Cancer Gene Therapy Week articles from August 2004

Cancer Gene Therapy Week archives from August 2004

Role of TEL-AML1 fusion gene in molecular pathogenesis of ALL elucidated.
August 2, 2004... 2004 AUG 2 - (NewsRx.com & NewsRx.net) -- The role of the TEL-AML1 fusion gene in the molecular pathogenesis of acute lymphoblastic leukemia is elucidated. "Balanced chromosomal translocations are frequently associated with hematopoietic...

P13K signaling essential for ABL oncogene-mediated B cell transformation.
August 2, 2004... 2004 AUG 2 - (NewsRx.com & NewsRx.net) -- Phosphoinositide 3-kinase signaling is essential for ABL oncogene-mediated B cell transformation. According to recent research from the United States, "BCR-ABL and v-ABL are oncogenic forms of the...

The kinase inhibitor p27Kip1 is deregulated in thyroid cancer.
August 2, 2004... 2004 AUG 2 - (NewsRx.com & NewsRx.net) -- The kinase inhibitor p27Kip1 is deregulated in thyroid cancer. "We show that treatment of a panel of thyroid carcinoma cell lines naturally harboring the RET/PTC1 oncogene, with the RET kinase...

Non-electrophoretic assays screen for chemical inhibitors of DNA ligase.
August 2, 2004... 2004 AUG 2 - (NewsRx.com & NewsRx.net) -- Non-electrophoretic assays screen for chemical inhibitors of DNA ligase. "A new rapid assay method for DNA ligases has been developed, which allows direct quantification of enzyme activity without...

Oncological impact of gene expression profiling reviewed.
August 2, 2004... 2004 AUG 2 - (NewsRx.com & NewsRx.net) -- The oncological impact of gene expression profiling has been reviewed. "Genomics has enabled the examination of the totality of disease at the transcriptome level," scientists in the United States...

PI3 kinase promotes CLL cell survival by preventing caspase 8 activation.
August 2, 2004... 2004 AUG 2 - (NewsRx.com & NewsRx.net) -- PI3 kinase promotes survival of chronic lymphocytic leukemia (CLL) B cells by preventing caspase-8 activation. According to scientists in Chicago, "[s]tudies to investigate signal transduction...

Balanced-PCR facilitates genomic DNA analysis.
August 2, 2004... 2004 AUG 2 - (NewsRx.com & NewsRx.net) -- A "balanced" polymerase chain reaction (PCR) assay facilitates analysis of mildly degraded genomic DNA. "Analysis of genomic DNA derived from cells and fresh or fixed tissues often requires whole...

Chiron acquires San Diego company.
August 2, 2004... 2004 AUG 2 - (NewsRx.com & NewsRx.net) -- Chiron Corp. (CHIR) and Sagres Discovery announced that Chiron has acquired Sagres. Sagres, a privately held company headquartered in Davis, California, focuses on the discovery and validation of...

Ensemble decision approach improves identification of disease-linked genes.
August 2, 2004... 2004 AUG 2 - (NewsRx.com & NewsRx.net) -- A novel approach to microarray data analysis may facilitate the identification of genes linked to malignancy and other disease states. "Current applications of microarrays focus on precise...

Canadian biotech company acquires NewBiotics Inc.
August 2, 2004... 2004 AUG 2 - (NewsRx.com & NewsRx.net) -- Celmed BioSciences has completed the acquisition of NewBiotics Inc., a biopharmaceutical developer of cancer therapies, Theratechnologies (TH) has announced. This all share transaction closed...

Hypoxia-inducible factors regulate prolyl hydroxylases.
August 2, 2004... 2004 AUG 2 - (NewsRx.com & NewsRx.net) -- Hypoxia-inducible factors regulate prolyl hydroxylase expression. "Hypoxia and induction of hypoxia-inducible factors (HIF-1alpha and HIF-2alpha) is a hallmark of many tumors," scientists in the...

Proteomics company names Dr. Wenpei Su as director of genomics applications.
August 2, 2004... 2004 AUG 2 - (NewsRx.com & NewsRx.net) -- CeMines, Inc., a privately held company founded in 2000 that uses genomics and proteomics information as the fundamental building blocks for gene regulation, has appointed Wenpei Su, PhD, as the...

Radiolabeled peptide nucleic acids elicit site-specific DNA damage.
August 2, 2004... 2004 AUG 2 - (NewsRx.com & NewsRx.net) -- Radiolabeled peptide nucleic acids elicit site-specific DNA damage. "Peptide nucleic acids (PNAs) bind tightly and sequence-specifically to single- and double-stranded nucleic acids, and are hence...

