patients surviving less than 1 year after diagnosis," scientists in the...

Research on Wiskott-Aldrich syndrome reported by K. Boztug et al.
August 4, 2008... "Wiskott-Aldrich syndrome (WAS) is an X-linked primary immunodeficiency disorder associated with microthrombocytopenia, eczema, autoimmunity and predisposition to malignant lymphoma. Although rare, few cases of somatic mosaicism have been...

New cancer gene therapy study results from Central South University described.(Report)
August 4, 2008... New research, 'Knocking down Wnt9a mRNA levels increases cellular proliferation,' is the subject of a report. "Wnts are secreted lipid-modified signaling proteins. Activation of Wnt signalling in many tissues has also been associated with...

Findings from Hamamatsu University, Department of Internal Medicine III advance knowledge in leukemia gene therapy.
August 4, 2008... New investigation results, 'KIS induces proliferation and the cell cycle progression through the phosphorylation of p27Kip1 in leukemia cells,' are detailed in a study published in Leukemia Research. According to recent research from Hamamatsu,...

With $2 M Nih Grant, Fsu Becomes One of Worlds Top Imaging Centers.
August 4, 2008... At Florida State University, the collective strength of biomedical research and the scientists who lead it has earned a $2 million High-End Instrumentation (HEI) grant from the National Institutes of Health (NIH). The one-year award will help...

New cancer gene therapy research from F. Wang and co-researchers described.
August 11, 2008... "RNA interference (RNAi) is an evolutionarily conserved process of gene silencing in multiple organisms, which has become a powerful tool for investigating gene function by reverse genetics. Herein, we constructed a short hairpin RNA (shRNA)...

Research from Chiba University yields new findings on cancer gene therapy.
August 11, 2008... "Despite improvement of surgical treatment and application of multi-modality therapies to advanced esophageal cancer, the prognosis is extremely poor in patients with T4 tumors. Based on the genetic background of esophageal cancer, we have...

Studies from Nankai University have provided new data on cancer gene therapy.
August 11, 2008... According to a study from Tianjin, People's Republic of China, "G250 is a tumor associated antigen that is found on > 90% of renal cell carcinoma (RCC). In order to develop a highly targeting gene vector for RCC gene therapy, G250 monoclonal...

Studies from S. Loiselmeyer et al further understanding of cancer gene therapy.
August 11, 2008... According to recent research published in the journal Frontiers in Bioscience, "Immunotherapy against cancer basically aims at either broadly stimulating the immune system or at engineering an immune response against a targeted tumor associated...

Study findings from University of Tsukuba provide new insights into leukemia gene therapy.
August 11, 2008... "To control severe GvHD while maintaining strong GvL effects in the context of allo-stem cell transplantation (allo-SCT), a phase I/II clinical trial of infusions of donor lymphocytes transduced with the herpes simplex virus thymidine kinase...

New findings from University of Texas, Institute of Molecular Medicine in the area of cancer gene therapy described.
August 11, 2008... A new study, '1alpha,25-Dihydroxyvitamin D3 down-regulates expression of prostate specific membrane antigen in prostate cancer cells,' is now available. "Prostate specific membrane antigen (PSMA) expression correlates with prostate cancer grade...

Reports from Novartis describe recent advances in cancer gene therapy.
August 11, 2008... Investigators publish new data in the report 'Tumor growth inhibition by synthetic and expressed siRNA targeting focal adhesion kinase.' "Focal adhesion kinase (FAK) was first identified as a viral Src substrate, and substantial experimental...

Research from Children's Cancer Institute reveals new findings on cancer gene therapy.(Report)
August 11, 2008... New research, 'siRNA targeting the IRF2 transcription factor inhibits leukaemic cell growth,' is the subject of a report. According to recent research published in the International Journal of Oncology, "Interferon regulatory factor (IRF) 1 and...

Tianjin Medical University, Department of Immunology reports research in cancer gene therapy.
August 11, 2008... Current study results from the report, 'Effects of raf kinase inhibitor protein expression on metastasis and progression of human epithelial ovarian cancer,' have been published. "Loss of function of metastasis suppressor genes is an important...

University of Granada publishes research in cancer gene therapy.(Report)
August 11, 2008... Research findings, 'Combined therapy using suicide gef gene and paclitaxel enhances growth inhibition of multicellular tumour spheroids of A-549 human lung cancer cells,' are discussed in a new report. According to a study from Granada, Spain,...

Baylor College of Medicine, College of Medicine describes research in osteosarcoma gene therapy.
August 11, 2008... Data detailed in 'Cell cycle regulator gene CDC5L, a potential target for 6p12-p21 amplicon in osteosarcoma' have been presented. According to recent research from the United States, "Osteosarcoma is a primary malignant tumor of bone arising...

Improved estrogen reception may sharpen fuzzy memory.
August 11, 2008... Estrogen treatments may sharpen mental performance in women with certain medical conditions, but University of Florida researchers suggest that recharging a naturally occurring estrogen receptor in the brain may also clear cognitive cobwebs...