CDKN2A/ARF gene mutation insignificant risk of FMM or MM in cancer aggregates.
August 2, 2004... 2004 AUG 2 - (NewsRx.com & NewsRx.net) -- The CDKN2A and ARF gene mutations confer an insignificant risk of familial malignant melanoma or malignant melanoma in cancer family aggregates. According to recent research published in the...

Reduced menin encourages intestinal cell tumorigenesis.
August 2, 2004... 2004 AUG 2 - (NewsRx.com & NewsRx.net) -- Reduced menin encourages intestinal cell tumorigenesis. "Menin, the product of the tumor suppressor gene MEN1, is widely expressed in mammalian endocrine and non-endocrine tissues, including...

Vet school professor using gene therapy to battle cancerous tumors.
August 9, 2004... 2004 AUG 9 - (NewsRx.com & NewsRx.net) -- Shulin Li, associate professor in the Louisiana State University (LSU) School of Veterinary Medicine's department of comparative biomedical sciences, is developing a gene therapy treatment for cancer...

Modified suppression subtractive hybridization detects tumor suppressor genes.
August 9, 2004... 2004 AUG 9 - (NewsRx.com & NewsRx.net) -- Modified suppression subtractive hybridization detects tumor suppressor genes. "Identification of tumor-specific antigens and genetic pathways may lead to potential diagnostic and therapeutic...

Replication-competent viruses offer a way to disseminate cancer therapy.
August 9, 2004... 2004 AUG 9 - (NewsRx.com & NewsRx.net) -- Replication-competent viruses offer a way to disseminate cancer therapy. "Most cases of cancer, when detected at an advanced stage, cannot be cured with conventional therapeutic modalities....

The cytokine inhibitor ISIS 104838 extends bioavailability upon oral intake.
August 9, 2004... 2004 AUG 9 - (NewsRx.com & NewsRx.net) -- The cytokine inhibitor ISIS 104838 extends bioavailability upon oral intake. According to a study from Belgium, "an in vivo study was performed to determine the tolerability and pharmacokinetics of...

Angiopoietin decoy alters angiogenesis to stop tumors.
August 9, 2004... 2004 AUG 9 - (NewsRx.com & NewsRx.net) -- Angiopoietin decoy alters angiogenesis to stop tumors. According to recent research from Italy, "the extracellular domain of the receptor tyrosine kinase Tie2/TEK (exTEK) has been used as an...

IFIX is a new interferon-inducible HIN-200 gene with anticancer properties.
August 9, 2004... 2004 AUG 9 - (NewsRx.com & NewsRx.net) -- IFIX is a new interferon-inducible HIN-200 gene with anticancer properties. "We identified IFIX as a new member of the hematopoietic interferon (IFN)-inducible nuclear protein with the...

U.S. Treasury approves bioscience, cancer drug companies Cuban products purchase.
August 9, 2004... 2004 AUG 9 - (NewsRx.com & NewsRx.net) -- YM BioSciences Inc. (YMBA), a cancer drug development company, announced that the U.S. Treasury Department has approved an agreement between YM BioSciences and CancerVax Corporation (CNVX). Under...

Murine models optimize high voltage-assisted drug delivery.
August 9, 2004... 2004 AUG 9 - (NewsRx.com & NewsRx.net) -- Murine models optimize high voltage-assisted drug delivery. According to recent research from Germany, "the artificial electrotransfer of bioactive agents such as drugs, peptides or therapeutical...

Bioresearch companies publish atomic structure of human histone deacetylase.
August 9, 2004... 2004 AUG 9 - (NewsRx.com & NewsRx.net) -- Syrrx Inc., a drug discovery company, has published the first atomic structure of a member of the class I histone deacetylases, human histone deacetylase 8 (HDAC8), in a recent issue of Structure. ...

Concurrent RNA interference reduces brain cancer proliferation.
August 9, 2004... 2004 AUG 9 - (NewsRx.com & NewsRx.net) -- Concurrent RNA interference reduces brain cancer proliferation. According to published research from the United States, "extracellular proteases have been shown to cooperatively influence matrix...

p53 mutants induce oncogenesis by transactivating growth-promoting genes.
August 9, 2004... 2004 AUG 9 - (NewsRx.com & NewsRx.net) -- p53 mutants induce oncogenesis by transactivating growth-promoting genes. "We have studied the mechanism of mutant p53-mediated oncogenesis using several tumor-derived mutants. Using a colony...

Overexpressed SOX9 transcription factor foils prostate cancer growth.
August 9, 2004... 2004 AUG 9 - (NewsRx.com & NewsRx.net) -- Overexpressed SOX9 transcription factor foils prostate cancer growth. According to recent research from the United States, "overexpression of mac25 in the prostate cancer cell line M12 effects a...

Genes associated with aggressive disease identified.
August 9, 2004... 2004 AUG 9 - (NewsRx.com & NewsRx.net) -- Several genes associated with aggressive oral squamous cell carcinoma (OSCC) have been identified. A group of researchers in Canada conducted a study "to classify OSCCs based on their gene...

Mus81 expression has critical role in genome integrity and tumor suppression.
August 9, 2004... 2004 AUG 9 - (NewsRx.com & NewsRx.net) -- Mus81 expression has a critical role in genome integrity and tumor suppression. "Mus81-Eme1 endonuclease has been implicated in the rescue of stalled replication forks and the resolution of meiotic...

eEPCs home to hypoxic lung metastases upon i.v. administration.
August 16, 2004... 2004 AUG 16 - (NewsRx.com & NewsRx.net) -- "We show that mouse embryonic endothelial progenitor cells (eEPCs) home preferentially to hypoxic lung metastases when administered intravenously," researchers writing in the journal Cancer Cell...

Methlonine synthase polymorphism D919G alters susceptibility to CNS lymphoma.
August 16, 2004... 2004 AUG 16 - (NewsRx.com & NewsRx.net) -- Methlonine synthase polymorphism D919G alters susceptibility to primary CNS lymphoma. "Primary central nervous system lymphomas (PCNSL) frequently reveal genomic instability. "We analyzed...

Performance of rapid HIV antibody detection assays evaluated.
August 16, 2004... 2004 AUG 16 - (NewsRx.com & NewsRx.net) -- Researchers have evaluated the performance of the OraQuick and Hema-Strip rapid HIV antibody detection assays by non-laboratorians. According to a study from the United States, "Rapid HIV antibody...

Steroid sulfatase inhibitors inhibit MCF-7 breast cancer cell gene activation.
August 16, 2004... 2004 AUG 16 - (NewsRx.com & NewsRx.net) -- Steroid sulfatase inhibitors inhibit MCF-7 breast cancer cell gene activation. According to recent research published in the Journal of Steroid Biochemistry and Molecular Biology, "A number of...

NIH renews funding to researchers for rb2 tumor-suppressing gene.
August 16, 2004... 2004 AUG 16 - (NewsRx.com & NewsRx.net) -- Antonio Giordano, MD, PhD, director of the Sbarro Institute for Cancer Research and Molecular Medicine, and co-director of the Center for Biotechnology in Temple University's College of Science and...

WT1 gene expression studied as marker for minimal residual disease JMML and MDS.
August 16, 2004... 2004 AUG 16 - (NewsRx.com & NewsRx.net) -- WT1 gene expression was studied as a marker for minimal residual disease in pediatric patients with juvenile myelo-monocytic leukemia and myelodysplastic syndromes. "The WT1 gene is considered to...

Company identifies 12,723 A to I RNA editing sites in the human transcriptome.
August 16, 2004... 2004 AUG 16 - (NewsRx.com & NewsRx.net) -- Compugen, Ltd., (CGEN) announced the systematic identification of adenosine to inosine (A to I) RNA editing sites in the human transcriptome, increasing the number of known A to I editing sites from...

Anti-CD44 mAbs induce differentiation and inhibit proliferation of AML cells.
August 16, 2004... 2004 AUG 16 - (NewsRx.com & NewsRx.net) -- Anti-CD44 monoclonal antibodies induce differentiation and inhibit proliferation of acute myeloid leukemia cells. "Acute myeloid leukemia (AML) is a clonal malignant disease characterized by an...

Tumor-focused biomedical company wins another electroporation patent.
August 16, 2004... 2004 AUG 16 - (NewsRx.com & NewsRx.net) -- Genetronics Biomedical Corp. (GEB), a late-stage biomedical company primarily developing cancer therapies focused on improving the quality of life of patients treated for solid tumors, has been granted...