New cancer gene therapy research reported from Medical College.(Report)
August 18, 2008... According to recent research published in the journal Advances in Therapy, "The purpose of this study was to determine whether ultrasound exposure combined with microbubble destruction could be used to enhance non-viral gene delivery in human...

Studies conducted at Kyushu University on cancer gene therapy recently published.
August 18, 2008... According to recent research published in the journal Bioscience Biotechnology and Biochemistry, "We constructed a novel cancer-specific regulatable adenoviral expression system comprising two vectors: one expressing rtTA, a reverse...

Vcu Massey Cancer Center and Vcu Institute of Molecular Medicine Researchers Publish Findings of a New Chemoprevention Gene Therapy That Kills Pancreatic Cancer Cells.
August 18, 2008... Researchers at the Virginia Commonwealth University Massey Cancer Center and the VCU Institute of Molecular Medicine have published findings that implicate a new chemoprevention gene therapy (CGT) for preventing and treating pancreatic cancer,...

New gene therapy study findings recently were reported by researchers at University of Pennsylvania, Medical Department.
August 18, 2008... "Gene transfer has been used to correct inherited immunodeficiencies, but in several patients integration of therapeutic retroviral vectors activated proto-oncogenes and caused leukemia. Here, we describe improved methods for characterizing...

Data on cancer gene therapy published by researchers at Chester Beatty Laboratories.
August 18, 2008... Data detailed in 'Radiation-mediated up-regulation of gene expression from replication-defective adenoviral vectors: implications for sodium iodide symporter gene therapy' have been presented. In this recent report published in the journal...

Researchers from Eberhard-Karls University, Department of Radiation Oncology report details of new studies and findings in the area of cancer gene therapy.
August 18, 2008... Investigators publish new data in the report 'Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair.' According to a study from Germany, "We have already reported that...

Researchers from Kinki University, Department of Urology detail findings in cancer gene therapy.(Report)
August 18, 2008... A new study, 'Delivery of PTEN via a novel gene microcapsule sensitizes prostate cancer cells to irradiation,' is now available. According to a study from Osaka, Japan, "The tumor suppressor gene MMAC/PTEN located on chromosome10q23.3 has dual...

Researchers from University of Texas, M. D. Anderson Cancer Center discuss findings in cancer gene therapy.(Report)
August 18, 2008... New investigation results, 'Targeting Lyn inhibits tumor growth and metastasis in Ewing's sarcoma,' are detailed in a study published in Molecular Cancer Therapeutics. "Src family tyrosine kinases (SFK) play an important role in growth and...

Study results from Vanderbilt University, Vanderbilt-Ingram Cancer Center broaden understanding of cancer gene therapy.
August 18, 2008... New investigation results, 'Genetic polymorphisms of metastasis suppressor gene NME1 and breast cancer survival,' are detailed in a study published in Clinical Cancer Research. According to a study from the United States, "Ample evidence...

Report summarizes gene therapy study findings from University of Erlangen, Nikolaus-Fiebiger Center for Molecular Medicine.
August 18, 2008... Scientists discuss in 'Wnt signaling inhibits Forkhead box O3a-induced transcription and apoptosis through up-regulation of serum- and glucocorticoid-inducible kinase 1' new findings in gene therapy. "In human cancers, mutations in components...

Study results from Tianjin Medical University, Life Science Research Center in the area of gene therapy published.(Report)
August 18, 2008... New research, 'Targeting alpha-fetoprotein represses the proliferation of hepatoma cells via regulation of the cell cycle,' is the subject of a report. According to recent research published in the journal Clinica Chimica Acta, "AFP is a...

Researchers from Seoul National University, Department of Nuclear Medicine describe findings in immunization.(Report)
August 18, 2008... Current study results from the report, 'Synergistic tumoricidal effect of combined hMUC1 vaccination and hNIS radioiodine gene therapy,' have been published. "We examined the merits of combinatorial hMUC1 vaccination and hNIS radioiodine gene...

Researchers from St. Vincent's Hospital, Department of Orthopaedics report on findings in osteosarcoma gene therapy.
August 18, 2008... Researchers detail in 'c-Jun knockdown sensitizes osteosarcoma to doxorubicin,' new data in osteosarcoma. "The oncogene c-Jun has been found to be up-regulated in a variety of cancers, including osteosarcoma. Doxorubicin is a frontline...

Researchers at Genome Sciences Center release new data on RNA research.
August 18, 2008... Research findings, 'Profiling the HeLa S3 transcriptome using randomly primed cDNA and massively parallel short-read sequencing,' are discussed in a new report. "Sequence-based methods for transcriptome characterization have typically relied on...

Yeditepe University details research in stem cell research.
August 18, 2008... A report, 'Use of hematopoietic stem cells in obstetrics and gynecology,' is newly published data in Transfusion and Apheresis Science. "Stem cells can be used in different areas of obstetrics and gynecology. Adult stem cells are specialized...

Introgen Therapeutics Reports Second Quarter 2008 Financial Results and Recent Corporate Highlights.(Financial report)
August 18, 2008... Introgen Therapeutics, Inc. (NASDAQ: INGN), a developer of targeted molecular therapies for cancer, announced its financial results for the quarter and six months ended June 30, 2008, and highlighted recent corporate and product developments...