Disruption of MKK4 signaling reveals its tumor-suppressor role in ESC.
August 16, 2004... 2004 AUG 16 - (NewsRx.com & NewsRx.net) -- Disruption of MKK4 signaling reveals its tumor-suppressor role in embryonic stem cells. "The dual Ser/Thr kinase MKK4 and its downstream targets JNK and p38 regulate critical cellular functions...

Group announces successful cancer surgery using tissue-bonding technology.
August 16, 2004... 2004 AUG 16 - (NewsRx.com & NewsRx.net) -- Consortium Service Management Group, Inc., (CTUM) (CSMG), announced the results of oncological clinical trials in Ukraine using the company's patented live biological tissue-bonding technology. ...

NK4 suppresses liver metastasis in murine colon cancer models.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- NK4 suppresses liver metastasis in murine colon cancer models. According to a study from Japan, "hepatocyte growth factor (HGF) is involved in malignant behavior of cancer cells by enhancing...

Complement receptor-related gene tumor vaccine induces antitumor activity.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- Mouse complement receptor-related gene y/p65-neutralized tumor vaccine induces antitumor activity in vivo. According to a study from Japan and the United States, "Two mouse tumor cell lines, Meth...

Thymidine phosphorylase activity predicts of 5'-dFUR sensitivity.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- Thymidine phosphorylase (TP) activity predicts the 5'-dFUR sensitivity of colorectal tumors. In a recent study from Japan, oncologists "confirmed that the enzyme activity" of TP "can substitute...

Adenovirus-mediated mda-7 gene therapy sensitizes lung tumors to radiation.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- Adenovirus-mediated mda-7 gene therapy sensitizes lung tumors to radiation. "Melanoma differentiation-associated gene-7 (mda-7), recently classified as interleukin-24 (approved gene symbol IL24),...

DNA vaccine targets human papillomavirus type 16 E6 or E7 oncoprotein.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- DNA vaccine targets human papillomavirus type 16 E6 or E7 oncoprotein According to recent research from the United States, "DNA vaccines expressing the E6 or E7 oncoproteins of human papilloma...

DNA microarrays useful for pediatric ALL classification.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- DNA microarray data is useful for classification of acute lymphoblastic leukemia (ALL) in children. According to recent research from Denmark, "[g]ene expression profiling is a promising tool for...

Pro-apoptotic therapy works with combined gene transfer to strike down glioma.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- Pro-apoptotic therapy works with combined gene transfer to strike down glioma. "Recently, we have reported the therapeutic efficacy of delivering initiator caspase (caspase-8) or executioner active...

Cell type-specific responses to chemotherapy determined.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- Cell type-specific responses to chemotherapy have been characterized in breast tumors. According to recent research from the United States, "[r]ecent microarray studies have identified distinct...

Local cytokine gene delivery + chemotherapy tested in mouse model of metastasis.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- University of Utah pharmaceutical researchers report that augmenting systemic paclitaxel therapy with local cytokine delivery using a non-viral vector inhibited mammary tumor growth and metastases in...

Cancer-focused genetics company reports second quarter 2004 financial results.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- Seattle Genetics, Inc. (SGEN) reported financial results for the second quarter ending June 30, 2004. Revenues for the second quarter of 2004 were $1.5 million, slightly higher than revenues in...

Plans for patented cancer therapy manufacturing facility in Poland approved.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- Lubgen Farma Sp. zo.o., a wholly owned subsidiary of S.R. Burzynski (OTCBB:BZYR), announced that the Polish government's chief pharmaceutical inspector in Warsaw, Poland, approved plans for a...

Therapeutic idiotype vaccines in B lymphoproliferative diseases reviewed.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- Investigators review therapeutic idiotype vaccines in B lymphoproliferative diseases in a recent issue of Expert Opinion on Biological Therapy. According to a study from the United States, "The...

Phase 2 clinical trial initiated for SGN-15 biomarker to set dosage.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- Seattle Genetics, Inc. (SGEN) has initiated a phase 2 clinical trial of SGN-15, an antibody-drug conjugate (ADC), for the treatment of non-small cell lung cancer (NSCLC). The phase II study will...

Aspirin-induced gene expression changes identified.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- Aspirin-induced changes in gene expression have been identified in colon tumor cells. "Aspirin and other non-steroidal anti-inflammatory drugs show efficacy in the prevention of colon cancer,"...

Human CXCR4 promoter is a unique target for renal cell carcinoma gene therapy.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- Human CXCR4 promoter is a unique target for renal cell carcinoma gene therapy. According to a study from Israel, "metastatic renal cell carcinoma (RCC) is often resistant to standard treatment,...

Bcl-2 can be targeted for cancer eradication.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- Bcl-2 can be targeted for cancer eradication. "The antiapoptotic members of the Bcl-2 family of proteins play multiple roles in cancer. These membrane-integrated proteins inhibit the pro-apoptotic...

Genes affected by endocrine disruption vary with age.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- The effect of endocrine disruption on gastric tumor gene expression varies with patient age. In a recent study, oncologists in South Korea "compared the differential expression profiles of genes...

NK4 gene transfer stops the dissemination of gallbladder cancer.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- NK4 gene transfer stops the dissemination of gallbladder cancer. According to a study from Japan, "gallbladder cancer cells are stimulated by hepatocyte growth factor (HGF) in vitro and in vivo. We...

n-Butyrate modulates the bystander effect of HSV-TK/ganciclovir gene therapy.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- n-Butyrate modulates the bystander effect of HSV-TK/ganciclovir gene therapy. "The efficacy of herpes simplex virus-thymidine kinase (HSV-TK)/ganciclovir gene therapy largely relies on the...

Conditionally replicating adenovirus locates EBV-positive nasopharyngeal cancer.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- Conditionally replicating adenovirus locates EBV-positive nasopharyngeal cancer. According to recent research published in the journal Molecular Therapy, "successful attainment of tumor-specific...

Interleukin-18 mutant gene transfer activates antitumor immunity.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- Interleukin-18 mutant gene transfer activates antitumor immunity. According to researchers in South Korea, "we report here that gene transfer using recombinant adenoviruses encoding interleukin...

Viral DNA recombination improves transgene expression in liver tumor cells.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- Viral DNA recombination improves transgene expression in liver tumor cells. "One strategy for improving selectivity of gene therapy is the use of a replication-activated adenovirus vector that...

The melanoma inhibitory activity promoter guides suicide gene therapy.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- The melanoma inhibitory activity promoter guides suicide gene therapy. "Suicide gene therapy of malignant melanoma essentially requires efficient gene transfer and highly selective therapeutic gene...

A novel mouse model will better depict carcinoembryonic antigen-based therapy.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- A novel mouse model will better depict carcinoembryonic antigen-based therapy. According to recent research from Canada, "many novel cancer therapies, including immunotherapy and gene therapy, are...

Gene expression profiling reveals novel estramustine phosphate targets.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- Gene expression profiling has been used to identify novel targets of estramustine phosphate (EMP) in prostate cancer cells. EMP is "a compound widely used for the treatment of hormone-refractory...

Prolactin-inducible protein expression elevated in prostate carcinomas.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- Prolactin-inducible protein (PIP) expression is elevated in prostate carcinomas. PIP, "also known as gross cystic disease fluid protein 15, is a predominant secretory protein in various body...

Interferon-inducible protein-10 needs CXCR3 for angiostatic activity.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- Interferon-inducible protein-10 needs CXCR3 for angiostatic activity. According to recent research from the United States, "human interferon-inducible protein 10 (IP-10; HGMW-approved gene symbol...

Combination gene therapy staunches melanoma growth and metastasis.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- Combination gene therapy staunches melanoma growth and metastasis. According to a study from South Korea, "transfection of the antiangiogenic angiostatin and endostatin genes was shown to be an...

Suppressed Bcl-X-L blocks the tumorigenic potential of oncogenic enzyme.
August 23, 2004... 2004 AUG 23 - (NewsRx.com & NewsRx.net) -- Suppressed Bcl-X-L blocks the tumorigenic potential of oncogenic enzyme. According to recent research published in the journal Blood, "deregulated apoptosis is a common finding in tumorigenesis....

Sulforaphane modulates genes linked to cancer formation.
August 30, 2004... 2004 AUG 30 - (NewsRx.com & NewsRx.net) -- Sulforaphane modulates genes linked to cancer formation. According to a study from the United States, "sulforaphane (SUL) is one member of the isothiocyanate class of cancer chemopreventive...

CRE-decoy oligonucleotides and chemotherapy reduce colorectal cancer growth.
August 30, 2004... 2004 AUG 30 - (NewsRx.com & NewsRx.net) -- CRE-decoy oligonucleotides and chemotherapy reduce colorectal cancer growth. According to a study from England, "the cAMP response element consensus sequence directs the transcription of a wide...