Findings from University of Maryland advance knowledge in bioengineering.
August 25, 2008... According to recent research from the United States, "Our past research has focused on identifying an effective carrier composed of histidine and lysine for delivery of nucleic acid into cells. For this purpose, we developed...

Findings from F. Wei and co-authors broaden understanding of cancer gene therapy.
August 25, 2008... "To evaluate the potential effect of anticancer and antiangiogenesis of Stx1(W203F) and Stx1(R170H), two attenuated mutants of Shiga-like toxin I (Stx1), in cancer gene therapy. Antiproliferative effects of these Stx1 mutants were tested in...

Findings from National Cheng-Kung University, Medical Department in cancer gene therapy reported.
August 25, 2008... "Cervical cancer is the second most common type of malignant tumor among women worldwide. When the disease is confined locally, it can be controlled with surgical resection and radiotherapy," scientists writing in the journal Cancer Gene...

New data from Sichuan University illuminate research in cancer gene therapy.(Report)
August 25, 2008... "Aurora kinase A has been demonstrated to be involved in the malignant progression of many types of cancer including prostate cancer, we therefore hypothesized that Aurora kinase A might work as a valuable target for prostate cancer treatment....

New findings from K. Kelly and co-researchers in the area of cancer gene therapy described.
August 25, 2008... According to recent research from the United States, "Many cancers can cause disability and pain by invading nerves. In particular, prostate carcinoma has a high propensity for neural invasion (NI) at an early stage." "Attempted surgical...

Research from Tulane University in the area of cancer gene therapy published.
August 25, 2008... According to a study from the United States, "Targeted gene delivery for induced apoptosis of transitional cell carcinomas was carried out in vivo in mice via utilization of the murine cyclooxygenase type 2 (Cox-2) promoter (Tis10). MB49 cells,...

Research on cancer gene therapy reported by scientists at University of Michigan.
August 25, 2008... "Selective gene transfer to tumor is critical in cancer gene therapy. We previously used ionizing radiation to improve adenovirus uptake in intrahepatic tumors but liver cytotoxicity associated with the viral administration still occurred,"...

Research reports on cancer gene therapy from Y.H. Li and colleagues provide new insights.
August 25, 2008... According to a study from Beijing, People's Republic of China, "Tumor growth and metastasis depend critically on blood vessel formation. Antiangiogenesis, therefore, represents a promising strategy for cancer therapy." "The kringle 5 (K5)...

Scientists at University of Helsinki report research in cancer gene therapy.
August 25, 2008... According to recent research from Helsinki, Finland, "Prior infection has primed most adult humans for a rapid neutralizing antibody (NAb) response when re-exposed to adenovirus. NAb induction can severely limit the efficacy of systemic...

Reports outline gene therapy study results from S. Yu et al.
August 25, 2008... According to recent research published in the journal Cancer Gene Therapy, "Recombinant human fibronectin fragment (FN-CH296, RetroNectin) has been widely used for retroviral gene therapy to enhance gene transfer efficiency. Based on the...

Research reports from M. Peled and co-authors provide new insights into gene therapy.
August 25, 2008... According to recent research from Or Yehuda, Israel, "Ad-PPE-Fas-c is an adenovector that expresses Fas-c under the control of the modified pre-proendothelin-1 (PPE-1) promoter. Fas-c is a chimeric death receptor containing the extracellular...

Studies from Columbus Children's Hospital in the area of gene therapy described.
August 25, 2008... "Fanconi anemia ( FA) is a rare recessive syndrome, characterized by congenital anomalies, bone marrow failure, and predisposition to cancer. Two earlier clinical trials utilizing gamma-retroviral vectors for the transduction of autologous FA...

Data from C.L. White and colleagues advance knowledge in reovirus.
August 25, 2008... "There is an emerging realization from animal models that the immune response may have both detrimental and beneficial therapeutic effects during cancer virotherapy. However, there is a dearth of clinical data on the immune response to viral...

New cancer gene therapy study findings have been published by scientists at Nara Medical University, Department of Pathology.(Report)
August 25, 2008... New research, 'Function of JunB in transient amplifying cell senescence and progression of human prostate cancer,' is the subject of a report. According to recent research from Nara, Japan, "Replicative senescence in cells acts as a barrier...

Nova Southeastern University, Department of Pharmaceutical Sciences details research in cancer gene therapy.
August 25, 2008... A report, 'Identification of HDM2 as a regulator of VEGF expression in cancer cells,' is newly published data in Life Sciences. "Overexpression of vascular endothelial growth factor (VEGF) and the extent of neoangiogenesis are closely...

Study data from University of Sao Paulo, Institute of Biomedical Science update understanding of cancer gene therapy.
August 25, 2008... Fresh data on cancer gene therapy are presented in the report 'Adhesion and protease activity in cell lines from human salivary gland tumors are regulated by the laminin-derived peptide AG73, syndecan-1 and beta1 integrin.' According to a study...