B7-1 gene transduction enhances immune response to metastatic tumor cells.
August 30, 2004... 2004 AUG 30 - (NewsRx.com & NewsRx.net) -- B7-1 gene transduction enhances immune response to metastatic tumor cells. According to recent research from Japan, "B7-1, a co-stimulatory factor, has been reported to induce cytotoxic T...

Receptor-specific polyplexes pinpoint breast cancer cells.
August 30, 2004... 2004 AUG 30 - (NewsRx.com & NewsRx.net) -- Receptor-specific polyplexes pinpoint breast cancer cells. "A series of novel nonviral vectors targeting the HER-2/neu gene product human epidermal growth factor receptor-2 (HER2) were constructed...

Maspin gene expression could be exploited as anti-cancer therapy.
August 30, 2004... 2004 AUG 30 - (NewsRx.com & NewsRx.net) -- Maspin gene expression could be exploited as anti-cancer therapy. "Maspin, which belongs to the serine protease inhibitor (serpin) superfamily, has been proposed as a potent tumor suppressor that...

Antisense RNA staunches glioma angiogenesis and growth.
August 30, 2004... 2004 AUG 30 - (NewsRx.com & NewsRx.net) -- Antisense RNA staunches glioma angiogenesis and growth. According to recent research from Japan, "malignant gliomas, most of which show an elevated level of vascular endothelial cell growth factor...

Midkine promoter-based gene therapy decimates malignant glioma.
August 30, 2004... 2004 AUG 30 - (NewsRx.com & NewsRx.net) -- Midkine promoter-based gene therapy decimates malignant glioma. "Little is known concerning promoters or gene therapy specific for malignant glioma. To explore the potential use of midkine promoter...

Bcl-2 antisense oligodeoxynucleotide chemosensitizes breast carcinoma cells.
August 30, 2004... 2004 AUG 30 - (NewsRx.com & NewsRx.net) -- Bcl-2 antisense oligodeoxynucleotide chemosensitizes breast carcinoma cells. According to recent research published in the journal Breast, "this study was designed to observe whether the rates of...

Indole-3-carbinol augments IFN responsiveness in breast tumor cells.
August 30, 2004... 2004 AUG 30 - (NewsRx.com & NewsRx.net) -- Indole-3-carbinol (I3C) augments IFNgammaR1 gene expression and interferon responsiveness in breast tumor cells. I3C, "a naturally occurring compound of Brassica vegetables, has promising...

Life sciences company reports on second quarter 2004 results.
August 30, 2004... 2004 AUG 30 - (NewsRx.com & NewsRx.net) -- ProMetic Life Sciences Inc. (TSX: PLI) reported on its business and financial results for the second quarter ended June 30, 2004. - Human cytotoxic T lymphocites (CTL) stimulated by PBI-1393 proven...

Lentiviral transfection of dendritic cells upregulates alloreactive T cells.
August 30, 2004... 2004 AUG 30 - (NewsRx.com & NewsRx.net) -- Lentiviral transfection of dendritic cells upregulates alloreactive T cells. According to recent research from Japan, "gene-modified dendritic cells (DCs) are promising targets for cancer...

Biotechnology company and ViroTarg sign anticancer license agreement.
August 30, 2004... 2004 AUG 30 - (NewsRx.com & NewsRx.net) -- Psiron Ltd signed a worldwide license agreement with ViroTarg Pty Limited, and its major shareholders, The University of Newcastle Research Associates (TUNRA) Ltd and SciCapital Pty Limited. The...

Mechanism described by which POU transcription factor represses growth in vitro.
August 30, 2004... 2004 AUG 30 - (NewsRx.com & NewsRx.net) -- Results of a study from Japan suggest the POU transcription factor human Skn-1a "represses growth of the cervical cancer cells through the partial resumption of the differentiation pathway followed by...

Child with atypical CML treated successfully with imatinib mesylate.
August 30, 2004... 2004 AUG 30 - (NewsRx.com & NewsRx.net) -- A child with atypical chronic myelogenous leukemia was treated successfully with imatinib mesylate. "Atypical chronic myelogenous leukemia (aCML) is a myelodysplastic/myeloproliferative disorder...

Triplex-forming oligonucleotides halt colon carcinoma growth in mice.
August 30, 2004... 2004 AUG 30 - (NewsRx.com & NewsRx.net) -- Triplex-forming oligonucleotides halt colon carcinoma growth in mice. "We have previously shown that oligonucleotides designed to bind in triplex fashion to a specific p53 binding site homology...